2021
Molecular mechanisms of estrogen action in female genital tract development
Alderman MH, Taylor HS. Molecular mechanisms of estrogen action in female genital tract development. Differentiation 2021, 118: 34-40. PMID: 33707128, PMCID: PMC8073215, DOI: 10.1016/j.diff.2021.01.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGene expressionSelective estrogen receptor modulatorsFemale genital tract developmentAberrant CpG methylationGenital tract developmentHistone modificationsEpigenetic regulationOrgan developmentCpG methylationTranscriptional pathwaysSpecific fetalEpigenetic modulationMolecular mechanismsFemale reproductive tractLate organogenesisHormonal regulationOrganogenesisEstrogen receptor modulatorsTract developmentReproductive tractIndependent fashionRegulationDisease statesEstrogen actionReceptor modulators
2020
3D in situ imaging of female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice
Ded L, Hwang JY, Miki K, Shi HF, Chung JJ. 3D in situ imaging of female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice. ELife 2020, 9: e62043. PMID: 33078708, PMCID: PMC7707823, DOI: 10.7554/elife.62043.Peer-Reviewed Original ResearchConceptsFemale reproductive tractFemale tractCalcium channel complexSitu molecular imagingReproductive tractMolecular insightsSuccessful fertilizationCatSper channelsMolecular signaturesSperm cellsSperm selectionChannel complexMouse spermatozoaFertilization siteSpermSperm migrationSpermatozoaMammalsPhosphorylationCatSper1ProteinSitu imagingAcrosomeUtero-tubal junctionSelection
2019
Coding and Legal Issues in Obstetric and Gynecologic Ultrasound
Shwayder JM, Copel JA, Stohl H. Coding and Legal Issues in Obstetric and Gynecologic Ultrasound. Obstetrics And Gynecology Clinics Of North America 2019, 46: 853-862. PMID: 31677758, DOI: 10.1016/j.ogc.2019.07.012.Chapters
2018
Metabolism of the oocyte and the preimplantation embryo
Scott R, Zhang M, Seli E. Metabolism of the oocyte and the preimplantation embryo. Current Opinion In Obstetrics & Gynecology 2018, 30: 163-170. PMID: 29708901, DOI: 10.1097/gco.0000000000000455.Peer-Reviewed Original ResearchB Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters
Johnson RM, Yu H, Strank N, Karunakaran K, Zhu Y, Brunham RC. B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters. Infection And Immunity 2018, 86: 10.1128/iai.00614-17. PMID: 29158429, PMCID: PMC5778355, DOI: 10.1128/iai.00614-17.Peer-Reviewed Original ResearchConceptsMemory lymphocyte clustersPeripheral blood mononuclear cellsT cell subsetsAntigen-presenting cellsT cell clonesB cell populationsT cellsLymphocyte clustersCell subsetsB cellsTissue-resident memory T cellsCD4 T-cell clonesCD4 T cell subsetsHuman peripheral blood mononuclear cellsCell clonesMemory T cellsBlood mononuclear cellsIL-13 responsesImmune B cellsB cell presentationCell populationsAdoptive transferImmune miceIntracellular bacterial pathogenChlamydia antigen
2015
The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility
Du H, Taylor HS. The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility. Cold Spring Harbor Perspectives In Medicine 2015, 6: a023002. PMID: 26552702, PMCID: PMC4691806, DOI: 10.1101/cshperspect.a023002.Peer-Reviewed Original ResearchConceptsReproductive tract developmentEndometrial developmentTract developmentPolycystic ovarian syndromeFemale reproductive tract developmentFemale reproductive trackOvarian syndromeEndometrial receptivityImplantation rateFemale infertilityGene expressionMüllerian defectsHOXA11 expressionGene mutationsReproductive trackAdult functionDevelopmental abnormalitiesHOXA10AbnormalitiesEndocrine disruptorsDiethylstilbestrolImplantationEssential regulatorExpressionActin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase
Hudson AM, Mannix KM, Cooley L. Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase. Genetics 2015, 201: 1117-1131. PMID: 26384358, PMCID: PMC4649639, DOI: 10.1534/genetics.115.181289.Peer-Reviewed Original ResearchConceptsKelch functionE3 ligaseCullin-RING E3 ligaseGermline ring canalsActin cytoskeletal organizationDrosophila kelch proteinUbiquitin ligase activityCross-link F-actinUbiquitin E3 ligaseRing canalsKelch proteinProtein substratesCytoskeletal defectsCytoskeletal organizationCytoskeletal remodelingLigase activityCullin 3KelchF-actinCytoskeletonLigaseProteasomeVivoCul3MutagenesisGrading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining
Ezaldein H, Lott JP, McNiff JM, Hui P, Buza N, Ko CJ. Grading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining. Journal Of Cutaneous Pathology 2015, 42: 519-526. PMID: 25951050, DOI: 10.1111/cup.12525.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCross-Sectional StudiesCyclin-Dependent Kinase Inhibitor p16FemaleGenitalia, FemaleHumansImmunohistochemistryMaleMiddle AgedNeoplasm ProteinsObserver VariationPapillomavirus InfectionsSensitivity and SpecificitySkin DiseasesSquamous Intraepithelial Lesions of the CervixUterine Cervical NeoplasmsConceptsGenital skin lesionsHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsP16 immunostainingSkin lesionsDiagnostic agreementIntraepithelial lesionsUseful adjunctive markerHigh-grade dysplasiaCross-sectional studyRoutine microscopic evaluationDegree of atypiaAdjunctive markerInter-observer agreementPrimary outcomeCervical lesionsHistopathologic assessmentHistopathologic evaluationConsensus diagnosisReactive atypiaEosin stainingOriginal diagnosisAtypiaLesions
2014
Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body
Talbert-Slagle K, Atkins KE, Yan KK, Khurana E, Gerstein M, Bradley EH, Berg D, Galvani AP, Townsend JP. Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body. PLOS Pathogens 2014, 10: e1004092. PMID: 24811311, PMCID: PMC4014458, DOI: 10.1371/journal.ppat.1004092.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2012
Plac8-Dependent and Inducible NO Synthase-Dependent Mechanisms Clear Chlamydia muridarum Infections from the Genital Tract
Johnson RM, Kerr MS, Slaven JE. Plac8-Dependent and Inducible NO Synthase-Dependent Mechanisms Clear Chlamydia muridarum Infections from the Genital Tract. The Journal Of Immunology 2012, 188: 1896-1904. PMID: 22238459, PMCID: PMC3303601, DOI: 10.4049/jimmunol.1102764.Peer-Reviewed Original ResearchConceptsGenital tract infectionCD4 T-cell clonesINOS-independent mechanismCD4 T cellsT cell clonesTract infectionsT cellsC. muridarum genital tract infectionCell clonesChlamydia muridarum infectionInducible NO synthase (iNOS) transcriptionT cell mechanismsT cell subsetsClearance of infectionGenital tract epitheliumT cell degranulationCytokine profileCell subsetsCell degranulationGenital tractClear infectionEffector functionsMouse modelNO productionVaccine development
2009
Stem Cells and Female Reproduction
Du H, Taylor HS. Stem Cells and Female Reproduction. Reproductive Sciences 2009, 16: 126-139. PMID: 19208782, PMCID: PMC3129037, DOI: 10.1177/1933719108329956.Peer-Reviewed Original ResearchConceptsStem cellsStem cell biologyEndometrial-derived stem cellsNon-reproductive tissuesDerived stem cellsReproductive biologyHematopoietic stem cellsCell biologyEtiology of endometriosisFemale reproductionMaternal diseaseEndometrial regenerationUterine disordersBone marrowRecent findingsBiologyMature oocytesReproductive diseasesCellsOocytesDiseaseTreatmentPotential implicationsReproductionEndometriosis
2008
Endocrine disruptors affect developmental programming of HOX gene expression
Taylor HS. Endocrine disruptors affect developmental programming of HOX gene expression. Fertility And Sterility 2008, 89: e57-e58. PMID: 18308065, PMCID: PMC2495774, DOI: 10.1016/j.fertnstert.2007.12.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndocrine DisruptorsFemaleGene Expression Regulation, DevelopmentalGenitalia, FemaleHomeodomain ProteinsHumans
2004
EMX2 Gene Expression in the Female Reproductive Tract and Aberrant Expression in the Endometrium of Patients with Endometriosis
Daftary GS, Taylor HS. EMX2 Gene Expression in the Female Reproductive Tract and Aberrant Expression in the Endometrium of Patients with Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 2390-2396. PMID: 15126568, DOI: 10.1210/jc.2003-031389.Peer-Reviewed Original ResearchMeSH KeywordsAdultBinding SitesCells, CulturedDNA-Binding ProteinsEndometriosisEndometriumFemaleGene ExpressionGenitalia, FemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansMenstrual CycleOligonucleotides, AntisenseProtein Structure, TertiaryRNA, MessengerStromal CellsTranscription FactorsTranscription, GeneticConceptsEndometrium of patientsPeriimplantation endometriumHOXA10 expressionMenstrual cycle-dependent expressionPrimary endometrial stromal cellsStromal cellsEndometrial HOXA10 expressionAbsence of endometriosisEndometrial stromal cellsEMX2 expressionReproductive tract developmentFemale reproductive tractHOXA10 antisenseHOXA10 levelsNormal endometriumSex steroidsEndometriosisEndometriumPeriimplantation periodEndometrial HOXA10Proliferative phaseReproductive tractAberrant expressionTract developmentMRNA levels
2002
Homeobox Gene Expression in Ovarian Cancer
Pando SM, Taylor HS. Homeobox Gene Expression in Ovarian Cancer. Cancer Treatment And Research 2002, 107: 231-245. PMID: 11775452, DOI: 10.1007/978-1-4757-3587-1_10.Peer-Reviewed Original ResearchConceptsHox genesHomeobox genesSpecific Hox genesVertebrate Hox genesHomeobox gene expressionVertebrate homeobox genesHomeotic complexPhenotype of miceHox complexVertebrate familiesHomologous genesMouse developmentSequence similarityDifferent organismsExpression patternsGene expressionBp sequenceGenesTargeted deletionInvertebratesGenomeHomeoboxSequenceFamilyVertebrates
2000
The oestrogen receptor (ER) in vulva, vagina and ovary
Schwartz PE. The oestrogen receptor (ER) in vulva, vagina and ovary. European Journal Of Cancer 2000, 36: 31-32. PMID: 11056307, DOI: 10.1016/s0959-8049(00)00214-8.Peer-Reviewed Original ResearchIn utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system
Block K, Kardana A, Igarashi P, Taylor H. In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system. The FASEB Journal 2000, 14: 1101-1108. PMID: 10834931, DOI: 10.1096/fasebj.14.9.1101.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell LineCycloheximideDiethylstilbestrolEstradiolFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGenitalia, FemaleHomeodomain ProteinsHumansIn Situ HybridizationLitter SizeMaleMiceMullerian DuctsOvaryPregnancyPrenatal Exposure Delayed EffectsRNA, MessengerTeratogensUterusVaginaConceptsHox gene expressionHox genesGene expressionExpression patternsPosterior Hox genesAnterior Hox genesReproductive tractAnterior transformationAcid regulationMolecular mechanismsReproductive tract developmentGenesHOXA10 gene expressionTract developmentExpressionCell culturesMullerian systemPregnant womenAnatomic abnormalitiesFemale offspringDrug usePosterior shiftPotential markerLater stagesMorphogensThe role of HOX genes in human implantation
Taylor H. The role of HOX genes in human implantation. Human Reproduction Update 2000, 6: 75-79. PMID: 10711832, DOI: 10.1093/humupd/6.1.75.Peer-Reviewed Original ResearchThe Role of HOX Genes in the Development and Function of the Female Reproductive Tract
Taylor H. The Role of HOX Genes in the Development and Function of the Female Reproductive Tract. Seminars In Reproductive Medicine 2000, 18: 081-090. PMID: 11299523, DOI: 10.1055/s-2000-13478.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndometriumFemaleGene Expression RegulationGenes, HomeoboxGenitalia, FemaleHomeodomain ProteinsHumansMiceMutationReproductionConceptsHox genesCommon genetic systemHox gene mutationsAdult functionReproductive tractEmbryonic patterningRegulatory genesGenetic systemTranscription factorsEmbryonic developmentFemale reproductive tractGenesReproductive tract developmentTract developmentGene mutationsMetazoansHuman endometrial developmentSpeciesRoleMutationsRegulationPatterningFunctionEndometrial developmentMüllerian systemImplantation in the Human: The Role of HOX Genes
Daftary G, Taylor H. Implantation in the Human: The Role of HOX Genes. Seminars In Reproductive Medicine 2000, 18: 311-320. PMID: 11299969, DOI: 10.1055/s-2000-12568.Peer-Reviewed Original ResearchConceptsHox genesHox gene expressionPattern of expressionTranscription factorsEssential regulatorGene expressionMolecular markersProper developmentPeri-implantation windowGenesTargeted disruptionEmbryonic periodReproductive tractPotential mechanismsExpressionRecent evidenceAdult uterusRegulatorHOXA11RoleUterine receptivityRegulationHOXA10MoleculesHumans
1997
A Conserved Hox Axis in the Mouse and Human Female Reproductive System: Late Establishment and Persistent Adult Expression of the Hoxa Cluster Genes
Taylor H, Heuvel G, Igarashi P. A Conserved Hox Axis in the Mouse and Human Female Reproductive System: Late Establishment and Persistent Adult Expression of the Hoxa Cluster Genes. Biology Of Reproduction 1997, 57: 1338-1345. PMID: 9408238, DOI: 10.1095/biolreprod57.6.1338.Peer-Reviewed Original ResearchConceptsHox genesHoxa-9Hoxa-13Hoxa-11Mammalian female reproductive systemFemale reproductive systemHOXA cluster genesTiming of geneHuman female reproductive systemReproductive systemTemporal colinearitySpatial colinearityCluster genesLate establishmentDevelopmental plasticityExpression patternsMolecular mechanismsParamesonephric ductsHOXA-10GenesAdult expressionEmbryonic miceColinearityPersistent expressionMüllerian tract
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