2020
Mortality in sickle cell disease: A population‐based study in an aboriginal community in the Gudalur Valley, Nilgiris, Tamil Nadu, India
Sheshadri V, Shabeer P, Santhirapala V, Jayaram A, Krishnamurti L, Menon N. Mortality in sickle cell disease: A population‐based study in an aboriginal community in the Gudalur Valley, Nilgiris, Tamil Nadu, India. Pediatric Blood & Cancer 2020, 68: e28875. PMID: 33381914, DOI: 10.1002/pbc.28875.Peer-Reviewed Original ResearchConceptsSickle cell diseaseCause of deathCell diseaseMortality rateSeverity of SCDAge groupsAboriginal populationAcute chest syndromePopulation-based studyPercent of deathsCrude mortality rateCommunity-based comprehensive careCause of mortalityCases of deathPaucity of dataCommon monogenic disorderChest syndromeMedian ageHospital recordsSCD patientsAutopsy questionnaireAboriginal communitiesComprehensive careLongitudinal cohortRemote Aboriginal communities
2019
The Relationship between Mental Health, Educational Attainment, Employment Outcomes, and Pain in Sickle Cell Disease
Harris K, Varughese T, Bauer A, Howdeshell S, Calhoun C, Abel R, King A. The Relationship between Mental Health, Educational Attainment, Employment Outcomes, and Pain in Sickle Cell Disease. Blood 2019, 134: 419. DOI: 10.1182/blood-2019-129874.Peer-Reviewed Original ResearchLength of painSickle cell diseaseSeverity of painHistory of depressionSevere painPain outcomesAnnual household incomePain crisisPain frequencyCell diseaseSocioeconomic statusMultivariate analysisSeverity of SCDSignificant associationEmployment statusMental healthHigher pain frequencyHospital admission frequencyEnd-organ damageFrequency of painVariety of complicationsPatients' educational attainmentCross-sectional studyOnly significant associationPatient survey data
2010
Iinsulin Levels and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) May Explain a Possible Important Role of the Pancreas In Sickle Cell Disease Patients Outcome
Seixas M, Lopes V, Cezar R, Carvalho G, Rocha L, Lyra I, Reis M, Goncalves M. Iinsulin Levels and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) May Explain a Possible Important Role of the Pancreas In Sickle Cell Disease Patients Outcome. Blood 2010, 116: 4811. DOI: 10.1182/blood.v116.21.4811.4811.Peer-Reviewed Original ResearchSickle cell diseaseC-reactive proteinInsulin levelsBlood cell countSCD patientsAspartate aminotransferaseHOMA-IRWBC countLactate dehydrogenaseHemoglobin concentrationCell countSeverity of SCDChronic sub-clinical inflammationWhite blood cell countSub-clinical inflammationHigher insulin levelsRed blood cell countCross-sectional studyLower insulin levelsHigher ferritin concentrationsHigher haptoglobin concentrationsImportant biomarkerInflammatory markersPain episodesChronic inflammation
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