2024
Ursodeoxycholic acid and severe COVID-19 outcomes in a cohort study using the OpenSAFELY platform
Costello R, Waller K, Smith R, Mells G, Wong A, Schultze A, Mahalingasivam V, Herrett E, Zheng B, Lin L, MacKenna B, Mehrkar A, Bacon S, Goldacre B, Tomlinson L, Tazare J, Rentsch C. Ursodeoxycholic acid and severe COVID-19 outcomes in a cohort study using the OpenSAFELY platform. Communications Medicine 2024, 4: 238. PMID: 39562612, PMCID: PMC11576861, DOI: 10.1038/s43856-024-00664-y.Peer-Reviewed Original ResearchCOVID-19 hospitalisationSevere COVID-19 outcomesCOVID-19 related hospitalisationCOVID-19 outcomesCohort studyPopulation-based cohort studyHazard ratioPrimary care recordsDeath registration dataOpenSAFELY-TPP platformApproval of NHS EnglandConfidence intervalsEstimate hazard ratiosCox proportional hazards regressionProportional hazards regressionPre-specified confoundersAbsolute risk reductionOpenSAFELY platformCare recordsNHS EnglandConfounder adjustmentEligible individualsRegistration dataHazards regressionHospital recordsAccessing breast cancer care in a protracted conflict: Qualitative exploration of the perspectives of women with breast cancer in northwest Syria
Marzouk M, Hamze M, Debel J, Alshemali A, Alameen B, Bakkour M, Galal B, Chagpar A, Atassi B, Khoshnood K, Abbara A. Accessing breast cancer care in a protracted conflict: Qualitative exploration of the perspectives of women with breast cancer in northwest Syria. Social Science & Medicine 2024, 361: 117364. PMID: 39357306, DOI: 10.1016/j.socscimed.2024.117364.Peer-Reviewed Original ResearchSyrian American Medical SocietyBreast cancer carePerspective of womenSemi-structured interviewsCancer careExperiences of accessing careBreast cancerAmerican Medical SocietyBreast cancer diagnosisAvailability of radiotherapyThematic saturationAccessing CareHealthcare staffOncology careNorthwest SyriaPeer supportSocial supportThematic analysisClinical careFinancial strainMultiple intersectional challengesCancer diagnosisCareAccess diagnosisHospital records
2023
Effect Modifiers of the Association of High-Flow Nasal Cannula and Bronchiolitis Length of Stay.
Winer J, Richardson T, Berg K, Berry J, Chang P, Etinger V, Hall M, Kim G, Meneses Paz J, Treasure J, Aronson P. Effect Modifiers of the Association of High-Flow Nasal Cannula and Bronchiolitis Length of Stay. Hospital Pediatrics 2023, 13: 1018-1027. PMID: 37795554, PMCID: PMC10593863, DOI: 10.1542/hpeds.2023-007295.Peer-Reviewed Original ResearchConceptsEffect of HFNCICU servicesEffect modifiersHigh-flow nasal cannula therapyMulticenter retrospective cohort studyPediatric Health Information SystemAge groupsHigh-flow nasal cannulaNon-ICU patientsRetrospective cohort studyComplex chronic conditionsMultivariable Poisson regressionFuture prospective studiesPotential effect modifiersInitial desaturationInitial tachypneaCohort studyClinical factorsNasal cannulaHospital recordsProspective studyHospitalized childrenChronic conditionsHFNCPatientsFrequency, Type, and Degree of Potential Harm of Adverse Safety Events among Pediatric Emergency Medical Services Encounters
Cicero M, Baird J, Brown L, Auerbach M, Adelgais K. Frequency, Type, and Degree of Potential Harm of Adverse Safety Events among Pediatric Emergency Medical Services Encounters. Prehospital Emergency Care 2023, 28: 883-889. PMID: 37698357, DOI: 10.1080/10903127.2023.2257775.Peer-Reviewed Original ResearchAdverse safety eventsDiagnosis/EMS encountersFluid administrationPediatric encountersSafety eventsCare categoriesClinical decisionEmergency medical services (EMS) patientsMedical service patientsCross-sectional studyPotential harmMedical service encountersChart reviewHospital recordsService patientsPrehospital recordsEMS patientsMedication administrationUnintended injuryFrequent associationPatientsClinical interventionsHarm severityEMS agenciesIdiopathic myointimal hyperplasia of the mesenteric veins: A systematic review and individual patient data regression analysis
Rozner R, Gisriel S, Damianos J, Grimshaw A, Rizwan R, Nawaz A, Chan K, Wan D, Pantel H, Bhutta A, Fenster M, Brandt L, Barbieri A, Robert M, Feuerstadt P, Li D. Idiopathic myointimal hyperplasia of the mesenteric veins: A systematic review and individual patient data regression analysis. Journal Of Gastroenterology And Hepatology 2023, 38: 1040-1046. PMID: 37086041, DOI: 10.1111/jgh.16193.Peer-Reviewed Original ResearchConceptsIdiopathic myointimal hyperplasiaColonic ischemiaMesenteric veinRectal bleedingRectal involvementMyointimal hyperplasiaSystematic reviewYounger ageMultivariate logistic regression analysisCurative surgical resectionInferior mesenteric veinPre-surgical identificationLogistic regression analysisRegression analysisIschemic colitisAbdominal painMucosal ulcerationEndoscopic findingsSelect patientsSurgical resectionUncommon causeDiagnostic delaySurgical treatmentClinical featuresHospital records
2022
Valproic acid–induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey
Hosseini H, Shafie M, Shakiba A, Ghayyem H, Mayeli M, Hassani M, Aghamollaii V. Valproic acid–induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey. Psychopharmacology 2022, 240: 149-156. PMID: 36459199, DOI: 10.1007/s00213-022-06289-0.Peer-Reviewed Original ResearchConceptsValproic acid (VPA)-induced hyperammonemiaVPA levelsLevels of VPASerum levelsNeuropsychiatric disordersElevated serum ammonia levelsAmmonia serum levelsValproic acid-induced hyperammonemiaRare adverse effectSerum ammonia levelAmmonia levelsVPA dosageNo significant differenceVPA-induced HANeuropsychiatric medicationsMethodsA totalTotal doseMedical historyTreatment durationHospital recordsPatientsHA groupClinical surveyHyperammonemiaSignificant differenceExplaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway
Mohus RM, Gustad LT, Furberg AS, Moen MK, Liyanarachi KV, Askim Å, Åsberg SE, DeWan AT, Rogne T, Simonsen GS, Nilsen TIL, Åsvold BO, Damås JK, Solligård E. Explaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway. Scientific Reports 2022, 12: 8436. PMID: 35589812, PMCID: PMC9118181, DOI: 10.1038/s41598-022-12569-8.Peer-Reviewed Original ResearchConceptsIncident bloodstream infectionCardiovascular risk factorsBloodstream infectionsBSI mortalityRisk factorsHigh riskHealth behaviorsFirst-time bloodstream infectionRisk of BSIPotential modifiable risk factorsPopulation-based HUNT StudyModifiable risk factorsSex differencesHospital recordsProspective studyHUNT StudyExcess riskMediation analysisCausal mediation analysisEffects of sexMortalityComorbiditiesWomenMenRisk
2020
Mortality in sickle cell disease: A population‐based study in an aboriginal community in the Gudalur Valley, Nilgiris, Tamil Nadu, India
Sheshadri V, Shabeer P, Santhirapala V, Jayaram A, Krishnamurti L, Menon N. Mortality in sickle cell disease: A population‐based study in an aboriginal community in the Gudalur Valley, Nilgiris, Tamil Nadu, India. Pediatric Blood & Cancer 2020, 68: e28875. PMID: 33381914, DOI: 10.1002/pbc.28875.Peer-Reviewed Original ResearchConceptsSickle cell diseaseCause of deathCell diseaseMortality rateSeverity of SCDAge groupsAboriginal populationAcute chest syndromePopulation-based studyPercent of deathsCrude mortality rateCommunity-based comprehensive careCause of mortalityCases of deathPaucity of dataCommon monogenic disorderChest syndromeMedian ageHospital recordsSCD patientsAutopsy questionnaireAboriginal communitiesComprehensive careLongitudinal cohortRemote Aboriginal communities
2019
Distinct predictive values of current neuroprognostic guidelines in post-cardiac arrest patients
Zhou SE, Maciel CB, Ormseth CH, Beekman R, Gilmore EJ, Greer DM. Distinct predictive values of current neuroprognostic guidelines in post-cardiac arrest patients. Resuscitation 2019, 139: 343-350. PMID: 30951843, PMCID: PMC6589093, DOI: 10.1016/j.resuscitation.2019.03.035.Peer-Reviewed Original ResearchConceptsPost-cardiac arrest patientsAmerican Heart AssociationArrest patientsPredictive valueDiffuse hypoxic-ischemic injurySingle tertiary care centerDistinct predictive valuesHypoxic-ischemic injuryOutcomes of patientsTertiary care centerLife-sustaining therapyIntensive care medicineFalse positive rateAAN guidelinesAHA guidelinesHospital recordsCardiac arrestHeart AssociationCare centerCurrent guidelinesCare medicineBetter outcomesBiochemical findingsPatientsAmerican Academy
2018
Chemotherapy effect on daytime sleepiness and contributing factors in older adults with cancer
Saberzadeh-Ardestani B, Khosravi B, Zebardast J, Sadighi S. Chemotherapy effect on daytime sleepiness and contributing factors in older adults with cancer. Journal Of Geriatric Oncology 2018, 10: 632-636. PMID: 30377061, DOI: 10.1016/j.jgo.2018.10.003.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsActivities of Daily LivingAgedAged, 80 and overAntineoplastic AgentsAnxietyCross-Sectional StudiesDepressionDisorders of Excessive SomnolenceFemaleHumansIranLogistic ModelsMaleMiddle AgedNeoplasmsPrevalenceQuality of LifeRisk FactorsSleep Initiation and Maintenance DisordersSleepinessConceptsHospital Anxiety and Depression ScaleInstrumental Activities of Daily Living (IADLAnxiety and Depression ScaleCancer Institute of IranCross-sectional studyDemographic dataPatients' sleep problemsQuality of lifePhysical activityPrevalence of excessive daytime sleepinessInstrumental activitiesDepression ScaleOlder adultsEffect of chemotherapy treatmentExcessive daytime sleepinessPredictors of excessive daytime sleepinessHospital recordsLogistic regressionEpworth Sleepiness ScalePsychological factorsCancer InstitutePredictors of daytime sleepinessSleep problemsSenior patientsSleep disturbanceAssociations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study
Braithwaite EC, Hill J, Pickles A, Glover V, O’Donnell K, Sharp H. Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study. Journal Of Developmental Origins Of Health And Disease 2018, 9: 425-431. PMID: 29631648, PMCID: PMC6075696, DOI: 10.1017/s2040174418000181.Peer-Reviewed Original ResearchConceptsInfant birth weightBirth weightPrenatal cortisolMaternal prenatal cortisolWirral Child HealthFetal growthChild healthAffective disordersDevelopment Study cohortGeneral population estimatesSex-dependent mannerSex-specific mechanismsInverse probability weightsSex-specific effectsCurve cortisolWeeks' gestationGestational ageHospital recordsStudy cohortRisk stratifierFetal programmingGeneral populationGlucocorticoid mechanismsSignificant associationCortisolEvaluation of the Association between Lithium Treatment and GSK3β Polymorphism in Bipolar Disorder Patients.
