2025
The Natural History of Congenital Hepatic Hemangiomas
Ostertag-Hill C, Fevurly R, Kulungowski A, Christison-Lagay E, McGuire A, Rialon K, Duggan E, Murillo R, Zurakowski D, Staffa S, Alomari A, Kozakewich H, Al-Ibraheemi A, Fishman S, Dickie B. The Natural History of Congenital Hepatic Hemangiomas. The Journal Of Pediatrics 2025, 281: 114523. PMID: 40023218, DOI: 10.1016/j.jpeds.2025.114523.Peer-Reviewed Original ResearchCongenital hepatic hemangiomasCongenital HHHepatic hemangiomaMedical therapyRetrospective review of patientsNatural historyReview of patientsKaplan-Meier curvesMonths of ageCongenital hemangiomaRetrospective reviewClinical presentationRespiratory failureClinical behaviorHeart failureHH volumeHistological findingsEarly recognitionResidual volumeGeneralized Estimating EquationsIncorrect diagnosisHemangiomaPatientsNo differenceRate of involution
2020
Comparing Image Segmentation Techniques for Determining 3D Orbital Cavernous Hemangioma Size on MRI.
Boparai R, Maeng M, Dunbar K, Godfrey K, Tooley A, Maher M, Kazim M. Comparing Image Segmentation Techniques for Determining 3D Orbital Cavernous Hemangioma Size on MRI. Ophthalmic Plastic And Reconstructive Surgery 2020, 36: 569-574. PMID: 32427734, DOI: 10.1097/iop.0000000000001651.Peer-Reviewed Original ResearchConceptsAverage tumor sizeTumor sizeInterobserver agreementHemangioma sizeOrbital cavernous hemangiomaConcordance correlation coefficientT2-weighted MRIEvaluate interobserver agreementCavernous hemangiomaLin's concordance correlation coefficientK-meansTumor boundariesSegmentation methodMRISignal intensitySubjective judgmentCorrelation coefficientImage segmentation methodImage segmentation techniquesParameter-dependent methodDegree of subjective judgmentK-means clusteringK-means clustering methodK-means clustering segmentationHemangioma
2019
Choroidal Hemangioma in a Black Patient With Sturge-Weber Syndrome: Challenges in Diagnosis.
Sarrafpour S, Tsui E, Mehta N, Modi YS, Finger PT. Choroidal Hemangioma in a Black Patient With Sturge-Weber Syndrome: Challenges in Diagnosis. Ophthalmic Surgery Lasers And Imaging Retina 2019, 50: 183-186. PMID: 30893453, DOI: 10.3928/23258160-20190301-09.Peer-Reviewed Original ResearchConceptsSturge-Weber syndromeChoroidal hemangiomaRight eyeNevus flammeusTotal exudative retinal detachmentExudative retinal detachmentPhysical exam findingsDark-skinned individualsChoroidal massRadiographic evidenceRetinal detachmentBlack patientsExam findingsVision lossVascular massConjunctival vascularityClinical examSyndromeHemangiomaExternal examinationDiagnosisUltrasound imagingEyesBlack teenagersPatients
2017
Nasal Reconstruction and Repair of Secondary Nasal Deformities Following Treatment of Nasal Hemangiomas
Lu X, Fan F, Wang H, You J. Nasal Reconstruction and Repair of Secondary Nasal Deformities Following Treatment of Nasal Hemangiomas. Journal Of Craniofacial Surgery 2017, 28: 427-433. PMID: 27755445, DOI: 10.1097/scs.0000000000003227.Peer-Reviewed Original ResearchConceptsSecondary nasal deformitiesNasal hemangiomaNasal deformityTube flapNasal appearanceNasal reconstructionRib cartilageLong-term esthetic resultsTreatment of hemangiomasResidual scar tissueFunctional scoresNasal alar defectsPatient's wishesQuestionnaire scoresPatientsScar tissueEsthetic resultsNasolabial sulcusRetardation of developmentNasal repairHemangiomaFlapNasal defectsAutogenous cartilage frameworkForehead flap
2016
GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation
Lim YH, Bacchiocchi A, Qiu J, Straub R, Bruckner A, Bercovitch L, Narayan D, Genomics Y, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate KA. GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation. American Journal Of Human Genetics 2016, 99: 443-450. PMID: 27476652, PMCID: PMC4974082, DOI: 10.1016/j.ajhg.2016.06.010.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedChild, PreschoolEnzyme ActivationGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11Human Umbilical Vein Endothelial CellsHumansInfantInfant, NewbornIntercellular Signaling Peptides and ProteinsMaleMAP Kinase Signaling SystemMelanocytesMitogen-Activated Protein KinasesMutationProto-Oncogene Proteins c-aktVascular NeoplasmsConceptsLobular capillary hemangiomaVascular tumorsKaposiform hemangioendotheliomaMonths of lifeYears of ageSomatic activating mutationsGNA14 mutationsHuman endothelial cellsPharmacologic interventionsSignificant complicationsCommon neoplasmCapillary hemangiomaInfantile hemangiomasLCH lesionsPrimary human endothelial cellsTherapeutic interventionsActivating mutationsGNA11 mutationsTumorsEndothelial cellsLesionsPotential targetHemangiomaGNA14Somatic mutations
