2025
Utilization, detection rate, and pathologies on lumbosacral plexus MRI: a 25-year institutional experience
Rahmani S, Hamilton C, Nguyen J, Zaree O, Kenny-Howell C, Kirsch C, Tu L. Utilization, detection rate, and pathologies on lumbosacral plexus MRI: a 25-year institutional experience. Clinical Imaging 2025, 125: 110529. PMID: 40494183, DOI: 10.1016/j.clinimag.2025.110529.Peer-Reviewed Original ResearchPlexus MRIAbnormal findingsImaging findingsClinical indicationsPlexus magnetic resonance imagingPredictors of abnormal findingsMRI examsAssociated with abnormal findingsAbnormal radiological featuresConfounding clinical featuresTertiary referral centerAbnormal imaging findingsAbnormal MRI findingsEvaluated clinical indicatorsNerve sheath tumorsClinically relevant pathologyMultivariate logistic regressionPercentage of casesMagnetic resonance imagingInfectious/inflammatory etiologyLumbar radiculopathySheath tumorsLumbosacral plexopathyPatient ageReferral centerThe role of hinged external fixation in the treatment of knee dislocation, subluxation and fracture‐dislocation: A systematic review of indications
Ayhan E, Levitt S, Abrams G, Stannard J, Medvecky M. The role of hinged external fixation in the treatment of knee dislocation, subluxation and fracture‐dislocation: A systematic review of indications. Journal Of Experimental Orthopaedics 2025, 12: e70275. PMID: 40390855, PMCID: PMC12086806, DOI: 10.1002/jeo2.70275.Peer-Reviewed Original ResearchKnee fracture-dislocationsHinged external fixatorComplex knee injuriesFracture-dislocationKnee injuriesKnee dislocationKnee-spanning external fixationTibiofemoral subluxationChronic KDTreatment of knee dislocationsExternal fixationSoft tissue injuriesEvaluation of patientsSystematic reviewInclusion criteriaKneeLigament deficiencyLevel IVReview of indicationsSubluxationClinical indicationsCapsular releaseNon-comparative evaluationExtensor mechanism disruptionChronic knee dislocationVariability of the posteromedial meniscocapsular junction of the knee on MRI: Pitfall to imaging diagnosis of ramp lesions
Porrino J, Marten E, Richardson M, Moran J, Shreve C, Lee H, Haims A. Variability of the posteromedial meniscocapsular junction of the knee on MRI: Pitfall to imaging diagnosis of ramp lesions. European Journal Of Radiology Open 2025, 14: 100647. PMID: 40585065, PMCID: PMC12206330, DOI: 10.1016/j.ejro.2025.100647.Peer-Reviewed Original ResearchRamp lesionsMeniscocapsular junctionMedial meniscusAnterior cruciate ligament deficiencyPatient ageRoutine MRIMRI findingsCruciate ligament deficiencyClinical historyClinical indicationsACL insufficiencyFemale sexAncillary findingsKnee MRILesionsNormal appearancePosteromedial joint capsuleMRIImaging diagnosisKnee studiesLigament deficiencyGeneral populationPosteromedial capsuleKneeJoint capsuleDrug-Coated Balloons for Coronary Artery Disease: From Theory to Practice
Moumneh M, Jamil Y, Nanna M, Damluji A. Drug-Coated Balloons for Coronary Artery Disease: From Theory to Practice. Current Treatment Options In Cardiovascular Medicine 2025, 27: 28. DOI: 10.1007/s11936-025-01084-4.Peer-Reviewed Original ResearchDrug-Coated BalloonCoronary artery diseasePercutaneous coronary interventionArtery diseaseIn-stent stenosisAcute coronary syndromeNovel DCBEffective drug deliveryIn-stent restenosisBleeding riskDrug-eluting stentsIncreased bleedingPatient selectionLarge-vessel diseaseStandard treatmentCoronary syndromeClinical indicationsDiabetes mellitusReduce complicationsReviewThe purposeCoronary interventionDe-novo small vessel diseaseClinical casesLesion preparationConsensus groupBiomarkers in Autosomal Dominant Tubulointerstitial Kidney Disease
Li M, Jiang L, Liu Z, You R, Li Y, Xiang C, Yang L, Zhang H, Zhou X. Biomarkers in Autosomal Dominant Tubulointerstitial Kidney Disease. Integrative Medicine In Nephrology And Andrology 2025, 12 DOI: 10.1097/imna-d-24-00050.Peer-Reviewed Original ResearchAutosomal dominant tubulointerstitial kidney diseaseChronic kidney diseaseTubulointerstitial kidney diseaseKidney diseaseProgressive chronic kidney diseaseDelay kidney failureVariable clinical featuresUric acid levelsControl blood pressureRenal interstitial fibrosisImprove patient outcomesPotential therapeutic targetClinical featuresClinical manifestationsTreatment optionsInterstitial fibrosisInsidious onsetClinical indicationsDisease progressionTubular proteinuriaEarly diagnosisBlood pressurePathological featuresAdvanced stageKidney failurePredictors of Right Ventricular Pacing in Patients Undergoing Implantable Defibrillator Placement
Hummel J, Lan Z, Jones P, Khera R, Stein K, Curtis J, Akar J. Predictors of Right Ventricular Pacing in Patients Undergoing Implantable Defibrillator Placement. Journal Of Cardiovascular Electrophysiology 2025, 36: 807-812. PMID: 39930894, DOI: 10.1111/jce.16570.Peer-Reviewed Original ResearchRV pacingICD implantationCardiac arrestRight ventricular (RV) pacingICD recipientsHistory of syncopeHistory of VTHistory of AFRight ventricular pacingPacing indicationsDefibrillator placementQRS durationValidation cohortICD RegistryVentricular tachycardiaBUN levelsPacing needsClinical indicationsVentricular pacingPatientsStudy populationTransvenous defibrillationDual chamberLogistic regressionSubcutaneous devices
2024
Association Between Cumulative Anticholinergic Use and White Matter Hyperintensity Burden
Li K, Krakauer C, Nelson J, Crane P, Andre J, Curl P, Yuh E, Ralston J, Gray S, MacDonald C. Association Between Cumulative Anticholinergic Use and White Matter Hyperintensity Burden. Alzheimer's & Dementia 2024, 20: e084407. PMCID: PMC11714981, DOI: 10.1002/alz.084407.Peer-Reviewed Original ResearchMagnetic resonance imagingDose-response relationshipWhite matter hyperintensitiesAssociated with higher dementia riskAssociated with greater WMH burdenAnticholinergic useCumulative anticholinergic useKaiser Permanente WashingtonMagnetic resonance imaging scansThought (ACTAnticholinergic medication useProspective cohort studyWhite matter hyperintensity burdenDementia riskAdult ChangesWhite matter hyperintensities burdensOlder adultsAnticholinergic medicationsClinical indicationsAnticholinergic burdenCohort studyLinear regression modelsTSDDsMedication useResonance imagingPATCH (Preferred Attachment Strategy for Optimal Electrocardiograms)-1 Study
Becker R, Harnett B, Wayne D, Mardis R, Meganathan K, Steen D. PATCH (Preferred Attachment Strategy for Optimal Electrocardiograms)-1 Study. Clinical Research In Cardiology 2024, 114: 497-506. PMID: 39527276, DOI: 10.1007/s00392-024-02572-6.Peer-Reviewed Original ResearchStable cardiovascular diseaseAmbulatory clinic visitsAmbulatory clinic settingCardiovascular diseaseS-ECGClinical research coordinatorsClinical indicationsClinic visitsResearch coordinatorsValvular heart diseaseCoronary artery diseaseMedical practiceParticipantsEssential hypertensionClinical settingLead placementAtrial fibrillationHeart diseaseHeart failureTreatment decisionsArtery diseaseST-TElectrocardiographyBaselineHeart rhythmUse of multiple micronutrient supplementation integrated into routine antenatal care: A discussion of research priorities
Firoz T, Daru J, Busch‐Hallen J, Tunçalp Ö, Rogers L. Use of multiple micronutrient supplementation integrated into routine antenatal care: A discussion of research priorities. Maternal And Child Nutrition 2024, 21: e13722. PMID: 39356051, PMCID: PMC11650040, DOI: 10.1111/mcn.13722.Peer-Reviewed Original ResearchMultiple micronutrient supplementationWorld Health OrganizationImplementation researchGestational ageAntenatal care recommendationsEvidence-to-decision frameworkImplementation research questionsPositive pregnancy experienceEvidence-to-DecisionRoutine antenatal careResearch prioritiesInclusion of outcomesHealth of womenMicronutrient supplementationClinical indicationsOptimal maternal nutritionAntenatal careIron-containing supplementsCare recommendationsPregnancy experienceStandard of careDiscussion of research prioritiesTechnical consultationPerinatal outcomesIFA supplementation
2023
Mass spectrometry on cerebrospinal fluid uncovers association of novel glycolysis biomarkers with Alzheimer’s disease in a complex clinical cohort
de Geus M, Leslie S, Wang W, Lam T, Broekman M, Neefjes S, Nairn A, Carlyle B, Arnold S. Mass spectrometry on cerebrospinal fluid uncovers association of novel glycolysis biomarkers with Alzheimer’s disease in a complex clinical cohort. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.078466.Peer-Reviewed Original ResearchAlzheimer's diseaseMild cognitive impairmentHospital neurology serviceNon-AD diagnosesDiagnostic lumbar puncturePrognosis of ADCerebrospinal fluid biomarkersClinic cohortFurther mechanistic studiesNeurology serviceFDG-PETBrain metabolismFluid biomarkersLumbar puncturePatient cohortClinical indicationsDisease progressionATN biomarkersClinical cohortTreatment responseComplex cohortBackground DiagnosisCSF samplesTreatment efficacyLinear regression analysisSelected-Lesion SRS as a Novel Strategy in Treatment of Patients with Multiple Brain Metastases
Singh C, Theriault B, An Y, Yu J, Knisely J, Shepard M, Wegner R, Warnick R, Peker S, Samanci Y, Trifiletti D, Lee C, Yang H, Bernstein K, Kondziolka D, Tripathi M, Mathieu D, Mantziaris G, Pikis S, Sheehan J, Chiang V. Selected-Lesion SRS as a Novel Strategy in Treatment of Patients with Multiple Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e150-e151. DOI: 10.1016/j.ijrobp.2023.06.971.Peer-Reviewed Original ResearchWhole-brain radiation therapyTreatment of patientsSystemic diseaseBrain metastasesLesion locationIntracranial lesionsPrior whole-brain radiation therapyMultiple brain metastasesBrain radiation therapyUntreated brain metastasesBrain metastasis treatmentCurrent practice patternsSigns/symptomsPresence of symptomsMATERIAL/METHODSImmunotherapy optionsSystemic therapyUntreated lesionsMedical oncologyPerilesional edemaDrug optionsClinical trialsPractice patternsClinical indicationsMetastasis treatment1-Year Outcomes in a Pooled Cohort of Harmony Transcatheter Pulmonary Valve Clinical Trial Participants
Gillespie M, McElhinney D, Jones T, Levi D, Asnes J, Gray R, Cabalka A, Fujimoto K, Qureshi A, Justino H, Bergersen L, Benson L, Haugan D, Boe B, Cheatham J. 1-Year Outcomes in a Pooled Cohort of Harmony Transcatheter Pulmonary Valve Clinical Trial Participants. JACC Cardiovascular Interventions 2023, 16: 1917-1928. PMID: 37278682, DOI: 10.1016/j.jcin.2023.03.002.Peer-Reviewed Original ResearchConceptsTranscatheter pulmonary valveRight ventricular outflow tractSevere pulmonary regurgitationPulmonary regurgitationPrimary analysisCardiac magnetic resonance imagingContinued Access StudyMild pulmonary regurgitationOne-year safetyMedian patient agePulmonary valve replacementLong-term valve performanceVentricular outflow tractFirst U.S. FoodClinical trial participantsMagnetic resonance imagingEligible patientsMost patientsPatient ageValve replacementHemodynamic outcomesPooled cohortPulmonary valveVentricular tachycardiaClinical indicationsImpaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis
Feher A, Miller E, Peters D, Mojibian H, Sinusas A, Hinchcliff M, Baldassarre L. Impaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis. Rheumatology International 2023, 43: 849-858. PMID: 36894756, PMCID: PMC12073471, DOI: 10.1007/s00296-023-05294-6.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementLV-GLSSystemic sclerosisWorse survivalClinical indicationsImpaired left ventricular global longitudinal strainLeft ventricular global longitudinal strainPresence of LGECMR strainLV cardiac indexWorse LV-GLSLV ejection fractionCox regression analysisGlobal longitudinal strainLV cardiac outputGlobal radialCardiac indexOverall survivalRetrospective cohortEjection fractionPrognostic valueAdverse outcomesCardiac outputGadolinium enhancementRV strainHopping as an Indicator of Chemotoxicity: Gait Analysis in Patients With Leukemia and Lymphoma
Parker K, Durben N, Oleson D, Yu Y, Lim J, Recht M, Lindemulder S. Hopping as an Indicator of Chemotoxicity: Gait Analysis in Patients With Leukemia and Lymphoma. Journal Of Pediatric Hematology/Oncology 2023, 45: e582-e589. PMID: 36898017, DOI: 10.1097/mph.0000000000002645.Peer-Reviewed Original ResearchConceptsFunctional movement analysisObserving gaitGait assessmentGait analysisMovement analysisQuality of Life QuestionnaireMean overall scoresSurvivors of acute lymphoblastic leukemiaQuality of lifeQuality-of-life assessmentGait parametersNeuromuscular changesLife QuestionnaireGaitQOL scoresParticipants 2General populationNeuromuscular functionOverall scorePrimary aimsParticipantsClinical indicationsScoresGAITRiteAssessmentNon-hyperemic pressure ratios – theoretical basis, clinical applications, and limitations
Chamié D, Maia J, Raminho T, Eurípedes L, Sant'Anna L, Caixeta A, Sant'Anna F. Non-hyperemic pressure ratios – theoretical basis, clinical applications, and limitations. Journal Of Transcatheter Interventions 2023, 31: 1-16. DOI: 10.31160/jotci202331a202208.Peer-Reviewed Original ResearchFractional flow reserveClinical outcome dataPercutaneous coronary interventionFlow reserveInstantaneous wave-free ratioPressure ratioCoronary interventionOutcome dataAtherosclerotic diseaseNon-hyperemic pressure ratiosAnatomical scenariosRobust body of evidenceStandard of careIdentification of myocardial ischemiaSuccess of percutaneous coronary interventionGuideline recommendationsCoronary atherosclerotic diseaseTranscatheter interventionsProcedure timeFunctional successHyperemic agentsClinical indicationsPatient discomfortMyocardial ischemiaClinical use
2022
Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs
Jing J, Ge W, Struck A, Fernandes M, Hong S, An S, Fatima S, Herlopian A, Karakis I, Halford J, Ng M, Johnson E, Appavu B, Sarkis R, Osman G, Kaplan P, Dhakar M, Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider H, Kim J, Swisher C, Gaspard N, Cervenka M, Rodriguez Ruiz A, Lee J, Tabaeizadeh M, Gilmore E, Nordstrom K, Yoo J, Holmes M, Herman S, Williams J, Pathmanathan J, Nascimento F, Fan Z, Nasiri S, Shafi M, Cash S, Hoch D, Cole A, Rosenthal E, Zafar S, Sun J, Westover M. Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs. Neurology 2022, 100: e1737-e1749. PMID: 36460472, PMCID: PMC10136018, DOI: 10.1212/wnl.0000000000201670.Peer-Reviewed Original ResearchConceptsGeneralized rhythmic delta activityLateralized rhythmic delta activityLateralized periodic dischargesRhythmic delta activityDelta activityPeriodic dischargesClass II evidencePrimary outcome measureMassachusetts General HospitalContributions of biasCritical illnessSecondary outcomesMedian ageInterrater reliability studyClinical indicationsGeneral HospitalMedian numberOutcome measuresProspective analysisExpert consensusSeizuresBrain monitoringInterrater reliabilityBrain activitySelection biasReal-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection.
Medvedeva N, Radcliffe C, Malinis M, Chen M, Azar M. Real-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection. PLOS ONE 2022, 17: e0277403. PMID: 36374789, PMCID: PMC9662742, DOI: 10.1371/journal.pone.0277403.Peer-Reviewed Original ResearchConceptsPET/CTClinical impactFDG PET/CTRetrospective chart reviewEmission tomography/Evaluation of infectionDiagnosis of infectionVariety of syndromesInfectious indicationsChart reviewCommon indicationTomography useUnknown etiologyEndovascular infectionTomography/Antimicrobial managementClinical indicationsReal-world assessmentInclusion criteriaClinical utilityPatientsTreatment managementUnknown originInfectionCTPrehospital emergency department care activations during the initial COVID-19 pandemic surge.
Leff R, Fleming-Nouri A, Venkatesh AK, Parwani V, Rothenberg C, Sangal RB, Flood CT, Goldenberg M, Wira C. Prehospital emergency department care activations during the initial COVID-19 pandemic surge. American Journal Of Disaster Medicine 2022, 17: 23-39. PMID: 35913181, DOI: 10.5055/ajdm.2022.0417.Peer-Reviewed Original ResearchConceptsCOVID-19 hospital admissionsCOVID-19 pandemic surgeTotal ED volumeNumber of patientsCOVID-19 hospitalizationScatterplot smoothing curvesPublic health measuresCritical medical conditionPublic health emergencyPrehospital presentationStroke activationHospital admissionPrimary outcomeTrauma activationsUrban EDAcademic EDCOVID-19 casesPrehospital settingClinical indicationsType of presentationMedical conditionsED volumePandemic surgeAbsolute decreaseHealth measuresChapter 8 Cardiac Magnetic Resonance Imaging
Mojibian H, Pouraliakbar H. Chapter 8 Cardiac Magnetic Resonance Imaging. 2022, 175-183. DOI: 10.1016/b978-0-323-80915-3.00023-5.Peer-Reviewed Original Research
2021
COVID-19 vaccine – Long term immune decline and breakthrough infections
Khoury J, Najjar-Debbiny R, Hanna A, Jabbour A, Abu Ahmad Y, Saffuri A, Abu-Sinni M, Shkeiri R, Elemy A, Hakim F. COVID-19 vaccine – Long term immune decline and breakthrough infections. Vaccine 2021, 39: 6984-6989. PMID: 34763949, PMCID: PMC8556595, DOI: 10.1016/j.vaccine.2021.10.038.Peer-Reviewed Original ResearchConceptsAntibody titersCOVID-19 vaccineBreakthrough infectionsSecond doseAntibody levelsPolymerase chain reactionBNT162b2 mRNA COVID-19 vaccineSARS-CoV-2 polymerase chain reactionMRNA COVID-19 vaccineStudy periodBreakthrough infection rateMedian antibody levelsMean antibody levelsLongitudinal prospective studyAntibody declineTiter elevationImmune declineProspective studyClinical indicationsMild casesHealthcare personnelInfection rateInfectionVaccinePeak levels
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