2024
Asymptomatic Rectal Bacterial Pathogens Show Large Prospective Relationships With HIV Incidence in a Cohort of Young Sexual and Gender Minorities: Implications for STI Screening and HIV Prevention
Baiers R, Ryan D, Clifford A, Munson E, D’Aquila R, Newcomb M, Mustanski B. Asymptomatic Rectal Bacterial Pathogens Show Large Prospective Relationships With HIV Incidence in a Cohort of Young Sexual and Gender Minorities: Implications for STI Screening and HIV Prevention. Open Forum Infectious Diseases 2024, 11: ofae444. PMID: 39183815, PMCID: PMC11342390, DOI: 10.1093/ofid/ofae444.Peer-Reviewed Original ResearchHIV seroconversionGeneralized Estimating EquationsChlamydia trachomatisNeisseria gonorrhoeaeHIV infectionPredictors of HIV seroconversionLongitudinal cohort studyPrevent HIV InfectionGender minoritiesSTI screeningRectal NGHIV preventionBiobehavioral interventionsHIV incidenceMultivariate GEE analysisAsymptomatic screeningMethods DataStatistically significant predictorsProspective relationshipHIVChicago metropolitan areaPredictive valueEstimating EquationsGEE analysisStatistically significant pairwise differencesVaccine development: obligate intracellular bacteria new tools, old pathogens: the current state of vaccines against obligate intracellular bacteria
van Schaik E, Fratzke A, Gregory A, Dumaine J, Samuel J. Vaccine development: obligate intracellular bacteria new tools, old pathogens: the current state of vaccines against obligate intracellular bacteria. Frontiers In Cellular And Infection Microbiology 2024, 14: 1282183. PMID: 38567021, PMCID: PMC10985213, DOI: 10.3389/fcimb.2024.1282183.Peer-Reviewed Original ResearchProtective immunityCD8+ T cell responsesEffective antibody-based vaccineT cell memory responsesImmune responseIntracellular bacteriaT cell responsesAntibody-based vaccinesObligate intracellular bacteriaNovel delivery platformCytotoxic CD8Chlamydia trachomatisMemory responsesHumoral responseSuccessful vaccinesAnimal modelsAntibody responseAntigen discoveryEfficacious vaccinesVaccine developmentEffective vaccineSARS-CoV-2CD8VaccineSARS-CoV-2 pandemic
2023
Expedited Partner Therapy: A Multicomponent Initiative to Boost Provider Counseling
Markowitz M, Ackerman-Banks C, Oliveira C, Fashina O, Pathy S, Sheth S. Expedited Partner Therapy: A Multicomponent Initiative to Boost Provider Counseling. Sexually Transmitted Diseases 2023, 51: 15-21. PMID: 37921862, PMCID: PMC11413968, DOI: 10.1097/olq.0000000000001894.Peer-Reviewed Original ResearchConceptsPartner therapyProvider counselingMulticomponent initiativesQuasi-experimental interrupted time-series studyExpedited Partner TherapyInterrupted time series studyRecords of patientsFrequent reinfectionsInterrupted time series modelObstetric indicationsGynecology clinicTherapy prescriptionPatients' perceptionsPatient acceptanceChlamydia trachomatisPatient encountersNeisseria gonorrhoeaeTherapyRegistered NursesTime-series studyPublic insurancePatientsAcademic obstetricsCounselingSignificant increaseEndometrial responses to bacterial and viral infection: a scoping review.
Lindsay C, Potter J, Grimshaw A, Abrahams V, Tong M. Endometrial responses to bacterial and viral infection: a scoping review. Human Reproduction Update 2023, 29: 675-693. PMID: 37290428, PMCID: PMC10477945, DOI: 10.1093/humupd/dmad013.Peer-Reviewed Original ResearchConceptsEndometrial responseViral infectionUterus/endometriumFull-text studiesInnate immune sensingInnate immune responseFree-text termsEmbase/MedlineIntrauterine infectionObstetric complicationsEndometrial productionCochrane LibraryFuture studiesImplantation failureNeisseria gonorrheaImmune cellsMost infectionsImmune responseUterine functionChlamydia trachomatisAnimal modelsImmune sensingEndometriumZika virusMajority of studiesSexually transmitted infections in adolescents and young adults: Chlamydia, gonorrhea, trichomonas, syphilis, herpes, and mycoplasma
Mullins T, Braverman P. Sexually transmitted infections in adolescents and young adults: Chlamydia, gonorrhea, trichomonas, syphilis, herpes, and mycoplasma. 2023, 923-941. DOI: 10.1016/b978-0-12-818872-9.00059-5.ChaptersYoung adultsNew diagnosisHuman immunodeficiency virus (HIV) infectionGenital herpes simplex virusImmunodeficiency virus infectionHerpes simplex virusGlobal health challengeCurable STIsHIV infectionViral STIsSignificant morbidityVirus infectionSimplex virusChlamydia trachomatisC. trachomatisNew infectionsN. gonorrhoeaeNeisseria gonorrhoeaeAge groupsHealth challengesYouth ages 15InfectionProtective factorsSTIsPsychological/behavioral
2022
Combining Cellular Immunology With RNAseq to Identify Novel Chlamydia T-Cell Subset Signatures
Johnson RM, Asashima H, Mohanty S, Shaw AC. Combining Cellular Immunology With RNAseq to Identify Novel Chlamydia T-Cell Subset Signatures. The Journal Of Infectious Diseases 2022, 225: 2033-2042. PMID: 35172331, PMCID: PMC9159333, DOI: 10.1093/infdis/jiac051.Peer-Reviewed Original ResearchConceptsProtective T cell clonesAntibacterial effector mechanismsT cells residentB cell helpT cell clonesCytokine polarizationImmune miceIL-10Protective immunityVaccine trialsIL-13Surrogate biomarkerEffector mechanismsGenital tractT cellsVaccine candidatesChlamydia trachomatisCells residentHelper functionCellular immunologyMouse studiesHuman investigationsReproductive tractGranzyme A.Investigational data
2019
Discordance in the Epithelial Cell-Dendritic Cell Major Histocompatibility Complex Class II Immunoproteome: Implications for Chlamydia Vaccine Development
Karunakaran KP, Yu H, Jiang X, Chan QWT, Foster LJ, Johnson RM, Brunham RC. Discordance in the Epithelial Cell-Dendritic Cell Major Histocompatibility Complex Class II Immunoproteome: Implications for Chlamydia Vaccine Development. The Journal Of Infectious Diseases 2019, 221: 841-850. PMID: 31599954, PMCID: PMC7457330, DOI: 10.1093/infdis/jiz522.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialBacterial VaccinesCD4-Positive T-LymphocytesCell LineChlamydia InfectionsChlamydia muridarumChlamydia trachomatisDendritic CellsEpithelial CellsEpitopes, T-LymphocyteFemaleHeLa CellsHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHost-Pathogen InteractionsHumansMiceMice, Inbred C57BLPeptidesConceptsCD4 T cellsDendritic cellsT cellsEpithelial cellsProtective immunityEffector phaseClass IChlamydia-specific CD4 T cellsPathogen-specific T cellsClass IIMajor histocompatibility complex (MHC) class II moleculesChlamydia vaccine developmentClearance of ChlamydiaClass II epitopesClass II moleculesMHC class IMucosal epithelial cellsInfected epithelial cellsImmune miceIntracellular bacterial pathogenChlamydia vaccineC trachomatisEpithelial cell linePresent epitopesChlamydia trachomatis
2017
Prevalence of Human Immunodeficiency Virus and Sexually Transmitted Infections Among Cisgender and Transgender Women Sex Workers in Greater Kuala Lumpur, Malaysia
Wickersham JA, Gibson BA, Bazazi AR, Pillai V, Pedersen CJ, Meyer JP, El-Bassel N, Mayer KH, Kamarulzaman A, Altice FL. Prevalence of Human Immunodeficiency Virus and Sexually Transmitted Infections Among Cisgender and Transgender Women Sex Workers in Greater Kuala Lumpur, Malaysia. Sexually Transmitted Diseases 2017, 44: 663-670. PMID: 28708696, PMCID: PMC5636657, DOI: 10.1097/olq.0000000000000662.Peer-Reviewed Original ResearchConceptsTransgender women sex workersHuman immunodeficiency virusInconsistent condom useCisgender women sex workersHIV prevalenceImmunodeficiency virusSex workersWomen sex workersDrug useCondom useHigh human immunodeficiency virusGlobal HIV prevalenceLast HIV testLifetime HIV testingPooled HIV prevalenceRespondent-driven samplingSTI prevalenceHIV testHIV burdenHIV testingMedian timeSTI preventionΧ testChlamydia trachomatisIndependent sample t-testDeclines in Human Papillomavirus (HPV)–Associated High-Grade Cervical Lesions After Introduction of HPV Vaccines in Connecticut, United States, 2008–2015
Niccolai LM, Meek JI, Brackney M, Hadler JL, Sosa LE, Weinberger DM. Declines in Human Papillomavirus (HPV)–Associated High-Grade Cervical Lesions After Introduction of HPV Vaccines in Connecticut, United States, 2008–2015. Clinical Infectious Diseases 2017, 65: 884-889. PMID: 28520854, DOI: 10.1093/cid/cix455.Peer-Reviewed Original ResearchConceptsCervical cancer screeningCervical lesionsRisk behaviorsHPV vaccinationVaccination coverageHuman papillomavirusCancer screeningBirth cohortHigh-grade cervical lesionsHPV vaccination coverageRates of CIN2Cervical intraepithelial neoplasiaHigh-grade lesionsSexual risk behaviorsSignificant declineHPV vaccineVaccine impactIntraepithelial neoplasiaCervical cancerRisk factorsSurveillance periodSimilar epidemiologyChlamydia trachomatisCohort patternsNegative binomial regression
2015
Risk-based screening for Chlamydia trachomatis and Neisseria gonorrhoeae prior to intrauterine device insertion
Grentzer J, Peipert J, Zhao Q, McNicholas C, Secura G, Madden T. Risk-based screening for Chlamydia trachomatis and Neisseria gonorrhoeae prior to intrauterine device insertion. Contraception 2015, 92: 313-318. PMID: 26093189, PMCID: PMC4575889, DOI: 10.1016/j.contraception.2015.06.012.Peer-Reviewed Original ResearchConceptsMultiple sexual partnersIntrauterine device insertionIUD insertionC. trachomatisN. gonorrhoeaeSexual partnersDevice insertionChlamydia trachomatisNeisseria gonorrhoeaeRisk-based screening strategiesScreening strategyCases of infectionInconsistent condom useRisk-based screeningPositive predictive valueContraceptive CHOICE ProjectGonorrhea infectionIUD usersUniversal screeningRisk-based strategyPredictive valueCondom useSecondary analysisTrachomatisGonorrhoeaePositive Testing for Neisseria gonorrhoeae and Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease in IUD Users
Birgisson N, Zhao Q, Secura G, Madden T, Peipert J. Positive Testing for Neisseria gonorrhoeae and Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease in IUD Users. Journal Of Women's Health 2015, 24: 354-359. PMID: 25836384, PMCID: PMC4440993, DOI: 10.1089/jwh.2015.5190.Peer-Reviewed Original ResearchConceptsPelvic inflammatory diseaseChlamydia trachomatisIUD usersInflammatory diseasesIUD useIntrauterine deviceContraceptive methodsSelf-reported pelvic inflammatory diseaseNew IUD usersNeisseria gonorrhoeaeMajor public health problemProspective cohort studyHigh-risk womenPublic health problemYears of ageContraceptive CHOICE ProjectBirth control methodsCohort studyWomen 14Subsequent infertilityUnintended pregnancyReversible contraceptionHigh riskPID ratesPositive testing
2014
Screening for Chlamydia trachomatis and Neisseria gonorrhoeae prior to intrauterine device insertion
Grentzer J, Peipert J, Zhao Q, McNicholas C, Secura G, Madden T. Screening for Chlamydia trachomatis and Neisseria gonorrhoeae prior to intrauterine device insertion. Contraception 2014, 90: 292. DOI: 10.1016/j.contraception.2014.05.203.Peer-Reviewed Original Research
2013
Sexually Transmitted Infection Prevalence in a Population Seeking No-Cost Contraception
McNicholas C, Peipert J, Maddipati R, Madden T, Allsworth J, Secura G. Sexually Transmitted Infection Prevalence in a Population Seeking No-Cost Contraception. Sexually Transmitted Diseases 2013, 40: 546-551. PMID: 23965768, PMCID: PMC3752093, DOI: 10.1097/olq.0b013e31829529eb.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBlack or African AmericanChlamydia InfectionsChlamydia trachomatisCohort StudiesContraceptionDemographyFemaleGonorrheaHumansMiddle AgedMissouriNeisseria gonorrhoeaeNucleic Acid Amplification TechniquesPrevalenceRiskSexually Transmitted DiseasesTrichomonas vaginalisTrichomonas VaginitisWhite PeopleYoung AdultConceptsChlamydia trachomatisCases of CTWhite womenStaff-administered questionnaireTransmitted Infection PrevalenceCurrent screening recommendationsContraceptive CHOICE ProjectBlack womenThird of participantsInfected womenContraceptive studyScreening recommendationsMultivariable analysisScreening guidelinesRisk factorsPrevalence ratesCost contraceptionMore infectionsPositive casesNeisseria gonorrhoeaeNucleic acid amplificationYounger ageCases of GCRisk profileOlder ageAntibody Signature of Spontaneous Clearance of Chlamydia trachomatis Ocular Infection and Partial Resistance against Re-challenge in a Nonhuman Primate Trachoma Model
Kari L, Bakios L, Goheen M, Bess L, Watkins H, Southern T, Song L, Whitmire W, Olivares-Zavaleta N, Caldwell H. Antibody Signature of Spontaneous Clearance of Chlamydia trachomatis Ocular Infection and Partial Resistance against Re-challenge in a Nonhuman Primate Trachoma Model. PLOS Neglected Tropical Diseases 2013, 7: e2248. PMID: 23738030, PMCID: PMC3667776, DOI: 10.1371/journal.pntd.0002248.Peer-Reviewed Original ResearchConceptsMajor Outer Membrane ProteinHumoral immune responseRe-challengeInfection eradicationDelayed clearancePrimary infectionProtective immunityAntigen-specific humoral immune responsesImmune responseT cell immunityAntigenic variationEtiological agent of trachomaAntibody recognitionAntibody recall responseHost protective immunityOcular infectionsRecall responsesWorld's leading causeChlamydia trachomatisChlamydial infectionAntibody signaturesSurrogate markerInfectious blindnessAgent of trachomaChlamydial antigen
2012
Comparing Two Methods of Detection for Chlamydia trachomatis in Liquid-Based Papanicolaou Tests
Levi AW, Beckman D, Hui P, Schofield K, Harigopal M, Chhieng DC. Comparing Two Methods of Detection for Chlamydia trachomatis in Liquid-Based Papanicolaou Tests. American Journal Of Clinical Pathology 2012, 138: 236-240. PMID: 22904135, DOI: 10.1309/ajcp2b7xqtcnamjp.Peer-Reviewed Original ResearchConceptsHC2 assayBD Viper SystemXTR TechnologyPositive predictive valueDNA assaysLiquid-based Papanicolaou testsNucleic acidsC trachomatisChlamydia trachomatisPredictive valueHybrid Capture 2Reverse transcriptase-polymerase chain reactionChlamydia trachomatis testingTranscriptase-polymerase chain reactionViper SystemComparable specificityCapture 2Papanicolaou testChlamydial infectionCytology samplesMethod of detectionThinPrep specimensTrachomatisAssaysSensitivity rateNod1, but not the ASC inflammasome, contributes to induction of IL-1β secretion in human trophoblasts after sensing of Chlamydia trachomatis
Kavathas PB, Boeras CM, Mulla MJ, Abrahams VM. Nod1, but not the ASC inflammasome, contributes to induction of IL-1β secretion in human trophoblasts after sensing of Chlamydia trachomatis. Mucosal Immunology 2012, 6: 235-243. PMID: 22763410, PMCID: PMC3465624, DOI: 10.1038/mi.2012.63.Peer-Reviewed Original ResearchMeSH KeywordsCARD Signaling Adaptor ProteinsCarrier ProteinsCell LineChlamydia trachomatisCytoskeletal ProteinsGene ExpressionHumansInflammasomesInterleukin-1betaMyeloid Differentiation Factor 88NLR Family, Pyrin Domain-Containing 3 ProteinNod1 Signaling Adaptor ProteinToll-Like Receptor 2Toll-Like Receptor 4TrophoblastsConceptsIL-1β secretionToll-like receptorsCT infectionIL-1βASC inflammasomeChlamydia trachomatisKey Toll-like receptorsNalp3/ASC inflammasomePro-inflammatory cytokinesIL-1β mRNAIL-1β productionInnate immune pathwaysNOD-like receptorsHuman trophoblast cellsIntracellular bacterial pathogenChlamydia infectionImmune pathwaysObligate intracellular bacterial pathogenTrophoblast cellsHuman trophoblastsCaspase-1InfectionSecretionInflammasomeNOD1
2011
A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates
Kari L, Whitmire W, Olivares-Zavaleta N, Goheen M, Taylor L, Carlson J, Sturdevant G, Lu C, Bakios L, Randall L, Parnell M, Zhong G, Caldwell H. A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates. Journal Of Experimental Medicine 2011, 208: 2217-2223. PMID: 21987657, PMCID: PMC3201208, DOI: 10.1084/jem.20111266.Peer-Reviewed Original ResearchConceptsOcular pathologyImmune correlates of protective immunityCorrelates of protective immunityMHC class II allelesClass II allelesRate of reinfectionNonhuman primatesDegree of efficacyImmune correlatesLive attenuated vaccinesBlinding diseaseChlamydia trachomatisPrevent trachomaChlamydial vaccineII allelesProtective immunityCynomolgus macaquesImmune responseRisk factorsBlinding trachomaPredictive valueTrachoma controlInfectious organismsPlasmid-deficient strainsTrachoma strainsEndometrial leukocyte subpopulations associated with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis genital tract infection
Reighard S, Sweet R, Miguel C, Miguel R, Chivukula M, Krishnamurti U, Cherpes T. Endometrial leukocyte subpopulations associated with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis genital tract infection. American Journal Of Obstetrics And Gynecology 2011, 205: 324.e1-324.e7. PMID: 21777898, PMCID: PMC3204313, DOI: 10.1016/j.ajog.2011.05.031.Peer-Reviewed Original ResearchConceptsEndometrial leukocyte subpopulationsC trachomatisLeukocyte subpopulationsN gonorrhoeaeT cellsT vaginalisChlamydia trachomatisB cellsNeisseria gonorrhoeaeEndometrial T cellsRobust inflammatory infiltrateGenital tract infectionT vaginalis infectionGenital tract pathogensPlasma cell numbersHost inflammatory responseInflammatory disease developmentUninfected womenTract infectionsInflammatory infiltrateTract pathogensVaginalis infectionInflammatory processEndocervical infectionInflammatory response
2010
Frameshift Mutations in a Single Novel Virulence Factor Alter the In Vivo Pathogenicity of Chlamydia trachomatis for the Female Murine Genital Tract
Sturdevant G, Kari L, Gardner D, Olivares-Zavaleta N, Randall L, Whitmire W, Carlson J, Goheen M, Selleck E, Martens C, Caldwell H. Frameshift Mutations in a Single Novel Virulence Factor Alter the In Vivo Pathogenicity of Chlamydia trachomatis for the Female Murine Genital Tract. Infection And Immunity 2010, 78: 3660-3668. PMID: 20547745, PMCID: PMC2937465, DOI: 10.1128/iai.00386-10.Peer-Reviewed Original ResearchConceptsChlamydia trachomatisGenital tractHuman isolatesHuman strainsHuman pathogen of global importanceIn vivo virulence characteristicsSusceptibility of mice to infectionPathogen of global importanceUpper genital tractMurine model of infectionMultiple in vitro passagesNegative selection pressureMice to infectionMurine genital tractIn vivo pathogenicityModel of infectionC3H/HeJ female miceGenome sequenceHost defense mechanismsVirulence genesSusceptibility to infectionVirulence factorsVirulence characteristicsNaive miceClearance phenotypeHome Screening Compared With Clinic-Based Screening for Sexually Transmitted Infections
Graseck A, Secura G, Allsworth J, Madden T, Peipert J. Home Screening Compared With Clinic-Based Screening for Sexually Transmitted Infections. Obstetrics And Gynecology 2010, 115: 745-752. PMID: 20308834, PMCID: PMC3119481, DOI: 10.1097/aog.0b013e3181d4450d.Peer-Reviewed Original ResearchConceptsHome screeningSelf-collected vaginal swabsClinic-based groupClinic-based testersProspective cohort studyHome-based testingClinic-based screeningSTI risk factorsAlternative screening strategiesContraceptive CHOICE ProjectAfrican American womenCohort studyTransmitted InfectionsPatient preferencesRisk factorsRegular providerClinic groupChlamydia trachomatisVaginal swabsMedical providersClinic testingNeisseria gonorrhoeaeParticipants' homesHome groupHome testing
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply