2025
Predictors of Right Ventricular Pacing in Patients Undergoing Implantable Defibrillator Placement
Hummel J, Lan Z, Jones P, Khera R, Stein K, Curtis J, Akar J. Predictors of Right Ventricular Pacing in Patients Undergoing Implantable Defibrillator Placement. Journal Of Cardiovascular Electrophysiology 2025, 36: 807-812. PMID: 39930894, DOI: 10.1111/jce.16570.Peer-Reviewed Original ResearchRV pacingICD implantationCardiac arrestRight ventricular (RV) pacingICD recipientsHistory of syncopeHistory of VTHistory of AFRight ventricular pacingPacing indicationsDefibrillator placementQRS durationValidation cohortICD RegistryVentricular tachycardiaBUN levelsPacing needsClinical indicationsVentricular pacingPatientsStudy populationTransvenous defibrillationDual chamberLogistic regressionSubcutaneous devices
2024
Impact of Time to Initiation of Targeted Temperature Management Among Patients with Out-of-Hospital Cardiac Arrest Undergoing Percutaneous Coronary Intervention
Kovach C, Leonard J, Messenger J, Waldo S, Perman S. Impact of Time to Initiation of Targeted Temperature Management Among Patients with Out-of-Hospital Cardiac Arrest Undergoing Percutaneous Coronary Intervention. Therapeutic Hypothermia And Temperature Management 2024, 15: 74-81. PMID: 39311798, DOI: 10.1089/ther.2024.0030.Peer-Reviewed Original ResearchOdds of neurologically favorable survivalOut-of-hospital cardiac arrestST-elevation myocardial infarctionNeurologically favorable survivalPercutaneous coronary interventionInitiation of targeted temperature managementTemperature management initiationFavorable survivalOverall survivalHospital dischargeVentricular tachycardiaTemperature managementSurvivors of ventricular tachycardiaVentricular fibrillationCoronary interventionAssociated with adverse clinical outcomesDelayed coronary angiographyProportion of patientsAdverse clinical outcomesPropensity-weighted analysisAssociated with decreased oddsAssociated with delayWithdrawal of life-sustaining careLife-sustaining careCoronary angiography
2023
Slow ventricular tachycardia induced by amiodarone overdose
Boivin Z, Pugliese N, Quinby P. Slow ventricular tachycardia induced by amiodarone overdose. JEM Reports 2023, 2: 100056. DOI: 10.1016/j.jemrpt.2023.100056.Peer-Reviewed Original ResearchSlow ventricular tachycardiaVentricular tachycardiaImplanted defibrillatorsExtensive past medical historyEpisodes of VTWide complex rhythmPast medical historyUnderlying cardiac conditionAcute amiodaroneAcute overdoseHeart failureHeroin overdoseArrhythmic complicationsBrief admissionCardiac outputMedical historyOverdrive pacingPolysubstance abuseEmergency physiciansCardiac conditionsPatientsOverdoseCocaine useAmiodaroneSubstance useOutcomes in patients with COVID-19 and new onset heart blocks: Insight from the National Inpatient Sample database
Shoura S, Teaima T, Sana M, Abbasi A, Atluri R, Yilmaz M, Hammo H, Ali L, Kanitsoraphan C, Park D, Alyousef T. Outcomes in patients with COVID-19 and new onset heart blocks: Insight from the National Inpatient Sample database. World Journal Of Cardiology 2023, 15: 448-461. PMID: 37900263, PMCID: PMC10600784, DOI: 10.4330/wjc.v15.i9.448.Peer-Reviewed Original ResearchHigh-degree atrioventricular blockLength of hospital stayAcute kidney injuryBundle branch blockCOVID-19 pneumoniaTotal hospital chargesKidney injuryCardiogenic shockSupraventricular tachycardiaMechanical ventilationVentricular tachycardiaCardiac arrestBundle branch block groupInpatient mortalityNational Inpatient Sample (NIS) databaseOdds of in-hospital mortalitySARS-CoV-2Left bundle branch blockNational Inpatient Sample databasePre-existing pacemakersStata version 17In-Hospital MortalityCardiac conduction systemInpatient Sample databaseOdds of inpatient mortality1-Year Outcomes in a Pooled Cohort of Harmony Transcatheter Pulmonary Valve Clinical Trial Participants
Gillespie M, McElhinney D, Jones T, Levi D, Asnes J, Gray R, Cabalka A, Fujimoto K, Qureshi A, Justino H, Bergersen L, Benson L, Haugan D, Boe B, Cheatham J. 1-Year Outcomes in a Pooled Cohort of Harmony Transcatheter Pulmonary Valve Clinical Trial Participants. JACC Cardiovascular Interventions 2023, 16: 1917-1928. PMID: 37278682, DOI: 10.1016/j.jcin.2023.03.002.Peer-Reviewed Original ResearchConceptsTranscatheter pulmonary valveRight ventricular outflow tractSevere pulmonary regurgitationPulmonary regurgitationPrimary analysisCardiac magnetic resonance imagingContinued Access StudyMild pulmonary regurgitationOne-year safetyMedian patient agePulmonary valve replacementLong-term valve performanceVentricular outflow tractFirst U.S. FoodClinical trial participantsMagnetic resonance imagingEligible patientsMost patientsPatient ageValve replacementHemodynamic outcomesPooled cohortPulmonary valveVentricular tachycardiaClinical indicationsCorrection: Impact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database
Khalil M, Maraey A, Aglan A, Akintoye E, Salem M, Elzanaty A, Younes A, Saeyeldin A, Barbhaiya C, Shokr M. Correction: Impact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database. Journal Of Interventional Cardiac Electrophysiology 2023, 1-1. PMID: 37009939, DOI: 10.1007/s10840-023-01539-3.Peer-Reviewed Original ResearchAtrial Fibrillation And Conduction Disease Are Associated With Cardiac Amyloidosis Subtypes
Patolia H, Chandramouli S, Cavalier J, Sen S, Arps K, Pokorney S, Karra R, Khouri M. Atrial Fibrillation And Conduction Disease Are Associated With Cardiac Amyloidosis Subtypes. Journal Of Cardiac Failure 2023, 29: 550-551. DOI: 10.1016/j.cardfail.2022.10.014.Peer-Reviewed Original ResearchAtrial fibrillationConduction diseaseVentricular tachycardiaCardiac amyloidosisHigh prevalencePresence of AFCross-sectional observational studyRight bundle branch blockHeart failure symptomsResults Patient characteristicsStandardized chart reviewSubtypes/genotypesPrevalence of arrhythmiasBundle branch blockLonger QRS intervalGenotype-related differencesATTR-CA patientsCardiac amyloidosis subtypesATTR-CMBaseline characteristicsChart reviewPatient characteristicsVentricular arrhythmiasAtrial arrhythmiasInfiltrative diseasePredicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring
Ginder C, Li J, Halperin J, Akar J, Martin D, Chattopadhyay I, Upadhyay G. Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring. Journal Of The American College Of Cardiology 2023, 81: 949-961. PMID: 36889873, DOI: 10.1016/j.jacc.2022.12.024.Peer-Reviewed Original ResearchConceptsAppropriate device therapyMalignant ventricular arrhythmiasDevice therapyVentricular arrhythmiasImplantable cardioverter-defibrillator therapyLogistic regressionSeparate multivariable logistic regressionsLead impedanceAppropriate ICD therapyCardioverter-defibrillator therapyCardiac resynchronization therapyMultivariable logistic regressionRemote monitoring dataShock lead impedanceAtrial lead impedanceICD therapyHeart failureResynchronization therapyAppropriate therapyAtrial tachyarrhythmiasVentricular tachycardiaVentricular fibrillationDefibrillator devicesHeart ratePatientsUsing real-world data from health systems to evaluate the safety and effectiveness of a catheter to treat ischemic ventricular tachycardia
Dhruva S, Zhang S, Chen J, Noseworthy P, Doshi A, Agboola K, Herrin J, Jiang G, Yu Y, Cafri G, Farr K, Mbwana M, Ross J, Coplan P, Drozda J. Using real-world data from health systems to evaluate the safety and effectiveness of a catheter to treat ischemic ventricular tachycardia. Journal Of Interventional Cardiac Electrophysiology 2023, 66: 1817-1825. PMID: 36738387, PMCID: PMC12306424, DOI: 10.1007/s10840-023-01496-x.Peer-Reviewed Original ResearchConceptsIschemic ventricular tachycardiaVentricular tachycardiaHealth system dataVT ablationSTSF catheterComposite outcomeHealth systemRisk differencePre-specified performance goalComposite safety outcomeReal-world safetyRoutine clinical practiceDrug Administration approvalAverage risk differenceThromboembolic eventsTotal patientsHeart failureProcedural complicationsMethodsAmong patientsAdministration approvalMayo ClinicSafety outcomesEffectiveness outcomesClinical practiceCatheter
2022
Life-threatening cardiac arrhythmia and sudden death during electronic gaming: An international case series and systematic review
Lawley C, Tester M, Sanatani S, Prendiville T, Beach C, Vinocur J, Horie M, Uhm J, Khongphatthanayothin A, Ayers M, Starling L, Yoshida Y, Shah M, Skinner J, Turner C. Life-threatening cardiac arrhythmia and sudden death during electronic gaming: An international case series and systematic review. Heart Rhythm 2022, 19: 1826-1833. PMID: 37850595, DOI: 10.1016/j.hrthm.2022.08.003.Peer-Reviewed Original ResearchConceptsInternational case seriesLife-threatening cardiac arrhythmiasCardiac arrhythmiasCase seriesSystematic reviewCatecholaminergic polymorphic ventricular tachycardiaPolymorphic ventricular tachycardiaLong QT syndromeLethal cardiac arrhythmiasCardiac eventsCoronary ischemiaCardiac surgeryVentricular arrhythmiasCardiac arrestSusceptible childrenVentricular tachycardiaVentricular fibrillationSudden deathCardiac conditionsArrhythmic triggersCardiac diagnosisPatientsQT syndromeSusceptible individualsArrhythmiasCardiac crises: Cardiac arrhythmias and cardiomyopathy during TANGO2 deficiency related metabolic crises
Miyake CY, Lay EJ, Beach CM, Ceresnak SR, Delauz CM, Howard TS, Janson CM, Jardine K, Kannankeril PJ, Kava M, Kim JJ, Liberman L, Macicek SL, Pham TD, Robertson T, Valdes SO, Webster G, Stephens SB, Milewicz DM, Azamian M, Ehsan SA, Houck KM, Soler-Alfonso C, Glinton KE, Tosur M, Li N, Xu W, Lalani SR, Zhang L. Cardiac crises: Cardiac arrhythmias and cardiomyopathy during TANGO2 deficiency related metabolic crises. Heart Rhythm 2022, 19: 1673-1681. PMID: 35568137, PMCID: PMC10642301, DOI: 10.1016/j.hrthm.2022.05.009.Peer-Reviewed Original ResearchConceptsVentricular tachycardiaCardiac crisisCardiac arrestMetabolic crisisIntravenous magnesiumAtrial pacingCardiac arrhythmiasRetrospective multicenter chart reviewType I Brugada patternInitiation of feedsMulticenter chart reviewMembrane oxygenation supportCurrent treatment optionsAutosomal recessive diseaseLethal cardiac arrhythmiasBrugada patternOxygenation supportCardiac manifestationsChart reviewQTc prolongationAntiarrhythmic drugsHeart blockSupraventricular tachycardiaTreatment optionsSuccessful treatmentImpact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database
Khalil M, Maraey A, Aglan A, Akintoye E, Salem M, Elzanaty A, Younes A, Saeyeldin A, Barbhaiya C, Shokr M. Impact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database. Journal Of Interventional Cardiac Electrophysiology 2022, 66: 323-331. PMID: 35314904, DOI: 10.1007/s10840-022-01187-z.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseNational Readmission DatabaseClinical outcomesVentricular tachycardiaCatheter ablationKidney diseaseHospital mortalityVT ablationOdds ratioCorresponding diagnosis codesUnderwent catheter ablationAcute kidney injuryTotal hospital chargesWorse clinical outcomesMean lengthMultivariable regression analysisCKD groupConclusionIn patientsGroup patientsKidney injurySecondary outcomesHospital chargesDiagnosis codesClinical dataEffective treatmentSAFETY AND EFFECTIVENESS OF THERMOCOOL STSF CATHETER FOR ABLATION OF ISCHEMIC VENTRICULAR TACHYCARDIA
Dhruva S, Zhang S, Chen J, Noseworthy P, Doshi A, Agboola K, Herrin J, Jiang G, Yu Y, Cafri G, Farr K, Ervin K, Ross J, Coplan P, Drozda J. SAFETY AND EFFECTIVENESS OF THERMOCOOL STSF CATHETER FOR ABLATION OF ISCHEMIC VENTRICULAR TACHYCARDIA. Journal Of The American College Of Cardiology 2022, 79: 116. DOI: 10.1016/s0735-1097(22)01107-x.Peer-Reviewed Original ResearchApproach to Wide Complex Tachycardia in Paediatric Patients
Escudero C, Tan R, Beach C, Dalal A, LaPage M, Hill A. Approach to Wide Complex Tachycardia in Paediatric Patients. CJC Pediatric And Congenital Heart Disease 2022, 1: 60-73. PMID: 37969244, PMCID: PMC10642107, DOI: 10.1016/j.cjcpc.2022.02.003.Peer-Reviewed Original ResearchWide complex tachycardiaPediatric patientsComplex tachycardiaVariety of causesYounger patientsChronic managementUnstable patientsTreatment optionsSupraventricular tachycardiaVentricular pacingAccessory pathwayVentricular tachycardiaDifferential diagnosisDiagnostic maneuversTachycardia terminationPatientsTachycardiaVentricular activationElectrocardiographic tracingsAberrant conductionUnderlying causeCareful reviewPotential causesCauseReviewGene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact
Dave J, Raad N, Mittal N, Zhang L, Fargnoli A, Oh JG, Savoia ME, Hansen J, Fava M, Yin X, Theofilatos K, Ceholski D, Kohlbrenner E, Jeong D, Wills L, Nonnenmacher M, Haghighi K, Costa KD, Turnbull IC, Mayr M, Cai CL, Kranias EG, Akar FG, Hajjar RJ, Stillitano F. Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact. Cardiovascular Research 2022, 118: 3140-3150. PMID: 35191471, PMCID: PMC9732517, DOI: 10.1093/cvr/cvac021.Peer-Reviewed Original ResearchConceptsAdeno-associated virus 9Ventricular tachycardiaCardiac functionStroke volumeHigh arrhythmia burdenSustained ventricular tachycardiaSudden cardiac deathCardiac magnetic resonancePre-symptomatic carriersYoung adult miceWeeks of ageDroplet digital polymerase chain reactionArrhythmia burdenVulnerable myocardiumCardiac deathEjection fractionPreclinical evidenceMalignant arrhythmiasVentricular dilationHumanized miceWT miceCardiac outputPolymerase chain reactionPLN-R14DelAdult mice
2021
Feasibility of using real-world data in the evaluation of cardiac ablation catheters: a test-case of the National Evaluation System for Health Technology Coordinating Center
Dhruva SS, Jiang G, Doshi AA, Friedman DJ, Brandt E, Chen J, Akar JG, Ross JS, Ervin KR, Farr K, Shah ND, Coplan P, Noseworthy PA, Zhang S, Forsyth T, Schulz WL, Yu Y, Drozda JP. Feasibility of using real-world data in the evaluation of cardiac ablation catheters: a test-case of the National Evaluation System for Health Technology Coordinating Center. BMJ Surgery Interventions & Health Technologies 2021, 3: e000089. PMID: 35047806, PMCID: PMC8749235, DOI: 10.1136/bmjsit-2021-000089.Peer-Reviewed Original ResearchPositive predictive valuePersistent atrial fibrillationIschemic ventricular tachycardiaAblation catheterHealth systemAtrial fibrillationVentricular tachycardiaCardiac ablation catheterAcute heart failureDuration of patientsHealth system dataCardiac tamponadeIschemic strokeRetrospective cohortHeart failureClinical outcomesEndpoint ascertainmentPredictive valueCatheterChart validationCoordinating CenterTachycardiaPatientsFibrillationParticipant populationArrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation
Raad N, Bittihn P, Cacheux M, Jeong D, Ilkan Z, Ceholski D, Kohlbrenner E, Zhang L, Cai CL, Kranias EG, Hajjar RJ, Stillitano F, Akar FG. Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation. Circulation 2021, 144: 441-454. PMID: 34024116, PMCID: PMC8456417, DOI: 10.1161/circulationaha.119.043502.Peer-Reviewed Original ResearchConceptsHuman PLNRapid pacingInterventricular activation delayHumanized mouse modelAction potential prolongationLocal conduction blockSteep repolarization gradientsArrhythmogenic featuresMacroreentrant circuitHemodynamic changesElectric remodelingElectrophysiological remodelingRight ventricleVentricular tachycardiaPotential prolongationSudden deathConduction blockMouse modelAdult knockArrhythmia susceptibilityAdrenergic stimulationStructural remodelingArrhythmogenic phenotypeArrhythmia mechanismsRegulatory protein phospholamban
2020
Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death
Ghovanloo MR, Atallah J, Escudero CA, Ruben PC. Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death. Frontiers In Physiology 2020, 11: 610436. PMID: 33414724, PMCID: PMC7783455, DOI: 10.3389/fphys.2020.610436.Peer-Reviewed Original ResearchSudden cardiac deathCatecholaminergic polymorphic ventricular tachycardiaAtrial action potential durationCPVT-like phenotypeOnset of symptomsPolymorphic ventricular tachycardiaPrimary electrical disordersStrong family historyCardiac electrical propertiesAction potential durationNovel SCN5A mutationUse-dependent inactivationCardiac ion channelsO'Hara-Rudy modelCardiac deathVentricular arrhythmiasSCD casesTachy-arrhythmiasVentricular tachycardiaFetal Echocardiography
Copel J. Fetal Echocardiography. 2020, 41-47. DOI: 10.1002/9781119635307.ch6.ChaptersCongenital heart diseaseFetal echocardiographyFetal tachycardiaHeart diseaseSignificant congenital heart diseaseReentrant atrial tachycardiaColor Doppler imagingPostnatal echocardiographyExtracardiac anomaliesAtrial tachycardiaAtrial flutterCardiac anomaliesVentricular extrasystolesVentricular tachycardiaFetal arrhythmiasDifferential diagnosisDoppler imagingEchocardiographyTachycardiaEtiological diversityFetal scanRational management strategyMultifactorial fashionArrhythmiasDiseaseSurvival Following Implantable Cardioverter‐Defibrillator Implantation in Patients With Amyloid Cardiomyopathy
Higgins AY, Annapureddy AR, Wang Y, Minges KE, Lampert R, Rosenfeld LE, Jacoby DL, Curtis JP, Miller EJ, Freeman JV. Survival Following Implantable Cardioverter‐Defibrillator Implantation in Patients With Amyloid Cardiomyopathy. Journal Of The American Heart Association 2020, 9: e016038. PMID: 32867553, PMCID: PMC7726970, DOI: 10.1161/jaha.120.016038.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillator implantationCardioverter-defibrillator implantationNonischemic cardiomyopathyCardiac amyloidosisDiabetes mellitusCerebrovascular diseaseVentricular tachycardiaMultivariable Cox proportional hazards regression modelsCox proportional hazards regression modelProportional hazards regression modelsKaplan-Meier survival curvesCox proportional hazards modelPropensity-matched cohortOutcomes of patientsHazards regression modelsProportional hazards modelCause mortalityICD implantationRenal functionMultivariable analysisConclusions MortalityRisk factorsRegistry dataAmyloid cardiomyopathyHigh risk
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