2023
Outcomes of cold snare EMR of nonampullary duodenal adenomas ≥1 cm: a multicenter study
Wilson N, Abdallah M, Schulman A, Mosko J, Saeed A, Kothari S, Kaul V, Kothari T, Phan J, Kumar A, Tofani C, Kim R, Westanmo A, Moy B, Dang F, Canakis A, Sharma N, Muniraj T, Azeem N, Bilal M. Outcomes of cold snare EMR of nonampullary duodenal adenomas ≥1 cm: a multicenter study. Gastrointestinal Endoscopy 2023, 99: 971-980.e1. PMID: 38092125, DOI: 10.1016/j.gie.2023.12.007.Peer-Reviewed Original ResearchNonampullary duodenal adenomasEndoscopic mucosal resectionCold snare endoscopic mucosal resectionSnare endoscopic mucosal resectionDuodenal adenomasUse of electrocauteryAdverse eventsMucosal resectionMulticenter studyUnderwater endoscopic mucosal resectionLarge duodenal adenomasMulticenter retrospective studyRetrospective multicenter studyPredictors of recurrenceAcceptable recurrence rateHigh-grade dysplasiaFuture prospective studiesCases of perforationAdenoma rateSecondary outcomesImmediate bleedingPrimary outcomeRecurrent adenomasIndependent predictorsProspective studyPost Allogeneic Stem Cell Transplant Outcomes Following Response to Hypomethylating Agent Therapy in Myelodysplastic Syndromes Are Predicted By Persistent International Prognostic Scoring System-Molecular Risk
Frumm S, Kim H, Kelkar A, Ho V, Gooptu M, Gibson C, Koreth J, Shapiro R, Romee R, Nikiforow S, Antin J, Soiffer R, Rolles B, Shimony S, Bewersdorf J, Kewan T, Alhajahjeh A, Luskin M, Garcia J, Chen E, Lane A, Wadleigh M, Winer E, Stone R, DeAngelo D, Zeidan A, Lindsley C, Cutler C, Stahl M. Post Allogeneic Stem Cell Transplant Outcomes Following Response to Hypomethylating Agent Therapy in Myelodysplastic Syndromes Are Predicted By Persistent International Prognostic Scoring System-Molecular Risk. Blood 2023, 142: 3618. DOI: 10.1182/blood-2023-185220.Peer-Reviewed Original ResearchHematopoietic stem cell transplantBlood count recoveryPost-HCT outcomesComplete remissionTime of diagnosisMyelodysplastic syndromeOverall survivalHigh riskLower riskAgent therapyCount recoveryMolecular riskInternational Working Group response criteriaShorter median overall survivalResponse criteriaDana-Farber Cancer InstituteHCT comorbidity indexImportant prognostic impactTAC/sirolimusHost disease (GVHD) prophylaxisMedian overall survivalProgression-free survivalStem cell transplantBone marrow biopsyFuture prospective studiesEarly Clinical Outcomes of Patients With Stress-Induced Cardiomyopathy Receiving Acute Mechanical Support in the US
Jang S, Webber F, Alam M, Bae J, Aggarwal A, Thomas A, Zarich S, Ahmad T, Miller P, Davila C. Early Clinical Outcomes of Patients With Stress-Induced Cardiomyopathy Receiving Acute Mechanical Support in the US. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101185. PMID: 39131072, PMCID: PMC11308019, DOI: 10.1016/j.jscai.2023.101185.Peer-Reviewed Original ResearchAcute mechanical circulatory supportStress-induced cardiomyopathyRenal replacement therapyCardiogenic shockIndex hospitalizationReplacement therapyIntra-aortic balloon pumpAggressive hemodynamic supportHospital mortality rateNationwide Readmissions DatabaseMechanical circulatory supportFuture prospective studiesLarge national databaseObserved mortality differencesHospital mortalityMore comorbiditiesHospital deathHemodynamic supportBalloon pumpMembrane oxygenationClinical outcomesCirculatory supportProspective studyAdministrative databasesImpellaEffect Modifiers of the Association of High-Flow Nasal Cannula and Bronchiolitis Length of Stay.
