2024
Bladder health in US women: population-based estimates from the RISE FOR HEALTH study
Smith A, Falke C, Rudser K, McGwin G, Brady S, Brubaker L, Kenton K, LaCoursiere D, Lewis C, Low L, Lowder J, Lukacz E, Mueller E, Newman D, Nodora J, Markland A, Putnam S, Rickey L, Rockwood T, Simon M, Stapleton A, Vaughan C, Wyman J, Sutcliffe S, Consortium P, Brubaker L, Fitzgerald C, Acevedo-Alvarez M, Hardacker C, Hebert-Beirne J, Griffith J, Kenton K, Simon M, Brown O, Geynisman-Tan J, Mueller M, Markland A, Vaughan C, Coyne-Beasley T, Burgio K, Lewis C, McGwin G, Williams B, Lukacz E, LaCoursiere D, Gahagan S, Nodora J, Low L, Miller J, Smith A, Rudser K, Brady S, Fok C, Harlow B, Scal P, Rockwood T, Newman D, Smith A, Berry A, Bilger A, Lipman T, Klusaritz H, Stapleton A, Wyman J, Sutcliffe S, James A, Lowder J, Meister M, Rickey L, Camenga D, Cunningham S, Norton J. Bladder health in US women: population-based estimates from the RISE FOR HEALTH study. American Journal Of Obstetrics And Gynecology 2024, 232: 538.e1-538.e13. PMID: 39521302, PMCID: PMC12056152, DOI: 10.1016/j.ajog.2024.10.044.Peer-Reviewed Original ResearchConceptsBladder healthGroup of womenHealth dimensionsUS womenUrinary symptomsWell-beingSample of community-dwelling womenMedian scoreCommunity-dwelling womenPopulation-based estimatesPopulation-based sampleScale scoreAbsence of urinary symptomsImpact of urinary symptomsPrevalence of urinary symptomsHealth variablesEligible participantsBaseline surveyFunction Index scoreOptimal healthSymptom toolsOnset of symptomsCohort studyPerceived impactHealthMIF-Modulated Spinal Proteins Associated with Persistent Bladder Pain: A Proteomics Study
Ye S, Agalave N, Ma F, Mahmood D, Al-Grety A, Khoonsari P, Leng L, Svensson C, Bucala R, Kultima K, Vera P. MIF-Modulated Spinal Proteins Associated with Persistent Bladder Pain: A Proteomics Study. International Journal Of Molecular Sciences 2024, 25: 4484. PMID: 38674069, PMCID: PMC11050327, DOI: 10.3390/ijms25084484.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Differentiation, B-LymphocyteCystitis, InterstitialDisease Models, AnimalFemaleHistocompatibility Antigens Class IIHyperalgesiaIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMiceProteomicsReceptors, CXCR4Receptors, ImmunologicSpinal CordUrinary BladderConceptsMacrophage migration inhibitory factorProtease activated receptor 4C-X-C chemokine receptor type 4Bladder hyperalgesiaBladder painSpinal proteinsMIF receptor CD74MIF antagonismL6-S1 spinal segmentsSpinal mechanismsInterstitial Cystitis/Bladder Pain SyndromeMIF receptorSeparate groups of miceChemokine receptor type 4Associated with reliefGroups of miceC-X-CMigration inhibitory factorChanges compared to controlsBladder inflammationPain syndromeFemale miceNo significant changesSham i.Receptor 4
2023
Preferences for Public Health Messaging Related to Bladder Health in Adolescent and Adult Women
Burgio K, Cunningham S, Newman D, Low L, Nodora J, Lipman T, Klusaritz H, James A, Rickey L, Gahagan S, Hebert-Beirne J, Kenton K, Williams B. Preferences for Public Health Messaging Related to Bladder Health in Adolescent and Adult Women. Journal Of Women's Health 2023, 32: 1120-1135. PMID: 37610853, PMCID: PMC10541935, DOI: 10.1089/jwh.2022.0463.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCommunicationFemaleFocus GroupsHumansPublic HealthQualitative ResearchSchoolsUrinary BladderOncological Outcomes for Patients with European Association of Urology Very High-risk Non–muscle-Invasive Bladder Cancer Treated with Bacillus Calmette-Guérin or Early Radical Cystectomy
