2025
The perils of pickleball: A two decade analysis of upper and lower extremity injuries from America’s fastest growing sport
Boroumand S, Park N, Katsnelson B, Qian E, Norman M, Joo P, Diatta F, Noel O, Moran J, Jimenez A. The perils of pickleball: A two decade analysis of upper and lower extremity injuries from America’s fastest growing sport. Journal Of Sports Sciences 2025, 43: 1378-1385. PMID: 40254855, DOI: 10.1080/02640414.2025.2496089.Peer-Reviewed Original ResearchConceptsLower extremity injuriesExtremity injuriesUS emergency departmentsAge groupsTwo-proportion z-testInjury trendsGeriatric age groupPickleball injuriesEmergency departmentUpper/lower extremitiesBonferroni correctionPediatric patientsEpidemiological analysisClinical variablesZ-testPatientsAdultsInjuryPickleballExtremitiesCharacterizing the epidemiology of traumatic ear injuries: A 20 year analysis of emergency department visits in the U.S
Boroumand S, Katsnelson B, Oh S, Lewis K, Huelsboemer L, Stögner V, Kauke-Navarro M, Haykal S, Pomahac B. Characterizing the epidemiology of traumatic ear injuries: A 20 year analysis of emergency department visits in the U.S. Injury 2025, 56: 112287. PMID: 40168889, DOI: 10.1016/j.injury.2025.112287.Peer-Reviewed Original ResearchEar injuryNon-geriatric adultsNEISS databaseFall risk measuresEmergency department visitsPublic health strategiesEmergency department dispositionGeriatric patientsPrevent such injuriesTwo-proportion z-testPhysical therapyHealth strategiesDepartment visitsFall injuriesPatient educationSports activitiesGeriatric adultsAge groupsAge demographicsBonferroni correctionEar lacerationsFragility of tissuesFrequency of hematomaIncident locationTraumatic injuryThe Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population
Dogan M, Prachason T, Lin B, Pries L, Arias-Magnasco A, Bortoletto R, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, van Os J, Rutten B, Brondino N, Colizzi M, Luykx J, Fusar-Poli L, Guloksuz S. The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population. Schizophrenia Bulletin Open 2025, 6: sgaf005. PMID: 40123716, PMCID: PMC11926675, DOI: 10.1093/schizbullopen/sgaf005.Peer-Reviewed Original ResearchPsychotic experiencesNegative life eventsAutistic traitsLife eventsCommunity Assessment of Psychic ExperiencesAssociated with psychotic experiencesAutism Spectrum QuotientModerating RolePsychosis expressionInteraction effectsPolygenic risk scoresRisk factorsEmotional neglectPsychic ExperiencesPhysical neglectModeration analysisCT subtypesAutism spectrumBonferroni correctionEmotional abuseGenetic overlapMultilevel linear regression modelsTrauma screeningSexual abusePhysical abuse
2024
Mediation analysis in longitudinal study with high-dimensional methylation mediators
Cui Y, Lin Q, Yuan X, Jiang F, Ma S, Yu Z. Mediation analysis in longitudinal study with high-dimensional methylation mediators. Briefings In Bioinformatics 2024, 25: bbae496. PMID: 39406521, PMCID: PMC11479716, DOI: 10.1093/bib/bbae496.Peer-Reviewed Original ResearchConceptsBody mass indexMediation analysisPaternal body mass indexGeneralized Estimating EquationsLinear mixed-effects modelsCohort dataMass indexMixed-effects modelsDNA methylation sitesHigh-dimensional mediation analysisLongitudinal studyBonferroni correctionAccurate parameter estimatesSobel testVariable selectionLongitudinal dataSimulation studyIndependence screeningMethylation sitesCpG sitesIndirect effectsParameter estimationLinearization methodHypothesis testingPre-treatment amino acids and risk of paclitaxel-induced peripheral neuropathy in SWOG S0221
Chen C, Zirpoli G, Budd G, Barlow W, Pusztai L, Hortobagyi G, Albain K, Godwin A, Thompson A, Henry N, Ambrosone C, Stringer K, Hertz D. Pre-treatment amino acids and risk of paclitaxel-induced peripheral neuropathy in SWOG S0221. Cancer Chemotherapy And Pharmacology 2024, 94: 311-321. PMID: 38814343, PMCID: PMC11878155, DOI: 10.1007/s00280-024-04680-6.Peer-Reviewed Original ResearchCIPN severityPeripheral neuropathyPaclitaxel-induced peripheral neuropathyEarly-stage breast cancerTrial of patientsBackgroundChemotherapy-induced peripheral neuropathyBody mass indexSerum amino acid concentrationsOver-Representation AnalysisDebilitating neurotoxicityPaclitaxel scheduleAnti-cancer agentsBreast cancerSelf-reported raceMass indexMetabolic pathways of amino acidsSerum concentrationsInverse associationAmino acid metabolic pathwaysPaclitaxelPrimary analysisBonferroni correctionTreatment limitationsS0221CIPNClinical and molecular characterization of urothelial (UC) vs. small cell carcinoma (SCC) of the urinary tract.
