2024
Six-month randomized, placebo controlled trial of synbiotic supplementation in women with polycystic ovary syndrome undergoing lifestyle modifications
Chudzicka-Strugała I, Kubiak A, Banaszewska B, Wysocka E, Zwozdziak B, Siakowska M, Pawelczyk L, Duleba A. Six-month randomized, placebo controlled trial of synbiotic supplementation in women with polycystic ovary syndrome undergoing lifestyle modifications. Archives Of Gynecology And Obstetrics 2024, 311: 499-506. PMID: 39636391, PMCID: PMC11890239, DOI: 10.1007/s00404-024-07833-3.Peer-Reviewed Original ResearchPolycystic ovary syndromeIntensive lifestyle modificationPlacebo groupLifestyle modificationSynbiotic groupMetabolic aspects of polycystic ovary syndromeSynbiotic supplementationImprovement of hyperandrogenismMarkers of endotoxemiaLow-density lipoprotein cholesterolPlacebo-controlled trialReduction of BMILong-term administrationBody fat percentageLPS-binding proteinAdministration of synbioticsObese subjectsReduced LHTotal testosteronePlaceboLipoprotein cholesterolLaboratory aspectsLipid profileTotal cholesterolSix-monthsCamp-style lifestyle modification program (CAMP) for diabetes prevention among rural women with prior GDM: study protocol for a three-arm cluster hybrid type 2 randomized controlled trial
Chen Y, Zhong Q, Lv W, Long Q, Wang M, Chen J, Willey J, Whittemore R, Guo J. Camp-style lifestyle modification program (CAMP) for diabetes prevention among rural women with prior GDM: study protocol for a three-arm cluster hybrid type 2 randomized controlled trial. BMC Public Health 2024, 24: 2570. PMID: 39304869, PMCID: PMC11414119, DOI: 10.1186/s12889-024-20080-0.Peer-Reviewed Original ResearchConceptsIntensive lifestyle modificationLifestyle modification programLifestyle interventionGestational diabetes mellitusImplementation outcomesHealth consultationModification programCluster randomized clinical trialBackgroundIntensive lifestyle interventionsImprove postpartum careRandomized clinical trialsHealth promotion programsUsual care groupRisk of type 2 diabetes mellitusPrimary care settingIn-person sessionsEffective delivery modelsRisk of T2DMGestational diabetes mellitus historyGeneralized Estimating EquationsChinese Clinical Trial RegistryPostpartum careTechnology-based supportUsual careClinical Trials Registry
2019
Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity
Srivastava G, Fox CK, Kelly AS, Jastreboff AM, Browne AF, Browne NT, Pratt JSA, Bolling C, Michalsky MP, Cook S, Lenders CM, Apovian CM. Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity. Obesity 2019, 27: 190-204. PMID: 30677262, PMCID: PMC6449849, DOI: 10.1002/oby.22385.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIntensive lifestyle interventionObesity pharmacotherapyLifestyle interventionSevere obesityPrediabetes/type 2 diabetesObesity-related comorbid diseasesNonalcoholic fatty liver diseasePediatric primary care providersIntensive lifestyle modificationFatty liver diseaseMore effective treatment strategiesObstructive sleep apneaEffective treatment optionPrimary care providersType 2 diabetesEffective treatment strategiesLifestyle modificationPharmacotherapy optionsBariatric surgeryComorbid diseasesLiver diseaseSleep apneaTreatment algorithmExcess adiposityInformed consent regulations
2014
Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial
Savoye M, Caprio S, Dziura J, Camp A, Germain G, Summers C, Li F, Shaw M, Nowicka P, Kursawe R, DePourcq F, Kim G, Tamborlane WV. Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial. Diabetes Care 2014, 37: 317-324. PMID: 24062325, PMCID: PMC3898759, DOI: 10.2337/dc13-1571.Peer-Reviewed Original ResearchConceptsStandard of careClinical careBlood glucoseObese adolescentsObese youthOral glucose tolerance test glucoseIntensive lifestyle modificationDiabetes Prevention ProgramStandard clinical careInsulin sensitivity indexHealthy lifestyle programType 2 diabetesRisk of T2DChildhood obesity epidemicΒ-cell dysfunctionLifestyle modificationControlled TrialsOGTT glucosePrimary outcomeGlucose toleranceInsulin resistanceLifestyle programAnthropometric assessmentEarly abnormalitiesGlucose levels
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