2015
Enucleation after Embolization of Liver Failure-Causing Giant Liver Hemangioma
Sharma A, Kaspar M, Siddiqui M, Kim J. Enucleation after Embolization of Liver Failure-Causing Giant Liver Hemangioma. American Journal Of Case Reports 2015, 16: 563-567. PMID: 26301888, PMCID: PMC4554336, DOI: 10.12659/ajcr.893298.Peer-Reviewed Original ResearchConceptsGiant hepatic hemangiomaSevere hepatic dysfunctionHepatic hemangiomaHepatic dysfunctionLiver failureSymptomatic giant hepatic hemangiomasGiant liver hemangiomaPreoperative arterial embolizationImpending liver failureCurrent treatment optionsCongenital tumorsSurgical enucleationArtery embolizationLiver resectionSurgical treatmentLiver hemangiomasConsumptive coagulopathyTreatment optionsElderly patientsSurgical centersHemangiomaMesenchymal tissueEnucleationEmbolizationTumor
2014
Hepatectomy for hemangioma; safe, but is it successful?
Groeschl R, Riggle K, Quebbeman E, Christians K, Turaga K, Tsai S, Gamblin T. Hepatectomy for hemangioma; safe, but is it successful? Hepatogastroenterology 2014, 61: 2009-13. PMID: 25713903.Peer-Reviewed Original ResearchConceptsLiver resectionHepatic hemangiomaAbdominal discomfortEffect of liver resectionMedian Follow-UpMedian lesion sizeHepatic hemangiomataHPB centersHepatic resectionPreoperative painConsecutive patientsPerioperative deathsHepatobiliary surgeonsMedian agePain reliefSignificant morbidityEvaluating patientsTreat such symptomsHemangioma resectionResectionFollow-upHemangiomaLesion sizePatientsPainSurgical management of hepatic hemangiomas: a multi-institutional experience
Miura J, Amini A, Schmocker R, Nichols S, Sukato D, Winslow E, Spolverato G, Ejaz A, Squires M, Kooby D, Maithel S, Li A, Wu M, Sarmiento J, Bloomston M, Christians K, Johnston F, Tsai S, Turaga K, Tsung A, Pawlik T, Gamblin T. Surgical management of hepatic hemangiomas: a multi-institutional experience. Hepato Pancreato Biliary 2014, 16: 924-928. PMID: 24946109, PMCID: PMC4238859, DOI: 10.1111/hpb.12291.Peer-Reviewed Original ResearchConceptsHepatic hemangiomaHemangioma resectionHemangioma sizeAbdominal symptomsImprovement of symptoms post-operativelyManagement of hepatic hemangiomasClavien grade 3Peri-operative dataSymptoms post-operativelyNon-operative managementOutcomes of patientsMulti-institutional experienceHigh-volume institutionsLife-threatening complicationsMedian ageRetrospective reviewSurgical indicationsSurgical managementGrade 3Post-operativelyClinico-pathologicalIntractable symptomsLiver centresResectionHemangiomaSuccessful treatment of visceral infantile hemangioma of the omentum and mesentery with propranolol
Rubinstein J, Christison-Lagay E. Successful treatment of visceral infantile hemangioma of the omentum and mesentery with propranolol. Journal Of Pediatric Surgery Case Reports 2014, 2: 302-304. DOI: 10.1016/j.epsc.2014.06.004.Peer-Reviewed Original ResearchThree-week-old boyHigh-output cardiac failureOutput cardiac failureAbdominal compartment syndromeBenign clinical courseLife-threatening eventsAcute abdomenGastrointestinal hemorrhageCutaneous presentationOperative explorationCompartment syndromeIntractable bleedingCardiac failureClinical courseCommon tumorsSerial imagingSuccessful treatmentInfantile hemangiomasVisceral structuresMedical interventionsHemangiomaGradual involutionHemorrhageOmentumPropranolol
2013
Management of Infantile Hemangiomas
Craiglow BG, Antaya RJ. Management of Infantile Hemangiomas. Pediatric Drugs 2013, 15: 133-138. PMID: 23456550, DOI: 10.1007/s40272-013-0008-6.Peer-Reviewed Original ResearchConceptsAdditional new therapiesTreatment of IHPotential pharmacotherapeutic approachBenign vascular neoplasmMost IHsOral propranololSuperficial IHsTopical timololMedical therapyCommon tumorsPharmacotherapeutic approachesVascular neoplasmInfantile hemangiomasNew therapiesSignificant disfigurementNew treatmentsVital structuresHemangiomaTreatmentTherapyIHCorticosteroidsImiquimodUlcerationNeoplasms
2012
Hepatic mesenchymal hamartoma and infantile hemangioma: a rare association
Behr GG, Fishman SJ, Caty MG, Kulungowski AM, Paltiel HJ, Alomari AI. Hepatic mesenchymal hamartoma and infantile hemangioma: a rare association. Journal Of Pediatric Surgery 2012, 47: 448-452. PMID: 22424336, DOI: 10.1016/j.jpedsurg.2011.10.049.Peer-Reviewed Original ResearchConceptsMesenchymal hamartomaLiver hemangiomaInfantile hemangiomasVascular anomalies centerHepatic mesenchymal hamartomaPathologic featuresMedical recordsRare associationLarge cohortRare coexistenceHamartomaHemangiomaComprehensive searchPatientsInfantsTrue associationAssociationAnomaly centerCohortDiagnosisLiverLessons from a liver hemangioma registry: subtype classification
Kulungowski AM, Alomari AI, Chawla A, Christison-Lagay ER, Fishman SJ. Lessons from a liver hemangioma registry: subtype classification. Journal Of Pediatric Surgery 2012, 47: 165-170. PMID: 22244411, DOI: 10.1016/j.jpedsurg.2011.10.037.Peer-Reviewed Original ResearchConceptsDiffuse hepatic hemangiomasMultifocal hepatic hemangiomasCutaneous infantile hemangiomasFocal hepatic hemangiomaHepatic hemangiomaInfantile hemangiomasMultiple cutaneous infantile hemangiomasBalanced sex distributionType of lesionCutaneous hemangiomasRegistry recordsSex distributionFocal lesionsPatientsHemangiomaFocal diseasePostnatal proliferationEarly detectionRegistrySubtype classificationLesionsDiffuseHypothyroidismInfantsTherapy
2010
Intractable Ventricular Tachycardia Secondary to Cardiac Hemangioma
Abu-Omar Y, Mezue K, Ali A, Kneeshaw J, Goddard M, Large S. Intractable Ventricular Tachycardia Secondary to Cardiac Hemangioma. The Annals Of Thoracic Surgery 2010, 90: 1347-1349. PMID: 20868844, DOI: 10.1016/j.athoracsur.2010.03.094.Peer-Reviewed Original ResearchConceptsVentricular tachycardiaLong-term medical therapyManagement of ventricular arrhythmiasIntractable ventricular tachycardiaCardiac tumorsSurgical resectionCardiac neoplasmsCardiac massSurgical treatmentMedical therapyMiddle-aged menVentricular arrhythmiasVentricular dysrhythmiasMedical managementTachycardiaSuccess rateDysrhythmiasResectionCryoablationHemangiomaNeoplasmsTumorTherapyArrhythmiasHistopathology
2008
MRI characteristics and classification of peripheral vascular malformations and tumors
Moukaddam H, Pollak J, Haims AH. MRI characteristics and classification of peripheral vascular malformations and tumors. Skeletal Radiology 2008, 38: 535-547. PMID: 19020874, DOI: 10.1007/s00256-008-0609-2.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingVascular malformationsVascular tumorsPeripheral vascular malformationsCommon vascular tumorSoft tissue massMultiple tissue planesPercutaneous sclerotherapyAnatomic extentSignificant morbidityTransarterial embolizationCongenital hemangiomaMRI characteristicsInfantile hemangiomasTissue massResonance imagingProliferative phaseMain treatmentTissue planesTumorsVital structuresHemangiomaMalformationsSignal voidLesions
2006
Radiology–Pathology Conference: sclerosing hemangioma of the lung
Neuman J, Rosioreanu A, Schuss A, Turi G, Yung E, Trow TK, Williams L, Katz DS. Radiology–Pathology Conference: sclerosing hemangioma of the lung. Clinical Imaging 2006, 30: 409-412. PMID: 17101410, DOI: 10.1016/j.clinimag.2006.05.030.Peer-Reviewed Original ResearchConceptsFluorodeoxyglucose positron emission tomography (FDG-PET) findingsPositron emission tomography findingsCharacteristic imaging findingsDefinitive diagnostic testTomography findingsImaging findingsUnusual tumorBenign neoplasmsDiagnostic testsHemangiomaLungPatientsBiopsyNeoplasmsTumorsFindingsPathology
2001
Expression of thyroid transcription factor-1 and other markers in sclerosing hemangioma of the lung.
Illei P, Rosai J, Klimstra D. Expression of thyroid transcription factor-1 and other markers in sclerosing hemangioma of the lung. Archives Of Pathology & Laboratory Medicine 2001, 125: 1335-9. PMID: 11570910, DOI: 10.5858/2001-125-1335-eottfa.Peer-Reviewed Original ResearchConceptsThyroid transcription factor-1Sclerosing hemangiomaTranscription factor 1Tumor cellsPulmonary epitheliumThyroid transcription factor-1 positivityFactor 1Expression of thyroid transcription factor-1Pale cellsLining cellsSolid areasPulmonary sclerosing hemangiomaCell typesPan-epithelialEpithelial tumorsFocal stainingEMA stainingVascular neoplasmPapillary structuresEpithelial markersAlveolar epitheliumHemangiomaNeoplastic cellsStaining intensityTumor
1994
Hepatic metastases and cavernous hemangiomas: distinction with standard- and triple-dose gadoteridol-enhanced MR imaging.
Mitchell D, Saini S, Weinreb J, De Lange E, Runge V, Kuhlman J, Parisky Y, Johnson C, Brown J, Schnall M. Hepatic metastases and cavernous hemangiomas: distinction with standard- and triple-dose gadoteridol-enhanced MR imaging. Radiology 1994, 193: 49-57. PMID: 8090921, DOI: 10.1148/radiology.193.1.8090921.Peer-Reviewed Original Research
1991
Adrenal Hemangioma: An Unusual Adrenal Mass Delineated with Magnetic Resonance Imaging
Honig S, Klavans M, Hyde C, Siroky M. Adrenal Hemangioma: An Unusual Adrenal Mass Delineated with Magnetic Resonance Imaging. Journal Of Urology 1991, 146: 400-402. PMID: 1856940, DOI: 10.1016/s0022-5347(17)37805-9.Peer-Reviewed Original Research
1990
Definitive diagnosis of hepatic hemangiomas: MR imaging versus Tc-99m-labeled red blood cell SPECT.
Birnbaum B, Weinreb J, Megibow A, Sanger J, Lubat E, Kanamuller H, Noz M, Bosniak M. Definitive diagnosis of hepatic hemangiomas: MR imaging versus Tc-99m-labeled red blood cell SPECT. Radiology 1990, 176: 95-101. PMID: 2191377, DOI: 10.1148/radiology.176.1.2191377.Peer-Reviewed Original ResearchConceptsSingle-photon emission CTMR imagingHepatic hemangiomaPerfusion blood pool mismatchMajor hepatic vesselsCases MR imagingT2-weighted spin-echo MR imagesPhoton emission CTMagnetic resonance imagingDiagnosis of lesionsLesion signal intensityRed blood cellsDefinitive diagnosisHypervascular metastasesTc-99mHemangiomaSpin-echo MR imagesEmission CTHepatic vesselsResonance imagingBlood cellsRecurrent aseptic meningitis for 24 years: diagnosis and treatment of an associated lesion.
Frieden T, Piepmeier J, Murdoch G, Bia F. Recurrent aseptic meningitis for 24 years: diagnosis and treatment of an associated lesion. The Yale Journal Of Biology And Medicine 1990, 63: 593-9. PMID: 2092416, PMCID: PMC2589416.Peer-Reviewed Original ResearchConceptsRecurrent aseptic meningitisAseptic meningitisCausative organismEpisodes of meningitisRecurrent lymphocytic meningitisInfectious disease consultationLeft lateral ventricleComputerized tomographic head scanningRecurrent meningitisCavernous hemangiomaLymphocytic meningitisDiagnostic challengeMagnetic resonance imaging techniquesLateral ventricleMeningitisAnatomical sourceHead scansDisease processLesionsPatientsImaging techniquesYearsHemangiomaVentriclePhysical agents
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