2025
CCTA and CACS for preoperative cardiovascular risk stratification in patients undergoing noncardiac surgery: A systematic review and meta-analysis
Kyriakoulis I, Kyriakoulis K, Aznaouridis K, Sunil Kumar S, Schizas D, Kokkinidis D. CCTA and CACS for preoperative cardiovascular risk stratification in patients undergoing noncardiac surgery: A systematic review and meta-analysis. Journal Of Cardiovascular Computed Tomography 2025 PMID: 40681455, DOI: 10.1016/j.jcct.2025.06.007.Peer-Reviewed Original ResearchCoronary artery calcium scoreCoronary Computed Tomography AngiographyMajor adverse cardiovascular eventsPooled positive predictive valueSevere CACSNegative predictive valuePostoperative major adverse cardiovascular eventsNoncardiac surgeryCardiovascular risk stratificationObstructive stenosisRisk stratificationCoronary artery calcium scoring resultsPreoperative coronary computed tomography angiographySpecificity of coronary computed tomography angiographyLong-term major adverse cardiovascular eventsMeta-analyses of proportionsLong-term postoperative periodPredictive valueArtery calcium scoreNoninvasive cardiac imagingMeta-analysisLong-term morbidityComputed tomography angiographyMyocardial perfusion imagingPositive predictive valueCoronary Computed Angiography and Coronary Artery Calcium Score for Preoperative Cardiovascular Risk Stratification in Patients Undergoing Noncardiac Surgery
Kyriakoulis I, Kumar S, Lianos G, Schizas D, Kokkinidis D. Coronary Computed Angiography and Coronary Artery Calcium Score for Preoperative Cardiovascular Risk Stratification in Patients Undergoing Noncardiac Surgery. Journal Of Cardiovascular Development And Disease 2025, 12: 159. PMID: 40278217, PMCID: PMC12027494, DOI: 10.3390/jcdd12040159.Peer-Reviewed Original ResearchCoronary artery calcium scoreMajor adverse cardiovascular eventsPostoperative major adverse cardiovascular eventsArtery calcium scoreNoncardiac surgeryCalcium scoreRisk stratificationComputed angiographySeverity of coronary artery diseasePreoperative imaging protocolRisk evaluation of patientsPreoperative risk stratificationHigh-risk patientsEvaluation of patientsInfluence surgical decisionsAdverse cardiovascular eventsCoronary artery diseaseCardiovascular risk stratificationPerioperative risk predictionSuperior prognostic performanceStratify patientsAnatomical assessmentSurgical decisionCardiovascular eventsPrognostic performance
2024
Lipoprotein(a) and Coronary Plaque in Asymptomatic Individuals: The Miami Heart Study at Baptist Health South Florida
Mszar R, Cainzos-Achirica M, Valero-Elizondo J, Lahan S, Al-Kindi S, Quispe R, Ali S, Arias L, Saxena A, Shah S, Cury R, Budoff M, Blaha M, Shapiro M, Sharma G, Santos R, Blankstein R, Feldman T, Fialkow J, Nasir K. Lipoprotein(a) and Coronary Plaque in Asymptomatic Individuals: The Miami Heart Study at Baptist Health South Florida. Circulation Cardiovascular Imaging 2024, 17: e016152. PMID: 39012945, DOI: 10.1161/circimaging.123.016152.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAsymptomatic DiseasesBiomarkersComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleFloridaHumansLipoprotein(a)MaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsPrevalenceProspective StudiesRisk AssessmentRisk FactorsUp-RegulationVascular CalcificationConceptsCoronary artery calcium scoreCoronary Computed Tomography AngiographyHigh-risk plaque featuresHigh-risk featuresArtery calcium scoreElevated Lp(aCoronary plaquesCalcium scorePlaque featuresHigh-risk coronary plaque featuresPresence of coronary plaqueRisk of atherosclerotic cardiovascular disease eventsClinical atherosclerotic cardiovascular diseaseLipid-Lowering TherapyCoronary plaque characteristicsAtherosclerotic cardiovascular disease eventsContemporary US cohortBaptist Health South FloridaCoronary plaque featuresAtherosclerotic cardiovascular diseaseAssessment of coronary atherosclerosisCardiovascular disease eventsNoninvasive gold standardAsymptomatic adultsIncreased risk
2023
ASSOCIATION OF METABOLIC SYNDROME, INFLAMMATION, CORONARY ARTERY CALCIUM SCORE, AND INCIDENT CARDIOVASCULAR DISEASE
Agboola O, Herrin J, Spatz E. ASSOCIATION OF METABOLIC SYNDROME, INFLAMMATION, CORONARY ARTERY CALCIUM SCORE, AND INCIDENT CARDIOVASCULAR DISEASE. Journal Of The American College Of Cardiology 2023, 81: 1841. DOI: 10.1016/s0735-1097(23)02285-4.Peer-Reviewed Original ResearchCoronary artery calcium scoreArtery calcium scoreIncident cardiovascularCalcium scoreMetabolic syndromeInflammationCardiovascularSyndrome
2022
Coronary Artery Calcium Score to Refine the Use of PCSK9i in Asymptomatic Individuals: A Multicohort Study
Cainzos‐Achirica M, Quispe R, Mszar R, Dudum R, Al Rifai M, Erbel R, Stang A, Jöckel K, Lehmann N, Schramm S, Schmidt B, Toth P, Rana J, Lima J, de Vasconcellos H, Lloyd‐Jones D, Joshi P, Ayers C, Khera A, Blaha M, Greenland P, Nasir K. Coronary Artery Calcium Score to Refine the Use of PCSK9i in Asymptomatic Individuals: A Multicohort Study. Journal Of The American Heart Association 2022, 11: e025737. PMID: 35943062, PMCID: PMC9496288, DOI: 10.1161/jaha.122.025737.Peer-Reviewed Original ResearchConceptsLow-density lipoprotein cholesterol levelsCoronary artery calciumAtherosclerotic cardiovascular diseaseLipoprotein cholesterol levelsClinically evident atherosclerotic cardiovascular diseaseSubclinical organ damageTraditional risk factorsHigh-risk scenariosRisk factorsAssociated with ASCVD eventsCholesterol levelsOrgan damageASCVD event ratesAtherosclerotic cardiovascular disease riskCoronary Artery Calcium TestingLow-density lipoprotein cholesterol <Coronary artery calcium scoreCoronary artery calcium burdenArtery calcium scoreASCVD eventsCalcium scoreArtery calciumFamilial hypercholesterolemiaPCSK9iMulticohort studySubclinical cardiovascular disease and polycystic ovary syndrome
Gomez JMD, VanHise K, Stachenfeld N, Chan JL, Merz NB, Shufelt C. Subclinical cardiovascular disease and polycystic ovary syndrome. Fertility And Sterility 2022, 117: 912-923. PMID: 35512975, PMCID: PMC10322116, DOI: 10.1016/j.fertnstert.2022.02.028.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeSubclinical cardiovascular diseaseCardiovascular diseaseOvary syndromeCoronary artery calcium scoreCarotid intima-media thicknessOvert cardiovascular diseaseArtery calcium scoreFlow-mediated dilationIntima-media thicknessCalcium scoreDiabetes mellitusMetabolic syndromeArterial stiffnessIrregular mensesInsulin resistanceEpicardial fatMetabolic disordersVascular endotheliumSyndromeHallmark featureDiseaseWomenHyperandrogenismDyslipidemiaUpdates on the Use of Subclinical Atherosclerosis to Predict Risk of Cardiovascular Events in Heterozygous Familial Hypercholesterolemia
Gallo A, Mszar R, Miname M. Updates on the Use of Subclinical Atherosclerosis to Predict Risk of Cardiovascular Events in Heterozygous Familial Hypercholesterolemia. Current Atherosclerosis Reports 2022, 24: 407-418. PMID: 35386094, DOI: 10.1007/s11883-022-01017-7.Peer-Reviewed Original ResearchConceptsComputed tomography coronary angiographyRisk of cardiovascular eventsHeterozygous familial hypercholesterolemiaCoronary artery calciumHeFH subjectsRisk stratificationTherapeutic managementFamilial hypercholesterolemiaCardiovascular eventsCoronary artery calcium scoreLong-term follow-upOptimization of risk stratificationSubclinical atherosclerotic cardiovascular diseaseImprove risk stratificationReduction of atherosclerotic progressionCarotid Doppler ultrasoundAtherosclerotic cardiovascular diseaseHeFH childrenCoronary angiographyArtery calciumCardiovascular riskDoppler ultrasoundAtherosclerotic burdenHeFHSubclinical atherosclerosisCalcium scoring in low-dose ungated chest CT scans using convolutional long-short term memory networks
Pieszko K, Shanbhag A, Killekar A, Lemley M, Otaki Y, Kriekinge SV, Kavanagh P, Miller RJ, Miller EJ, Bateman T, Dey D, Berman D, Slomka P. Calcium scoring in low-dose ungated chest CT scans using convolutional long-short term memory networks. Proceedings Of SPIE--the International Society For Optical Engineering 2022, 12032: 120323a-120323a-7. PMID: 36277935, PMCID: PMC9585987, DOI: 10.1117/12.2613147.Peer-Reviewed Original ResearchCoronary artery calcium scoreCAC scanCoronary orbital atherectomy treatment of Hispanic and Latino patients: A real‐world comparative analysis
Beohar N, Stone G, Martinsen B, Parise H, Vinardell J, Heimowitz T, Koelbl C, Leon M, Kirtane A. Coronary orbital atherectomy treatment of Hispanic and Latino patients: A real‐world comparative analysis. Catheterization And Cardiovascular Interventions 2022, 99: 1752-1757. PMID: 35312163, PMCID: PMC9540752, DOI: 10.1002/ccd.30158.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsNon-HL groupNon-HL patientsHL patientsLatino patientsHigh prevalenceRetrospective analysisHL groupLargest real-world experienceReal-world comparative analysesCoronary artery calcium scoreOrbital atherectomy treatmentAdverse cardiac eventsArtery calcium scoreMount Sinai Medical CenterPercutaneous coronary interventionCardiovascular disease mortalityHigh-risk populationOverall mean ageSinai Medical CenterClinical trial researchElectronic health recordsAngiographic complicationsAtherectomy useOA use
2021
Rationale and pathways forward in the implementation of coronary artery calcium-based enrichment of randomized trials
Cainzos-Achirica M, Anugula D, Mszar R, Grandhi G, Patel K, Bittencourt M, Blankstein R, Blaha M, Blumenthal R, Ray K, Bhatt D, Nasir K. Rationale and pathways forward in the implementation of coronary artery calcium-based enrichment of randomized trials. American Heart Journal 2021, 243: 54-65. PMID: 34587511, DOI: 10.1016/j.ahj.2021.09.006.Peer-Reviewed Original ResearchConceptsCoronary artery calciumRandomized Controlled TrialsPrognostic enrichmentCoronary artery calcium scoreCoronary artery calcium dataAdd-on therapyRisk reduction therapyFood and Drug AdministrationComputed tomography imagesArtery calciumCardiovascular riskRandomized trialsEnrichment paradigmDrug AdministrationPrimary preventionTomography imagesRCT participantsTherapyTrialsLogistical barriersRiskPrognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts
Akintoye E, Afonso L, Jayanna M, Bao W, Briasoulis A, Robinson J. Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts. Journal Of The American Heart Association 2021, 10: e019589. PMID: 34092110, PMCID: PMC8477885, DOI: 10.1161/jaha.120.019589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationBiomarkersCardiovascular DiseasesCholesterolClinical Decision-MakingCoronary Artery DiseaseDecision Support TechniquesDyslipidemiasFemaleHeart Disease Risk FactorsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedPractice Guidelines as TopicPredictive Value of TestsPrimary PreventionPrognosisRisk AssessmentTime FactorsUnited StatesVascular CalcificationConceptsPooled Cohort EquationsCoronary artery calcium scoreCholesterol treatment guidelinesArtery calcium scoreAtherosclerotic cardiovascular diseaseCohort EquationsRisk enhancersCalcium scoreTreatment guidelinesCardiovascular diseaseAmerican Heart Association/American CollegeAtherosclerotic cardiovascular disease eventsBackground Limited dataIntermediate-risk participantsIntermediate-risk patientsCardiovascular disease eventsLarge prospective cohortIncremental valueNet reclassification indexStatin therapyCAC testingProspective cohortPrognostic utilityC-statisticReclassification index
2020
Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease
Lowenstern A, Alexander KP, Hill CL, Alhanti B, Pellikka PA, Nanna MG, Mehta RH, Cooper LS, Bullock-Palmer RP, Hoffmann U, Douglas PS. Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease. JAMA Cardiology 2020, 5: 193-201. PMID: 31738382, PMCID: PMC6865842, DOI: 10.1001/jamacardio.2019.4973.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseOlder patientsMyocardial infarctionCV deathNoninvasive testsArtery diseaseNoninvasive evaluationElevated coronary artery calcium scoresDeath/myocardial infarctionPositive noninvasive test resultsPossible coronary artery diseaseProspective Multicenter Imaging StudyCoronary artery calcium scoreNonwhite race/ethnicityComparative effectiveness designArtery calcium scoreCoronary artery calciumMinority of patientsCause of morbidityNoninvasive test resultsFunctional test resultsAge-specific approachesBest noninvasive testPositive test resultsOlder age groups
2019
LEFT VENTRICULAR MASS INDEX IMPROVES RISK ASSESSMENT OVER THE POOLED COHORT EQUATION (PCE) OR CORONARY ARTERY CALCIUM (CAC) SCORE IN THE INTERMEDIATE RISK POPULATION
Akintoye E, Egbe A, Adegbala O, Christodoulidis G, Briasoulis A, Afonso L. LEFT VENTRICULAR MASS INDEX IMPROVES RISK ASSESSMENT OVER THE POOLED COHORT EQUATION (PCE) OR CORONARY ARTERY CALCIUM (CAC) SCORE IN THE INTERMEDIATE RISK POPULATION. Journal Of The American College Of Cardiology 2019, 73: 1767. DOI: 10.1016/s0735-1097(19)32373-3.Peer-Reviewed Original Research
2017
Relative predictive value of lung cancer screening CT versus myocardial perfusion attenuation correction CT in the evaluation of coronary calcium
Bailey G, Healy A, Young BD, Sharma E, Meadows J, Chun HJ, Wu WC, Choudhary G, Morrison AR. Relative predictive value of lung cancer screening CT versus myocardial perfusion attenuation correction CT in the evaluation of coronary calcium. PLOS ONE 2017, 12: e0175678. PMID: 28437443, PMCID: PMC5402939, DOI: 10.1371/journal.pone.0175678.Peer-Reviewed Original ResearchConceptsCoronary artery calcium scoreECG-gated cardiac CTCardiac CTMACE predictionLung cancerTotal coronary artery calcium scoreArtery calcium scoreCardiovascular risk assessmentSame patient populationPrediction of MACEAttenuation correction CTAgatston methodCalcium scoreCoronary calciumPatient populationRelative predictive valueElevated riskMajor vesselsPredictive valueCutoff valueVessel basisSecondary analysisSimilar AUCWeak correlationGold standard
2009
Quantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging
Curillova Z, Yaman B, Dorbala S, Kwong R, Sitek A, El Fakhri G, Anagnostopoulos C, Di Carli M. Quantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2009, 36: 1603-1610. PMID: 19387640, PMCID: PMC3117296, DOI: 10.1007/s00259-009-1121-1.Peer-Reviewed Original ResearchConceptsCoronary artery calcium scoreCoronary artery calciumCoronary vasodilator functionCoronary flow reserveCoronary artery diseaseHyperemic myocardial blood flowMyocardial blood flowVasodilator functionWeak inverse correlationCAC scoreCoronary artery calcium contentFlow reserveIncreasing CAC scorePer-vessel basisPer-patient basisInverse correlationBody mass indexCoronary calcium contentCoronary risk factorsCoronary vascular resistancePET/CT imagingConclusionIn patientsArtery calciumVascular resistanceMass index
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