Contieri R, Hensley P, Tan W, Grajales V, Bree K, Nogueras-Gonzalez G, Lee B, Navai N, Dinney C, Kamat A. Oncological Outcomes for Patients with European Association of Urology Very High-risk Non–muscle-Invasive Bladder Cancer Treated with Bacillus Calmette-Guérin or Early Radical Cystectomy. European Urology Oncology 2023, 6: 590-596. PMID: 37558542, DOI: 10.1016/j.euo.2023.07.012.Peer-Reviewed Original ResearchConceptsNon-muscle-invasive bladder cancerCancer-specific mortalityBacillus Calmette-GuerinHigh-grade recurrenceHigh-risk non-muscle-invasive bladder cancerOverall survivalBladder cancerEuropean Urological AssociationOncological outcomesNo significant differenceEarly RCPatients treated with bacillus Calmette-GuerinTreated with bacillus Calmette-GuerinNon-muscle invasive bladder cancerIntravesical BCGContemporary cohort of patientsCancer-specific mortality ratesProgression rateBacillus Calmette-Guerin groupEarly radical cystectomyMedian Follow-UpInvasive bladder cancerSignificant differenceCohort of patientsEarly surgical removalUrothelial Oxidative Stress and ERK Activation Mediate HMGB1-Induced Bladder Pain
Ye S, Mahmood D, Ma F, Leng L, Bucala R, Vera P. Urothelial Oxidative Stress and ERK Activation Mediate HMGB1-Induced Bladder Pain. Cells 2023, 12: 1440. PMID: 37408274, PMCID: PMC10217556, DOI: 10.3390/cells12101440.Peer-Reviewed Original ResearchConceptsHigh mobility group box 1Macrophage migration inhibitory factorBladder painOxidative stressDisulfide HMGB1Mobility group box 1MIF-deficient miceNovel potential therapeutic strategyMigration inhibitory factorGroup box 1Potential therapeutic strategyOxidative stress productionN-acetylcysteine amideERK activationIntravesical treatmentMicturition volumeMicturition parametersReceptor 4Mechanical thresholdPainTherapeutic strategiesBox 1Bladder tissueInhibitory factorWestern blotIs it time to reconsider how we document pediatric uroflow studies?: A study from the SPU Voiding Dysfunction task force
Van Batavia J, Pohl H, Farhat W, Chiang G, BaniHani A, Collett-Gardere T, Franco I. Is it time to reconsider how we document pediatric uroflow studies?: A study from the SPU Voiding Dysfunction task force. Journal Of Pediatric Urology 2023, 19: 546-554. PMID: 37302925, PMCID: PMC11931716, DOI: 10.1016/j.jpurol.2023.04.018.Peer-Reviewed Original ResearchMeSH KeywordsChildElectromyographyHumansReproducibility of ResultsUrinary BladderUrination DisordersUrodynamicsAvelumab First-line Maintenance Therapy for Advanced Urothelial Carcinoma: Comprehensive Clinical Subgroup Analyses from the JAVELIN Bladder 100 Phase 3 Trial
Grivas P, Park S, Voog E, Caserta C, Gurney H, Bellmunt J, Kalofonos H, Ullén A, Loriot Y, Sridhar S, Yamamoto Y, Petrylak D, Sternberg C, Gupta S, Huang B, Costa N, Laliberte R, di Pietro A, Valderrama B, Powles T. Avelumab First-line Maintenance Therapy for Advanced Urothelial Carcinoma: Comprehensive Clinical Subgroup Analyses from the JAVELIN Bladder 100 Phase 3 Trial. European Urology 2023, 84: 95-108. PMID: 37121850, DOI: 10.1016/j.eururo.2023.03.030.Peer-Reviewed Original ResearchConceptsBest supportive careProgression-free survivalAdvanced urothelial carcinomaPlatinum-based chemotherapyOverall survivalHazard ratioUrothelial carcinomaAnalysis of OSFirst-line maintenance therapyRelevant subgroupsCox proportional hazards modelClinical subgroup analysisPhase 3 trialKaplan-Meier methodProportional hazards modelFirst-line maintenanceMetastatic UCMaintenance therapyStable diseaseSupportive careComplete responsePartial responseAdvanced cancerPD-L1Maintenance treatmentDevelopment of a tool to assess bladder health knowledge, attitudes, and beliefs (BH‐KAB)
LaCoursiere D, Low L, Putnam S, Wyman J, Newman D, Cunningham S, Rickey L, Berry A, Gahagan S, Vaughan C, Brown O, Brady S, Consortium P. Development of a tool to assess bladder health knowledge, attitudes, and beliefs (BH‐KAB). Neurourology And Urodynamics 2023, 42: 1055-1067. PMID: 36905331, PMCID: PMC10293102, DOI: 10.1002/nau.25168.Peer-Reviewed Original ResearchConceptsBladder healthHealth knowledgeLower Urinary Tract Symptoms (PLUS) Research ConsortiumPelvic muscle exercisesUrinary tract infectionImpact of pregnancyPelvic floor disordersHealth Longitudinal StudyOveractive bladderTract infectionsUrinary incontinenceBladder functionMuscle exercisesFluid intakeHealth education programmingMedical conditionsBaseline assessmentConsortium studyExisting questionnairesClinical conversationsIncontinenceLongitudinal studyContent validityMeasures knowledgeItem developmentHealthy bladder storage and emptying functions in community‐dwelling women measured by a 2‐day bladder health diary
Lukacz E, Falke C, Geynisman‐Tan J, Wyman J, Mueller E, Markland A, Rickey L, Lowder J, Rudser K, Low L, Newman D, Consortium T. Healthy bladder storage and emptying functions in community‐dwelling women measured by a 2‐day bladder health diary. Neurourology And Urodynamics 2023, 42: 725-735. PMID: 36891924, PMCID: PMC10101892, DOI: 10.1002/nau.25169.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCross-Sectional StudiesFemaleHumansIndependent LivingMedical RecordsNocturiaPainUrinary BladderConceptsCommunity-dwelling womenBladder functionBladder storageUS cross-sectional studyPlanned secondary analysisCross-sectional studyDaytime voidsUrgency episodesVoiding frequencyEligible womenUrinary leakagePostvoid dribblingBladder problemsHealthy functionAbsence of leakageHealth diaryMost womenHealth instrumentsSecondary analysisPainWomenHealth researchPrevalenceFurther investigationDescriptive statisticsPediatric neurogenic bowel dysfunction: ICCS review document
Kelly M, Benninga M, Yang S, Franco I, Payne C, Wei C, Rodriguez L, Beierwaltes P, Tanaka S. Pediatric neurogenic bowel dysfunction: ICCS review document. Journal Of Pediatric Urology 2023, 19: 232-239. PMID: 36828731, DOI: 10.1016/j.jpurol.2023.01.015.Peer-Reviewed Original ResearchMeSH KeywordsChildConsensusFecal IncontinenceHumansIntestinal DiseasesNeurogenic BowelQuality of LifeUrinary BladderConceptsInternational Children's Continence SocietyNeurogenic bowel dysfunctionBowel dysfunctionLower urinary tract dysfunctionUrinary tract dysfunctionQuality of lifeNon-systematic reviewEvidence-based informationTract dysfunctionMonitoring of individualsHistory takingPhysical assessmentDysfunctionDiagnostic studiesCurrent literatureChildrenReviewCare
2022
Validation of bladder health scales and function indices for women’s research
Constantine M, Rockwood T, Rickey L, Bavendam T, Low L, Lowder J, Markland A, McGwin G, Mueller E, Newman D, Putnam S, Rudser K, Smith A, Stapleton A, Miller J, Lukacz E, Consortium O, Brubaker L, Mueller E, Acevedo-Alvarez M, Fitzgerald C, Hardacker C, Hebert-Beirne J, Lavender M, Griffith J, Kenton K, Simon M, Geynisman-Tan J, Markland A, Coyne-Beasley T, Burgio K, Lewis C, McGwin G, Vaughan C, Williams B, Lukacz E, Gahagan S, LaCoursiere D, Nodora J, Miller J, Low L, Harlow B, Rudser K, Brady S, Chu H, Constantine M, Fok C, Scal P, Rockwood T, Newman D, Smith A, Berry A, Bilger A, Klusaritz H, Lipman T, Stapleton A, Wyman J, Sutcliffe S, James A, Lowder J, Meister M, Rickey L, Brault M, Camenga D, Cunningham S, Barthold J. Validation of bladder health scales and function indices for women’s research. American Journal Of Obstetrics And Gynecology 2022, 228: 566.e1-566.e14. PMID: 36596439, PMCID: PMC10425263, DOI: 10.1016/j.ajog.2022.12.319.Peer-Reviewed Original ResearchConceptsFunction IndexKnown-groups validityBladder healthHealth ScaleLower urinary tract symptomsPopulation-based validation studyUrinary tract symptomsClinical Research CenterCondition-specific questionnaireIntraclass correlation coefficient modelT-testWomen's health researchHealth researchMode of administrationConvergent validityIntraclass correlation coefficientComparison of womenTract symptomsBladder diaryUrinary conditionFunction testingOptimal healthAdult womenChi-squareWomenOncologic outcomes of neoadjuvant chemotherapy in patients with micropapillary variant urothelial carcinoma of the bladder
Rahman S, Lokeshwar S, Syed J, Javier-Desloges J, Press B, Choksi A, Rajwa P, Pradere B, Ploussard G, Kim J, Monaghan T, Renzulli J, Shariat S, Leapman M. Oncologic outcomes of neoadjuvant chemotherapy in patients with micropapillary variant urothelial carcinoma of the bladder. Urologic Oncology Seminars And Original Investigations 2022, 41: 107.e1-107.e8. PMID: 36481253, DOI: 10.1016/j.urolonc.2022.09.008.Peer-Reviewed Original ResearchConceptsVariant urothelial carcinomaNeoadjuvant chemotherapySubset of patientsUrothelial carcinomaOverall survivalPathologic responseRadical cystectomyNAC useClinical stage II diseaseHospital-based registry studyNeoadjuvant platinum-based chemotherapyPathologic lymph node positivityCox proportional hazards modelNational Cancer DatabaseStage II diseaseLymph node positivityPathologic complete responsePlatinum-based chemotherapyKaplan-Meier analysisMultivariable logistic regressionAnalysis of patientsBladder urothelial carcinomaProportional hazards modelCT2 diseasePathologic upstagingThe effect of mesenchymal stem cells-derived exosomes on the prostate, bladder, and renal cancer cell lines
Rezaeian A, Khatami F, Heidari Keshel S, Akbari M, Mirzaei A, Gholami K, Mohammadi Farsani R, Aghamir S. The effect of mesenchymal stem cells-derived exosomes on the prostate, bladder, and renal cancer cell lines. Scientific Reports 2022, 12: 20924. PMID: 36463254, PMCID: PMC9719468, DOI: 10.1038/s41598-022-23204-x.Peer-Reviewed Original ResearchConceptsExpression of epithelial to mesenchymal transitionCancer cell linesProstate cancerMesenchymal stem cells-derived exosomesCell linesCells-derived exosomesHormone-refractory prostate cancerMSC-exosomesKidney cancer cell linesPercentage of apoptotic cellsProliferation of cancer cellsDecreased Bcl2 expressionEpithelial to mesenchymal transitionAnti-angiogenic effectsRenal cancer cell linesGene expression changesRealtime PCR methodKidney tumor cell lineOsteopontin variantsTumor cell linesVEGF-CAntitumor effectBladder cancerHormone-sensitiveRenal cancerNeed for Public Health Messaging Related to Bladder Health from Adolescence to Advanced Age
Burgio K, Cunningham S, Newman D, Low L, Nodora J, Lipman T, Gahagan S, Klusaritz H, James A, Rickey L, Kenton K, Hebert-Beirne J, Williams B, Brubaker L, Acevedo-Alvarez M, M. Fitzgerald C, T. Hardacker C, Lavender M, Geynisman-Tan J, W. Griffith J, Simon M, D. Markland A, Coyne-Beasley T, E. Lewis C, McGwin G, P. Vaughan C, S. Lukacz E, Gahagan S, LaCoursiere D, M. Miller J, L. Harlow B, D. Rudser K, S. Brady S, Chu H, S. Fok C, Scal P, Rockwood T, L. Smith A, Berry A, Klusaritz H, E. Stapleton A, F. Wyman J, Sutcliffe S, S. James A, L. Lowder J, R. Meister M, A. Brault M, R. Camenga D, Brubaker L, Barthold J. Need for Public Health Messaging Related to Bladder Health from Adolescence to Advanced Age. Journal Of Women's Health 2022, 32: 224-238. PMID: 36454206, PMCID: PMC9940805, DOI: 10.1089/jwh.2022.0185.Peer-Reviewed Original ResearchConceptsBladder healthPublic health messagingAge groupsHealth messagingPriority audienceIndividual prevention strategiesPublic healthAdvanced agePrevention strategiesUniform desireRisk statusLife courseHealthFocus group dataAgeStudy of habitsAdult women's experiencesFocus groupsMore researchWomen's experiencesGroupGroup dataParticipantsBladderSymptomsRISE FOR HEALTH: Rationale and protocol for a prospective cohort study of bladder health in women
Smith A, Rudser K, Harlow B, McGwin G, Barthold J, Brady S, Brubaker L, Cunningham S, Griffith J, Kenton K, Klusaritz H, Lewis C, Lukacz E, Maki J, Markland A, Mueller E, Newman D, Nodora J, Rickey L, Rockwood T, Simon M, Wyman J, Sutcliffe S, Consortium F. RISE FOR HEALTH: Rationale and protocol for a prospective cohort study of bladder health in women. Neurourology And Urodynamics 2022, 42: 998-1010. PMID: 36321762, PMCID: PMC10151425, DOI: 10.1002/nau.25074.Peer-Reviewed Original ResearchConceptsLower urinary tract symptomsBladder healthCohort studyLower Urinary Tract Symptoms (PLUS) Research ConsortiumProspective longitudinal cohort studyStudy designBladder health promotionProspective cohort studyUrinary tract symptomsClinical Research CenterLongitudinal cohort studySubset of participantsTract symptomsPrevention interventionsHealth promotionHealth StudySelf-administered surveyAdult womenEvidence basePerson assessmentNecessary evidence baseStudy proceduresWomenMultilevel factorsHealthVoided Volume for Assessment of Bladder Emptying After Female Pelvic Floor Surgery: A Randomized Controlled Trial
Popiel P, Getaneh F, Yeh J, Rickey L, Bercik R, Harmanli O. Voided Volume for Assessment of Bladder Emptying After Female Pelvic Floor Surgery: A Randomized Controlled Trial. Urogynecology 2022, 28: 811-818. PMID: 36409638, DOI: 10.1097/spv.0000000000001230.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansPelvic FloorPostoperative ComplicationsUrinary BladderUrinary IncontinenceUrinary Tract InfectionsUrinationConceptsUrogynecologic surgeryRF groupVoided volumeSV groupUrinary tract infection rateAssessment of bladderUrinary tract infectionML of salinePelvic floor surgerySpontaneous VTVoid trialBaseline characteristicsCatheter removalPrimary outcomePrior hysterectomyTract infectionsUrinary incontinenceControlled TrialsFemale pelvic floor surgeryPatient satisfactionUrogynecologic proceduresFailure rateSurgeryInfection rateGroup SVVesical clear cell adenocarcinoma of Müllerian origin treated conservatively with partial cystectomy
Harold JA, Casilla-Lennon M, Kenney PA, Ratner ES. Vesical clear cell adenocarcinoma of Müllerian origin treated conservatively with partial cystectomy. BMJ Case Reports 2022, 15: e245015. PMID: 35383096, PMCID: PMC8984011, DOI: 10.1136/bcr-2021-245015.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, Clear CellAgedCystectomyFemaleHumansUrinary BladderUrinary Bladder DiseasesUrinary Bladder NeoplasmsConceptsClear cell adenocarcinomaPartial cystectomyCell adenocarcinomaMüllerian originPAX-8 stainingExtensive endometriosisAdjuvant therapyFinal pathologyTotal hysterectomyTransurethral resectionBladder massResidual tumorCystectomyAdenocarcinomaHysterectomyEndometriosisResectionTherapyTumorsPathologyWomen
2021
Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat
Tabata H, Sasaki M, Kataoka-Sasaki Y, Shinkai N, Ichihara K, Masumori N, Kocsis JD, Honmou O. Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. BMC Urology 2021, 21: 156. PMID: 34774029, PMCID: PMC8590770, DOI: 10.1186/s12894-021-00923-3.Peer-Reviewed Original ResearchConceptsHunner-type ICBladder pain syndromeAnti-inflammatory pathwayMSC groupMesenchymal stem cellsPain syndromeAnimal modelsToll-like receptor 7 agonistTherapeutic efficacyBehavior testsRight external jugular veinFemale Sprague-Dawley ratsGFP-positive mesenchymal stem cellsReceptor 7 agonistChronic pelvic painAnti-inflammatory effectsEfficacious treatment optionExperimental animal modelsSprague-Dawley ratsExternal jugular veinReal-time polymerase chain reactionMRNA expression levelsPositive mesenchymal stem cellsStem cellsHunner lesionsIntravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain
Ye S, Ma F, Mahmood DFD, Meyer-Siegler KL, Menard RE, Hunt DE, Leng L, Bucala R, Vera PL. Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain. PLOS ONE 2021, 16: e0255975. PMID: 34424927, PMCID: PMC8382170, DOI: 10.1371/journal.pone.0255975.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorHigh mobility group box 1Bladder painMIF receptorHMGB1 releaseBladder hyperalgesiaMobility group box 1MIF receptor CD74Migration inhibitory factorGroup box 1Primary urothelial cellsInhibitory factor receptorWarrants further investigationCD74 receptorReceptor CD74Micturition parametersReceptor antagonistReceptor 4Box 1PainInhibitory factorHyperalgesiaCD74Urothelial cellsNovel targetUrine and Tissue Bacterial Loads Correlate With Voiding Behaviors in a Murine Urinary Tract Infection Model
Zhu K, Hill WG, Li F, Shi B, Chai TC. Urine and Tissue Bacterial Loads Correlate With Voiding Behaviors in a Murine Urinary Tract Infection Model. Urology 2021, 154: 344.e1-344.e7. PMID: 34010680, DOI: 10.1016/j.urology.2021.05.009.Peer-Reviewed Original ResearchConceptsUrinary tract infectionKidney bacterial loadsBacterial loadVoiding behaviorChronic urinary tract infectionMurine urinary tract infection modelSpot assayTissue bacterial loadUrinary tract infection modelChronic pyelonephritisUrinary frequencyBladder capacityTract infectionsChronic cystitisUrine cultureInfected miceFemale miceHistology changesMurine modelInfected bladdersDays postinfectionTissue fibrosisPolyuriaInfection modelE. coli UTI89
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