2025
A flexible Bayesian g-formula for causal survival analyses with time-dependent confounding
Chen X, Hu L, Li F. A flexible Bayesian g-formula for causal survival analyses with time-dependent confounding. Lifetime Data Analysis 2025, 31: 394-421. PMID: 40227517, DOI: 10.1007/s10985-025-09652-3.Peer-Reviewed Original ResearchConceptsG-formulaBalance scoresHealth system electronic health recordDiscrete survival dataTime-to-event outcomesPosterior sampling algorithmParametric g-formulaElectronic health recordsBayesian additive regression treesTime-varying treatmentsHypothetical intervention scenariosAdditive regression treesLongitudinal observational studyGeneral classModel misspecificationHealth recordsEmpirical performanceSampling algorithmObservational studySurvival dataIntervention scenariosScoresTreatment strategiesMisspecificationCausality analysis
2024
The Impact of Non-Pain Factors on Pain Interference Among U.S. Service Members and Veterans with Symptoms of Mild Traumatic Brain Injury
Kennedy E, Manhapra A, Miles S, Martindale S, Rowland J, Mobasher H, Myers M, Panahi S, Walker W, Pugh M. The Impact of Non-Pain Factors on Pain Interference Among U.S. Service Members and Veterans with Symptoms of Mild Traumatic Brain Injury. Journal Of Neurotrauma 2024 PMID: 38907690, DOI: 10.1089/neu.2024.0126.Peer-Reviewed Original ResearchPredictors of pain interferencePain interferenceMild traumatic brain injuryTraumatic brain injuryU.S. service membersPain intensityAssociated with pain interferenceAssociated with functional limitationsService membersRates of traumatic brain injuryPain interference scoresPain intensity scoresHistory of traumatic brain injuryProspective longitudinal observational studyNon-pain symptomsTraumatic brain injury historyLongitudinal observational studyHolistic treatment approachSymptoms of mild traumatic brain injuryBrain injuryFunctional limitationsPain scoresChronic painIdentifying fatigueTargeting comorbiditiesPredicting clinical outcomes of SARS-CoV-2 infection during the Omicron wave using machine learning
Cogill S, Nallamshetty S, Fullenkamp N, Heberer K, Lynch J, Lee K, Aslan M, Shih M, Lee J. Predicting clinical outcomes of SARS-CoV-2 infection during the Omicron wave using machine learning. PLOS ONE 2024, 19: e0290221. PMID: 38662748, PMCID: PMC11045098, DOI: 10.1371/journal.pone.0290221.Peer-Reviewed Original ResearchConceptsHigh-risk groupSARS-CoV-2 infectionAnticoagulant useAdverse outcomesPredictor of adverse outcomesHigher risk of adverse outcomesLower body mass indexRisk of adverse outcomesVaccination of high-risk groupsOral anticoagulant useOutcome of SARS-CoV-2 infectionRetrospective longitudinal observational studySARS-CoV-2U.S. Veterans Health AdministrationClinical outcomes of SARS-CoV-2 infectionIdentification of patientsBody mass indexVeterans Health AdministrationPredictors of hospitalizationEscalation of careLongitudinal observational studyClinical outcomesOmicron SARS-CoV-2 variantSARS-CoV-2 variantsUnvaccinated patientsImpact of Pre-Diagnostic Risk Factors on Short- and Long-Term Ovarian Cancer Survival Trajectories: A Longitudinal Observational Study