Winer J, Richardson T, Berg K, Berry J, Chang P, Etinger V, Hall M, Kim G, Meneses Paz J, Treasure J, Aronson P. Effect Modifiers of the Association of High-Flow Nasal Cannula and Bronchiolitis Length of Stay. Hospital Pediatrics 2023, 13: 1018-1027. PMID: 37795554, PMCID: PMC10593863, DOI: 10.1542/hpeds.2023-007295.Peer-Reviewed Original ResearchConceptsEffect of HFNCICU servicesEffect modifiersHigh-flow nasal cannula therapyMulticenter retrospective cohort studyPediatric Health Information SystemAge groupsHigh-flow nasal cannulaNon-ICU patientsRetrospective cohort studyComplex chronic conditionsMultivariable Poisson regressionFuture prospective studiesPotential effect modifiersInitial desaturationInitial tachypneaCohort studyClinical factorsNasal cannulaHospital recordsProspective studyHospitalized childrenChronic conditionsHFNCPatientsMechanical thrombectomy beyond 24 hours from last known well in tandem lesions: A multicenter cohort study.
Rodriguez-Calienes A, Hassan A, Siegler J, Galecio-Castillo M, Farooqui M, Jumaa M, Janjua N, Divani A, Ribo M, Abraham M, Petersen N, Fifi J, Guerrero W, Malik A, Nguyen T, Sheth S, Yoo A, Linares G, Lu Y, Vivanco-Suarez J, Ortega-Gutierrez S. Mechanical thrombectomy beyond 24 hours from last known well in tandem lesions: A multicenter cohort study. Interventional Neuroradiology 2023, 15910199231196960. PMID: 37642978, DOI: 10.1177/15910199231196960.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageNIH Stroke ScaleMechanical thrombectomyHospital mortalityComplete reperfusionTandem lesionsFunctional independenceAnterior circulation tandem lesionsEffectiveness of MTMulticenter cohort studyLarge vessel occlusionFuture prospective studiesTreatment of patientsOutcomes of interestMulticenter registryStroke ScaleCohort studyIntracranial hemorrhageProspective studyVessel occlusionHematoma 2Treatment weightingPatientsInverse probabilityMortalitySex and frequency of pain episodes are associated with acute pain trajectories in adolescents with sickle cell disease
Astles R, Liu Z, Gillespie S, Lai K, Maillis A, Morris C, Lane P, Krishnamurti L, Bakshi N. Sex and frequency of pain episodes are associated with acute pain trajectories in adolescents with sickle cell disease. PAIN Reports 2023, 8: e1084. PMID: 37559677, PMCID: PMC10409410, DOI: 10.1097/pr9.0000000000001084.Peer-Reviewed Original ResearchHigher health care utilizationHealth care utilizationSickle cell diseaseAcute pain trajectoriesPain intensity scoresEmergency departmentPain trajectoriesPain episodesCell diseaseHigher mean pain intensity scoreIntensity scoresMean pain intensity scoreAcute pain episodesFrequency of painAdolescent female patientsFuture prospective studiesElectronic health recordsIntranasal opioidsPain frequencyAcute painPain intensityRetrospective reviewCare utilizationFemale patientsProspective studyAssociation between statin exposure and short-term mortality in patients with high-grade acute-on-chronic liver failure
Chapin S, Kaplan D, Taddei T, Mahmud N. Association between statin exposure and short-term mortality in patients with high-grade acute-on-chronic liver failure. JHEP Reports 2023, 5: 100740. PMID: 37215188, PMCID: PMC10193237, DOI: 10.1016/j.jhepr.2023.100740.Peer-Reviewed Original ResearchChronic liver failureShort-term mortalityRetrospective cohort studyStatin exposureLiver failureStatin useCohort studyLogistic regression modelsLower oddsHigh short-term mortalityVeterans Health Administration patientsDose exposureMultivariable logistic regression modelClasses of medicationsFuture prospective studiesVeterans Health AdministrationDose-dependent reductionPotential beneficial effectsStatin therapyTerm mortalityAnalytic cohortRegression modelsProspective studyReduced oddsACLFIdentifying treatment heterogeneity in atrial fibrillation using a novel causal machine learning method
