2024
Advanced Imaging Modalities in Cardiotoxicity: The Roles of Cardiac CT, MRI, and PET in Cardio-oncology
Arbune A, Khattab M, Henry M, Baldassarre L. Advanced Imaging Modalities in Cardiotoxicity: The Roles of Cardiac CT, MRI, and PET in Cardio-oncology. Current Treatment Options In Cardiovascular Medicine 2024, 27: 5. DOI: 10.1007/s11936-024-01061-3.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsBaseline risk stratificationCardiac computed tomographyCardiac magnetic resonanceAdvanced cardiac imaging modalitiesPositron emission tomographyCardiac imaging modalitiesCoronary artery calciumRisk stratificationCardio-OncologyImaging modalitiesCardiac massEvaluate immune checkpoint inhibitorsImmune checkpoint inhibitor myocarditisImmune checkpoint inhibitor therapyAdvanced cardiac imaging techniquesCardiac positron emission tomographyDiagnosis of cardiotoxicityNoninvasive diagnostic testCardiac imaging techniquesRisk stratification toolCardio-oncology patientsAdvanced imaging modalitiesCoronary flow reserveImaging techniquesThe Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)
Miller R, Lemley M, Shanbhag A, Ramirez G, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Bateman T, Acampa W, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0). Journal Of Nuclear Medicine 2024, 65: 1795-1801. PMID: 39362762, PMCID: PMC11533915, DOI: 10.2967/jnumed.124.268292.Peer-Reviewed Original ResearchCoronary artery calciumCT attenuation correction imagesStress total perfusion deficitMyocardial perfusion imagingTotal perfusion deficitAttenuation correction imagesPerfusion imagingREFINE SPECTImprove prediction of adverse outcomesPerfusion deficitsSPECT myocardial perfusion imagingIncreased risk of MACEPredictive of adverse outcomesMedian Follow-UpInvasive coronary angiographyRisk of MACEAdverse cardiovascular eventsCAC scoreExperience MACECoronary angiographyArtery calciumInternational registryCardiovascular eventsFollow-upClinical dataLow-density lipoprotein-cholesterol and subclinical coronary atherosclerosis in a middle-aged asymptomatic U.S. population: The Miami Heart Study at Baptist Health South Florida
Hagan K, Mszar R, Cainzos-Achirica M, Blaha M, Shapiro M, Arias L, Saxena A, Cury R, Budoff M, Feldman T, Fialkow J, Al-Kindi S, Nasir K. Low-density lipoprotein-cholesterol and subclinical coronary atherosclerosis in a middle-aged asymptomatic U.S. population: The Miami Heart Study at Baptist Health South Florida. Atherosclerosis 2024, 397: 118551. PMID: 39216228, DOI: 10.1016/j.atherosclerosis.2024.118551.Peer-Reviewed Original ResearchConceptsLow-density lipoprotein cholesterolCoronary artery calciumCAC 0Low-density lipoprotein cholesterol levelsHigh-risk plaquesCoronary plaquesNoncalcified plaqueLipoprotein cholesterolPlaque prevalenceCross-sectional analysisLow-density lipoprotein cholesterol <Cardiovascular risk categoryLow-risk groupCross-sectional analysis of baseline dataSubclinical coronary atherosclerosisHigher-risk groupsCardiovascular risk levelHeart StudyAnalysis of baseline dataArtery calciumAsymptomatic cohortAsymptomatic adultsCoronary atherosclerosisSubclinical atherosclerosisLow-risk participantsCardiovascular Risk Estimation and Stratification Among Individuals with Hypercholesterolemia
Bosco G, Mszar R, Piro S, Sabouret P, Gallo A. Cardiovascular Risk Estimation and Stratification Among Individuals with Hypercholesterolemia. Current Atherosclerosis Reports 2024, 26: 537-548. PMID: 38965183, DOI: 10.1007/s11883-024-01225-3.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresCardiovascular risk stratificationLow-density lipoprotein cholesterolCoronary artery calciumRisk stratificationRisk estimatesRisk scoreCardiovascular risk calculatorsEarly life stagesClinical risk scoreCardiovascular risk estimationNegative risk markersPersonalized treatment strategiesElevated lipid levelsImpact of hypercholesterolemiaCardiovascular risk predictionLife stagesArtery calciumInflammatory markersTreatment initiationLipid parametersSubclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus
Mszar R, Katz M, Grandhi G, Osei A, Gallo A, Blaha M. Subclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus. Current Atherosclerosis Reports 2024, 26: 217-230. PMID: 38662272, DOI: 10.1007/s11883-024-01202-w.Peer-Reviewed Original ResearchConceptsCoronary artery calciumType 2 diabetes mellitusAtherosclerotic cardiovascular diseaseDiabetes mellitusCardiovascular riskAtherosclerotic burdenIncreased CACComputed tomography coronary angiographyRisk of cardiovascular eventsIncreased risk of atherosclerotic cardiovascular diseaseLow-density lipoprotein cholesterolRisk of atherosclerotic cardiovascular diseaseMarkers of dyslipidemiaThoracic aorta calcificationCoronary Artery Calcium TestingStratify cardiovascular riskPrimary prevention settingSubclinical atherosclerotic burdenAorta calcificationCardiovascular disease preventionAssessment of subclinical atherosclerosisPrimary hypercholesterolemiaStatin therapyCoronary angiographyArtery calciumAI-Defined Cardiac Anatomy Improves Risk Stratification of Hybrid Perfusion Imaging
Miller R, Shanbhag A, Killekar A, Lemley M, Bednarski B, Kavanagh P, Feher A, Miller E, Bateman T, Builoff V, Liang J, Newby D, Dey D, Berman D, Slomka P. AI-Defined Cardiac Anatomy Improves Risk Stratification of Hybrid Perfusion Imaging. JACC Cardiovascular Imaging 2024, 17: 780-791. PMID: 38456877, PMCID: PMC11222053, DOI: 10.1016/j.jcmg.2024.01.006.Peer-Reviewed Original ResearchComputed tomography attenuation correctionMajor adverse cardiovascular eventsCoronary artery calciumLV massMyocardial perfusion imagingPerfusion imagingSingle-photon emission computed tomography/computed tomographyIncreased risk of MACEAssociated with major adverse cardiovascular eventsRisk of Major Adverse Cardiovascular EventsCardiac chamber volumesMedian Follow-UpCT-based volumesRight ventricular volumesImprove cardiovascular risk assessmentAdverse cardiovascular eventsQuartile of LV massContinuous net reclassification indexCoronary artery diseaseNet reclassification indexCardiovascular risk assessmentTomography/Computed TomographyConsecutive patientsImprove risk predictionPrognostic utility
2023
Vessel Distribution Of Coronary Artery Calcium From Gated CT And Low-dose Ungated CT Imaging Does Not Improve The Prediction Of MACE In Patients Referred For SPECT
Zhou J, Shanbhag A, Bednarski B, Huang C, Miller R, Han D, Pieszko K, Lemley M, Bateman T, Miller E, Dey D, Berman D, Slomka P. Vessel Distribution Of Coronary Artery Calcium From Gated CT And Low-dose Ungated CT Imaging Does Not Improve The Prediction Of MACE In Patients Referred For SPECT. Journal Of Cardiovascular Computed Tomography 2023, 17: s47-s48. DOI: 10.1016/j.jcct.2023.05.119.Peer-Reviewed Original ResearchCorrection to: Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging
Feher A, Pieszko K, Miller R, Lemley M, Shanbhag A, Huang C, Miras L, Liu Y, Sinusas A, Miller E, Slomka P. Correction to: Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging. Journal Of Nuclear Cardiology 2023, 30: 860-863. PMID: 36598750, DOI: 10.1007/s12350-022-03196-x.Peer-Reviewed Original Research
2022
Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging
Feher A, Pieszko K, Miller R, Lemley M, Shanbhag A, Huang C, Miras L, Liu YH, Sinusas AJ, Miller EJ, Slomka PJ. Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging. Journal Of Nuclear Cardiology 2022, 30: 590-603. PMID: 36195826, DOI: 10.1007/s12350-022-03099-x.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsMyocardial perfusion imagingAdverse cardiovascular eventsSPECT myocardial perfusion imagingCAC scoringCardiovascular eventsPrediction of MACECoronary artery calcification (CAC) scoringMACE-free survivalClinical risk factorsCoronary artery calciumCT myocardial perfusion imagingReceiver operator characteristic curveSPECT/CT myocardial perfusion imagingSPECT/CTOperator characteristic curveCT myocardial perfusionArtery calciumCAC scoreAnalysis patientsMACE predictionSingle centerHigher event ratesRisk factorsRisk scoreCoronary Artery Calcium Score to Refine the Use of PCSK9i in Asymptomatic Individuals: A Multicohort Study
Cainzos‐Achirica M, Quispe R, Mszar R, Dudum R, Al Rifai M, Erbel R, Stang A, Jöckel K, Lehmann N, Schramm S, Schmidt B, Toth P, Rana J, Lima J, de Vasconcellos H, Lloyd‐Jones D, Joshi P, Ayers C, Khera A, Blaha M, Greenland P, Nasir K. Coronary Artery Calcium Score to Refine the Use of PCSK9i in Asymptomatic Individuals: A Multicohort Study. Journal Of The American Heart Association 2022, 11: e025737. PMID: 35943062, PMCID: PMC9496288, DOI: 10.1161/jaha.122.025737.Peer-Reviewed Original ResearchConceptsLow-density lipoprotein cholesterol levelsCoronary artery calciumAtherosclerotic cardiovascular diseaseLipoprotein cholesterol levelsClinically evident atherosclerotic cardiovascular diseaseSubclinical organ damageTraditional risk factorsHigh-risk scenariosRisk factorsAssociated with ASCVD eventsCholesterol levelsOrgan damageASCVD event ratesAtherosclerotic cardiovascular disease riskCoronary Artery Calcium TestingLow-density lipoprotein cholesterol <Coronary artery calcium scoreCoronary artery calcium burdenArtery calcium scoreASCVD eventsCalcium scoreArtery calciumFamilial hypercholesterolemiaPCSK9iMulticohort studyThe Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain A Meta-Analysis
Agha AM, Pacor J, Grandhi GR, Mszar R, Khan SU, Parikh R, Agrawal T, Burt J, Blankstein R, Blaha MJ, Shaw LJ, Al-Mallah MH, Brackett A, Cainzos-Achirica M, Miller EJ, Nasir K. The Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain A Meta-Analysis. JACC Cardiovascular Imaging 2022, 15: 1745-1757. PMID: 36202453, DOI: 10.1016/j.jcmg.2022.03.031.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseAcute chest painCoronary artery calciumCoronary artery diseaseStable chest painNonobstructive coronary artery diseaseMajor adverse cardiac eventsAdverse cardiac eventsChest painCardiac eventsLow prevalenceAbsence of CACHealth care delivery modelsCare delivery modelsA Meta-AnalysisNegative predictive valueCAC assessmentArtery calciumCAC scoreIntermediate riskArtery diseaseCoronary CTACTA assessmentPrognostic valueTomography angiographyUpdates on the Use of Subclinical Atherosclerosis to Predict Risk of Cardiovascular Events in Heterozygous Familial Hypercholesterolemia
Gallo A, Mszar R, Miname M. Updates on the Use of Subclinical Atherosclerosis to Predict Risk of Cardiovascular Events in Heterozygous Familial Hypercholesterolemia. Current Atherosclerosis Reports 2022, 24: 407-418. PMID: 35386094, DOI: 10.1007/s11883-022-01017-7.Peer-Reviewed Original ResearchConceptsComputed tomography coronary angiographyRisk of cardiovascular eventsHeterozygous familial hypercholesterolemiaCoronary artery calciumHeFH subjectsRisk stratificationTherapeutic managementFamilial hypercholesterolemiaCardiovascular eventsCoronary artery calcium scoreLong-term follow-upOptimization of risk stratificationSubclinical atherosclerotic cardiovascular diseaseImprove risk stratificationReduction of atherosclerotic progressionCarotid Doppler ultrasoundAtherosclerotic cardiovascular diseaseHeFH childrenCoronary angiographyArtery calciumCardiovascular riskDoppler ultrasoundAtherosclerotic burdenHeFHSubclinical atherosclerosis
2021
Long-Term Prognostic Implications and Role of Further Testing in Adults Aged ≤55 Years With a Coronary Calcium Score of Zero (from the Multi-Ethnic Study of Atherosclerosis)
