Relationships between patient‐reported and clinician‐rated toxicities and daily functioning in older adults with advanced cancer undergoing systemic therapy
Culakova E, Mohamed M, Flannery M, Jensen‐Battaglia M, Zhang Z, Ramsdale E, Tylock R, Stauffer F, Wells M, Magnuson A, Loh K, Gada U, Janelsins M, Mohile S. Relationships between patient‐reported and clinician‐rated toxicities and daily functioning in older adults with advanced cancer undergoing systemic therapy. Cancer 2025, 131: e35766. PMID: 39945245, PMCID: PMC11822747, DOI: 10.1002/cncr.35766.Peer-Reviewed Original ResearchConceptsActivities of daily livingInstrumental ADLOlder adultsPatient-reported toxicityAdvanced cancerPhysical performanceActivities of daily living impairmentPRO-CTCAEInstrumental activities of daily livingShort Physical Performance BatteryImpaired activities of daily livingFunctional declineMitigate functional declinePhysical Performance BatteryImpaired instrumental ADLSystemic therapyGeneralized Estimating EquationsClinician-ratedIADL impairmentPerformance BatteryRisk of treatment-related toxicityDaily livingMonths of treatment initiationPatient reportsTreatment-related toxicity
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