Altınbaş K, Yeşilbaş D, İnce B, Cansız A, Sılan F, Özdemir Ö, Gülöksüz S. Evaluation of the Association between Lithium Treatment and GSK3β Polymorphism in Bipolar Disorder Patients. Turkish Journal Of Psychiatry 2018, 29: 73-78. PMID: 30215834, DOI: 10.5080/u20582.Peer-Reviewed Original ResearchConceptsMean ageLithium treatmentTreatment responseGSK-3βBipolar disorder type IBipolar disorder patientsLack of evidenceClinical predictorsHospital recordsTreatment adherenceTreatment optionsDisease onsetFirst episodeReal-time PCRIndividualized treatmentPharmacogenomic findingsBlood samplesDisorder patientsSide effectsAG genotypeClinical practiceScale scoreBipolar disorderPatientsSample cohort
2017
Public Health Data in Action: An Analysis of Using Louisiana Vital Statistics for Quality Improvement and Payment Reform
Danilack V, Gee R, Berthelot D, Gurvich R, Muri J. Public Health Data in Action: An Analysis of Using Louisiana Vital Statistics for Quality Improvement and Payment Reform. Maternal And Child Health Journal 2017, 21: 988-994. PMID: 28316039, DOI: 10.1007/s10995-016-2254-z.Peer-Reviewed Original ResearchConceptsICD-9-CM codesEarly deliveryBirth certificatesHospital recordsPremature ruptureWomen's HospitalNational Perinatal Information CenterEarly term birthGestational hypertensive disordersSpontaneous active laborTerm singleton birthsHospital discharge recordsAdministrative dataAbnormal heart rateHypertensive disordersGestational diabetesFetal distressTerm birthsActive laborSingleton birthsMaternal deliveryHeart rateCommon reasonDischarge dataMedical reasons
2015
Change in radiotherapy treatment volumes with initial alkylating chemotherapy in anaplastic gliomas
Jairam V, Rutter C, Yu J, Bindra R. Change in radiotherapy treatment volumes with initial alkylating chemotherapy in anaplastic gliomas. Journal Of Radiation Oncology 2015, 4: 163-167. DOI: 10.1007/s13566-015-0193-8.Peer-Reviewed Original ResearchAdjuvant chemotherapyAnaplastic astrocytomaRT volumeAnaplastic gliomasGlioma patientsMaximal responseAnaplastic glioma patientsRadiotherapy treatment volumesStable diseaseSalvage radiotherapyPathologic factorsHospital recordsChemotherapyPatientsIndependent sample t-testRadiotherapyTarget volumePercentage changeVolumetric reductionTreatment volumeSample t-testProgressionT-testGliomasSalvage
2014
ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data
Li J, Li X, Wang Q, Hu S, Wang Y, Masoudi FA, Spertus JA, Krumholz HM, Jiang L, Group F. ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data. The Lancet 2014, 385: 441-451. PMID: 24969506, PMCID: PMC4415374, DOI: 10.1016/s0140-6736(14)60921-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedAspirinChinaClopidogrelFemaleFibrinolytic AgentsHealthcare DisparitiesHospital MortalityHospitals, RuralHospitals, UrbanHumansMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionPatient AdmissionPercutaneous Coronary InterventionQuality of Health CareRetrospective StudiesTiclopidineTreatment OutcomeConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionHospital mortalityHospital admissionMyocardial infarctionRetrospective analysisPrimary percutaneous coronary interventionAcute myocardial infarction admissionsProportion of patientsUse of aspirinPercutaneous coronary interventionMyocardial infarction admissionsTwo-stage random sampling designQuality of careAnalysis of treatmentBaseline characteristicsCardiac eventsHospital outcomesHospital stayCoronary interventionFamily Planning CommissionClinical profileHospital recordsMedian lengthSTEMI admissions
2012
‘Bovine’ Aortic Arch – A Marker for Thoracic Aortic Disease
Hornick M, Moomiaie R, Mojibian H, Ziganshin B, Almuwaqqat Z, Lee ES, Rizzo JA, Tranquilli M, Elefteriades JA. ‘Bovine’ Aortic Arch – A Marker for Thoracic Aortic Disease. Cardiology 2012, 123: 116-124. PMID: 23037917, DOI: 10.1159/000342071.Peer-Reviewed Original ResearchConceptsThoracic aortic diseaseAortic diseaseBA groupRadiology reportsAortic expansion rateAortic growth rateThoracic aortic aneurysmAortic dissectionAortic ruptureHospital recordsAortic aneurysmAortic archAnatomic variantsClinical significanceGeneral populationMRI scansPatientsBA prevalenceDiseasePrevalenceDissectionReportRuptureAneurysmsGroup
2010
Association of Preanesthesia Hypertension With Adverse Outcomes
Wax D, Porter S, Lin H, Hossain S, Reich D. Association of Preanesthesia Hypertension With Adverse Outcomes. Journal Of Cardiothoracic And Vascular Anesthesia 2010, 24: 927-930. PMID: 20817562, DOI: 10.1053/j.jvca.2010.06.022.Peer-Reviewed Original ResearchConceptsAdverse outcomesRisk factorsBlood pressureBaseline SBP >Diastolic BP <Surgery hoursBaseline systolic BPPreinduction blood pressureSystolic BP >Adult elective surgical patientsStandard risk factorsIn-Hospital DeathIncidence of adverse outcomesBaseline systolic BP >Independent predictor of adverse outcomesNormalization of blood pressurePredictor of adverse outcomesElective surgical patientsHospital recordsCalendar yearDelay of surgeryIndependent risk factorAdverse cardiovascular outcomesIntraoperative heart rateCase cancellationsBurden of Seasonal Influenza Hospitalization in Children, United States, 2003 to 2008
Dawood FS, Fiore A, Kamimoto L, Bramley A, Reingold A, Gershman K, Meek J, Hadler J, Arnold KE, Ryan P, Lynfield R, Morin C, Mueller M, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Kirschke D, Finelli L, Network E. Burden of Seasonal Influenza Hospitalization in Children, United States, 2003 to 2008. The Journal Of Pediatrics 2010, 157: 808-814. PMID: 20580018, DOI: 10.1016/j.jpeds.2010.05.012.Peer-Reviewed Original ResearchConceptsSevere outcomesInfluenza hospitalizationsHospitalization ratesHospitalized childrenEmerging Infections Program NetworkIntensive care unit admissionInfections Program NetworkSeasonal influenza hospitalizationsCare unit admissionLaboratory-confirmed influenzaPopulation-based surveillanceUnderlying medical conditionsHigher hospitalization ratesRate of hospitalizationProportion of childrenRapid diagnostic testsUnit admissionRespiratory failureBacterial coinfectionClinical courseHospital recordsSeasonal influenzaMedical historyDisease burdenIncidence rate
2003
Accuracy of cystoscopy in the diagnosis of ureteral injury in benign gynecologic surgery
Dandolu V, Mathai E, Chatwani A, Harmanli O, Pontari M, Hernandez E. Accuracy of cystoscopy in the diagnosis of ureteral injury in benign gynecologic surgery. International Urogynecology Journal 2003, 14: 427-431. PMID: 14677006, DOI: 10.1007/s00192-003-1095-7.Peer-Reviewed Original ResearchConceptsUreteral injuryGynecologic surgeryRisk factorsBenign conditionsAccuracy of cystoscopyHigh-grade cystoceleRetrospective chart reviewBenign gynecologic surgeryTemple University HospitalNegative cystoscopyChart reviewPostoperative periodPrevious surgeryHospital recordsLarge uterusUniversity HospitalPartial obstructionCystoscopySurgeryInjuryUreteral patencyStudy periodEctopic insertionCystocelePatency
2001
Improving access to mammograms through community-based influenza clinics A quasi-experimental study
Shenson D, Cassarino L, DiMartino D, Marantz P, Bolen J, Good B, Alderman M. Improving access to mammograms through community-based influenza clinics A quasi-experimental study. American Journal Of Preventive Medicine 2001, 20: 97-102. PMID: 11165449, DOI: 10.1016/s0749-3797(00)00281-6.Peer-Reviewed Original ResearchConceptsInfluenza clinicsBreast cancer screeningUse of mammogramsPopulation-based surveyFurther control groupRadiology facilitiesPreventive health practicesNumber of mammogramsHospital recordsMammography statusRelative riskMammography useAvailable interventionsOlder womenControl groupQuasi-experimental studyClinicHealth practicesTelephone callsWomenMammography facilitiesFurther studiesMammographySemirural countyMammograms
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