2025
Cost-effective pricing of long-acting injectable HIV pre-exposure prophylaxis for adolescent girls and young women in South Africa: a model-based analysis
Jin E, Ahmed A, Bekker L, Rousseau E, Dugdale C, Flanagan C, Wallace M, Freedberg K, Orrell C, Reddy K, Paltiel A, Ciaranello A, Neilan A. Cost-effective pricing of long-acting injectable HIV pre-exposure prophylaxis for adolescent girls and young women in South Africa: a model-based analysis. The Lancet Global Health 2025, 13: e1230-e1239. PMID: 40441175, DOI: 10.1016/s2214-109x(25)00119-6.Peer-Reviewed Original ResearchConceptsHIV pre-exposure prophylaxisPre-exposure prophylaxisLife yearsIncremental cost-effectiveness ratioTDF-FTCCAB-LAAdolescent girlsYoung womenHIV-related careHealth-care sector perspectiveDaily oral tenofovir disoproxil fumarateIncrease life-yearsDaily oral TDF-FTCOral tenofovir disoproxil fumaratePrEP programmesCumulative HIV-transmissionHIV incidencePrEP persistenceTenofovir disoproxil fumarateCost-effectiveness ratioHIV transmissionCost-effectiveModel-projected outcomesSouth AfricaPrEP drugsImpact of scaling up harm reduction interventions on injecting risk behaviours, ART outcomes and HIV incidence among people who inject drugs in Kenya
Walker J, Akiyama M, Artenie A, Cleland C, Lizcano J, Musyoki H, Nyakowa M, Cherutich P, Kurth A, Vickerman P. Impact of scaling up harm reduction interventions on injecting risk behaviours, ART outcomes and HIV incidence among people who inject drugs in Kenya. International Journal Of Drug Policy 2025, 140: 104824. PMID: 40328143, DOI: 10.1016/j.drugpo.2025.104824.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyHIV incidenceAssociated with lower HIV incidenceEffectiveness of HIV prevention interventionsViral suppressionRisk behaviorsReduced risk of HIV acquisitionIncrease ART uptakeHIV prevention interventionsRisk of HIV acquisitionLower HIV incidenceBio-behavioural surveyHIV viral loadProportion of peopleRespondent-driven samplingART uptakeDried blood spot samplesHIV outcomesReduction interventionsPreventive interventionsART coverageBlood spot samplesInjection risk behaviorsEvidence gapsHIV acquisitionAlcohol Use and the Pre-exposure Prophylaxis Continuum of Care Among Men in Rural South Africa: Results from a Longitudinal Study
Castle A, Busang J, Dreyer J, Herbst C, Okesola N, Chimbindi N, Zuma T, Jarolimova J, Hahn J, Psaros C, Shenoi S, Shahmanesh M, Siedner M. Alcohol Use and the Pre-exposure Prophylaxis Continuum of Care Among Men in Rural South Africa: Results from a Longitudinal Study. AIDS And Behavior 2025, 1-12. PMID: 40185960, DOI: 10.1007/s10461-025-04694-y.Peer-Reviewed Original ResearchPrEP initiationHazardous alcohol useRural South AfricaAlcohol useOral HIV pre-exposure prophylaxisAlcohol consumptionHIV pre-exposure prophylaxisSouth AfricaPre-exposure prophylaxisImpact of alcohol useRisk alcohol useAlcohol use levelsAUDIT-C criteriaAlcohol use groupPrEP implementation effortsContinuum of careSexual health servicesOral PrEPHIV incidenceHazardous alcohol consumptionYoung menLogistic regression modelsSecondary data analysisInitiate PrEPNo/low riskHIV Trends in Metropolitan US Cities From 2014 to 2021: Baseline Data for the Ending the HIV Epidemic Initiative.