Chawla N, Mercier B, Govindarajan A, Li X, Castro D, Ebrahimi H, Barragan-Carrillo R, Zang P, LeVee A, Dizman N, Hsu J, Meza L, Zengin Z, Salgia N, Chehrazi-Raffle A, Dorff T, Pal S, Tripathi A. Clinical and molecular characterization of urothelial (UC) vs. small cell carcinoma (SCC) of the urinary tract. Journal Of Clinical Oncology 2024, 42: 682-682. DOI: 10.1200/jco.2024.42.4_suppl.682.Peer-Reviewed Original ResearchSmall cell carcinomaFeatures of small cell carcinomaGenome sequencePrevalence of genomic alterationsSmall cell carcinoma patientsSmall cell carcinoma groupFrequency of CDKN2APrevalence of TP53Fisher's exact testTumor gradeCell carcinomaPathological variablesUse of bloodUrinary tractBladder cancerExact testGenomic alterationsProportion Z testGenomic profilingGenomic featuresPathological featuresTherapeutic strategiesGenomic datasetsGenomic characteristicsBonferroni correction
2022
Guided Growth Procedures: Broken Tension Band Implants in Patients With Blount Disease
Chapman P, Dueber D, Stephenson L, Scott A, Lerman J, Powell K, Nossov S, Franklin C, Westberry D, Ackman J, Walker J. Guided Growth Procedures: Broken Tension Band Implants in Patients With Blount Disease. Journal Of Pediatric Orthopaedics 2022, 42: e435-e440. PMID: 35200213, DOI: 10.1097/bpo.0000000000002103.Peer-Reviewed Original ResearchConceptsBody mass indexImplant breakagePerioperative factorsBlount diseaseMm screwsAssociated with increased BMIRetrospective case-control studyIncreased BMICase-control studyUnivariate logistic regressionLate-onset Blount diseaseTension band platingIncreasing varus deformityVarus deformityTBI proceduresPatient demographicsMass indexScrew implantsLevel IIIPatientsOrthopaedic centersImplant factorsMetaphyseal screwBonferroni correctionBand plating
2021
A Single Center Review of Pediatric Nasal Bone Fractures - An Analysis of Concomitant Injuries, Management, and Outcomes.
Pandher M, Mukherjee TJ, Halsey JN, Luthringer MM, Povolotskiy R, Hoppe IC, Granick MS. A Single Center Review of Pediatric Nasal Bone Fractures - An Analysis of Concomitant Injuries, Management, and Outcomes. Eplasty 2021, 21: e4. PMID: 35603017.Peer-Reviewed Original ResearchNasal bone fracturesNon-surgical managementTraumatic brain injuryBone fracturesBrain injuryLevel one trauma centerConcomitant facial fracturesConcomitant facial injuriesSingle-center reviewIntensive care unitSignificant differencesAnalysis of treatmentConcomitant injuriesWatchful waitingCare unitClosed reductionCommon etiologyTrauma centerIntracranial hemorrhageCenter reviewFacial fracturesFacial injuriesFracture casesInjuryBonferroni correctionA Pilot Investigation of Nonpharmacological Pain Management Intervention Groups in Methadone Maintenance Treatment
DiMeola KA, Haynes J, Barone M, Beitel M, Madden LM, Cutter CJ, Raso A, Gaeta M, Zheng X, Barry DT. A Pilot Investigation of Nonpharmacological Pain Management Intervention Groups in Methadone Maintenance Treatment. Journal Of Addiction Medicine 2021, 16: 229-234. PMID: 34145187, PMCID: PMC8678387, DOI: 10.1097/adm.0000000000000877.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentCurrent pain intensityPain intensityMaintenance treatmentAcute increaseIntervention groupCurrent chronic painMood statesCognitive behavioral therapyMMT clinicsChronic painAcute improvementAcute reductionAcute changesSpecific mood statesPainExergame interventionGroup attendanceUnvalidated measuresMonday-FridayPilot investigationBonferroni correctionPatientsT-testIntervention
2020
De novo damaging variants associated with congenital heart diseases contribute to the connectome
Ji W, Ferdman D, Copel J, Scheinost D, Shabanova V, Brueckner M, Khokha MK, Ment LR. De novo damaging variants associated with congenital heart diseases contribute to the connectome. Scientific Reports 2020, 10: 7046. PMID: 32341405, PMCID: PMC7184603, DOI: 10.1038/s41598-020-63928-2.Peer-Reviewed Original ResearchMeSH KeywordsConnectomeDNA HelicasesDNA-Binding ProteinsExomeFemaleHeart Defects, CongenitalHistone-Lysine N-MethyltransferaseHomeodomain ProteinsHumansMaleMi-2 Nucleosome Remodeling and Deacetylase ComplexMutationMutation, MissenseMyeloid-Lymphoid Leukemia ProteinNerve Tissue ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 11Receptor, Notch1ConceptsDe novo variantsNDD genesCardiac patterningDe novo damaging variantsDamaging de novo variantsCHD genesDamaging variantsGenesProtein truncatingGenetic originNovo variantsGene mutationsPatterningRecent studiesDendritic developmentVariantsMutationsNeurogenesisSynaptogenesisBonferroni correction
2019
Caudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder
Vattimo E, Barros V, Requena G, Sato J, Fatori D, Miguel E, Shavitt R, Hoexter M, Batistuzzo M. Caudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder. European Child & Adolescent Psychiatry 2019, 28: 1607-1617. PMID: 30972581, DOI: 10.1007/s00787-019-01320-w.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGroup cognitive behavioral therapyPediatric obsessive-compulsive disorderRight caudateTreatment responseCognitive behavioral therapyCaudate nucleusPossible neural substrateTreatment respondersGM volumeStructural magnetic resonance imagingNeural substratesPrevious evidenceNeurobiological underpinningsOrbitofrontal cortexAge-matched controlsTotal GM volumeMagnetic resonance imagingBrain structuresResonance imagingChildrenRespondersBonferroni correctionCaudatePatientsInitial Results From An Opioid Dependence Whole Exome Sequencing Study
Gelernter J, Sherva R, Zhao H, Kranzler H, Farrer L. Initial Results From An Opioid Dependence Whole Exome Sequencing Study. European Neuropsychopharmacology 2019, 29: s732. DOI: 10.1016/j.euroneuro.2017.06.056.Peer-Reviewed Original ResearchOpioid dependenceWhole-exome sequencesAfrican AmericansCase/control studySubstance use disordersSensory neuron developmentRisk markersPain perceptionSynaptic responsesWhole-exome sequencing studiesOD diagnosisUse disordersControl studySynaptic plasticityNeuron developmentExome sequencing studiesSynapse functionEuropean AmericansPrdm12Myotonic dystrophyGene-based testsBonferroni correctionCommon risk variantsOD riskRisk variants
2017
A Pilot Study of Mining Association Between Psychiatric Stressors and Symptoms in Tweets
Du J, Zhang Y, Tao C, Xu H. A Pilot Study of Mining Association Between Psychiatric Stressors and Symptoms in Tweets. 2017, 1254-1257. DOI: 10.1109/bibm.2017.8217838.Peer-Reviewed Original Research
2016
Amygdala volume is reduced in early course schizophrenia
Rich AM, Cho YT, Tang Y, Savic A, Krystal JH, Wang F, Xu K, Anticevic A. Amygdala volume is reduced in early course schizophrenia. Psychiatry Research Neuroimaging 2016, 250: 50-60. PMID: 27035063, PMCID: PMC4904038, DOI: 10.1016/j.pscychresns.2016.02.006.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingAmygdala volumeSchizophrenia patientsSubcortical structuresEarly course schizophrenia patientsEarly illness courseChronic schizophrenia patientsNeuropathology of schizophreniaMajor subcortical structuresSmaller amygdala volumesEarly course schizophreniaHealthy comparison subjectsBonferroni correctionGray matter volumeAcute stress responseMedication useIllness coursePathophysiologic changesGlobus pallidusIllness phaseNucleus accumbensHigh riskComparison subjectsMatter volumeHR subjects
2015
Gene-based and pathway-based genome-wide association study of alcohol dependence
Lingjun Z, ZHANG CK, SAYWARD FG, CHEUNG KH, Kesheng W, KRYSTAL JH, Hongyu Z, Xingguang L. Gene-based and pathway-based genome-wide association study of alcohol dependence. General Psychiatry 2015, 27: 111-118. PMID: 26120261, PMCID: PMC4466852, DOI: 10.11919/j.issn.1002-0829.215031.Peer-Reviewed Original ResearchGenome-wide association studiesRisk genesAssociation studiesBiological signaling processesPXN geneGene pathwaysSignaling processesGlycan degradationInteraction pathwayGenetic markersTransporter pathwaysGenesDiscovery samplePathwayReplication sampleAfrican American casesRisk pathwaysMultiple testingBonferroni correctionNew evidence
2013
Quantitative Susceptibility Mapping of Multiple Sclerosis Lesions at Various Ages
Chen W, Gauthier SA, Gupta A, Comunale J, Liu T, Wang S, Pei M, Pitt D, Wang Y. Quantitative Susceptibility Mapping of Multiple Sclerosis Lesions at Various Ages. Radiology 2013, 271: 183-92. PMID: 24475808, PMCID: PMC4263629, DOI: 10.1148/radiol.13130353.Peer-Reviewed Original ResearchConceptsNormal-appearing white matterMS lesionsMultiple sclerosis lesionsEnhanced lesionsQuantitative susceptibility mappingMR examinationsSclerosis lesionsConventional magnetic resonance imagingMagnetic resonance imagingT2-weighted imagesMS patientsPathophysiologic featuresCerebrospinal fluidOnline supplemental materialWhite matterLesionsQSM imagesResonance imagingPatientsMR imagingThree-dimensional gradient-echo sequenceGradient echo sequenceMonthsBonferroni correctionAgeDiscovery and validation of blood biomarkers for suicidality
Le-Niculescu H, Levey DF, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB. Discovery and validation of blood biomarkers for suicidality. Molecular Psychiatry 2013, 18: 1249-1264. PMID: 23958961, PMCID: PMC3835939, DOI: 10.1038/mp.2013.95.Peer-Reviewed Original ResearchMeSH KeywordsAcetyltransferasesAdultAgedBiomarkersBipolar DisorderGene ExpressionGene Expression ProfilingGenomicsHumansIntracellular Signaling Peptides and ProteinsMaleMAP Kinase Kinase Kinase 3Membrane ProteinsMiddle AgedMyristoylated Alanine-Rich C Kinase SubstrateOligonucleotide Array Sequence AnalysisPsychotic DisordersPTEN PhosphohydrolaseSuicidal IdeationSuicideConceptsBlood biomarkersMood disordersBlood gene expression biomarkersConvergent functional genomics approachCase-case designVisual analog scaleHigh-risk populationSimple visual analog scaleBlood expression levelsAge-matched cohortCause of deathMajor mood disordersBlood of subjectsBonferroni correctionExpression levelsBipolar disorder subjectsPsychosis subjectsBlood levelsFuture hospitalizationTime of testingMedication targetsPast hospitalizationHospitalization dataBipolar cohortCompleter groupProfiling of Childhood Adversity-Associated DNA Methylation Changes in Alcoholic Patients and Healthy Controls
Zhang H, Wang F, Kranzler HR, Zhao H, Gelernter J. Profiling of Childhood Adversity-Associated DNA Methylation Changes in Alcoholic Patients and Healthy Controls. PLOS ONE 2013, 8: e65648. PMID: 23799031, PMCID: PMC3683055, DOI: 10.1371/journal.pone.0065648.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlcoholismAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyBlack or African AmericanCase-Control StudiesChild AbuseCpG IslandsDNA MethylationEpigenesis, GeneticFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMiddle AgedNerve Tissue ProteinsNociceptin ReceptorPolymorphism, Single NucleotidePromoter Regions, GeneticReceptors, NicotinicReceptors, OpioidRetinal DehydrogenaseRGS ProteinsSequence Analysis, DNATranscription, GeneticWhite PeopleYoung AdultConceptsHealthy controlsAD patientsChildhood adversityDNA methylation changesIllumina GoldenGate methylation arrayPeripheral blood DNA methylation levelsBlood DNA methylation levelsAlcoholic patientsControl subjectsLinear regression analysisMethylation changesPatientsMethylation levelsPromoter regionEA casesBonferroni correctionRegression analysisP-valueAfrican AmericansOverall methylation levels
2011
Depressive symptom dimensions and cardiac prognosis following myocardial infarction: results from the ENRICHD clinical trial
Bekke-Hansen S, Trockel M, Burg M, Taylor C. Depressive symptom dimensions and cardiac prognosis following myocardial infarction: results from the ENRICHD clinical trial. Psychological Medicine 2011, 42: 51-60. PMID: 21682949, DOI: 10.1017/s0033291711001000.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCognitive Behavioral TherapyComorbidityDepressive DisorderFemaleHumansMaleMiddle AgedMyocardial InfarctionPrincipal Component AnalysisPrognosisProportional Hazards ModelsPsychiatric Status Rating ScalesRecurrenceRisk FactorsSeverity of Illness IndexSocial IsolationSocial SupportTime FactorsConceptsDepressive symptom dimensionsMyocardial infarctionSomatic depressive symptomsDepressive symptomsCardiovascular mortalityCardiac prognosisClinical trialsSubsequent mortalitySymptom dimensionsCoronary Heart Disease (ENRICHD) clinical trialRecurrent non-fatal myocardial infarctionBeck Depression Inventory itemsNon-fatal myocardial infarctionBonferroni correctionEarly cardiac morbidityAcute myocardial infarctionSomatic symptom severityCardiac morbidityCardiovascular morbidityCause mortalityInitial infarctionCox regressionEnhancing RecoveryPsychosocial interventionsSignificant association
2010
Measuring venous oxygenation using the photoplethysmograph waveform
Walton ZD, Kyriacou PA, Silverman DG, Shelley KH. Measuring venous oxygenation using the photoplethysmograph waveform. Journal Of Clinical Monitoring And Computing 2010, 24: 295-303. PMID: 20644985, DOI: 10.1007/s10877-010-9248-y.Peer-Reviewed Original ResearchConceptsVenous saturationVenous systemRegional venous oxygen saturationPeripheral venous waveformCardiac surgery patientsVenous oxygen saturationPeripheral venous systemPhotoplethysmograph waveformsWilcoxon signed-rank testVenous waveformSurgery patientsAtrial contractionSigned-rank testVenous bloodVenous oxygenationOxygen saturationGold standardPPG characteristicsHigh complianceBonferroni correctionSignificant differencesPPG analysisBloodPPG waveformPatients
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