2025
Aortic valve calcium as a novel risk marker for kidney function deterioration: The MESA study
Abdollahi A, Sani M, Shabani M, Matuck B, Blaha M, Wu C, Ambale-Venkatesh B, Budoff M, Strom J, Rotter J, Post W, Blumenthal R, Bluemke D, Ghahramani N, Lima J, Whelton S. Aortic valve calcium as a novel risk marker for kidney function deterioration: The MESA study. European Journal Of Internal Medicine 2025, 136: 49-55. PMID: 40263084, DOI: 10.1016/j.ejim.2025.03.037.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisRisk of incident chronic kidney diseaseIncident chronic kidney diseaseAortic valve calciumInternational Classification of DiseasesChronic kidney diseaseCardiac CT scansAdjusted Cox proportional hazards regression modelsMultivariable adjusted Cox proportional hazards regression modelsParticipants free of chronic kidney diseaseCardiovascular diseaseMulti-Ethnic Study of Atherosclerosis studyValve calciumCT scanCVD risk factorsHistory of cardiovascular diseaseCategorized as 0Higher risk of incident CKDFree of chronic kidney diseaseAssociated with increased risk of mortalityMulti-Ethnic StudyAtherosclerotic CVD risk factorsMulti-ethnic cohortAPOE-e4 genotypeClassification of diseasesLEFT-TO-RIGHT CARDIAC CHAMBER VOLUME RATIOS AS PREDICTORS OF CARDIOVASCULAR EVENTS: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)
Hoballah M, Chehab O, Abdollahi A, Wu C, Scarpa B, Post W, Allen N, Bluemke D, Venkatesh B, Lima J. LEFT-TO-RIGHT CARDIAC CHAMBER VOLUME RATIOS AS PREDICTORS OF CARDIOVASCULAR EVENTS: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA). Journal Of The American College Of Cardiology 2025, 85: 2109. DOI: 10.1016/s0735-1097(25)02593-8.Peer-Reviewed Original ResearchMulti-Ethnic StudyEvaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems
Aminorroaya A, Dhingra L, Oikonomou E, Khera R. Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems. Circulation Genomic And Precision Medicine 2025, 18: e004632. PMID: 39846171, PMCID: PMC11835527, DOI: 10.1161/circgen.124.004632.Peer-Reviewed Original ResearchConceptsYale New Haven Health SystemHealth systemVanderbilt University Medical CenterHealth system electronic health recordUniversity Medical CenterCoronary Artery Risk DevelopmentMulti-Ethnic Study of AtherosclerosisElectronic health recordsMedical CenterUS health systemHealth system patientsAssociated with significantly higher oddsMulti-Ethnic StudyUS-based cohortStudy of atherosclerosisSignificantly higher oddsHealth recordsUK BiobankAtherosclerosis RiskRisk DevelopmentHigher oddsElevated Lp(aUniversal screeningSystem patientsStudy cohort
2024
Marginal interaction test for detecting interactions between genetic marker sets and environment in genome-wide studies
Shen L, Amei A, Liu B, Xu G, Liu Y, Oh E, Zhou X, Wang Z. Marginal interaction test for detecting interactions between genetic marker sets and environment in genome-wide studies. G3: Genes, Genomes, Genetics 2024, 15: jkae263. PMID: 39538414, PMCID: PMC11708225, DOI: 10.1093/g3journal/jkae263.Peer-Reviewed Original ResearchGene-environment interactionsStudies of complex diseasesMulti-Ethnic Study of AtherosclerosisComplex diseasesGenetic marker setsGenome-wide analysisGenome-wide studiesHuman complex diseasesGene-alcohol interactionsMulti-Ethnic StudyGenetic main effectsStudy of atherosclerosisSignal transduction pathwaysAssociated with hypertensionBlood pressureSystolic blood pressureGenetic markersEnvironmental factorsAlcohol intakeGenetic variantsTransduction pathwaysSurvival pathwaysMarker setsPathway analysisRare variantsGenome-Wide Association Study of Acute Lymphoblastic Leukemia in Hispanic/Latino Children Identifies a Putatively Novel Risk Locus at Chromosome 5q31.1
