2023
0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial
Sun H, Zinchuk A, Locascio J, Kushida C, Thomas R, Westover M. 0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial. Sleep 2023, 46: a230-a231. DOI: 10.1093/sleep/zsad077.0522.Peer-Reviewed Original ResearchObstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudyPrimary analysisIndividual treatment effectsIntroduction Obstructive sleep apneaSecondary analysisLong-term Efficacy StudyBaseline cognitive scoresBrain age indexBaseline AHIBaseline polysomnogramMulticenter trialRandomized trialsSleep apneaAdherence ratesOSA treatmentTwo-armGroup 2Group 1Efficacy studiesCognitive impairmentCPAPBaseline cognitionMore depressionCognitive scores
2020
Increase in Number of Depression Symptoms Over Time is Related to Worse Cognitive Outcomes in Older Adults With Type 2 Diabetes
Ravona-Springer R, Heymann A, Lin H, Liu X, Berman Y, Schwartz J, Soleimani L, Sano M, Beeri M. Increase in Number of Depression Symptoms Over Time is Related to Worse Cognitive Outcomes in Older Adults With Type 2 Diabetes. American Journal Of Geriatric Psychiatry 2020, 29: 1-11. PMID: 33127316, PMCID: PMC7771631, DOI: 10.1016/j.jagp.2020.09.022.Peer-Reviewed Original ResearchConceptsDepressive symptomsEpisodic memorySemantic categorizationGlobal cognitionCognitive declineExecutive functionCognitive domainsCognitive outcomesAssociated with worse cognitive outcomesAssociated with lower baseline cognitive scoresCognitive Decline studyNumber of depressive symptomsEvaluation of depressionOlder adultsBaseline cognitive scoresCognitively normal participantsAttention/working memoryGeriatric Depression ScaleIsrael DiabetesCognitive testsCognitive functionNormal participantsCognitionType 2 diabetesCognitive scoresFrailty Is Associated With Postoperative Delirium But Not With Postoperative Cognitive Decline in Older Noncardiac Surgery Patients.
Mahanna-Gabrielli E, Zhang K, Sieber F, Lin H, Liu X, Sewell M, Deiner S, Boockvar K. Frailty Is Associated With Postoperative Delirium But Not With Postoperative Cognitive Decline in Older Noncardiac Surgery Patients. Anesthesia & Analgesia 2020, 130: 1516-1523. PMID: 32384341, PMCID: PMC7875454, DOI: 10.1213/ane.0000000000004773.Peer-Reviewed Original ResearchMeSH KeywordsAgedCognitionCognition DisordersData Interpretation, StatisticalDeliriumElective Surgical ProceduresElectroencephalographyFemaleFollow-Up StudiesFrail ElderlyFrailtyGeriatric AssessmentHumansMaleMental RecallNeuropsychological TestsPostoperative Cognitive ComplicationsPostoperative ComplicationsProspective StudiesRisk FactorsSeverity of Illness IndexSurveys and QuestionnairesConceptsPostoperative cognitive dysfunctionNoncardiac surgeryPostoperative deliriumPreoperative frailtySurgery patientsAssociated with increased odds of postoperative deliriumAssociated with postoperative deliriumOdds of postoperative deliriumProspective cohort study of patientsCohort study of patientsAmerican Society of Anesthesiologists (ASAThirty-one patientsCardiac surgery patientsElective noncardiac surgeryNoncardiac surgery patientsType of surgeryStudy of patientsFollow-up 3 monthsProspective cohort studyFRAIL scaleIntensive care unitAssociated with increased oddsBaseline cognitive scoresOdds of deliriumConfusion Assessment Method
2017
Cognition and the course of prodromal Parkinson's disease
Weintraub D, Chahine LM, Hawkins KA, Siderowf A, Eberly S, Oakes D, Seibyl J, Stern MB, Marek K, Jennings D, Investigators T. Cognition and the course of prodromal Parkinson's disease. Movement Disorders 2017, 32: 1640-1645. PMID: 29063713, PMCID: PMC5722226, DOI: 10.1002/mds.27189.Peer-Reviewed Original ResearchConceptsSpeed/attentionCognitive declineProdromal participantsBaseline neuropsychological test performanceExecutive function/Role of cognitionNeuropsychological test performanceFuture cognitive declineBaseline cognitive scoresCognitive domainsGlobal cognitionBaseline cognitionCognitive scoresCognitionTest performanceFuture declinePD-convertersDopamine systemHyposmic individualsProdromal PDLongitudinal changesFunction/ParticipantsDopamine transporter bindingIndividuals
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