2022
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease
Khera AV, Wang M, Chaffin M, Emdin CA, Samani NJ, Schunkert H, Watkins H, McPherson R, Erdmann J, Elosua R, Boerwinkle E, Ardissino D, Butterworth A, Di Angelantonio E, Naheed A, Danesh J, Chowdhury R, Krumholz H, Sheu W, Rich S, Rotter J, Chen Y, Gabriel S, Lander E, Saleheen D, Kathiresan S. Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease. Circulation Genomic And Precision Medicine 2022, 15: e003598. PMID: 36215124, PMCID: PMC9771961, DOI: 10.1161/circgen.121.003598.Peer-Reviewed Original ResearchConceptsMolecular subtypesCAD riskHigher systolic blood pressureCoronary artery disease patientsEndothelial nitric oxide synthase geneDamaging missense variantsRisk of CADSystolic blood pressureCoronary artery diseaseRisk of hypertensionNitric oxide synthase geneMissense variantsNitric oxide synthesisRare variantsOxide synthase geneDiscrete molecular subtypesNitric Oxide SignalingLow density lipoprotein receptor geneArtery diseaseBlood pressureEndothelial functionVascular toneDisease patientsCAD casesCholesterol concentrationsMachine learning models for prediction of adverse events after percutaneous coronary intervention
Niimi N, Shiraishi Y, Sawano M, Ikemura N, Inohara T, Ueda I, Fukuda K, Kohsaka S. Machine learning models for prediction of adverse events after percutaneous coronary intervention. Scientific Reports 2022, 12: 6262. PMID: 35428765, PMCID: PMC9012739, DOI: 10.1038/s41598-022-10346-1.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse eventsRisk scoreHospital mortalityCoronary interventionConsecutive coronary artery disease patientsCoronary artery disease patientsAdverse periprocedural eventsLow-risk patientsMajor adverse eventsGood discriminationMulticenter registryPeriprocedural eventsDisease patientsClinical decisionLogistic regressionSpecific interventionsRisk predictionOverall risk predictionPatientsScoresInterventionMortalityAdequate discriminationOutcomes
2021
Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis
Navarese EP, Lansky AJ, Kereiakes DJ, Kubica J, Gurbel PA, Gorog DA, Valgimigli M, Curzen N, Kandzari DE, Bonaca MP, Brouwer M, Umińska J, Jaguszewski MJ, Raggi P, Waksman R, Leon MB, Wijns W, Andreotti F. Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis. European Heart Journal 2021, 42: 4638-4651. PMID: 34002203, PMCID: PMC8669551, DOI: 10.1093/eurheartj/ehab246.Peer-Reviewed Original ResearchConceptsSpontaneous myocardial infarctionStable coronary artery disease patientsCoronary artery disease patientsElective coronary revascularisationMedical therapyCardiac mortalityMyocardial infarctionCoronary revascularisationCause mortalityDisease patientsPre-specified primary endpointCoronary artery diseaseRate ratioDeath risk reductionRandom-effects modelMultivessel diseaseMortality findingsPrimary endpointSecondary endpointsStable patientsStroke riskSurvival benefitArtery diseaseCardiac deathRevascularisationCardiovascular Benefit of CPAP Is Modified by the Sleep Apnea Related Pulse Rate Response in Coronary Artery Disease Patients with Nonsleepy OSA: Findings from the RICCADSA Randomized Controlled Trial
Azarbarzin A, Zinchuk A, Wellman D, Taranto Montemurro L, Vena D, Gell L, Messineo L, White D, Gottlieb D, Redline S, Peker Y, Sands S. Cardiovascular Benefit of CPAP Is Modified by the Sleep Apnea Related Pulse Rate Response in Coronary Artery Disease Patients with Nonsleepy OSA: Findings from the RICCADSA Randomized Controlled Trial. 2021, a1103-a1103. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1103.Peer-Reviewed Original ResearchCoronary artery disease patientsPulse rate responsesCardiovascular benefitsDisease patientsRate responseCPAPPatientsOSATrials
2013
Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control study
Vemparala K, Roy A, Bahl V, Prabhakaran D, Nath N, Sinha S, Nandi P, Pandey R, Reddy K, Manhapra A, Lakshmy R. Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control study. BMC Cardiovascular Disorders 2013, 13: 104. PMID: 24245738, PMCID: PMC3871012, DOI: 10.1186/1471-2261-13-104.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseEndothelial progenitor cellsPCAD patientsVascular cell senescencePremature CADVascular senescenceEvidence of CADPremature coronary artery disease patientsNumber of EPCsCoronary artery disease patientsPremature coronary artery diseaseProgenitor cellsCase-control studyCell senescenceYears of ageReal-time polymerase chain reactionTime polymerase chain reactionCAD epidemicEPC senescenceYounger patientsArtery diseaseDisease patientsPolymerase chain reactionRandom patientsIndia Institute
2012
Trends in Smoking Cessation Counseling: Experience From American Heart Association‐Get With The Guidelines
Huang P, Kim C, Lerman A, Cannon C, Dai D, Laskey W, Peacock W, Hernandez A, Peterson E, Smith E, Fonarow G, Schwamm L, Bhatt D. Trends in Smoking Cessation Counseling: Experience From American Heart Association‐Get With The Guidelines. Clinical Cardiology 2012, 35: 396-403. PMID: 22753250, PMCID: PMC6652349, DOI: 10.1002/clc.22023.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationCardiovascular DiseasesChi-Square DistributionCounselingFemaleGuideline AdherenceHumansMaleMiddle AgedMultivariate AnalysisPractice Guidelines as TopicQuality ImprovementRisk AssessmentRisk FactorsRisk Reduction BehaviorSmokingSmoking CessationSmoking PreventionTime FactorsUnited StatesConceptsAmerican Heart AssociationGWTG-CADGWTG-StrokeHeart AssociationSystematic quality improvement programmeCoronary artery disease patientsNational guideline recommendationsSuccessful smoking cessationQuality Improvement ProgramCessation counselingSmoking contributesStroke admissionsGuideline recommendationsRecent smokersSignificant morbidityStroke careStroke patientsSmoking cessationDisease patientsCardiovascular carePatientsAdmissionStudy periodStrokeCare
2011
Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome
Morgan TM, House JA, Cresci S, Jones P, Allayee H, Hazen SL, Patel Y, Patel RS, Eapen DJ, Waddy SP, Quyyumi AA, Kleber ME, März W, Winkelmann BR, Boehm BO, Krumholz HM, Spertus JA. Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome. BMC Medical Genomics 2011, 12: 127. PMID: 21957892, PMCID: PMC3190329, DOI: 10.1186/1471-2350-12-127.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAminohydrolasesCohort StudiesFemaleFormate-Tetrahydrofolate LigaseGenetic VariationGenome-Wide Association StudyGenotypeHumansKaplan-Meier EstimateMaleMethylenetetrahydrofolate Dehydrogenase (NADP)Middle AgedMultienzyme ComplexesMyocardial InfarctionPolymorphism, Single NucleotideProportional Hazards ModelsRisk FactorsWhite PeopleConceptsAcute coronary syndromeCoronary syndromeCoronary artery disease patientsKaplan-Meier survival analysisACS risk factorsCoronary artery diseaseUniversity-affiliated hospitalMyocardial infarction patientsPremature myocardial infarctionRace-adjusted analysesACS mortalityArtery diseaseCox regressionBorderline significanceDisease patientsInfarction patientsMyocardial infarctionRisk factorsMortality hazardIndependent cohortSurvival analysisDiverse cohortPatientsRelevant covariatesBackgroundGenome-wide association studies
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