Gupta R, Vermund S. HIV Trends in Metropolitan US Cities From 2014 to 2021: Baseline Data for the Ending the HIV Epidemic Initiative. American Journal Of Public Health 2025, 115: 217-220. PMID: 39778137, PMCID: PMC11715565, DOI: 10.2105/ajph.2024.307890.Peer-Reviewed Original ResearchConceptsDifference-in-differences analysisMetropolitan statistical areasHIV Epidemic initiativeMetropolitan US cityReduce HIV incidenceHIV diagnosisHIV incidenceHIV trendsEpidemic initiativeHIV casesHIV epidemicProgrammatic evaluationIncident infectionsProgrammatic effectivenessHIVStatistical areasDiagnostic rateUS citiesBaseline trendsRate trendsBaselineEHEBaseline datasUnited StatesIncidence
2024
PrEP your step: Implementing an online crowdsourcing contest to engage young people in HIV prevention in Washington DC, USA
Taggart T, Mathews A, Junious T, Lindsey J, Augustine A, Debnam C, Boyd Y, Wright S, Tucker J, Magnus M. PrEP your step: Implementing an online crowdsourcing contest to engage young people in HIV prevention in Washington DC, USA. PLOS ONE 2024, 19: e0313882. PMID: 39556546, PMCID: PMC11573147, DOI: 10.1371/journal.pone.0313882.Peer-Reviewed Original ResearchConceptsPrEP messagingSemi-structured interviewsHigh risk of HIVCommunity engagementCrowdsourced messagesYoung peopleCross-sectional surveyRisk of HIVPre-exposure prophylaxisPublic health impactImplementation researchPromote PrEPHIV preventionMedical providersConvenience sampleHIV incidenceCommunity partnersPromotion messagesEngaging young peopleWorld Health OrganizationThematic codingSurvey participantsPrEPHealth impactsSocial marketingIntersecting Epidemics: Examining the Impact of Internalized Homophobia and Depression Symptoms on HIV Testing Through a Suicide Syndemic Among Young Black Men Who Have Sex with Men
Boyd D, Martinez O, Mammadli T, Shamrock O, Abu-Ba’are G, Dyer T. Intersecting Epidemics: Examining the Impact of Internalized Homophobia and Depression Symptoms on HIV Testing Through a Suicide Syndemic Among Young Black Men Who Have Sex with Men. Journal Of Racial And Ethnic Health Disparities 2024, 1-12. PMID: 39476098, DOI: 10.1007/s40615-024-02225-4.Peer-Reviewed Original ResearchRates of suicidal behaviorSuicidal behaviorYoung BMSMHIV testingInternalized homophobiaDepressive symptomsImpact of internalized homophobiaHIV prevention continuumTargeted mental health interventionsHIV prevention servicesMental health interventionsYoung Black menHIV prevention behaviorsMental health vulnerabilitiesElevated rates of suicidal behaviorPrevention continuumPreventive servicesHealth interventionsHolistic healthHIV incidencePreventive behaviorsSubstance useBMSMHIV epidemicDepressionAsymptomatic Rectal Bacterial Pathogens Show Large Prospective Relationships With HIV Incidence in a Cohort of Young Sexual and Gender Minorities: Implications for STI Screening and HIV Prevention
Baiers R, Ryan D, Clifford A, Munson E, D’Aquila R, Newcomb M, Mustanski B. Asymptomatic Rectal Bacterial Pathogens Show Large Prospective Relationships With HIV Incidence in a Cohort of Young Sexual and Gender Minorities: Implications for STI Screening and HIV Prevention. Open Forum Infectious Diseases 2024, 11: ofae444. PMID: 39183815, PMCID: PMC11342390, DOI: 10.1093/ofid/ofae444.Peer-Reviewed Original ResearchHIV seroconversionGeneralized Estimating EquationsChlamydia trachomatisNeisseria gonorrhoeaeHIV infectionPredictors of HIV seroconversionLongitudinal cohort studyPrevent HIV InfectionGender minoritiesSTI screeningRectal NGHIV preventionBiobehavioral interventionsHIV incidenceMultivariate GEE analysisAsymptomatic screeningMethods DataStatistically significant predictorsProspective relationshipHIVChicago metropolitan areaPredictive valueEstimating EquationsGEE analysisStatistically significant pairwise differencesHigh rates of deferring antiretroviral treatment for patients with HIV and substance use disorders: Results from a national sample of HIV physicians in Ukraine