Ngufor C, Yao X, Inselman J, Ross J, Dhruva S, Graham D, Lee J, Siontis K, Desai N, Polley E, Shah N, Noseworthy P, MN; New Haven C. Identifying treatment heterogeneity in atrial fibrillation using a novel causal machine learning method. American Heart Journal 2023, 260: 124-140. PMID: 36893934, PMCID: PMC10615250, DOI: 10.1016/j.ahj.2023.02.015.Peer-Reviewed Original ResearchConceptsOral anticoagulantsAtrial fibrillationPatient subgroupsComposite outcomeIschemic strokeEffect of OACsLifelong oral anticoagulationNonvitamin K antagonistNew oral anticoagulantsNonvalvular atrial fibrillationPrimary composite outcomeGlomerular filtration rateFuture prospective studiesOptumLabs Data WarehousePopulation-level effectivenessOAC useOral anticoagulationVASc scoreCause mortalityK antagonistsPrimary endpointWarfarin usersRenal functionAF patientsEntire cohort
2021
Nocardiosis and elevated beta-d-glucan in solid organ transplant recipients
Ringer M, Radcliffe C, Kerantzas CA, Malinis M, Azar MM. Nocardiosis and elevated beta-d-glucan in solid organ transplant recipients. IDCases 2021, 26: e01322. PMID: 34786341, PMCID: PMC8577490, DOI: 10.1016/j.idcr.2021.e01322.Peer-Reviewed Case Reports and Technical NotesSOT recipientsBeta-d-glucan (BDG) testingSolid organ transplantation recipientsSolid organ transplant recipientsElevated BDG levelsOrgan transplant recipientsOrgan transplantation recipientsCases of nocardiosisFuture prospective studiesCases of patientsInvasive fungal infectionsBDG testingTransplant recipientsTransplantation recipientsClinical courseCase seriesProspective studyCase definitionIdentified causeElevated betaBDG levelsNocardiosisCausal associationFungal infectionsRecipientsFactors affecting the resolution of acute non-infectious anterior scleritis
Abdel-Aty A, Kombo N. Factors affecting the resolution of acute non-infectious anterior scleritis. British Journal Of Ophthalmology 2021, 106: 1672-1677. PMID: 34210671, DOI: 10.1136/bjophthalmol-2021-318808.Peer-Reviewed Original ResearchConceptsNon-steroidal anti-inflammatory drugsSystemic non-steroidal anti-inflammatory drugsNon-infectious anterior scleritisAnterior scleritisHispanic raceNSAID useTumor necrosis factor-alpha inhibitorsNecrosis factor-alpha inhibitorsCox proportionate hazards modelDiffuse anterior scleritisNodular anterior scleritisRecords of patientsFuture prospective studiesDifferent patient groupsAnti-inflammatory drugsAcute scleritisBilateral scleritisNecrotising scleritisSystemic corticosteroidsImmunomodulatory therapyTopical corticosteroidsPatient characteristicsLupus erythematosusLupus diagnosisPatient group
2020
Opioid-Sparing Cardiac Anesthesia: Secondary Analysis of an Enhanced Recovery Program for Cardiac Surgery.
Grant M, Isada T, Ruzankin P, Gottschalk A, Whitman G, Lawton J, Dodd-O J, Barodka V. Opioid-Sparing Cardiac Anesthesia: Secondary Analysis of an Enhanced Recovery Program for Cardiac Surgery. Anesthesia & Analgesia 2020, 131: 1852-1861. PMID: 32889848, DOI: 10.1213/ane.0000000000005152.Peer-Reviewed Original ResearchConceptsIntraoperative opioid administrationEnhanced recovery programmeOpioid administrationCardiac surgeryNonopioid interventionsPostoperative outcomesNumber of interventionsOpioid patientsSecondary analysisSerratus anterior plane blockMorphine sulfate equivalentsOpioid-sparing strategiesPostoperative pain scoresFuture prospective studiesLength of stayLinear mixed-effects regression modelsMixed-effects regression modelsIntraoperative dexmedetomidineLower opioidPreoperative gabapentinMultimodal analgesiaPain scoresPostoperative complicationsOpioid usePlane blockPharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research
Bikdeli B, Madhavan MV, Gupta A, Jimenez D, Burton JR, Der Nigoghossian C, Chuich T, Nouri SN, Dreyfus I, Driggin E, Sethi S, Sehgal K, Chatterjee S, Ageno W, Madjid M, Guo Y, Tang LV, Hu Y, Bertoletti L, Giri J, Cushman M, Quéré I, Dimakakos EP, Gibson CM, Lippi G, Favaloro EJ, Fareed J, Tafur AJ, Francese DP, Batra J, Falanga A, Clerkin KJ, Uriel N, Kirtane A, McLintock C, Hunt BJ, Spyropoulos AC, Barnes GD, Eikelboom JW, Weinberg I, Schulman S, Carrier M, Piazza G, Beckman JA, Leon MB, Stone GW, Rosenkranz S, Goldhaber SZ, Parikh SA, Monreal M, Krumholz HM, Konstantinides SV, Weitz JI, Lip GYH, Group T. Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research. Thrombosis And Haemostasis 2020, 120: 1004-1024. PMID: 32473596, PMCID: PMC7516364, DOI: 10.1055/s-0040-1713152.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2COVID-19Respiratory syndrome coronavirus 2Subgroup of patientsCOVID-19 patientsFuture prospective studiesManagement of thrombosisSyndrome coronavirus 2Coronavirus disease 2019Mechanism of actionViral illnessThrombotic eventsRandomized trialsProspective studyAntithrombotic effectCoronavirus 2Antithrombotic agentsAntithrombotic drugsAntiviral effectDisease 2019Thrombotic diseaseAntithrombotic propertiesDosing approachWorldwide pandemicAssessment of Patient and Caregiver Attitudes and Approaches to Decision-Making Regarding Bone Marrow Transplant for Sickle Cell Disease
Bakshi N, Katoch D, Sinha C, Ross D, Quarmyne M, Loewenstein G, Krishnamurti L. Assessment of Patient and Caregiver Attitudes and Approaches to Decision-Making Regarding Bone Marrow Transplant for Sickle Cell Disease. JAMA Network Open 2020, 3: e206742. PMID: 32469414, PMCID: PMC7260617, DOI: 10.1001/jamanetworkopen.2020.6742.Peer-Reviewed Original ResearchConceptsBone marrow transplantCaregivers of patientsSickle cell diseasePatient decision aidMarrow transplantMedian ageCurative treatmentCell diseaseGroup 2Group 1Caregiver attitudesNovel disease-modifying therapiesDisease-modifying therapiesSickle cell clinicAssessment of patientsFuture prospective studiesRandomized clinical trialsParent trialProspective studyTreatment optionsClinical trialsNeeds assessment phaseMAIN OUTCOMECell clinicPatients
2019
A Doppler Echocardiographic Pulmonary Flow Marker of Massive or Submassive Acute Pulmonary Embolus
Afonso L, Sood A, Akintoye E, Gorcsan J, Rehman M, Kumar K, Javed A, Kottam A, Cardozo S, Singh M, Palla M, Ando T, Adegbala O, Shokr M, Briasoulis A. A Doppler Echocardiographic Pulmonary Flow Marker of Massive or Submassive Acute Pulmonary Embolus. Journal Of The American Society Of Echocardiography 2019, 32: 799-806. PMID: 31056367, DOI: 10.1016/j.echo.2019.03.004.Peer-Reviewed Original ResearchConceptsMassive pulmonary embolismSubmassive pulmonary embolismPulmonary embolismSubsegmental pulmonary embolismMcConnell's signExtent of PEDoppler flow patternsAcute pulmonary emboliFuture prospective studiesCharacteristic curve analysisSpectral Doppler interrogationAlternative imaging modalityNoninvasive signsUnderwent echocardiographyEchocardiographic parametersPulmonary hypertensionPulmonary emboliEchocardiography parametersProspective studyDoppler interrogationTomographic angiographyDeceleration timeDoppler variablesClinical utilityPatientsIncreased Fragility Fracture Rates in Older Men With Osteomyelitis
Hsieh E, Shiau S, Nolan O, Gibert CL, Bedimo RJ, Rodriguez-Barradas MC, Justice AC, Womack JA, Yin MT. Increased Fragility Fracture Rates in Older Men With Osteomyelitis. Clinical Infectious Diseases 2019, 69: 1239-1242. PMID: 30715288, PMCID: PMC6743834, DOI: 10.1093/cid/ciz077.Peer-Reviewed Original Research
2018
How Common—and How Serious— Is Clostridium difficile Colitis After Geriatric Hip Fracture? Findings from the NSQIP Dataset
Bovonratwet P, Bohl DD, Russo GS, Ondeck NT, Nam D, Della Valle CJ, Grauer JN. How Common—and How Serious— Is Clostridium difficile Colitis After Geriatric Hip Fracture? Findings from the NSQIP Dataset. Clinical Orthopaedics And Related Research® 2018, 476: 453-462. PMID: 29443839, PMCID: PMC6260047, DOI: 10.1007/s11999.0000000000000099.Peer-Reviewed Original ResearchConceptsHip fracture surgeryClostridium difficile colitisDifficile colitisGeriatric hip fracturesChronic care facilitiesHip fractureFracture surgeryPostoperative lengthGeriatric patientsHigh riskPreoperative anemiaCurrent smokersCare facilitiesStrict hand hygieneProphylactic antibiotic regimensFuture prospective studiesHospital quality metricsLarge database studiesStepwise multivariate modelLarge national databasePostdischarge dataAntibiotic regimensInfectious diagnosisPreoperative factorsProphylactic antibiotics