Liu T, Langie J, Yang W, Morimoto L, Ma X, Metayer C, Lupo P, Scheurer M, Yang J, Wiemels J, Chiang C, de Smith A. Genome-Wide Association Study of Acute Lymphoblastic Leukemia in Hispanic/Latino Children Identifies a Putatively Novel Risk Locus at Chromosome 5q31.1. Blood 2024, 144: 317. DOI: 10.1182/blood-2024-208796.Peer-Reviewed Original ResearchGenome-wide association studiesMulti-Ethnic Study of AtherosclerosisCalifornia Childhood Leukemia StudySingle nucleotide polymorphismsMinor allele frequencyRisk lociHispanic/Latino individualsHispanic/Latino populationFixed-effect inverse-variance weighted meta-analysisMeta-analysis genome-wide association studyInverse-variance weighted meta-analysisHispanic Community Health Study/Study of LatinosHispanic Community Health Study/StudyHigher risk of acute lymphoblastic leukemiaHigher risk allele frequencyOdds of acute lymphoblastic leukemiaGenome-wide significant association signalsImputation quality scoreSNPs' minor allele frequencyRisk of acute lymphoblastic leukemiaGenome-wide significance thresholdAcute lymphoblastic leukemia riskEuropean ancestry populationsGenome-wide imputationMulti-Ethnic StudyEffect of neighborhood and individual-level socioeconomic factors on breast cancer screening adherence in a multi-ethnic study
Kasper G, Momen M, Sorice K, Mayhand K, Handorf E, Gonzalez E, Devlin A, Brownstein K, Esnaola N, Fisher S, Lynch S. Effect of neighborhood and individual-level socioeconomic factors on breast cancer screening adherence in a multi-ethnic study. BMC Public Health 2024, 24: 63. PMID: 38166942, PMCID: PMC10763410, DOI: 10.1186/s12889-023-17252-9.Peer-Reviewed Original ResearchConceptsLow breast cancerBreast cancerRace/ethnicityOdds ratioAnnual breast cancer screeningMultivariable mixed-effects logistic regression modelSocioeconomic statusBreast cancer mortalityIndividual-level socioeconomic factorsCross-sectional studyMixed effects logistic regression modelsMulti-Ethnic StudyBreast cancer screeningLogistic regression modelsMulti-ethnic populationResultsNineteen percentScreening interventionsCancer mortalityCancer screeningInsurance statusCancerSES indicatorsAdherenceConfidence intervalsSignificant predictors
2023
Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis
Chehab O, Abdollahi A, Whelton S, Wu C, Ambale-Venkatesh B, Post W, Bluemke D, Tsai M, Lima J. Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis. Journal Of The American College Of Cardiology 2023, 82: 2280-2291. PMID: 38057070, PMCID: PMC11730445, DOI: 10.1016/j.jacc.2023.10.016.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceInterstitial myocardial fibrosisNative T1 timeMyocardial fibrosisCardiac remodelingMulti-Ethnic Study of AtherosclerosisElevated Lp(aMyocardial scarAssociated with greater prevalenceCardiac magnetic resonance measurementsMulti-Ethnic StudyMeasurement of extracellular volumeParameters of cardiac remodelingAssociated with left atrial enlargementStudy of atherosclerosisLate gadolinium enhancementLeft atrial remodelingCine cardiac magnetic resonanceLeft atrial enlargementAssociation of lipoprotein(aT1 timesAssociation of Lp(aGreater prevalencePrognostic thresholdGadolinium enhancementAssociation of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis
Wettersten N, Katz R, Greenberg J, Gutierrez O, Lima J, Sarnak M, Schrauben S, Deo R, Bonventre J, Vasan R, Kimmel P, Shlipak M, Ix J. Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis. The American Journal Of Cardiology 2023, 196: 11-18. PMID: 37086700, PMCID: PMC10204591, DOI: 10.1016/j.amjcard.2023.02.031.Peer-Reviewed Original ResearchConceptsPlasma soluble urokinase plasminogen activator receptorSoluble urokinase plasminogen activator receptorKidney tubule injuryCardiac structural abnormalitiesUrokinase plasminogen activator receptorCardiovascular diseasePlasminogen activator receptorLower LVEFTubule injurySystemic inflammationVentricular mass/volume ratioStructural abnormalitiesChitinase-3-like protein 1Activator receptorTwofold greater concentrationCardiac magnetic resonance imagingKidney tubule healthChronic kidney diseaseIncident cardiovascular diseaseGlomerular filtration rateVentricular ejection fractionProtein 1Chemoattractant protein-1Multi-Ethnic StudyAlpha-1-microglobulin
2022
Kidney Tubule Injury and Dysfunction Biomarkers and Risk of Incident Hypertension in Community-Living Individuals: Results From the Multi-Ethnic Study of Atherosclerosis
Malhotra R, Katz R, Kimmel P, Ramachandran V, Al-Rousan T, Greenberg J, Parikh C, Bonventre J, Schelling J, Sarnak M, Gutierrez O, Shlipak M, Ix J. Kidney Tubule Injury and Dysfunction Biomarkers and Risk of Incident Hypertension in Community-Living Individuals: Results From the Multi-Ethnic Study of Atherosclerosis. Journal Of The American Society Of Nephrology 2022, 33: 529-529. DOI: 10.1681/asn.20223311s1529a.Peer-Reviewed Original ResearchBaseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA
Wong KH, Muddasani V, Peterson C, Sheibani N, Arkin C, Cheong I, Majersik JJ, Biffi A, Petersen N, Falcone GJ, Sansing LH, de Havenon AH. Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA. American Journal Of Hypertension 2022, 36: 144-147. PMID: 36315490, PMCID: PMC11484580, DOI: 10.1093/ajh/hpac122.Peer-Reviewed Original ResearchConceptsBlood pressure variabilityHigh blood pressure variabilitySerum inflammatory markersPlasmin-antiplasmin complexC-reactive proteinInterleukin-6Inflammatory markersBlood pressureStudy visitPressure variabilityBaseline serum IL-6Visit blood pressure variabilityLipid-lowering medicationsMean blood pressureSerum IL-6Markers of inflammationSystolic blood pressureBaseline study visitBody mass indexOnly IL-6Major vascular diseasesMulti-Ethnic StudyBaseline serum biomarkersPatient age categoryPost Hoc AnalysisPrediction of telomere length and telomere attrition using a genetic risk score: The multi-ethnic study of atherosclerosis (MESA)
Castro-Diehl C, Smith J, Zhao W, Wang X, Mukherjee B, Seeman T, Needham B. Prediction of telomere length and telomere attrition using a genetic risk score: The multi-ethnic study of atherosclerosis (MESA). Frontiers In Aging 2022, 3: 1021051. PMID: 36304436, PMCID: PMC9592760, DOI: 10.3389/fragi.2022.1021051.Peer-Reviewed Original ResearchMulti-Ethnic Study of AtherosclerosisGenetic risk scoreMulti-Ethnic StudyGenome-wide association studiesStudy of atherosclerosisAssociated with TLEuropean ancestry genome-wide association studiesEuropean ancestryRisk scoreTL-associated genetic variantsShorter TLEuropean ancestry populationsPredictive of telomere lengthHispanic participantsRace/ethnic groupsLinear mixed effects modelsShorter telomere lengthMixed effects modelsAfrican AmericansTelomere attritionExam 1Association studiesRelative TLTelomere lengthT/S ratioDNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors
Wang Y, Zhao W, Ammous F, Song Y, Du J, Shang L, Ratliff S, Moore K, Kelly K, Needham B, Roux A, Liu Y, Butler K, Kardia S, Mukherjee B, Zhou X, Smith J. DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors. Frontiers In Cardiovascular Medicine 2022, 9: 848768. PMID: 35665255, PMCID: PMC9162507, DOI: 10.3389/fcvm.2022.848768.Peer-Reviewed Original ResearchBody mass indexCardiovascular risk factorsNeighborhood socioeconomic disadvantageMulti-Ethnic Study of AtherosclerosisNeighborhood-level disadvantagePoor cardiovascular healthSocioeconomic statusSocioeconomic disadvantageRisk factorsCardiovascular healthAssociated with poor cardiovascular healthSocial disadvantageAdult socioeconomic statusBody mass index adjustmentAssociations of individual-HDL-CPrincipal components of ancestryGenetic principal componentsMeasures of obesityLow socioeconomic statusPopulation-based cohortMulti-Ethnic StudyStudy of atherosclerosisHDL-C associationHigh-density lipoprotein cholesterol
2021
Long-Term Prognostic Implications and Role of Further Testing in Adults Aged ≤55 Years With a Coronary Calcium Score of Zero (from the Multi-Ethnic Study of Atherosclerosis)
Cainzos-Achirica M, Acquah I, Dardari Z, Mszar R, Greenland P, Blankstein R, Bittencourt M, Rajagopalan S, Al-Kindi S, Polak J, Blumenthal R, Blaha M, Nasir K. Long-Term Prognostic Implications and Role of Further Testing in Adults Aged ≤55 Years With a Coronary Calcium Score of Zero (from the Multi-Ethnic Study of Atherosclerosis). The American Journal Of Cardiology 2021, 161: 26-35. PMID: 34794615, PMCID: PMC8607758, DOI: 10.1016/j.amjcard.2021.08.067.Peer-Reviewed Original ResearchConceptsAortic valve calciumCoronary artery calciumCoronary calcium scoreLong-term prognosisCardiovascular diseaseICA-IMTCoronary calcium score of zeroCalcium score of zeroHigh-sensitivity C-reactive protein levelsLong-term prognostic significanceC-reactive protein levelsMedian Follow-UpMulti-Ethnic StudyMitral annular calciumEvent ratesPremature family historyThoracic aortic calciumScore of zeroCardiovascular disease eventsAnkle-brachial indexValve calciumAnnular calciumPrognostic significancePrognostic implicationsAortic calciumBayesian Sparse Mediation Analysis with Targeted Penalization of Natural Indirect Effects
Song Y, Zhou X, Kang J, Aung M, Zhang M, Zhao W, Needham B, Kardia S, Liu Y, Meeker J, Smith J, Mukherjee B. Bayesian Sparse Mediation Analysis with Targeted Penalization of Natural Indirect Effects. Journal Of The Royal Statistical Society Series C (Applied Statistics) 2021, 70: 1391-1412. PMID: 34887595, PMCID: PMC8653861, DOI: 10.1111/rssc.12518.Peer-Reviewed Original ResearchNatural indirect effectMulti-Ethnic Study of AtherosclerosisMediation analysisMediator-outcome effectsMulti-Ethnic StudyStudy of atherosclerosisCausal mediation analysisLIFECODES birth cohortBirth cohortEpidemiological studiesJoint prior distributionPotential mediatorsHigh-dimensional mediation analysisGaussian mixtureHigh-dimensional mediatorsIndirect effectsPrior distributionEstimation accuracyExposure-mediated effectsBayesian paradigmExposure effectsAvailability of measurementsComposite structuresIncreasing availability of measurementsBayesian hierarchical models for high‐dimensional mediation analysis with coordinated selection of correlated mediators
Song Y, Zhou X, Kang J, Aung M, Zhang M, Zhao W, Needham B, Kardia S, Liu Y, Meeker J, Smith J, Mukherjee B. Bayesian hierarchical models for high‐dimensional mediation analysis with coordinated selection of correlated mediators. Statistics In Medicine 2021, 40: 6038-6056. PMID: 34404112, PMCID: PMC9257993, DOI: 10.1002/sim.9168.Peer-Reviewed Original ResearchPerformance of the Pooled Cohort Equations in Hispanic Individuals Across the United States: Insights From the Multi‐Ethnic Study of Atherosclerosis and the Dallas Heart Study
Rosario K, Mehta A, Ayers C, Gonzalez P, Pandey A, Khera R, Kaplan R, Blaha MJ, Khera A, Blumenthal RS, Nasir K, Rodriguez CJ, Joshi PH. Performance of the Pooled Cohort Equations in Hispanic Individuals Across the United States: Insights From the Multi‐Ethnic Study of Atherosclerosis and the Dallas Heart Study. Journal Of The American Heart Association 2021, 10: e018410. PMID: 33870702, PMCID: PMC8200750, DOI: 10.1161/jaha.120.018410.Commentaries, Editorials and LettersUsing Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis
Baradaran H, Delic A, Wong KH, Sheibani N, Alexander M, McNally JS, Majersik JJ, De Havenon A. Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis. Cerebrovascular Diseases Extra 2021, 11: 37-43. PMID: 33601394, PMCID: PMC7989729, DOI: 10.1159/000514373.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersCarotid Intima-Media ThicknessCarotid StenosisFemaleHumansInflammation MediatorsInterleukin-6Ischemic StrokeMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsUltrasonography, DopplerUnited StatesVascular StiffnessConceptsIschemic strokeCarotid distensibilityCarotid stenosisMulti-Ethnic StudyInterleukin-6Primary outcomeRisk factorsInflammation measurementsClinical trial inclusion criteriaSecondary analysisPrimary ischemic strokeIncident ischemic strokeTrial inclusion criteriaVascular risk factorsSystolic blood pressureTraditional risk factorsBaseline study visitCox regression modelIschemic stroke riskStroke risk predictionPrimary prevention effortsUltrasound-derived measurementsIncident strokeMean followPatient age
2020
Social regulation of inflammation related gene expression in the multi-ethnic study of atherosclerosis
Brown K, Diez-Roux A, Smith J, Needham B, Mukherjee B, Ware E, Liu Y, Cole S, Seeman T, Kardia S. Social regulation of inflammation related gene expression in the multi-ethnic study of atherosclerosis. Psychoneuroendocrinology 2020, 117: 104654. PMID: 32387875, PMCID: PMC7685527, DOI: 10.1016/j.psyneuen.2020.104654.Peer-Reviewed Original ResearchConceptsGene expressionMulti-Ethnic Study of AtherosclerosisGene set enrichment testGene Ontology databaseGene expression dataMulti-Ethnic StudyLifetime discriminationStudy of atherosclerosisDifferential gene expressionInflammation-related genesExpression dataGene setsChronic burdenSocial factorsGene transcriptionRelated gene expressionOntology databaseGenesInflammatory responseTranscriptionGlobal analysisElastic net penalized regressionAdverse social factorsGlobal expressionExpression of inflammation-related genes
2019
Bayesian Shrinkage Estimation of High Dimensional Causal Mediation Effects in Omics Studies
Song Y, Zhou X, Zhang M, Zhao W, Liu Y, Kardia S, Roux A, Needham B, Smith J, Mukherjee B. Bayesian Shrinkage Estimation of High Dimensional Causal Mediation Effects in Omics Studies. Biometrics 2019, 76: 700-710. PMID: 31733066, PMCID: PMC7228845, DOI: 10.1111/biom.13189.Peer-Reviewed Original ResearchConceptsMediation analysisEffect of socioeconomic statusPotential mediatorsMulti-Ethnic StudyCausal mediation analysisCardiometabolic outcomesDNA methylation regionsSocioeconomic statusHigh-throughput technologiesMediation effectGenomic dataEpidemiological dataMethylation regionsHigh-dimensional mediatorsBayesian inference methodsContinuous shrinkage priorsHigh-dimensional settingsBayesian shrinkage estimatorsJoint analysisOutcomesShrinkage priorsPathwayNull caseInference methodsBiomedical studiesThe Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies
Wiemels J, Muskens I, Li S, Pandey P, Roy R, Hansen H, Siegmund K, Mueller B, Ma X, Metayer C, de Smith A. The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies. Blood 2019, 134: 2510. DOI: 10.1182/blood-2019-131455.Peer-Reviewed Original ResearchTransient abnormal myelopoiesisNon-DS subjectsDS neonatesDown syndromeTrisomy 21Hematopoietic stem cellsBlood cell proportionsT cellsHigher CD8 T cellsCell proportionEpigenome-wide association studiesMean beta valueNon-DS controlsCD8 T cellsCD4 T cellsLow B cellsAcute lymphoblastic leukemiaAcute megakaryoblastic leukemiaMulti-Ethnic StudyNeonatal DNA methylationEthnicity-stratified analysisSignificant DMRsIllumina Infinium MethylationEPIC arrayChromosome 21Non-Latino whites
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