2025
Charting the Course for Careers in Interventional Heart Failure: Training, Challenges, and Future Directions
Cheng R, Villela M, Masoumi A, Esposito M, Baran D, Rommel K, Fudim M, Mahfoud F, Lansky A, Burkhoff D, Kapur N. Charting the Course for Careers in Interventional Heart Failure: Training, Challenges, and Future Directions. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 102569. PMID: 40231064, PMCID: PMC11993878, DOI: 10.1016/j.jscai.2025.102569.Peer-Reviewed Original ResearchTranscatheter valve therapiesHeart failureValve therapyCardiogenic shockCoronary interventionLow ejection fractionDevice-based therapiesTraining pathwaysComplexity of therapeutic optionsEndomyocardial biopsyEjection fractionImplantable pressure sensorTherapeutic optionsHeart transplantationAdvanced HFAtrial pressureImprove outcomesCardiology training
2023
Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation
Lamy J, Taoutel R, Chamoun R, Akar J, Niederer S, Mojibian H, Huber S, Baldassarre L, Meadows J, Peters D. Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation. The International Journal Of Cardiovascular Imaging 2023, 40: 107-117. PMID: 37857929, PMCID: PMC11378145, DOI: 10.1007/s10554-023-02968-x.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementLA reservoir strainLeft atrial pressureLA volumeReservoir strainLA fibrosisLA strainStiffness indexLA late gadolinium enhancementAtrial stiffness indexMaximal LA volumeAtrial fibrillation cohortLA minimum volumeAtrial tissue fibrosisMaximum LA volumeCardiac MR examsAtrial stiffnessAtrial strainAF ablationAtrial pressureAF cohortAtrial fibrillationAtrial fibrosisPatient subgroupsLGE volumeThe importance of forward flow and venous congestion in diuretic response in acute heart failure: Insights from the ESCAPE trial
Eder M, Griffin M, Moreno-Villagomez J, Bellumkonda L, Maulion C, Asher J, Wilson F, Cox Z, Ivey-Miranda J, Rao V, Butler J, Borlaug B, McCallum W, Ramos-Mastache D, Testani J. The importance of forward flow and venous congestion in diuretic response in acute heart failure: Insights from the ESCAPE trial. International Journal Of Cardiology 2023, 381: 57-61. PMID: 37023862, DOI: 10.1016/j.ijcard.2023.04.002.Peer-Reviewed Original ResearchConceptsRight atrial pressureDiuretic efficiencyRight atrial areaDiuretic responseVenous congestionHeart failureCardio-renal interactionsLoop diuretic doseAcute heart failureRenal perfusion pressureLow cardiac outputMean arterial pressureRight ventricular systolicCongestive heart failureVentricular ejection fractionNet fluid outputForward flowDiuretic doseDiuretic resistanceTTE parametersCardiac indexVentricular systolicArterial pressureAtrial pressureEjection fraction
2022
Neurovascular Dysregulation and Acute Exercise Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome A Randomized, Placebo-Controlled Trial of Pyridostigmine
Joseph P, Pari R, Miller S, Warren A, Stovall MC, Squires J, Chang CJ, Xiao W, Waxman AB, Systrom DM. Neurovascular Dysregulation and Acute Exercise Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome A Randomized, Placebo-Controlled Trial of Pyridostigmine. CHEST Journal 2022, 162: 1116-1126. PMID: 35526605, DOI: 10.1016/j.chest.2022.04.146.Peer-Reviewed Original ResearchConceptsME/CFSInvasive cardiopulmonary exercise testRight atrial pressureCardiac outputNeurovascular dysregulationAtrial pressurePostexertional malaiseExercise intoleranceMyalgic encephalomyelitis/chronic fatigue syndromePeak exercise oxygen uptakeRight ventricular filling pressuresEnd pointPlacebo-controlled trialPrimary end pointSecondary end pointsVentricular filling pressureCardiopulmonary exercise testChronic fatigue syndromeExercise oxygen uptakeA RandomizedIntractable fatigueOral pyridostigminePyridostigmine groupExercise capacitySystemic hemodynamicsInferior Vena Cava Diameter Measurement Provides Distinct and Complementary Information to Right Atrial Pressure in Acute Decompensated Heart Failure
Griffin M, Ivey-Miranda J, McCallum W, Sarnak M, Eder M, Bellumkonda L, Maulion C, Wilson FP, Rao VS, Testani J. Inferior Vena Cava Diameter Measurement Provides Distinct and Complementary Information to Right Atrial Pressure in Acute Decompensated Heart Failure. Journal Of Cardiac Failure 2022, 28: 1217-1221. PMID: 35301109, DOI: 10.1016/j.cardfail.2022.02.014.Peer-Reviewed Original ResearchConceptsRight atrial pressureAcute decompensated heart failureDecompensated heart failureIVC diameterAtrial pressureHeart failureInferior vena cava diameter (IVCD) measurementBaseline right atrial pressureInferior vena cava (IVC) measurementsPulmonary artery catheterVena cava diameter measurementsArtery catheterHemoglobin levelsIntravascular volumeVenous systemESCAPE trialIVC measurementsBlood volumeRAP measurementsSurvival ratePatientsVolume assessmentHigh complianceModest correlationMedian
2020
Relationship between NT-pro Brain Natriuretic Peptide and Filling Pressures in Ambulatory Patients with Left Ventricular Assist Devices and Accuracy to Detect Need for Optimization
Abbas A, Akintoye E, Duque E, Briasoulis A, Alvarez P. Relationship between NT-pro Brain Natriuretic Peptide and Filling Pressures in Ambulatory Patients with Left Ventricular Assist Devices and Accuracy to Detect Need for Optimization. The Journal Of Heart And Lung Transplantation 2020, 39: s344. DOI: 10.1016/j.healun.2020.01.390.Peer-Reviewed Original ResearchPulmonary capillary wedge pressureRight atrial pressureVentricular assist devicePulmonary artery pressureNT-proBNPAmbulatory patientsAssist deviceNatriuretic peptideN-terminal pro-brain natriuretic peptideNT-pro-brain natriuretic peptidePro-brain natriuretic peptideCapillary wedge pressureNT-proBNP levelsRight heart catheterizationMedian NT-proBNPBrain natriuretic peptideBest cutoff valuePg/mLWedge pressureArtery pressureHeart catheterizationAtrial pressurePatient characteristicsHemodynamic optimizationNoninvasive markerElectrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010
Shoji S, Kohsaka S, Sawano M, Okamura T, Hirata A, Sugiyama D, Ohkubo T, Nakamura Y, Watanabe M, Kadota A, Ueshima H, Okayama A, Miura K, Group F. Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010. Journal Of Atherosclerosis And Thrombosis 2020, 28: 34-43. PMID: 32188793, PMCID: PMC7875149, DOI: 10.5551/jat.54171.Peer-Reviewed Original ResearchConceptsFuture cardiovascular eventsBNP concentrationsCardiovascular eventsElevated BNPGeneral populationB-type natriuretic peptide concentrationsElectrocardiographic Left Atrial AbnormalityJapanese Circulation Society guidelinesB-type natriuretic peptideP-wave terminal forceContemporary general populationEarliest detectable markerElevated BNP concentrationsHistory of hypertensionNatriuretic peptide concentrationsJapanese populationGeneral population cohortHigher BNP concentrationsRepresentative Japanese populationGeneral Japanese populationLeft atrial abnormalityAtrial pressureElectrocardiogram (ECG) markersElectrocardiographic findingsNatriuretic peptideFirst-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution
Rao VS, Turner JM, Griffin M, Mahoney D, Asher J, Jeon S, Yoo PS, Boutagy N, Feher A, Sinusas A, Wilson FP, Finkelstein F, Testani JM. First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution. Circulation 2020, 141: 1043-1053. PMID: 31910658, PMCID: PMC7331276, DOI: 10.1161/circulationaha.119.043062.Peer-Reviewed Original ResearchConceptsStandard PD solutionExperimental heart failureHeart failurePD solutionsAdverse eventsPeritoneal dialysisSignificant discomfortSodium removalEnd-stage renal diseaseEnd pointElevated right atrial pressureMaintenance of euvolemiaPrimary end pointSecondary end pointsRight atrial pressureHuman proofLoss of responseSolute removalPorcine experimentsAtrial pressureRenal diseaseLoop diureticsSerum electrolytesHuman studiesPeritoneal membrane
2019
Pulmonary Arterial Elastance and INTERMACS-Defined Right Heart Failure Following Left Ventricular Assist Device
Muslem R, Ong C, Tomashitis B, Schultz J, Ramu B, Craig M, Van Bakel A, Gilotra N, Sharma K, Hsu S, Whitman G, Leary P, Cogswell R, Lozonschi L, Houston B, Zijlstra F, Caliskan K, Bogers A, Tedford R. Pulmonary Arterial Elastance and INTERMACS-Defined Right Heart Failure Following Left Ventricular Assist Device. Circulation Heart Failure 2019, 12: e005923. PMID: 31401840, DOI: 10.1161/circheartfailure.119.005923.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedCardiac CatheterizationEchocardiographyElasticityFemaleHeart FailureHeart VentriclesHeart-Assist DevicesHumansMaleMiddle AgedPostoperative ComplicationsPulmonary ArteryRegistriesRetrospective StudiesStroke VolumeSurvival RateUnited StatesVascular ResistanceVentricular Function, RightConceptsSevere acute right heart failureAcute right heart failureRight heart failureSystolic pulmonary artery pressurePulmonary artery pressureVentricular assist device implantationPulmonary arterial elastanceAssist device implantationRight atrial pressureArtery pressureVentricular assist deviceAtrial pressureHeart failureArterial elastanceDevice implantationAssist deviceSevere right heart failureIndependent hazard ratioStrongest hemodynamic predictorRight heart catheterizationLarge academic centerDevice survival ratesPreimplant variablesCause mortalityHeart catheterizationINFERIOR VENA CAVA DIAMETER MEASUREMENT PROVIDES DISTINCT AND COMPLEMENTARY INFORMATION TO RIGHT ATRIAL PRESSURE IN ACUTE DECOMPENSATED HEART FAILURE
Griffin M, Rao V, Mahoney D, Stewart B, Struyk G, Shamlian P, Pattoli M, Gomez N, Raghavendra P, Barnett J, Thomas A, Wycallis E, Fleming J, Testani J. INFERIOR VENA CAVA DIAMETER MEASUREMENT PROVIDES DISTINCT AND COMPLEMENTARY INFORMATION TO RIGHT ATRIAL PRESSURE IN ACUTE DECOMPENSATED HEART FAILURE. Journal Of The American College Of Cardiology 2019, 73: 1006. DOI: 10.1016/s0735-1097(19)31613-4.Peer-Reviewed Original Research
2018
Three-Dimensional Ultrasound Imaging of Inferior Vena Cava Outperforms Standard Two-Dimensional Imaging as a Diagnostic Tool in Heart Failure
Struyk G, Essa M, Flueckiger P, Bregasi A, McNamara R, Sugeng L, Testani J, Lin B. Three-Dimensional Ultrasound Imaging of Inferior Vena Cava Outperforms Standard Two-Dimensional Imaging as a Diagnostic Tool in Heart Failure. Journal Of Cardiac Failure 2018, 24: s41. DOI: 10.1016/j.cardfail.2018.07.119.Peer-Reviewed Original ResearchRight atrial pressureJugular venous pressureHeart failureCollapsibility indexIVC diameterDiagnostic performanceInferior vena cava diameterSphericity indexMethods 200 patientsIntravascular volume statusVena cava diameterCertain clinical variablesROC curve analysisDiuretic therapyAtrial pressureVenous pressureVolume statusClinical parametersClinical variablesIVC diameter measurementsCHF diagnosisIVC measurementsIVC areaASE guidelinesIVC parameters
2016
Platypnea-Orthodeoxia Syndrome: To Shunt or Not to Shunt, That is the Question
Klein MR, Kiefer TL, Velazquez EJ. Platypnea-Orthodeoxia Syndrome: To Shunt or Not to Shunt, That is the Question. Texas Heart Institute Journal 2016, 43: 264-6. PMID: 27303248, PMCID: PMC4894711, DOI: 10.14503/thij-15-5280.Peer-Reviewed Original ResearchConceptsRight atrial pressurePatent foramenAtrial pressureLow right atrial pressureRight-sided heart catheterizationFirst-line therapyPlatypnea-orthodeoxia syndromePercutaneous patent foramenPulmonary arteriovenous malformationsUpright positionCardiac causesHeart catheterizationTransient hypoxemiaTransthoracic echocardiogramTransthoracic echocardiographyLeft shuntingSyncopal episodesPercutaneous closureTransesophageal echocardiogramEmergency departmentOxygen supplementationIntracardiac shuntingArteriovenous malformationsChest radiographsOxygen saturation
2010
Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival
Testani JM, Chen J, McCauley BD, Kimmel SE, Shannon RP. Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival. Circulation 2010, 122: 265-272. PMID: 20606118, PMCID: PMC3025294, DOI: 10.1161/circulationaha.109.933275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood ProteinsBlood VolumeExtracellular FluidFemaleGlomerular Filtration RateHeart FailureHematocritHumansKidneyMaleMiddle AgedPulmonary Wedge PressureSerum AlbuminSodium Chloride Symporter InhibitorsSodium Potassium Chloride Symporter InhibitorsTreatment OutcomeVentricular PressureConceptsDecompensated heart failureRenal functionAggressive decongestionHeart failurePulmonary Artery Catheterization Effectiveness trialPulmonary capillary wedge pressureAggressive fluid removalCapillary wedge pressureIntravascular volume depletionRight atrial pressureCongestive heart failureEvidence of hemoconcentrationAggressive diuresisIntravascular substancesWedge pressureAtrial pressureBaseline characteristicsLoop diureticsTop tertileVolume depletionEffectiveness trialExtravascular fluidFluid removalHemoconcentrationHigh doses
2005
Fluid responsiveness in spontaneously breathing patients: A review of indexes used in intensive care
Coudray A, Romand JA, Treggiari M, Bendjelid K. Fluid responsiveness in spontaneously breathing patients: A review of indexes used in intensive care. Critical Care Medicine 2005, 33: 2757-2762. PMID: 16352956, DOI: 10.1097/01.ccm.0000189942.24113.65.Peer-Reviewed Original ResearchConceptsIll patientsFluid responsivenessRight atrial pressureProspective clinical studyCardiac output changesTrials RegisterAtrial pressureCardiac preloadFluid challengePreload reserveFluid therapyIntensive careBedside indicatorsCardiac outputCochrane groupIdentification of reportsStroke volumeFluid replacementClinical studiesHemodynamic responseRespiratory variationThermodilution techniqueFluid infusionMethodological qualityClinical utility
2003
Novel technique for isolated accessory right heart transplantation for congenital heart disease
Elefteriades J, Lovoulos C, Edwards R, Tittle S, Riley T, Tang P, Rocco E, Kopf G. Novel technique for isolated accessory right heart transplantation for congenital heart disease. Journal Of Thoracic And Cardiovascular Surgery 2003, 125: 1283-1290. PMID: 12830045, DOI: 10.1016/s0022-5223(02)73617-9.Peer-Reviewed Original ResearchConceptsRight heartSuperior vena cavaRight thoracotomyCardiopulmonary bypassPulmonary arteryDonor heartsVena cavaRight ventricleDonor's superior vena cavaDonor pulmonary arteryDonor right ventricleRight atrial pressureMean arterial pressureCongenital heart diseaseAdult mongrel dogsNovel therapeutic alternativesHeart transplantationPulmonary hypertensionArterial pressureAtrial pressureSuperior venaSinus rhythmAortic valveHeart diseaseLeft atriumInteratrial septal mobility predicts larger shunts across patent foramen ovales: An analysis with transmitral Doppler scanning
Fox E, Picard M, Chow C, Levine R, Schwamm L, Kerr A. Interatrial septal mobility predicts larger shunts across patent foramen ovales: An analysis with transmitral Doppler scanning. American Heart Journal 2003, 145: 730-736. PMID: 12679772, DOI: 10.1067/mhj.2003.5.Peer-Reviewed Original ResearchConceptsAtrial septal aneurysmCryptogenic strokeDegree of rightLarge shuntBubble scoreMitral inflow profileCerebral ischemic eventsEtiology of strokeRight atrial pressurePatent foramen ovaleSaline contrast studySize of shuntHigh-intensity signalIschemic eventsParadoxical embolismAtrial pressureConsecutive patientsSeptal aneurysmPatent foramenSeptal motionForamen ovaleRisk factorsContrast studiesDoppler scanningPatients
1996
Prevalence of Pulmonary Hypertension in Limited and Diffuse Scleroderma
Battle R, Davitt M, Cooper S, Buckley L, Leib E, Beglin P, Tischler M. Prevalence of Pulmonary Hypertension in Limited and Diffuse Scleroderma. CHEST Journal 1996, 110: 1515-1519. PMID: 8989070, DOI: 10.1378/chest.110.6.1515.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBlood PressureCross-Sectional StudiesEchocardiography, DopplerElectrocardiographyFemaleHumansHypertension, PulmonaryMaleMiddle AgedProspective StudiesPulmonary ArteryPulmonary Diffusing CapacityPulmonary VentilationScleroderma, SystemicTricuspid Valve InsufficiencyConceptsPulmonary artery systolic pressurePulmonary hypertensionDiffuse sclerodermaTricuspid regurgitationSignificant end-organ damageProspective cross-sectional studyTranstricuspid pressure gradientUndiagnosed pulmonary hypertensionEnd-organ damageRight atrial pressureSuccessful treatment strategyCross-sectional studyAtrial pressureMost patientsConsecutive patientsSystolic pressureDoppler echocardiogramOutpatient clinicRespiratory indexClinical signsTreatment strategiesHypertensionPatientsNoninvasive assessmentScleroderma
1995
Change in Atrial Natriuretic Peptide Concentration after Acute Plasma Volume Expansion in Normal Pregnancy and Preeclampsia
Özcan T, Senöz S, Sahin N, Direm B, Gökmen O. Change in Atrial Natriuretic Peptide Concentration after Acute Plasma Volume Expansion in Normal Pregnancy and Preeclampsia. Gynecologic And Obstetric Investigation 1995, 39: 229-233. PMID: 7635365, DOI: 10.1159/000292416.Peer-Reviewed Original ResearchConceptsAtrial natriuretic peptideLevels of atrial natriuretic peptideNormotensive pregnant womenPlasma ANP levelsANP levelsPlasma volume expansionPregnant womenPlasma levels of atrial natriuretic peptideAtrial natriuretic peptide secretionAtrial natriuretic peptide concentrationsResponse to volume expansionNatriuretic peptide concentrationsBlood volume expansionRight atrial pressureAcute plasma volume expansionDegree of volume expansionPreeclamptic subjectsNormotensive pregnanciesPreeclamptic patientsPreeclamptic womenNormal pregnancyNatriuretic peptidePlasma levelsAtrial pressurePostinfusion levels
1992
Left Ventricular Diastolic Function during Positive End-expiratory Pressure: Impact of Right Ventricular Ischemia and Ventricular Interaction
Schulman D, Biondi J, Zohgbi S, Cecchetti A, Zaret B, Soufer R. Left Ventricular Diastolic Function during Positive End-expiratory Pressure: Impact of Right Ventricular Ischemia and Ventricular Interaction. American Journal Of Respiratory And Critical Care Medicine 1992, 145: 515-521. PMID: 1546829, DOI: 10.1164/ajrccm/145.3.515.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureLeft ventricular end-diastolic pressure-volume relationEnd-expiratory pressureRCA occlusionEnd-diastolic volumeEnd-systolic volumeCardiac outputEjection fractionRight ventricularAddition of PEEPRight coronary artery occlusionEnd-diastolic pressure-volume relationRight ventricular ischemiaVentricular diastolic functionVentricular ejection fractionCoronary artery occlusionArtery occlusionAtrial pressureDiastolic functionPressure-volume relationVentricular ischemiaAnesthetized dogsVentricular interactionLV volumesRVEDV
1987
Correlation of pulmonary ACE activity and capillary surface area during postnatal development
Pitt B, Lister G, Davies P, Reid L. Correlation of pulmonary ACE activity and capillary surface area during postnatal development. Journal Of Applied Physiology 1987, 62: 2031-2041. PMID: 3036759, DOI: 10.1152/jappl.1987.62.5.2031.Peer-Reviewed Original ResearchConceptsPulmonary ACE activityEndothelial cell surface areaACE activityPostnatal developmentDifferential postnatal developmentPulmonary arterial circulationAge-dependent increaseCO diffusing capacityCell surface areaDays of ageSeptal dimensionAtrial pressureVentilated lambsCapillary surface areaLung volumeArterial circulationAlveolar septaPulmonary microcirculationBenzoyl-phenylalanylFunctional assessmentPulmonary angiotensinDiffusing capacityDLCOAge groupsFunctional manifestations
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