Ottesen T, Wickersham J, Lawrence J, Antoniak S, Zezuilin O, Polonsky M, Antonyak S, Rozanova J, Dvoriak S, Pykalo I, Filippovych M, Altice F. High rates of deferring antiretroviral treatment for patients with HIV and substance use disorders: Results from a national sample of HIV physicians in Ukraine. PLOS ONE 2024, 19: e0305086. PMID: 39028735, PMCID: PMC11259278, DOI: 10.1371/journal.pone.0305086.Peer-Reviewed Original ResearchConceptsAntiretroviral therapy prescriptionAntiretroviral therapyCD4 countSubstance use disordersIncreased levels of stigmaNational sampleLevel of stigmaIndependent of risk groupSuboptimal antiretroviral therapyInitiate antiretroviral therapyPopulation of peopleHIV expertsHIV incidenceHIV physiciansHIV treatmentKey populationsTransgender womenAntiretroviral treatmentFeeling thermometerDrinking alcoholSex workersPhysiciansSex partnersPWHRisk groupsAlcohol Use Disorder and HIV Risk in a National Survey of Men Who Have Sex with Men in Ukraine
Gabriel W, Sazonova Y, Kulchynska R, LaMonaca K, Salyuk T, Smyrnov P, Altice F. Alcohol Use Disorder and HIV Risk in a National Survey of Men Who Have Sex with Men in Ukraine. International Journal Of Behavioral Medicine 2024, 1-17. PMID: 38914921, DOI: 10.1007/s12529-024-10272-8.Peer-Reviewed Original ResearchHIV transmission riskAssociated with HIV transmissionAlcohol use disorderHIV transmissionAlcohol consumptionTargeted HIV prevention strategiesPotential alcohol use disordersBehaviors associated with HIV transmissionRisk behaviors associated with HIV transmissionUnknown HIV statusHIV prevention strategiesPrevalent HIV infectionAssociated with increased likelihoodLikelihood of HIV acquisitionPre-exposure prophylaxisMultivariate regressionProblematic alcohol consumptionUse disorderConclusionThe high prevalenceMSM participantsHIV testingProblematic alcohol useHIV incidenceHIV statusHIV riskEfficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men : A Randomized Controlled Trial.
Gao Y, Zhan Y, Sun Y, Zheng W, Zhang W, Fu L, Guo Z, Lin Y, Li Y, Zheng L, Zhan Y, Zhu Z, Duan J, Zhang G, Huang T, Su B, Yu M, Wu G, Ouyang L, Zhao J, Wang G, Zhou Y, Qian H, Fitzpatrick T, Vermund S, Zou H. Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men : A Randomized Controlled Trial. Annals Of Internal Medicine 2024, 177: 719-728. PMID: 38801778, DOI: 10.7326/m23-3317.Peer-Reviewed Original ResearchVoluntary medical male circumcisionEfficacy of VMMCPreventing incident HIV infectionsRandomized Controlled TrialsMedical male circumcisionIncident HIV infectionIntervention groupInsertive anal intercoursePractice insertive anal intercourseMale circumcisionAnal intercourseIncidence rate of syphilisHIV infectionRates of syphilisMale sex partnersSexually transmitted infectionsIntention-to-treat analysisPrevent HIV InfectionHIV incidenceControl groupHIV riskIncidence rateHerpes simplex virus type 2HIV seroconversionSelf-ReportAn mHealth Intervention for Gay and Bisexual Men’s Mental, Behavioral, and Sexual Health in a High-Stigma, Low-Resource Context (Project Comunică): Protocol for a Randomized Controlled Trial
Leluțiu-Weinberger C, Filimon M, Hoover D, Lixandru M, Hanu L, Dogaru B, Kovacs T, Fierbințeanu C, Ionescu F, Manu M, Mariș A, Pană E, Dorobănțescu C, Streinu-Cercel A, Pachankis J. An mHealth Intervention for Gay and Bisexual Men’s Mental, Behavioral, and Sexual Health in a High-Stigma, Low-Resource Context (Project Comunică): Protocol for a Randomized Controlled Trial. JMIR Research Protocols 2024, 13: e52853. PMID: 38709550, PMCID: PMC11106696, DOI: 10.2196/52853.Peer-Reviewed Original ResearchConceptsINTERNATIONAL REGISTERED REPORT IDENTIFIERRandomized Controlled TrialsHIV incidenceBisexual menSexually transmitted infection testingHIV transmission risk behaviorsHIV risk reduction strategiesAttention control conditionCognitive behavioral therapy skillsHigh HIV incidenceInformation-motivation-behaviorRisk of HIVTransmission risk behaviorsSexual health communicationParticipant follow-upFollow-upLow-resource contextsLow-resource countriesSexual health goalsBehavioral therapy skillsMHealth interventionsRisk reduction strategiesFinding social supportHeavy alcohol useHIV diagnosisExperience of social harms among female sex workers following HIV self-test distribution in Malawi: results of a cohort study
Mee P, Neuman M, Kumwenda M, Lora W, Sikwese S, Sambo M, Fielding K, Indravudh P, Hatzold K, Johnson C, Corbett E, Desmond N. Experience of social harms among female sex workers following HIV self-test distribution in Malawi: results of a cohort study. BMC Infectious Diseases 2024, 22: 978. PMID: 38468208, PMCID: PMC10926537, DOI: 10.1186/s12879-024-09178-3.Peer-Reviewed Original ResearchConceptsHIV self-test useHIV self-testingFemale sex workersHIV self-test distributionPeer distributorsFacility-based HIV testingSelf-test distributionEnd-line dataStandard testing servicesSex workersGeneralised estimating equationsRelationship problemsSocial harmService delivery approachesBackgroundIn MalawiHIV testingActivity diaryEnd-lineHIV incidenceBlantyre districtConclusionsLittle evidenceTesting servicesCohort studyProspective cohortVerbal abuseMultiply robust generalized estimating equations for cluster randomized trials with missing outcomes
Rabideau D, Li F, Wang R. Multiply robust generalized estimating equations for cluster randomized trials with missing outcomes. Statistics In Medicine 2024, 43: 1458-1474. PMID: 38488532, PMCID: PMC12186826, DOI: 10.1002/sim.10027.Peer-Reviewed Original ResearchPropensity score modelMarginal regression parametersWeighted generalized estimating equationsRobust estimationCluster randomized trialRegression parametersMarginal meansMean modelIterative algorithmMonte Carlo simulationsGeneralized Estimating EquationsOutcome modelBotswana Combination Prevention ProjectCarlo simulationsEquationsCorrelation parametersEstimationReduce HIV incidenceHIV prevention measuresScore modelMultipliersRandomized trialsHIV incidencePrevention ProjectExamining HIV Knowledge and Sexually Risky Behaviors among Female Sex Workers in Kampala, Uganda
Ssenyonjo J, Mistler C, Adler T, Shrestha R, Kyambadde P, Copenhaver M. Examining HIV Knowledge and Sexually Risky Behaviors among Female Sex Workers in Kampala, Uganda. International Journal Of Environmental Research And Public Health 2024, 21: 163. PMID: 38397654, PMCID: PMC10888220, DOI: 10.3390/ijerph21020163.Peer-Reviewed Original ResearchConceptsFemale sex workersHealthcare providersHIV testingHIV preventionHistory of HIV testingRates of sexually transmitted infectionsCondom usageSex workersProvider-level barriersDevelopment of targeted interventionsPrimary HIV preventionHIV test resultsHealth education programsHIV transmission riskHIV prevention educationSexually transmitted infectionsHIV knowledgeHIV incidencePreventive interventionsFocus groupsTargeted interventionsReduce alcohol intakeHIV transmissionPrevention educationAlcohol intakePreferences and decisional considerations relating to opioid agonist therapy among Ukrainian people who use drugs: A conjoint analysis survey.
Bromberg D, Madden L, Fraenkel L, Muthulingam D, Rhoades D, Dvoriak S, Dumchev K, Pykalo I, Altice F. Preferences and decisional considerations relating to opioid agonist therapy among Ukrainian people who use drugs: A conjoint analysis survey. PLOS Global Public Health 2024, 4: e0002725. PMID: 38277422, PMCID: PMC10817130, DOI: 10.1371/journal.pgph.0002725.Peer-Reviewed Original ResearchOpioid agonist therapyWithdrawal symptomsAdverse side effectsAgonist therapySide effectsOpioid use disorderQuality-of-life improvementUse disorderCombined HIVHIV incidenceClinical decision-makingDosing frequencyRespondent-driven samplingOpioidOpioid epidemicAssess preferencesClinical concernPatient preferencesPatientsDelivery strategiesTherapyDisordersHIVPatient concernsWithdrawal
2023
Increasing Spiritual Beliefs are Associated With Lower HIV Incidence Among Black Men Who Have Sex With Men: Results From HPTN 061 Longitudinal Study
Ransome Y, Taggart T, Huang A, Vermund S, Mayer K, Nunn A. Increasing Spiritual Beliefs are Associated With Lower HIV Incidence Among Black Men Who Have Sex With Men: Results From HPTN 061 Longitudinal Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 196-202. PMID: 37850978, DOI: 10.1097/qai.0000000000003278.Peer-Reviewed Original ResearchConceptsHIV seroconversionHIV incidenceBehavioral HIV prevention interventionsLower HIV incidenceProportional hazards regressionHIV prevention interventionsBlack menSpiritual beliefsOne-unit increaseHazards regressionLongitudinal riskPrevention interventionsHIVBiomedical assessmentLower hazard rateLongitudinal studyMenMonthsSeroconversionLongitudinal analysisReligious service attendanceIncidenceBaselineBMSMHigher proportionDaily Oral HIV Pre-exposure Prophylaxis Among Young Men Who Have Sex With Men in the United States: Cost-saving at Generic Drug Price
Amick A, Eskibozkurt G, Hosek S, Flanagan C, Landovitz R, Jin E, Wilson C, Freedberg K, Weinstein M, Kazemian P, Paltiel A, Ciaranello A, Neilan A. Daily Oral HIV Pre-exposure Prophylaxis Among Young Men Who Have Sex With Men in the United States: Cost-saving at Generic Drug Price. Clinical Infectious Diseases 2023, 78: 402-410. PMID: 37823865, PMCID: PMC10874274, DOI: 10.1093/cid/ciad566.Peer-Reviewed Original ResearchPre-exposure prophylaxisHIV incidenceRisk of HIVOral PrEPAnnual screeningHuman immunodeficiency virus (HIV) pre-exposure prophylaxisOral HIV pre-exposure prophylaxisHIV pre-exposure prophylaxisIncremental cost-effectiveness ratioHIV RNA levelsYoung menCost-effectiveness ratioAnnual HIVHigher discontinuationPrEP retentionAntiretroviral therapyDrug pricesHIV careLow adherenceLifetime horizonNew infectionsHIVIncidencePrEPRNA levelsGlobal HIV control: is the glass half empty or half full?
Nachega J, Musoke P, Kilmarx P, Gandhi M, Grinsztejn B, Pozniak A, Rawat A, Wilson L, Mills E, Altice F, Mellors J, Quinn T. Global HIV control: is the glass half empty or half full? The Lancet HIV 2023, 10: e617-e622. PMID: 37506723, PMCID: PMC10733629, DOI: 10.1016/s2352-3018(23)00150-9.Peer-Reviewed Original ResearchCombination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis
Powers K, Mutale W, Rosenberg N, Graybill L, Mollan K, Freeborn K, Saidi F, Maman S, Mulenga P, Jahn A, Nyirenda R, Stringer J, Vermund S, H. B. Combination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis. Journal Of The International AIDS Society 2023, 26: e26128. PMID: 37403422, PMCID: PMC10320044, DOI: 10.1002/jia2.26128.Peer-Reviewed Original ResearchConceptsFemale HIV transmissionMaternal HIV acquisitionMaternal HIV incidenceHIV prevention strategiesPost-partum periodAntiretroviral therapyHIV transmissionMale partnersHIV acquisitionHIV incidenceANC patientsPrevention strategiesCombination HIV prevention strategiesCombination HIV prevention interventionSuppressive antiretroviral therapyPre-exposure prophylaxisVertical HIV transmissionAntenatal care programsCombination HIV preventionHIV prevention interventionsANC initiationART initiationUnsuppressed HIVIncident infectionsUndiagnosed HIVHigh-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan
Sanaubarova A, Pujol-Hodge E, Dzissyuk N, Lemey P, Vermund S, Brown A, Ali S. High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan. Viruses 2023, 15: 1407. PMID: 37515095, PMCID: PMC10384832, DOI: 10.3390/v15071407.Peer-Reviewed Original ResearchConceptsAntiretroviral therapySubtype A6Drug-resistant mutationsDrug resistanceEffective antiretroviral therapySuppressive antiretroviral therapyAntiretroviral drug resistanceDrug resistance monitoringHigh-level drug resistanceDrug regimensHIV incidenceHIV epidemicHIV-1Sustained transmissionMolecular epidemiologySubtypesPLHIVHIVG190SDifferent mutational pathwaysMutationsK101ED67NHigh levelsA62V
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply