2023
Mediastinal Staging in Non–Small-Cell Lung Cancer: Saying Goodbye to Mediastinoscopy
Dunne E, Fick C, Jones D. Mediastinal Staging in Non–Small-Cell Lung Cancer: Saying Goodbye to Mediastinoscopy. Journal Of Clinical Oncology 2023, 41: 3785-3790. PMID: 37267507, PMCID: PMC10419653, DOI: 10.1200/jco.23.00867.Peer-Reviewed Original ResearchConceptsMediastinal lymph nodesCell lung cancerConfirmatory mediastinoscopyFine-needle aspirationPositron emission tomographyLymph nodesNodal metastasisEBUS-FNALung cancerEndobronchial ultrasound-guided fine-needle aspirationOncology Grand Rounds seriesNegative findingsUltrasound-guided fine-needle aspirationThoracic Surgeons guidelinesRandomized noninferiority trialStandard of careTumor genomic analysisOwn clinical practiceResectable NSCLCN1 diseaseNodal diseaseMediastinal stagingAccurate stagingForceps biopsySurgeons guidelinesOne-Carbon (Folate) Metabolism Pathway at Birth and Risk of Childhood Acute Lymphoblastic Leukemia: A Biomarker Study in Newborns
Metayer C, Imani P, Dudoit S, Morimoto L, Ma X, Wiemels J, Petrick L. One-Carbon (Folate) Metabolism Pathway at Birth and Risk of Childhood Acute Lymphoblastic Leukemia: A Biomarker Study in Newborns. Cancers 2023, 15: 1011. PMID: 36831356, PMCID: PMC9953980, DOI: 10.3390/cancers15041011.Peer-Reviewed Original ResearchAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaOne-carbon metabolism nutrientsRace/ethnicityLymphoblastic leukemiaFolic acid intakeTime of conceptionOne-carbon metabolism pathwaySubsequent leukemiaFirst trimesterAcid intakeCommon cancerDNA methylation programmingChildhood leukemiaLeukemiaNegative findingsBlood spotsBiomarker studiesPathway metabolitesFolic acidAges 0Key vitaminsPregnancyLast weekFolate pathway
2022
Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing
Quraishi IH, Brown FC, Johnson MH, Hirsch LJ. Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing. Epilepsy & Behavior 2022, 134: 108854. PMID: 35905518, DOI: 10.1016/j.yebeh.2022.108854.Peer-Reviewed Original ResearchConceptsResponsive neurostimulation systemWada testingEpileptiform activityElicitation of seizuresTemporal lobe resectionInternal carotid arteryMedial temporal structuresHippocampal vasculatureIpsilateral activationLobe resectionPosterior circulationElectrographic seizuresTemporal lobectomyElectrographic changesIntractable epilepsyClinical correlatesWada testCarotid arteryHippocampal spikesNegative findingsNeurostimulation systemHippocampal EEGHippocampal activityPatientsTransient increase
2021
Misreporting of Results of Research in Psychiatry
Bowcut J, Levi L, Livnah O, Ross JS, Knable M, Davidson M, Davis JM, Weiser M. Misreporting of Results of Research in Psychiatry. Schizophrenia Bulletin 2021, 47: 1254-1260. PMID: 33860793, PMCID: PMC8379531, DOI: 10.1093/schbul/sbab040.Peer-Reviewed Original Research
2020
Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus.
Samuel AM, Munger AM, Lee FY, Friedlaender GE, Ibe IK, Lindskog DM. Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus. Orthopedics 2020, 43: e498-e502. PMID: 32882054, DOI: 10.3928/01477447-20200827-05.Peer-Reviewed Original ResearchConceptsRadionuclide bone scanBone scanMRI scansPositive findingsNegative findingsMagnetic resonance imaging (MRI) scansBone scan findingsProgression of lesionsResonance imaging scansDiagnosis of enchondromaAcademic medical centerBivariate logistic regressionAssociation of boneScan findingsAggressive featuresRadiographic findingsEndosteal scallopingBenign enchondromaImaging scansMedical recordsMedical CenterMalignant lesionsCartilaginous lesionsEnchondromaPatients
2016
An Approach to Improve the Negative Predictive Value and Clinical Utility of Transthoracic Echocardiography in Suspected Native Valve Infective Endocarditis
Sivak JA, Vora AN, Navar AM, Schulte PJ, Crowley AL, Kisslo J, Corey GR, Liao L, Wang A, Velazquez EJ, Samad Z. An Approach to Improve the Negative Predictive Value and Clinical Utility of Transthoracic Echocardiography in Suspected Native Valve Infective Endocarditis. Journal Of The American Society Of Echocardiography 2016, 29: 315-322. PMID: 26850679, PMCID: PMC6052444, DOI: 10.1016/j.echo.2015.12.009.Peer-Reviewed Original ResearchConceptsInitial transthoracic echocardiographyNative valve infective endocarditisTransthoracic echocardiographyTransesophageal echocardiographyNegative predictive valueInfective endocarditisPredictive valueNegative resultsNegative findingsNative valve endocarditisValve endocarditisClinical suspicionIntermediate riskSingle institutionTransthoracic approachCurrent guidelinesTransthoracic studyDiagnostic characteristicsRetrospective analysisClinical utilityPatientsEndocarditisEchocardiographyDiagnostic performanceGold standard
2012
Relying on Injection Drug Users to Access and Adhere to HIV Therapeutics
Broadhead R, Borch C, van Hulst Y, Gauchat G, Tehrani S, Stringer K, Heckathorn D, Altice F. Relying on Injection Drug Users to Access and Adhere to HIV Therapeutics. Journal Of Drug Issues 2012, 42: 127-146. DOI: 10.1177/0022042612446581.Peer-Reviewed Original ResearchPeer-driven interventionRespondent-driven samplingSocial supportDrug usersPositive health-seeking behaviourActive injection drug usersAdherence studiesInjection drug usersFuture adherence studiesHealth-seeking behaviourCash rewardsCorrelates of participationHIV therapeuticsMedical careNegative findingsIDUsImportant implications
2010
Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis
Reyes MM, Panza KE, Martin A, Bloch MH. Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 50: 63-72. PMID: 21156271, PMCID: PMC3645909, DOI: 10.1016/j.jaac.2010.10.008.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsPlacebo-controlled trialTime-lag biasMajor depressive disorderYears of ageReuptake inhibitorsAntidepressant trialsPediatric depressionDepressive disorderTreatment respondersMAIN OUTCOMESystematic reviewMeta-analysisPositive findingsNegative findingsNegative trialsMedical literatureAntidepressantsTrialsPublication of findingsNegative resultsChild psychiatryEfficacyFindingsPublication time
2001
Relationship between duration of pain and secondary signs of obstruction of the urinary tract on unenhanced helical CT.
Varanelli M, Coll D, Levine J, Rosenfield A, Smith R. Relationship between duration of pain and secondary signs of obstruction of the urinary tract on unenhanced helical CT. American Journal Of Roentgenology 2001, 177: 325-30. PMID: 11461855, DOI: 10.2214/ajr.177.2.1770325.Peer-Reviewed Original ResearchConceptsDuration of painUnenhanced helical CTFlank painSecondary signsCT studiesAcute ureterolithiasisSystem dilatationHelical CTUreteral dilatationUreteral obstructionPerinephric fluidUnenhanced CT studiesPerinephric strandingPeriureteral strandingConsecutive patientsUrinary tractPainDilatationNegative findingsNephromegalyObstructionPatientsCTUreterolithiasisSignificant increase
1998
Serotonin Transporter Protein Gene Polymorphism and Personality Measures in African American and European American Subjects
Gelernter J, Kranzler H, Coccaro EF, Siever LJ, New AS. Serotonin Transporter Protein Gene Polymorphism and Personality Measures in African American and European American Subjects. American Journal Of Psychiatry 1998, 155: 1332-1338. PMID: 9766763, DOI: 10.1176/ajp.155.10.1332.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack PeopleCarrier ProteinsFemaleGene FrequencyGenotypeHumansIntronsMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsPersonalityPersonality DisordersPolymorphism, GeneticPromoter Regions, GeneticSerotoninSerotonin Plasma Membrane Transport ProteinsSubstance-Related DisordersWhite PeopleConceptsOverall negative findingsSLC6A4 promoter polymorphismNormal comparison subjectsPsychiatric diagnostic groupsProtein gene polymorphismsAmerican subjectsSynaptic inactivationComparison subjectsPromoter polymorphismPsychiatric diagnosisEuropean-American subjectsGene polymorphismsNeuroticism scoresDiagnostic groupsDemographic featuresNegative findingsHarm avoidanceNeurotransmitter serotoninSubstance dependenceSerotonin transporterPersonality disorderSLC6A4 polymorphismsDemographic factorsPresent findingsPromoter region
1992
Can MR imaging effectively replace diagnostic arthroscopy?
Ruwe P, Wright J, Randall R, Lynch J, Jokl P, McCarthy S. Can MR imaging effectively replace diagnostic arthroscopy? Radiology 1992, 183: 335-9. PMID: 1561332, DOI: 10.1148/radiology.183.2.1561332.Peer-Reviewed Original ResearchConceptsDiagnostic arthroscopyUnnecessary diagnostic arthroscopyMagnetic resonance imagingImmediate arthroscopyConsecutive patientsKnee injuriesChronic injuryUnderwent reconstructionMeans of consensusPatientsMR imagesArthroscopyResonance imagingNegative findingsMR imagingNormal functionInjuryNet savingsImagingMRKnee
1986
Does the cholecystokinin antagonist proglumide possess antipsychotic activity?
Innis R, Bunney B, Charney D, Price L, Glazer W, Sternberg D, Rubin A, Heninger G. Does the cholecystokinin antagonist proglumide possess antipsychotic activity? Psychiatry Research 1986, 18: 1-7. PMID: 3737785, DOI: 10.1016/0165-1781(86)90056-9.Peer-Reviewed Original ResearchConceptsPsychosis ratingsPlacebo-controlled studyRole of cholecystokininCentral dopaminergic activityCCK receptor antagonistsPathogenesis of schizophreniaMesocortical neuronsNeuroleptic medicationNeurotransmitter statusReceptor antagonistDopaminergic activityAntipsychotic activitySchizophrenic patientsCholecystokininNegative findingsPreclinical researchProglumidePatientsSchizophreniaPotential reasonsMedicationsPathogenesisAntagonistMidbrainNeuropeptides
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