Kim S, Tworoger S, Rosen B, McLaughlin J, Risch H, Narod S, Kotsopoulos J. Impact of Pre-Diagnostic Risk Factors on Short- and Long-Term Ovarian Cancer Survival Trajectories: A Longitudinal Observational Study. Cancers 2024, 16: 972. PMID: 38473333, PMCID: PMC11154316, DOI: 10.3390/cancers16050972.Peer-Reviewed Original ResearchOvarian cancer-specific mortalityLongitudinal observational studyAll-Cause MortalityCancer-specific mortalityPredictor of ovarian cancer survivalRisk factorsPopulation-based longitudinal observational studyRisk of all-cause mortalityProvincial cancer registryObservational studySurvival trajectoriesInvasive epithelial ovarian cancerHistory of breastfeedingOvarian cancer survivalExtended Cox proportional hazards modelsCox proportional hazards modelsPredictor of all-cause mortalityCancer RegistryAssociated with long-term overall survivalProportional hazards modelLifestyle factorsAll-CauseCancer survivalDiagnosis of ovarian cancerOverall survival
2023
NCOG-29. THE NEURO-ONCOLOGY MAGNITUDE OF CLINICAL BENEFIT SCALE (NEURO-MCBS) AS A COMPREHENSIVE AND CLINICALLY RELEVANT ASSESSMENT TOOL TO DETERMINE CLINICAL BENEFIT FROM TARGETED THERAPIES IN CNS TUMORS
Kurz S, Renovanz M, Rieger J, Bombach P, Grosse L, Rieger D, Hucker S, Hille H, Hippler M, Oener O, Ruhm K, Beha J, Malek H, Moeller Y, Bitzer M, Malek N, Tabatabai G. NCOG-29. THE NEURO-ONCOLOGY MAGNITUDE OF CLINICAL BENEFIT SCALE (NEURO-MCBS) AS A COMPREHENSIVE AND CLINICALLY RELEVANT ASSESSMENT TOOL TO DETERMINE CLINICAL BENEFIT FROM TARGETED THERAPIES IN CNS TUMORS. Neuro-Oncology 2023, 25: v220-v220. PMCID: PMC10639832, DOI: 10.1093/neuonc/noad179.0842.Peer-Reviewed Original ResearchProgression-free survivalCNS tumorsBrain metastasesTargeted therapyClinical benefitTherapy optionsFirst-line therapy optionTreatment efficacyDegree of clinical benefitClinical utilityMagnitude of Clinical Benefit ScaleNeuro-oncological conditionsSecondary CNS tumorsOutcome dataPhase I studyComprehensive molecular profilingOff-label therapyOutcome measuresAssessment of treatment efficacyClinical outcome dataAssess treatment efficacySurvival outcome dataPFS2/PFS1 ratioLongitudinal observational studyPerformance status
2022
Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)
Tuan JJ, Zapata H, Barakat L, Andrews L, Behnegar A, Kim YW, Kayani J, Mutic S, Ryall L, Turcotte B, Critch-Gilfillan T, Zhao M, Salahuddin S, Gupta S, Sutton R, Friedland G, Emu B, Ogbuagu O. Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH). BMC Infectious Diseases 2022, 22: 744. PMID: 36131232, PMCID: PMC9491266, DOI: 10.1186/s12879-022-07737-0.Peer-Reviewed Original ResearchConceptsT cell responsesAnti-spike IgGVisit 3SARS-CoV-2Older PWHVisit 2Immune responseSingle-center longitudinal observational studyVirus-specific T cell responsesVaccine-induced humoral immunityLong-term protective immunityT cell immune responsesOlder peopleMedian age 61RBD IgG levelsPrimary study outcomeCOVID-19 vaccinationImmune response evaluationLongitudinal observational studyCOVID-19 vaccineWilcoxon signed-rank testBNT162b2 boosterBNT162b2 vaccinationCD8 responsesDetectable CD4Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes
Lotan R, Ravona-Springer R, Shakked J, Lin H, Ouyang Y, Shahar D, Bezalel S, Agarwal P, Dhana K, Heymann A, Sano M, Schnaider Beeri M. Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes. Diabetes Research And Clinical Practice 2022, 190: 109989. PMID: 35820563, DOI: 10.1016/j.diabres.2022.109989.Peer-Reviewed Original ResearchConceptsDietary patternsCognitive declineCognitive trajectoriesType 2 diabetes mellitusOlder adultsMultivariable-adjusted modelsType 2 diabetesLongitudinal observational studyGreater intakeExecutive functionObservational studyIsrael DiabetesDiet intakeGlobal cognitionMultivariate modelT2DCognitionIntakeAdultsAdherenceDietMaking National Cancer Institute–Designated Comprehensive Cancer Center Knowledge Accessible to Community Oncologists via an Online Tumor Board: Longitudinal Observational Study
Kalra M, Henry E, McCann K, Karuturi MS, Bustamante Alvarez JG, Parkes A, Wesolowski R, Wei M, Mougalian SS, Durm G, Qin A, Schonewolf C, Trivedi M, Armaghani AJ, Wilson FH, Iams WT, Turk AA, Vikas P, Cecchini M, Lubner S, Pathak P, Spencer K, Koshkin VS, Labriola MK, Marshall CH, Beckermann KE, , Sharifi MN, Bejjani AC, Hotchandani V, Housri S, Housri N. Making National Cancer Institute–Designated Comprehensive Cancer Center Knowledge Accessible to Community Oncologists via an Online Tumor Board: Longitudinal Observational Study. JMIR Cancer 2022, 8: e33859. PMID: 35588361, PMCID: PMC9164098, DOI: 10.2196/33859.Peer-Reviewed Original ResearchPrescription Stimulants and the Risk of Psychosis
Gallagher KE, Funaro MC, Woods SW. Prescription Stimulants and the Risk of Psychosis. Journal Of Clinical Psychopharmacology 2022, 42: 308-314. PMID: 35489031, DOI: 10.1097/jcp.0000000000001552.Peer-Reviewed Original ResearchConceptsObservational studySystematic reviewPsychosis riskCohort studyPrescription stimulantsRetrospective cohort studyProspective cohort studyCase-control studySelf-controlled case seriesInternational Prospective RegisterLongitudinal observational studyMeta-Analyses (PRISMA) guidelinesRisk of psychosisPreferred Reporting ItemsLarge-scale observational studyMPH exposureCase seriesTherapeutic dosesProspective RegisterBias assessmentEligible studiesPsychotic eventsLower riskPsychotic symptomsReporting Items
2021
Immunosuppressive Therapy in Primary Membranous Nephropathy with Compromised Renal Function
Ramachandran R, Prabakaran R, Priya G, Nayak S, Kumar P, Kumar A, Kumar V, Agrawal N, Rathi M, Kohli H, Nada R. Immunosuppressive Therapy in Primary Membranous Nephropathy with Compromised Renal Function. Nephron 2021, 146: 138-145. PMID: 34818240, DOI: 10.1159/000518609.Peer-Reviewed Original ResearchConceptsPMN patientsRenal dysfunctionAnti-PLA2RClinical remissionInduce remissionMembranous nephropathyFollow-upPrimary membranous nephropathyCompromised renal functionEnd-stage renal diseaseAdverse event profileProspective longitudinal observational studyPercentage of patientsCKD stage 3Immunosuppressive therapyImmunosuppressive treatmentLongitudinal observational studyRenal functionEvent profileCKD stageClinical outcomesUnit protocolRemissionNephrotic stateRenal diseaseThe role of choroidal optical coherence tomography for follow-up of carotid cavernous fistula with anterior drainage
Arat Y, İnam O, Yavas G, Arat A. The role of choroidal optical coherence tomography for follow-up of carotid cavernous fistula with anterior drainage. Eye 2021, 36: 2020-2027. PMID: 34408315, PMCID: PMC9500102, DOI: 10.1038/s41433-021-01744-2.Peer-Reviewed Original ResearchConceptsChoroidal vascularity indexCarotid-cavernous fistulaCentral foveal thicknessSubfoveal choroidal thicknessChoroidal thickness measurementsOptical coherence tomographyTortuosity indexFollow-upCavernous fistulaCoherence tomographySpectral-domain optical coherence tomographyClinically unaffected eyesOcclusion of fistulaAnterior drainageChoroidal thicknessFoveal thicknessUnaffected eyesLongitudinal observational studyEndovascular treatmentEvaluate occlusionSpontaneous resolutionVascular indexCarotid angiogramFistulaObservational studyRates of Incidental Findings in Brain Magnetic Resonance Imaging in Children
Li Y, Thompson WK, Reuter C, Nillo R, Jernigan T, Dale A, Sugrue LP, Brown J, Dougherty R, Rauschecker A, Rudie J, Barch D, Calhoun V, Hagler D, Hatton S, Tanabe J, Marshall A, Sher K, Heeringa S, Hermosillo R, Banich M, Squeglia L, Bjork J, Zucker R, Neale M, Herting M, Sheth C, Huber R, Reeves G, Hettema J, Howlett K, Cloak C, Baskin-Sommers A, Rapuano K, Gonzalez R, Karcher N, Laird A, Baker F, James R, Sowell E, Dick A, Hawes S, Sutherland M, Bagot K, Bodurka J, Breslin F, Morris A, Paulus M, Gray K, Hoffman E, Weiss S, Rajapakse N, Glantz M, Nagel B, Ewing S, Goldstone A, Pfefferbaum A, Prouty D, Rosenberg M, Bookheimer S, Tapert S, Infante M, Jacobus J, Giedd J, Shilling P, Wade N, Uban K, Haist F, Heyser C, Palmer C, Kuperman J, Hewitt J, Cottler L, Isaiah A, Chang L, Edwards S, Ernst T, Heitzeg M, Puttler L, Sripada C, Iacono W, Luciana M, Clark D, Luna B, Schirda C, Foxe J, Freedman E, Mason M, McGlade E, Renshaw P, Yurgelun-Todd D, Albaugh M, Allgaier N, Chaarani B, Potter A, Ivanova M, Lisdahl K, Do E, Maes H, Bogdan R, Anokhin A, Dosenbach N, Glaser P, Heath A, Casey B, Gee D, Garavan H, Dowling G, Brown S. Rates of Incidental Findings in Brain Magnetic Resonance Imaging in Children. JAMA Neurology 2021, 78: 578-587. PMID: 33749724, PMCID: PMC7985817, DOI: 10.1001/jamaneurol.2021.0306.Peer-Reviewed Original ResearchConceptsBrain magnetic resonance imagingMagnetic resonance imagingIncidental findingPediatric populationCommon incidental findingsGeneral pediatric populationBrain magnetic resonanceStructural magnetic resonance imagingLongitudinal observational studyBoard-certified neuroradiologistsUrgent medical interventionBaseline structural magnetic resonance imagingPercentage of childrenPotential clinical significanceNormal anatomic variantsCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyCohort studyTwin gestationsOverall prevalenceNeurologic disordersAnatomic variantsClinical significanceObservational studyMAIN OUTCOME
2020
Development and validation of a predictive model of drug-resistant genetic generalized epilepsy.
Choi H, Detyniecki K, Bazil C, Thornton S, Crosta P, Tolba H, Muneeb M, Hirsch LJ, Heinzen EL, Sen A, Depondt C, Perucca P, Heiman GA, Adcock J, Andrade D, Cavalleri G, Costello D, Delanty N, Dugan P, Goldstein D, Kwan P, Nascimento F, O’Brien T, Radthke R, Smith P, Thomas R. Development and validation of a predictive model of drug-resistant genetic generalized epilepsy. Neurology 2020, 95: e2150-e2160. PMID: 32759205, PMCID: PMC7713754, DOI: 10.1212/wnl.0000000000010597.Peer-Reviewed Original ResearchConceptsGenetic generalized epilepsyCatamenial epilepsyGeneralized epilepsyPsychiatric conditionsOngoing longitudinal observational studyGeneralized tonic clonicTertiary epilepsy centerNegative prognostic factorCase-control studyLongitudinal observational studyClinical prediction modelAED resistanceTonic clonicPrognostic factorsSeizure typesEpilepsy centersAntiepileptic drugsAbsence seizuresObservational studyOngoing longitudinal studyEpilepsyCase statusAED responsePatientsExternal testing datasetConverging on Bladder Health through Design Thinking: From an Ecology of Influence to a Focused Set of Research Questions
Lewis J, Brady S, Sutcliffe S, Smith A, Mueller E, Rudser K, Markland A, Stapleton A, Gahagan S, Cunningham SD, Consortium P. Converging on Bladder Health through Design Thinking: From an Ecology of Influence to a Focused Set of Research Questions. International Journal Of Environmental Research And Public Health 2020, 17: 4340. PMID: 32560510, PMCID: PMC7345219, DOI: 10.3390/ijerph17124340.Peer-Reviewed Original ResearchConceptsUrinary tract symptomsBladder healthTract symptomsLower urinary tract symptomsProtective factorsLongitudinal observational studyBladder functionObservational studyCandidate riskPrevention effortsRapid-cycle prototypingWomenSymptomsResearch ConsortiumSubstantial numberTransdisciplinary consortiumHealthRiskFocused research questionsPrevention
2018
Factors Affecting Breastfeeding Outcomes at Six Months in Preterm Infants
Wang Y, Briere C, Xu W, Cong X. Factors Affecting Breastfeeding Outcomes at Six Months in Preterm Infants. Journal Of Human Lactation 2018, 35: 80-89. PMID: 29723482, DOI: 10.1177/0890334418771307.Peer-Reviewed Original ResearchConceptsPreterm infantsPrevalence of breastfeedingLevel of breastfeeding self-efficacyMothers of very preterm infantsFactors associated with exclusive breastfeedingPreterm mother-infant dyadsIntensive careBreastfeeding practicesLate preterm infantsVery preterm infantsInfant gestational ageMonths corrected ageNeonatal intensive careYoung maternal ageElevated EPDS scoresPerception of breastfeeding self-efficacyImprove breastfeeding durationGestational agePostpartum depressive symptomsCorrected ageLongitudinal observational studyPreterm mothersDepressive symptomsPretermMaternal agePersistence of abnormalities in white matter in children with type 1 diabetes
Fox LA, Hershey T, Mauras N, Arbeláez AM, Tamborlane WV, Buckingham B, Tsalikian E, Englert K, Raman M, Jo B, Shen H, Reiss A, Mazaika P, for the Diabetes Research in Children Network (DirecNet). Persistence of abnormalities in white matter in children with type 1 diabetes. Diabetologia 2018, 61: 1538-1547. PMID: 29654376, PMCID: PMC5991628, DOI: 10.1007/s00125-018-4610-6.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsBiomarkersBlood GlucoseCase-Control StudiesChildChild DevelopmentChild, PreschoolCognitive DysfunctionDiabetes Mellitus, Type 1Diffusion Tensor ImagingFemaleGlycated HemoglobinHumansLeukoencephalopathiesLongitudinal StudiesMagnetic Resonance ImagingMalePrognosisRisk FactorsTime FactorsUnited StatesConceptsType 1 diabetesNon-diabetic childrenWhite matter microstructureWhite matterAltered white matter developmentContinuous glucose monitoring (CGM) profilesFractional anisotropyConclusions/interpretationThese resultsPersistence of abnormalitiesLongitudinal observational studyWhite matter growthYoung childrenWhite matter developmentMild cognitive deficitsHigher fractional anisotropyDiabetes groupClinical centersMethodsOne hundredObservational studyDiabetesInterpretationThese resultsCognitive deficitsHyperglycaemiaDiabetes researchAdverse effectsPCORnet Antibiotics and Childhood Growth Study: Process for Cohort Creation and Cohort Description
Block J, Bailey L, Gillman M, Lunsford D, Boone-Heinonen J, Cleveland L, Finkelstein J, Horgan C, Jay M, Reynolds J, Sturtevant J, Forrest C, Group P, Adams W, Appelhans B, Brickman A, Bian J, Daley M, Davidson A, Dempsey A, Dugas L, Eneli I, Fitzpatrick S, Heerman W, Horberg M, Hsia D, Ingber J, Isasi C, Janicke D, Kane D, Kharbanda E, Meltzer D, Messito M, Nadkarni P, O'Bryan K, Peay H, Puro J, Ranade D, Rao G, Tirado-Ramos A, Rayas M, Razzaghi H, Ricket I, Rosenman M, Siegel R, Solomonides T, Taveras E, Taylor B, Tolia V, Willis Z, VanWormer J, Wysocki T, Zhou X. PCORnet Antibiotics and Childhood Growth Study: Process for Cohort Creation and Cohort Description. Academic Pediatrics 2018, 18: 569-576. PMID: 29477481, PMCID: PMC9746871, DOI: 10.1016/j.acap.2018.02.008.Peer-Reviewed Original ResearchConceptsAntibiotic prescriptionsAntibiotic useObservational studySex-specific body mass indexCohort inclusion criteriaEarly antibiotic useSame-day heightSingle antibiotic prescriptionsBody mass indexLongitudinal observational studyClinical Research NetworkBroad-spectrum antibioticsMonths of agePCORnet common data modelCohort creationSevere obesityNational PatientMass indexCohort descriptionObesity prevalenceInclusion criteriaCohort characteristicsHealth care dataCare dataClinical research
2017
Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy
Rahimy E, Li FY, Hagberg L, Fuchs D, Robertson K, Meyerhoff DJ, Zetterberg H, Price RW, Gisslén M, Spudich S. Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy. The Journal Of Infectious Diseases 2017, 215: 1132-1140. PMID: 28368497, PMCID: PMC5426376, DOI: 10.1093/infdis/jix013.Peer-Reviewed Original ResearchConceptsPrimary HIV infectionCombination antiretroviral therapyHIV infectionNeurofilament light chainAntiretroviral therapyCreatinine levelsCerebrospinal fluidN-acetylaspartateAbnormal blood-brain barrier (BBB) permeabilityPrimary human immunodeficiency virus (HIV) infectionBlood-brain barrier disruptionHuman immunodeficiency virus (HIV) infectionBlood-brain barrier permeabilityNeuropsychological performanceImmunodeficiency virus infectionParietal gray matterYears of treatmentLongitudinal observational studyCART durationCART initiationMedian intervalNeuronal injuryAlbumin quotientNfL levelsCSF levels
2016
School breakfast and body mass index: a longitudinal observational study of middle school students
Wang S, Schwartz MB, Shebl FM, Read M, Henderson KE, Ickovics JR. School breakfast and body mass index: a longitudinal observational study of middle school students. Pediatric Obesity 2016, 12: 213-220. PMID: 26989876, PMCID: PMC7075461, DOI: 10.1111/ijpo.12127.Peer-Reviewed Original ResearchConceptsBreakfast eatersRace/ethnicityExcessive weight gainOverweight/obesityBody mass indexLongitudinal observational studyOverall dietLongitudinal analysisSchool breakfastIncreased oddsHealthy weightMass indexBreakfast patternsWeight statusObservational studyIncrease riskWeight gainBreakfastWeight changeSecond breakfastAdditional researchEatersLatent transition analysisYears
2008
The design of an observational study of hypertension management, adherence and pressure control in Blood Pressure Success Zone Program participants
Payne K, J. J, Daley W, Khan Z, Ishak K, Stark K, Purkayastha D, Flack J, Velázquez E, Nesbitt S, Morisky D, Califf R, Committee F. The design of an observational study of hypertension management, adherence and pressure control in Blood Pressure Success Zone Program participants. International Journal Of Clinical Practice 2008, 62: 1313-1321. PMID: 18647193, PMCID: PMC2658016, DOI: 10.1111/j.1742-1241.2008.01840.x.Peer-Reviewed Original ResearchConceptsAntihypertensive medicationsObservational studyInteractive voice response systemPressure controlUsual care visitsBlood pressure controlLongitudinal observational studyHealth education programsUsual careCare visitsEligible subjectsTreatment satisfactionHypertension managementPatient satisfactionStudy completionHealthcare databasesVoice response systemProgram participantsMedicationsStudy designPhysiciansAdherenceProgram enrollmentEnrollmentNationwide initiative
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply