2025
Development and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults.
Nanna M, Wojdyla D, Peterson E, Navar A, Williamson J, Colantonio L, Wang S, Jamil Y, Bertoni A, Nahid M, Damluji A, Goyal P, Chaudhry S, Gill T, Alexander K. Development and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults. Journal Of The American Heart Association 2025, 14: e038949. PMID: 40401627, DOI: 10.1161/jaha.124.038949.Peer-Reviewed Original ResearchConceptsRisk of cognitive impairmentAtherosclerotic cardiovascular disease eventsAtherosclerotic cardiovascular diseaseRisk prediction modelCognitive impairmentOlder adultsMeasures of healthIncident cognitive impairmentOlder person's riskPooled Cohort EquationsCardiovascular diseaseRisk of deathCohort EquationsFramingham OffspringOlder personsExternal validationFunctional statusPersonal riskIncidence riskValidation cohortYoung adultsInternal validityFraminghamCohortTreatment decisionsHeart failure risk stratification using artificial intelligence applied to electrocardiogram images: a multinational study
Dhingra L, Aminorroaya A, Sangha V, Pedroso A, Asselbergs F, Brant L, Barreto S, Ribeiro A, Krumholz H, Oikonomou E, Khera R. Heart failure risk stratification using artificial intelligence applied to electrocardiogram images: a multinational study. European Heart Journal 2025, 46: 1044-1053. PMID: 39804243, PMCID: PMC12086686, DOI: 10.1093/eurheartj/ehae914.Peer-Reviewed Original ResearchYale New Haven Health SystemELSA-BrasilPCP-HFUK BiobankHF riskBrazilian Longitudinal Study of Adult HealthLongitudinal Study of Adult HealthBrazilian Longitudinal StudyRisk of new-onset HFPooled Cohort EquationsPrimary HF hospitalizationsHigher HF riskHarrell's C-statisticRisk of deathNew-onset HFCohort EquationsHealth systemComprehensive clinical evaluationAdult HealthHeart failureIncident HFHF hospitalizationBaseline HFC-statisticPrevent HF
2024
Performance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study
Camargos A, Barreto S, Brant L, Ribeiro A, Dhingra L, Aminorroaya A, Bittencourt M, Figueiredo R, Khera R. Performance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study. Open Heart 2024, 11: e002762. PMID: 38862252, PMCID: PMC11168182, DOI: 10.1136/openhrt-2024-002762.Peer-Reviewed Original ResearchConceptsPooled Cohort EquationsELSA-BrasilRisk scoreCardiovascular diseaseCVD eventsCommunity-based cohort studyArea under the receiver operating characteristic curveCVD risk scoreELSA-Brasil studyIncident CVD eventsMiddle-income countriesAdjudicated CVD eventsCardiovascular disease riskCVD scoreCohort EquationsNational guidelinesRisk stratification scoresWhite womenAge/sex groupsCohort studyProspective cohortLMICsSex/race groupsHigher incomeRisk discrimination
2021
Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts
Akintoye E, Afonso L, Jayanna M, Bao W, Briasoulis A, Robinson J. Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts. Journal Of The American Heart Association 2021, 10: e019589. PMID: 34092110, PMCID: PMC8477885, DOI: 10.1161/jaha.120.019589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationBiomarkersCardiovascular DiseasesCholesterolClinical Decision-MakingCoronary Artery DiseaseDecision Support TechniquesDyslipidemiasFemaleHeart Disease Risk FactorsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedPractice Guidelines as TopicPredictive Value of TestsPrimary PreventionPrognosisRisk AssessmentTime FactorsUnited StatesVascular CalcificationConceptsPooled Cohort EquationsCoronary artery calcium scoreCholesterol treatment guidelinesArtery calcium scoreAtherosclerotic cardiovascular diseaseCohort EquationsRisk enhancersCalcium scoreTreatment guidelinesCardiovascular diseaseAmerican Heart Association/American CollegeAtherosclerotic cardiovascular disease eventsBackground Limited dataIntermediate-risk participantsIntermediate-risk patientsCardiovascular disease eventsLarge prospective cohortIncremental valueNet reclassification indexStatin therapyCAC testingProspective cohortPrognostic utilityC-statisticReclassification indexPerformance of the Pooled Cohort Equations in Hispanic Individuals Across the United States: Insights From the Multi‐Ethnic Study of Atherosclerosis and the Dallas Heart Study
Rosario K, Mehta A, Ayers C, Gonzalez P, Pandey A, Khera R, Kaplan R, Blaha MJ, Khera A, Blumenthal RS, Nasir K, Rodriguez CJ, Joshi PH. Performance of the Pooled Cohort Equations in Hispanic Individuals Across the United States: Insights From the Multi‐Ethnic Study of Atherosclerosis and the Dallas Heart Study. Journal Of The American Heart Association 2021, 10: e018410. PMID: 33870702, PMCID: PMC8200750, DOI: 10.1161/jaha.120.018410.Commentaries, Editorials and Letters
2020
Performance of the Pooled Cohort Equations to Estimate Atherosclerotic Cardiovascular Disease Risk by Body Mass Index
Khera R, Pandey A, Ayers CR, Carnethon MR, Greenland P, Ndumele CE, Nambi V, Seliger SL, Chaves PHM, Safford MM, Cushman M, Xanthakis V, Ramachandran V, Mentz RJ, Correa A, Lloyd-Jones DM, Berry JD, de Lemos JA, Neeland IJ. Performance of the Pooled Cohort Equations to Estimate Atherosclerotic Cardiovascular Disease Risk by Body Mass Index. JAMA Network Open 2020, 3: e2023242. PMID: 33119108, PMCID: PMC7596579, DOI: 10.1001/jamanetworkopen.2020.23242.Peer-Reviewed Original ResearchConceptsHigh-sensitivity C-reactive proteinPooled Cohort EquationsASCVD riskAtherosclerotic cardiovascular diseaseBody mass indexBMI categoriesCohort EquationsObesity categoriesCohort studySevere obesityWaist circumferenceBMI groupsMass indexUnderweight categoryAtherosclerotic cardiovascular disease riskMean baseline BMIRisk of ASCVDUsual clinical measuresCardiovascular disease riskC-reactive proteinPooled individual-level dataSevere obesity groupLongitudinal cohort studyNormal weight categoryAdults ages 40PROGNOSTIC UTILITY OF RISK ENHANCERS RECOMMENDED IN THE 2018 ACC/AHA CHOLESTEROL TREATMENT GUIDELINES OVER THE POOLED COHORT EQUATION: INSIGHTS FROM 3 LARGE PROSPECTIVE COHORTS
Akintoye E, Briasoulis A, Robinson J. PROGNOSTIC UTILITY OF RISK ENHANCERS RECOMMENDED IN THE 2018 ACC/AHA CHOLESTEROL TREATMENT GUIDELINES OVER THE POOLED COHORT EQUATION: INSIGHTS FROM 3 LARGE PROSPECTIVE COHORTS. Journal Of The American College Of Cardiology 2020, 75: 1833. DOI: 10.1016/s0735-1097(20)32460-8.Peer-Reviewed Original Research
2019
LEFT VENTRICULAR MASS INDEX IMPROVES RISK ASSESSMENT OVER THE POOLED COHORT EQUATION (PCE) OR CORONARY ARTERY CALCIUM (CAC) SCORE IN THE INTERMEDIATE RISK POPULATION
Akintoye E, Egbe A, Adegbala O, Christodoulidis G, Briasoulis A, Afonso L. LEFT VENTRICULAR MASS INDEX IMPROVES RISK ASSESSMENT OVER THE POOLED COHORT EQUATION (PCE) OR CORONARY ARTERY CALCIUM (CAC) SCORE IN THE INTERMEDIATE RISK POPULATION. Journal Of The American College Of Cardiology 2019, 73: 1767. DOI: 10.1016/s0735-1097(19)32373-3.Peer-Reviewed Original Research
2017
Biochemical risk markers and 10-year incidence of atherosclerotic cardiovascular disease: independent predictors, improvement in pooled cohort equation, and risk reclassification
Akintoye E, Briasoulis A, Afonso L. Biochemical risk markers and 10-year incidence of atherosclerotic cardiovascular disease: independent predictors, improvement in pooled cohort equation, and risk reclassification. American Heart Journal 2017, 193: 95-103. PMID: 29129262, DOI: 10.1016/j.ahj.2017.08.002.Peer-Reviewed Original ResearchConceptsPooled Cohort EquationsNet reclassification indexBiochemical risk markersBiomarker scoreCohort EquationsC-statisticRisk markersTreatment decisionsPrimary atherosclerotic cardiovascular disease (ASCVD) preventionAtherosclerotic cardiovascular disease preventionCategorical net reclassification indexSensitivity C-reactive proteinCategory-free net reclassification indexN-terminal prohormoneBrain natriuretic peptideAtherosclerotic cardiovascular diseaseC-reactive proteinCardiovascular disease preventionMulti-Ethnic StudyRate of incidentsASCVD preventionIndependent predictorsNet reclassificationNatriuretic peptideRisk reclassification
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