2018
A transdiagnostic neuroanatomical signature of psychiatric illness
Gong Q, Scarpazza C, Dai J, He M, Xu X, Shi Y, Zhou B, Vieira S, McCrory E, Ai Y, Yang C, Zhang F, Lui S, Mechelli A. A transdiagnostic neuroanatomical signature of psychiatric illness. Neuropsychopharmacology 2018, 44: 869-875. PMID: 30127342, PMCID: PMC6461829, DOI: 10.1038/s41386-018-0175-9.Peer-Reviewed Original ResearchConceptsHealthy controlsPsychiatric illnessFamilial vulnerabilityUnaffected first-degree relativesFirst-degree relativesSeverity of symptomsGray matter volumeGreater gray matter volumePost-traumatic stress disorderStructural magnetic resonanceDifferent diagnostic categoriesFamily-wise error correctionPutamen enlargementObsessive-compulsive disorderPsychiatric diagnosisMatter volumePutamen volumePsychiatric groupsGeneral psychopathologyNeuroanatomical signatureUnaffected relativesStress disorderTransdiagnostic alterationsDiagnostic categoriesMental healthS22. A TRANSDIAGNOSTIC NEUROANATOMICAL SIGNATURE OF PSYCHIATRIC ILLNESS
Qiyong G, Scarpazza C, Dai J, He M, Xu X, Shi Y, Zhou B, Vreira S, McCrory E, Yang C, Zang F, Lui S, Mechelli A. S22. A TRANSDIAGNOSTIC NEUROANATOMICAL SIGNATURE OF PSYCHIATRIC ILLNESS. Schizophrenia Bulletin 2018, 44: s331-s331. PMCID: PMC5888883, DOI: 10.1093/schbul/sby018.809.Peer-Reviewed Original ResearchGray matter volumeHealthy controlsPsychiatric illnessMatter volumeMagnetic resonance imaging (MRI) scansHigher gray matter volumeFamilial vulnerabilityStructural magnetic resonance imaging (MRI) scansResonance imaging scansUnaffected first-degree relativesFirst-degree relativesSeverity of symptomsGreater gray matter volumePost-traumatic stress disorderDifferent diagnostic categoriesPutamen enlargementObsessive-compulsive disorderImaging scansBilateral putamenPsychiatric diagnosisPutamen volumeTrans-diagnostic approachPsychiatric groupsGeneral psychopathologyNeuroanatomical signature
2014
Effects of Δ9-tetrahydrocannabinol in individuals with a familial vulnerability to alcoholism
Ranganathan M, Sewell RA, Carbuto M, Elander J, Schnakenberg A, Radhakrishnan R, Pittman B, D’Souza D. Effects of Δ9-tetrahydrocannabinol in individuals with a familial vulnerability to alcoholism. Psychopharmacology 2014, 231: 2385-2393. PMID: 24424782, DOI: 10.1007/s00213-013-3402-4.Peer-Reviewed Original ResearchConceptsPerceptual alterationsRewarding effectsSubjective effectsAlcohol-related behaviorsΔ9-THCExecutive functionEffects of alcoholSpatial memoryMemory impairmentCounterbalanced orderAlcohol problemsFamilial vulnerabilityCannabinoid receptor functionΔ9-tetrahydrocannabinolCannabinoid Δ9-tetrahydrocannabinolFirst human studyDouble-blind conditionsCB1R functionOutcome measuresIndividualsMemoryMeasuresAlcoholismSecondary outcome measuresHuman studies
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