2016
The Efficacy of Bisphosphonates with Core Decompression and Mesenchymal Stem Cells Compared with Bisphosphonates Alone in the Treatment of Osteonecrosis of the Hip: A Retrospective Study
Gianakos A, Moya-Angeler J, Duggal S, Zambrana L, Fields K, Mintz D, Cornell C, Lane J. The Efficacy of Bisphosphonates with Core Decompression and Mesenchymal Stem Cells Compared with Bisphosphonates Alone in the Treatment of Osteonecrosis of the Hip: A Retrospective Study. HSS Journal ® 2016, 12: 137-144. PMID: 27385942, PMCID: PMC4916091, DOI: 10.1007/s11420-016-9487-7.Peer-Reviewed Original ResearchModified Harris Hip ScoreVisual analogue scoreTotal hip arthroplastyBisphosphonate therapyCore decompressionMesenchymal stem cellsFunctional outcomeTreatment groupsHip replacementFemoral headEfficacy of bisphosphonatesFicat stage IRadiologic outcome measuresHarris hip scoreYear of diagnosisTreatment of osteonecrosisFuture prospective studiesEarly-stage ONFHInclusion/exclusion criteriaStem cellsJoint preserving proceduresTotal hip replacementProgression of collapseFicat stageInstitution's registryManagement of Small Nonfunctional Pancreatic Neuroendocrine Tumors
Grisotti G, Khan S. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumors. Difficult Decisions In Surgery: An Evidence-Based Approach 2016, 641-653. DOI: 10.1007/978-3-319-27365-5_56.Peer-Reviewed Original ResearchNonfunctional pancreatic neuroendocrine tumorsPancreatic neuroendocrine tumorsSmall Nonfunctional Pancreatic Neuroendocrine TumorsNeuroendocrine tumorsSmall pancreatic neuroendocrine tumorsType 1Multiple endocrine neoplasia type 1Von Hippel-Lindau diseaseRole of surgeryFuture prospective studiesStandard of careHippel-Lindau diseaseNeurofibromatosis type 1Selective treatment approachSurgical resectionProspective studyNonsurgical approachHepatopancreaticobiliary surgeryMalignant potentialPancreatic tumorsPNET diagnosisSmall tumorsTuberous sclerosisCancer susceptibility syndromeTreatment approachesDigital health application for real-time patient-reported outcomes during prostate radiotherapy.
Yang D, Thea J, An Y, Yu J. Digital health application for real-time patient-reported outcomes during prostate radiotherapy. Journal Of Clinical Oncology 2016, 34: 157-157. DOI: 10.1200/jco.2016.34.2_suppl.157.Peer-Reviewed Original ResearchPatient-reported outcomesQuality of lifeProstate radiotherapyTreatment periodExpanded Prostate Index CompositeClinical practice surveyDaily radiation treatmentsGenitourinary Cancers SymposiumFuture prospective studiesProstate cancer patientsClinical trial dataPatient Data CollectionPaucity of dataClinical research toolCancer SymposiumRoutine followPatient reportingProspective studySingle institutionCancer patientsClinical trialsSide effectsQOL domainsPatientsTrial data
2014
Imaging and Functional Testing to Assess Clinical and Subclinical Neurological Events After Transcatheter or Surgical Aortic Valve Replacement A Comprehensive Review
Spaziano M, Francese DP, Leon MB, Généreux P. Imaging and Functional Testing to Assess Clinical and Subclinical Neurological Events After Transcatheter or Surgical Aortic Valve Replacement A Comprehensive Review. Journal Of The American College Of Cardiology 2014, 64: 1950-1963. PMID: 25444149, DOI: 10.1016/j.jacc.2014.07.986.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementAortic valve replacementNeurological eventsValve replacementFuture comparative trialsFuture prospective studiesProspective studyPoor prognosisComparative trialsSubclinical cognitive declineSurrogate endpointsCognitive declineTesting modalitiesTAVRTranscatheterOperator experienceModalitiesFunctional testingImagingPrognosisClinicalSymptomsIncidenceComprehensive reviewEndpoint
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