2025
Multiple sclerosis diagnosis and its differential diagnosis in patients presenting with type four ‘mirror pattern’ CSF oligoclonal bands
Marastoni D, Sicchieri M, Pizzini F, Scartezzini A, Virla F, Turano E, Anni D, Bertolazzo M, Ziccardi S, Camera V, Tamanti A, Marini M, Lippi G, Bonetti B, Solomon A, Calabrese M. Multiple sclerosis diagnosis and its differential diagnosis in patients presenting with type four ‘mirror pattern’ CSF oligoclonal bands. Journal Of Neurology 2025, 272: 207. PMID: 39954124, PMCID: PMC11829897, DOI: 10.1007/s00415-025-12947-y.Peer-Reviewed Original ResearchConceptsCentral nervous systemCSF oligoclonal bandsOligoclonal bandsDiagnosis of MSAlternative diagnosesCerebrospinal fluidDemyelinating eventCentral nervous system demyelinating eventMultiple sclerosisInitial central nervous systemOligoclonal banding patternsRadiological follow-upDiagnostic work-upFrequent alternative diagnosesGroup of patientsMethodsSeventy-six patientsCentral nervous system disordersConclusionThe diagnosisMultiple sclerosis diagnosisClinical attacksMRI lesionsParaclinical examinationsDifferential diagnosisFollow-upWork-up
2024
Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis
Toljan K, Daboul L, Raza P, Martin M, Cao Q, O’Donnell C, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Sati P, Ontaneda D. Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis. Multiple Sclerosis Journal 2024, 30: 1268-1277. PMID: 39234802, PMCID: PMC11421977, DOI: 10.1177/13524585241271988.Peer-Reviewed Original ResearchConceptsCentral vein signPositive predictive valueOligoclonal bandsDiagnostic performanceMS diagnosisCerebrospinal fluidMultiple sclerosisPredictive valueNegative predictive valueCerebrospinal fluid testingRadiological suspicionDiagnostic accuracyImaging biomarkersDiagnosisDiagnostic biomarkersMonthsSclerosisBiomarkersPilot studyBaselineSelection 3
2021
Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome
Lebrun-Frénay C, Rollot F, Mondot L, Zephir H, Louapre C, Le Page E, Durand-Dubief F, Labauge P, Bensa C, Thouvenot E, Laplaud D, de Seze J, Ciron J, Bourre B, Cabre P, Casez O, Ruet A, Mathey G, Berger E, Moreau T, Al Khedr A, Derache N, Clavelou P, Guennoc AM, Créange A, Neau JP, Tourbah A, Camdessanché JP, Maarouf A, Callier C, Vermersch P, Kantarci O, Siva A, Azevedo C, Makhani N, Cohen M, Pelletier D, Okuda D, Vukusic S, Kantarci O, Siva A, Pelletier D, Okuda D, Azevedo C, Makhani N, Radji F, Morel N, Grosset-Jeannin D, Ungureanu A, Boyer L, Suchet L, Elias Z, Lebrun-Frénay C, Cohen M, Mondot L, Thouvenot E, Ciron J, Durand-Dubief F, Brochet B, Ruet A, Ouallet J, Defer G, Branger P, Derache N, Clavelou P, Taithe F, Alkhedr A, Fromont A, Moreau T, Tourbah A, Casez O, Berger E, Zephir H, Outteryck O, Vermersch P, Hautecoeur P, Androdias G, Ionescu I, Pelletier J, Audoin B, Maarouf A, Ayrignac X, Carra-Dalliere C, Labauge P, Debouverie M, Mathey G, Cabre P, Laplaud D, Wiertlevski S, Bresch S, Castelnovo G, Papeix C, Louapre C, Maillart E, Lubetzki C, Stankoff B, Fontaine B, Giannesini C, Heinzleff O, Créange A, Bourre B, Gout O, Guegen A, Bensa C, Le Page E, Michel L, Magy L, De Seze J, Collongues N, Leray E, Guennoc A, Biotti D, Camdessanché J, De Broucker T, Sehaki S, Devys-Meyer N, Bereau M, Cappe C, Kounkou K, Dumont E, Lescieux E, Protin A, Kane M, Boucher J, Petit J, Tabellah Kasonde I, De Vilmarrest A, Nicol M, Malbezin M, Olaiz J, Rigaud-Bully C, Casey R, Rollot F, Vukusic I, Debard N, Cotton F, Abdelalli A, Di Lelio B, Pinna F, Guillemin F, Ziegler A, Callier C, Zehrouni K, Hodel J, Wahab A, Zedet M, Fagniez O, Laage C, Pottier C, Slesari I, Sampaio M, Neau J, Rabois E, Castex C, Hebant B, Guillaume M, Vimont C, Muraz R, Le Port D, Henry C, Berthe C, Freitas N, Visneux V, Forestier M, Beltran S, Meunier G, Servan J, Pico F, Chatagner V. Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome. JAMA Network Open 2021, 4: e2128271. PMID: 34633424, PMCID: PMC8506228, DOI: 10.1001/jamanetworkopen.2021.28271.Peer-Reviewed Original ResearchConceptsGadolinium-enhancing lesionsSpinal cord lesionsClinical eventsMultiple sclerosisRisk of conversionCord lesionsRisk factorsMRI scansPhase III clinical trialsMagnetic resonance imaging (MRI) scansEarly clinical diseaseFirst clinical eventDisease-modifying therapiesEarly clinical eventsSpinal cord involvementAge 37 yearsResonance imaging scansPotential treatment effectsMS careCohort studyCord involvementStudy entryTertiary centerClinical symptomsOligoclonal bands
2020
IgG Index Revisited: Diagnostic Utility and Prognostic Value in Multiple Sclerosis
Zheng Y, Cai M, Yang F, Zhou J, Fang W, Shen C, Zhang Y, Ding M. IgG Index Revisited: Diagnostic Utility and Prognostic Value in Multiple Sclerosis. Frontiers In Immunology 2020, 11: 1799. PMID: 32973754, PMCID: PMC7468492, DOI: 10.3389/fimmu.2020.01799.Peer-Reviewed Original ResearchConceptsCohort of clinically isolated syndromeOligoclonal band positivityOligoclonal band statusOligoclonal bandsIgG indexPrognostic valueDiagnostic utilityMultiple sclerosisExpanded Disability Status Scale worseningAccurate diagnosis of multiple sclerosisMS diagnosisAttack of MSNegative oligoclonal bandsAsian populationsClinically isolated syndromeDiagnosis of multiple sclerosisElevated IgG indexEarly disease activityClinical relapseRetrospective studyDisease activityClinical challengeMS patientsAccurate diagnosisPredictive valueRadiologically Isolated Syndrome: 10‐Year Risk Estimate of a Clinical Event
Lebrun‐Frenay C, Kantarci O, Siva A, Sormani M, Pelletier D, Okuda D, Azevedo C, Amato M, Bensa C, Berger E, Brochet B, Ciron J, Cohen M, Inglese M, Keegan B, Labauge P, Laplaud D, Le Page E, Louapre C, Makhani N, Mathey G, Mondot L, Montalban X, Pelletier J, Seze J, deStefano N, Thouvenot E, Tintore M, Tutuncuoglu M, Uygunoglu U, Vermersch P, Weinshenker B, Zeydan B. Radiologically Isolated Syndrome: 10‐Year Risk Estimate of a Clinical Event. Annals Of Neurology 2020, 88: 407-417. PMID: 32500558, DOI: 10.1002/ana.25799.Peer-Reviewed Original ResearchConceptsFirst clinical eventSubsequent clinical eventsGadolinium-enhancing lesionsSpinal cord lesionsClinical eventsRIS subjectsCord lesionsIndependent predictorsMultivariate Cox regression modelMagnetic resonance imaging (MRI) characteristicsBaseline independent predictorsWorldwide cohort studiesPositive cerebrospinal fluidCox regression modelAnn NeurolIsolated SyndromeRIS diagnosisCohort studySymptom onsetMale sexMultiple sclerosisOligoclonal bandsInfratentorial lesionsMean ageClinical management
2019
Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome
Makhani N, Lebrun C, Siva A, Narula S, Wassmer E, Brassat D, Brenton JN, Cabre P, Carra Dallière C, de Seze J, Durand Dubief F, Inglese M, Langille M, Mathey G, Neuteboom RF, Pelletier J, Pohl D, Reich DS, Ignacio Rojas J, Shabanova V, Shapiro ED, Stone RT, Tenembaum S, Tintoré M, Uygunoglu U, Vargas W, Venkateswaren S, Vermersch P, Kantarci O, Okuda DT, Pelletier D, . Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome. Multiple Sclerosis Journal - Experimental Translational And Clinical 2019, 5: 2055217319836664. PMID: 30915227, PMCID: PMC6429663, DOI: 10.1177/2055217319836664.Peer-Reviewed Original ResearchOligoclonal bandsMultiple sclerosisCerebrospinal fluidDiagnostic criteriaCentral nervous system demyelinationMagnetic resonance imaging criteriaFirst clinical eventCerebrospinal fluid analysisNervous system demyelinationOptimal diagnostic criteriaDiagnostic indexMagnetic resonanceSpecificity 72.7Historical cohortProspective studyClinical eventsMRI criteriaSensitivity 66.7Imaging criteriaDiagnostic certaintySpecificity 83.3SyndromeFluid analysisSensitivity 76.5Demyelination
2017
Radiologically isolated syndrome in children
Makhani N, Lebrun C, Siva A, Brassat D, Carra Dallière C, de Seze J, Du W, Durand Dubief F, Kantarci O, Langille M, Narula S, Pelletier J, Rojas JI, Shapiro ED, Stone RT, Tintoré M, Uygunoglu U, Vermersch P, Wassmer E, Okuda DT, Pelletier D. Radiologically isolated syndrome in children. Neurology Neuroimmunology & Neuroinflammation 2017, 4: &na;. PMID: 28959703, PMCID: PMC5614726, DOI: 10.1212/nxi.0000000000000395.Peer-Reviewed Original ResearchFirst clinical eventSpinal cord lesionsCNS demyelinationClinical eventsCord lesionsOligoclonal bandsRadiologic evolutionIncidental MRI findingsSubsequent clinical symptomsOutcome of childrenInitial neuroimagingMean followClinical characteristicsRadiologic outcomesMRI findingsClinical symptomsHistorical cohortRadiologic dataMRI criteriaIncidental findingCommon reasonMRI scansDemyelinationSubstantial riskChildren
2015
Biomarkers in multiple sclerosis
Housley WJ, Pitt D, Hafler DA. Biomarkers in multiple sclerosis. Clinical Immunology 2015, 161: 51-58. PMID: 26143623, DOI: 10.1016/j.clim.2015.06.015.Peer-Reviewed Original ResearchConceptsMultiple sclerosisB cell chemoattractant CXCL13Myelin-reactive T cellsMacrophage marker CD163Reactive T cellsMarkers of neurodegenerationKIR4.1 antibodiesMS seraClinical outcomesOligoclonal bandsYKL-40Disease progressionT cellsMS susceptibilityCerebrospinal fluidPotential biomarkersViral titersClinical useBiomarkersBiomarker researchSclerosisProgressionDisease diagnosisCD163CXCL13
2010
Risk of Multiple Sclerosis after Idiopathic Optic Neuritis in a Pakistani Population
Kazim S, Islam M, Khan M, Hameed B, Shafqat S. Risk of Multiple Sclerosis after Idiopathic Optic Neuritis in a Pakistani Population. Canadian Journal Of Neurological Sciences / Journal Canadien Des Sciences Neurologiques 2010, 37: 258-263. PMID: 20437939, DOI: 10.1017/s0317167100010027.Peer-Reviewed Original ResearchConceptsBaseline brain magnetic resonance imagingBrain magnetic resonance imagingMagnetic resonance imagingIdiopathic optic neuritisTen-year riskOptic neuritisMultiple sclerosisOligoclonal bandsCerebrospinal fluid oligoclonal bandsDiagnosis of MSKaplan-Meier survival analysisWestern populationsFive-year riskCSF oligoclonal bandsRisk of progressionSingle academic centerStructured telephone interviewDemyelinating lesionsMS riskSouth Asian populationFemale genderLower riskAcademic centersChart notesSurvival analysis
1980
Antibodies to Myelin Basic Protein in Cerebrospinal Fluid of Patients with Multiple Sclerosis
Panitch H, Hafler D, Johnson K. Antibodies to Myelin Basic Protein in Cerebrospinal Fluid of Patients with Multiple Sclerosis. 1980, 98-105. DOI: 10.1007/978-3-642-67554-6_17.Peer-Reviewed Original ResearchMyelin basic proteinMultiple sclerosisCerebrospinal fluidSolid-phase radioimmunoassayBasic proteinActive diseaseAutoimmune responseOligoclonal bandsCSF IgGIgG classIgG concentrationsPatientsPhase radioimmunoassayAntibodiesSclerosisDiseaseNonspecific adherenceRemissionPathogenesisIgGAntigenRadioimmunoassay
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