Cainzos-Achirica M, Acquah I, Dardari Z, Mszar R, Greenland P, Blankstein R, Bittencourt M, Rajagopalan S, Al-Kindi S, Polak J, Blumenthal R, Blaha M, Nasir K. Long-Term Prognostic Implications and Role of Further Testing in Adults Aged ≤55 Years With a Coronary Calcium Score of Zero (from the Multi-Ethnic Study of Atherosclerosis). The American Journal Of Cardiology 2021, 161: 26-35. PMID: 34794615, PMCID: PMC8607758, DOI: 10.1016/j.amjcard.2021.08.067.Peer-Reviewed Original ResearchConceptsAortic valve calciumCoronary artery calciumCoronary calcium scoreLong-term prognosisCardiovascular diseaseICA-IMTCoronary calcium score of zeroCalcium score of zeroHigh-sensitivity C-reactive protein levelsLong-term prognostic significanceC-reactive protein levelsMedian Follow-UpMulti-Ethnic StudyMitral annular calciumEvent ratesPremature family historyThoracic aortic calciumScore of zeroCardiovascular disease eventsAnkle-brachial indexValve calciumAnnular calciumPrognostic significancePrognostic implicationsAortic calciumCoronary Calcium to Rule Out Obstructive Coronary Artery Disease in Patients With Acute Chest Pain
Grandhi G, Mszar R, Cainzos-Achirica M, Rajan T, Latif M, Bittencourt M, Shaw L, Batlle J, Blankstein R, Blaha M, Cury R, Nasir K. Coronary Calcium to Rule Out Obstructive Coronary Artery Disease in Patients With Acute Chest Pain. JACC Cardiovascular Imaging 2021, 15: 271-280. PMID: 34656462, DOI: 10.1016/j.jcmg.2021.06.027.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary Computed Tomography AngiographyCoronary artery calciumNegative predictive valueCoronary artery diseaseAcute coronary syndromePositive predictive valueAcute chest painChest painIntermediate riskEmergency departmentDiagnostic accuracyEvaluation of acute coronary syndromeArtery diseaseCAC testingPredictive valueRegistry of patientsTriage of patientsPain RegistryArtery calciumCoronary revascularizationCoronary syndromeInvasive proceduresPatientsRevascularizationRationale and pathways forward in the implementation of coronary artery calcium-based enrichment of randomized trials
Cainzos-Achirica M, Anugula D, Mszar R, Grandhi G, Patel K, Bittencourt M, Blankstein R, Blaha M, Blumenthal R, Ray K, Bhatt D, Nasir K. Rationale and pathways forward in the implementation of coronary artery calcium-based enrichment of randomized trials. American Heart Journal 2021, 243: 54-65. PMID: 34587511, DOI: 10.1016/j.ahj.2021.09.006.Peer-Reviewed Original ResearchConceptsCoronary artery calciumRandomized Controlled TrialsPrognostic enrichmentCoronary artery calcium scoreCoronary artery calcium dataAdd-on therapyRisk reduction therapyFood and Drug AdministrationComputed tomography imagesArtery calciumCardiovascular riskRandomized trialsEnrichment paradigmDrug AdministrationPrimary preventionTomography imagesRCT participantsTherapyTrialsLogistical barriersRiskCoronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study
Suzuki H, Davis-Plourde K, Beiser A, Kunimura A, Miura K, DeCarli C, Maillard P, Mitchell GF, Vasan RS, Seshadri S, Fujiyoshi A. Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study. Circulation Cardiovascular Imaging 2021, 14: e011753. PMID: 34256573, PMCID: PMC8323993, DOI: 10.1161/circimaging.120.011753.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAsymptomatic DiseasesCoronary AngiographyCoronary Artery DiseaseDiffusion Tensor ImagingFemaleHumansLeukoencephalopathiesMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsSex FactorsTime FactorsVascular CalcificationConceptsCoronary artery calciumWhite matter injurySubtle white matter injuryAsymptomatic middle-aged menCAC scoreMiddle-aged menFractional anisotropyCAC groupDiffusion tensor imaging-based measuresCarotid-femoral pulse wave velocityLog-transformed CAC scoreSecondary analysisBrain magnetic resonance imagingPredictors of strokePulse wave velocityCross-sectional associationsMagnetic resonance diffusion tensorImaging-based measuresMagnetic resonance imagingLower fractional anisotropyFramingham Heart StudyMiddle-age adultsArtery calciumMultivariable adjustmentAortic stiffness
2020
Lessons from KEEPS: the Kronos Early Estrogen Prevention Study
Miller VM, Taylor HS, Naftolin F, Manson JE, Gleason CE, Brinton EA, Kling JM, Cedars MI, Dowling NM, Kantarci K, Harman SM. Lessons from KEEPS: the Kronos Early Estrogen Prevention Study. Climacteric 2020, 24: 139-145. PMID: 32880220, PMCID: PMC8108428, DOI: 10.1080/13697137.2020.1804545.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyCarotid intima-medial thicknessPrevention StudyCardiovascular diseaseOral conjugated equine estrogenClinical CVD eventsUse of MHTOvert cardiovascular diseasePlacebo-controlled trialConjugated equine estrogensCoronary artery calciumIntima-medial thicknessMode of deliveryUptake of estrogensMood/anxietyAge-related increaseGenetic variantsCVD eventsAgatston unitsArtery calciumSymptom reliefPlacebo pillsEquine estrogensMenopausal womenMenopausal symptomsPROGNOSTIC IMPLICATIONS OF ABSENCE OF CORONARY ARTERY CALCIUM IN ASYMPTOMATIC INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Rajan T, Mszar R, Ali S, Asif R, Cainzos-Achirica M, Blaha M, Blankstein R, Virani S, Al-Mallah M, Bittencourt M, Khurram N. PROGNOSTIC IMPLICATIONS OF ABSENCE OF CORONARY ARTERY CALCIUM IN ASYMPTOMATIC INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS: A SYSTEMATIC REVIEW AND META-ANALYSIS. Journal Of The American College Of Cardiology 2020, 75: 1581. DOI: 10.1016/s0735-1097(20)32208-7.Peer-Reviewed Original ResearchAge-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease
Lowenstern A, Alexander KP, Hill CL, Alhanti B, Pellikka PA, Nanna MG, Mehta RH, Cooper LS, Bullock-Palmer RP, Hoffmann U, Douglas PS. Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease. JAMA Cardiology 2020, 5: 193-201. PMID: 31738382, PMCID: PMC6865842, DOI: 10.1001/jamacardio.2019.4973.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseOlder patientsMyocardial infarctionCV deathNoninvasive testsArtery diseaseNoninvasive evaluationElevated coronary artery calcium scoresDeath/myocardial infarctionPositive noninvasive test resultsPossible coronary artery diseaseProspective Multicenter Imaging StudyCoronary artery calcium scoreNonwhite race/ethnicityComparative effectiveness designArtery calcium scoreCoronary artery calciumMinority of patientsCause of morbidityNoninvasive test resultsFunctional test resultsAge-specific approachesBest noninvasive testPositive test resultsOlder age groups
2019
Interplay of Coronary Artery Calcium and Risk Factors for Predicting CVD/CHD Mortality The CAC Consortium
Grandhi GR, Mirbolouk M, Dardari ZA, Al-Mallah MH, Rumberger JA, Shaw LJ, Blankstein R, Miedema MD, Berman DS, Budoff MJ, Krumholz HM, Blaha MJ, Nasir K. Interplay of Coronary Artery Calcium and Risk Factors for Predicting CVD/CHD Mortality The CAC Consortium. JACC Cardiovascular Imaging 2019, 13: 1175-1186. PMID: 31734198, DOI: 10.1016/j.jcmg.2019.08.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCause of DeathComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseDiabetes MellitusDyslipidemiasFemaleHeart Disease Risk FactorsHumansHypertensionMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrevalencePrognosisRetrospective StudiesRisk AssessmentSmokingTime FactorsUnited StatesVascular CalcificationConceptsCoronary artery calciumCoronary heart diseaseRisk factorsCause-specific mortalityRF burdenCause mortalityArtery calciumCAC scoreCVD mortalityAbsence of CACHigher CAC scoresCHD mortality ratesCurrent cigarette smokingCardiovascular disease deathsCAC ConsortiumCAC testingMulticenter cohortCigarette smokingDisease deathsHeart diseasePrognostic informationBaseline riskFamily historyMost deathsMortality rate
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply