2025
Standardization of Bone Marrow Reporting for Myelodysplastic Syndromes/Neoplasms on Behalf of the International Consortium for Myelodysplastic Syndromes/Neoplasms.
Gisriel S, Aakash F, Bennett J, Hasserjian R, Loghavi S, DeZern A, Santini V, Savona M, Brunner A, Buckstein R, Wei A, Della Porta M, Komrokji R, Borate U, Sekeres M, Platzbecker U, Fenaux P, Roboz G, van de Loosdrecht A, Zeidan A, Xu M. Standardization of Bone Marrow Reporting for Myelodysplastic Syndromes/Neoplasms on Behalf of the International Consortium for Myelodysplastic Syndromes/Neoplasms. Archives Of Pathology & Laboratory Medicine 2025 PMID: 40059041, DOI: 10.5858/arpa.2024-0322-ra.Peer-Reviewed Original ResearchData extractionHealth care professionalsEvidence-based guidelinesBone marrowCare professionalsClinical decision-makingReporting guidelinesEfficient data extractionStandard bone marrowBone marrow specimensBone marrow reportsMarrow specimensInstitutional databaseClinical hematologistsHematologists-oncologistsClinical trialsGuidelinesHematopathologistsDecision-makingMarrowCollege of American Pathologists PathologyBoneHealthRegistryProfessionalsImpact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma
Castro D, Gebrael G, Meza L, Li X, Tripathi N, Tandar C, Sayegh N, Zengin Z, Chehrazi-Raffle A, Govindarajan A, Dizman N, Barragan-Carrillo R, Ebrahimi H, Mercier B, Chawla N, Jaime-Casas S, Salgia N, Zugman M, Hsu J, Philip E, Bergerot C, Agarwal N, Pal S. Impact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma. JCO Oncology Advances 2025 DOI: 10.1200/oa.24.00015.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaProgression-free survivalImpact of insurance statusOverall survivalRenal cell carcinomaSurvival outcomesCell carcinomaAssociated with significantly better PFSAssociated with significantly better survival outcomesAssociated with better progression-free survivalInsurance statusFirst-line systemic therapyMedicaid/no insuranceBetter survival outcomesKaplan-Meier methodLog-rank testAssociated with lower riskSystemic therapyPrimary insurance typeNo significant differenceNational Cancer Institute-designated cancer centerInstitutional databasePrivate insuranceCancer CenterLow risk
2024
Small Cell Bladder Cancer: Treatment Patterns for Local Disease and Associated Outcomes. A Retrospective Cohort Study
Bakaloudi D, Koehne E, Diamantopoulos L, Holt S, Sekar R, Ghali F, Vakar-Lopez F, Nyame Y, Psutka S, Gore J, de la Calle C, Lin D, Schade G, Liao J, Hsieh A, Yezefski T, Hawley J, Yu E, Montgomery R, Grivas P, Wright J. Small Cell Bladder Cancer: Treatment Patterns for Local Disease and Associated Outcomes. A Retrospective Cohort Study. Clinical Genitourinary Cancer 2024, 22: 102208. PMID: 39265260, DOI: 10.1016/j.clgc.2024.102208.Peer-Reviewed Original ResearchSmall cell bladder cancerConcurrent chemoradiotherapyNeoadjuvant chemotherapySEER-Medicare databaseMedian OSLocoregional therapySEER-MedicareBladder cancerHistological subtypesOverall survivalInstitutional databaseCompare outcomesOptimal locoregional therapyAggressive histologic subtypeNon-metastatic stageNon-metastatic diseaseSEER-Medicare datasetMultivariate Cox analysisFollow-up/deathLocalized diseaseCox analysisCystectomyTreatment patternsTreatment responseMultivariate analysisAutomated MRI liver segmentation for anatomical segmentation, liver volumetry, and the extraction of radiomics
Gross M, Huber S, Arora S, Ze’evi T, Haider S, Kucukkaya A, Iseke S, Kuhn T, Gebauer B, Michallek F, Dewey M, Vilgrain V, Sartoris R, Ronot M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey J. Automated MRI liver segmentation for anatomical segmentation, liver volumetry, and the extraction of radiomics. European Radiology 2024, 34: 5056-5065. PMID: 38217704, PMCID: PMC11245591, DOI: 10.1007/s00330-023-10495-5.Peer-Reviewed Original ResearchMagnetic resonance imagingRadiomics feature extractionLiver volumetryIntraclass correlation coefficientRadiomic featuresLiver segmentationAutomated liver volumetryHepatocellular carcinoma patientsMann-Whitney U testAutomated liver segmentationManual segmentationQuantitative imaging biomarkersCarcinoma patientsRetrospective studyInstitutional databaseAnatomical localizationClinical relevanceManual volumetryMann-WhitneyU testExternal validationInternal test setImaging biomarkersInclusion criteriaResultsIn total
2023
Cytologic evaluation of upper urinary tract specimens: An institutional retrospective study using The Paris System for Reporting Urine Cytology second edition with histopathologic follow‐up
Khajir G, Sun T, Wang H, Sprenkle P, Adeniran A, Cai G, Levi A. Cytologic evaluation of upper urinary tract specimens: An institutional retrospective study using The Paris System for Reporting Urine Cytology second edition with histopathologic follow‐up. Cytopathology 2023, 35: 235-241. PMID: 37916579, DOI: 10.1111/cyt.13328.Peer-Reviewed Original ResearchHigh-grade urothelial carcinomaLow-grade urothelial carcinomaUpper urinary tractUrothelial carcinomaUrinary tractCytologic evaluationCytology specimensInstitutional retrospective studyParis SystemHigh-grade malignancyAtypical urothelial cellsCytologic categoriesRetrospective studyInstitutional databaseCytological diagnosisUrinary cytopathologyHistopathologicMalignant cellsBenign casesUrothelial cellsTPS categoryCarcinomaReporting systemTractAUCOncotype DX results increase concordance in adjuvant chemotherapy recommendations for early-stage breast cancer
Licata L, Viale G, Giuliano M, Curigliano G, Chavez-MacGregor M, Foldi J, Oke O, Collins J, Del Mastro L, Puglisi F, Montemurro F, Vernieri C, Gerratana L, Giordano S, Rognone A, Sica L, Gentilini O, Cascinu S, Pusztai L, Giordano A, Criscitiello C, Bianchini G. Oncotype DX results increase concordance in adjuvant chemotherapy recommendations for early-stage breast cancer. Npj Breast Cancer 2023, 9: 51. PMID: 37291235, PMCID: PMC10250312, DOI: 10.1038/s41523-023-00559-6.Peer-Reviewed Original ResearchEarly-stage breast cancerAdjuvant chemotherapy recommendationsChemotherapy recommendationsOncotype DX resultsClinicopathologic featuresRecurrence scorePhysician uncertaintyBreast cancerDiscordant recommendationsAdjuvant chemotherapy resultsAddition of chemotherapyChemotherapy resultsOncotype DXInstitutional databasePhysician judgmentBreast oncologistsClinical practiceOncologistsCancerAssay resultsRS resultsChange recommendationsPredictive informationChemotherapyRecommendations
2022
Impact of the COVID-19 pandemic on cardiology fellow echocardiography education at a large academic center
Varghese M, Strom J, Kannam J, Fostello S, Riley M, Manning W. Impact of the COVID-19 pandemic on cardiology fellow echocardiography education at a large academic center. BMC Medical Education 2022, 22: 863. PMID: 36514029, PMCID: PMC9747257, DOI: 10.1186/s12909-022-03880-z.Peer-Reviewed Original ResearchConceptsTransesophageal echocardiogramCardiology fellowsMethodsOur institutional databaseStudy periodClinical responseInstitutional databaseAcademic centersElective proceduresPandemic recoveryPandemic recovery periodCOVID-19 pandemicPre-pandemic volumesEchocardiography volumesTTEEchocardiographyCardiologyNIMG-02. PACS-INTEGRATED AUTO-SEGMENTATION WORKFLOW FOR BRAIN METASTASES USING NNU-NET
Jekel L, Bousabarah K, Lin M, Merkaj S, Kaur M, Avesta A, Aneja S, Omuro A, Chiang V, Scheffler B, Aboian M. NIMG-02. PACS-INTEGRATED AUTO-SEGMENTATION WORKFLOW FOR BRAIN METASTASES USING NNU-NET. Neuro-Oncology 2022, 24: vii162-vii162. PMCID: PMC9661012, DOI: 10.1093/neuonc/noac209.622.Peer-Reviewed Original ResearchReal‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease
Nagpal S, Scierka LE, Castro‐Dominguez Y, Kansal D, Kunnirickal S, Hussain Y, Love K, Aboian E, Smolderen KG, Mena‐Hurtado C. Real‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease. Catheterization And Cardiovascular Interventions 2022, 100: 776-784. PMID: 36129818, DOI: 10.1002/ccd.30405.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsManual compressionClosure deviceCommon femoral artery diseaseVascular Quality Initiative databaseFemoral artery diseasePropensity-matched cohortPseudoaneurysm rateRetroperitoneal bleedingArtery diseaseRetrospective reviewMean ageBaseline variablesInstitutional databaseNonsignificant reductionNonsignificant decreaseVascular interventionsMortality ratePatientsCompression useCollagen plugDiseaseInitiative databaseProcedural metricsDevice useNodal Positivity in Early-Stage Triple-Negative Breast Cancer: Implications for Preoperative Immunotherapy
Mittendorf EA, Kantor O, Weiss A, Richardson E, Garrido-Castro A, Portnow LH, Krop IE, Lin NU, Winer EP, Tolaney SM, King TA. Nodal Positivity in Early-Stage Triple-Negative Breast Cancer: Implications for Preoperative Immunotherapy. Annals Of Surgical Oncology 2022, 30: 100-106. PMID: 35941343, DOI: 10.1245/s10434-022-12357-8.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerNational Cancer DatabaseNormal clinical examinationAxillary ultrasoundNegative clinical examinationClinical examinationUpfront surgeryCT2 tumorsInstitutional databaseBreast cancerEarly-stage triple-negative breast cancerStage triple-negative breast cancerAddition of immunotherapyNodal positivity ratePathologic nodal statusNode-positive patientsEvent-free survivalNode-positive diseaseRisk-benefit ratioCT1-2N0NCDB cohortPreoperative immunotherapyResultsFor patientsPositive nodesPreoperative chemotherapyAn Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center.
Wang JD, Sebastian C, Walther Z, Suresh T, Lacy J, Zhang X, Jain D. An Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center. Archives Of Pathology & Laboratory Medicine 2022, 147: 185-192. PMID: 35512224, DOI: 10.5858/arpa.2021-0457-oa.Peer-Reviewed Original ResearchConceptsLiver biopsyUnknown primaryIHC markersPrimary siteTrue carcinomaTertiary care medical centerAvailable clinicopathologic dataSquamous cell carcinomaClinicopathologic dataHepatic metastasesNonepithelial tumorsCell carcinomaInstitutional databaseClinical managementStain usePractice patternsNeuroendocrine neoplasmsImmunohistochemical markersMedical CenterMorphologic patternsIndividualized approachCarcinomaBiopsyMetastasisTumorsBovine Aortic Arch: A Result of Chance or Mandate of Inheritance?
Shang M, Vinholo TF, Buntin J, Zafar MA, Ziganshin BA, Elefteriades JA. Bovine Aortic Arch: A Result of Chance or Mandate of Inheritance? The American Journal Of Cardiology 2022, 172: 115-120. PMID: 35321803, PMCID: PMC9978865, DOI: 10.1016/j.amjcard.2022.02.030.Peer-Reviewed Original ResearchConceptsBovine archThoracic aortic aneurysmAortic aneurysmThoracic aortic aneurysm diseaseAortic arch configurationAortic aneurysm diseaseSecond-degree relativesInstitutional databaseAneurysm diseaseChest imagingPatientsAneurysmsAvailable scansGenetic mutationsArch resultsArchArch configurationFamily membersSample populationProbandsScansMagnetic resonanceResult of chancePrevious studiesChestGrowth rate of ascending thoracic aortic aneurysms in a non-referral-based population
Weininger G, Mori M, Yousef S, Hur DJ, Assi R, Geirsson A, Vallabhajosyula P. Growth rate of ascending thoracic aortic aneurysms in a non-referral-based population. Journal Of Cardiothoracic Surgery 2022, 17: 14. PMID: 35109884, PMCID: PMC8812194, DOI: 10.1186/s13019-022-01761-6.Peer-Reviewed Original ResearchConceptsAneurysm growth rateAortic dilatationAortic aneurysmStudy populationCT scanInitial aneurysm sizeTrue natural historyPatients age 50High-risk patientsMedian time intervalLarge institutional databaseThoracic aortic aneurysmComputed tomography scanAortic aneurysm diseaseRisk patientsAortic sizeInstitutional databaseTomography scanAneurysm diseaseRadiologic diagnosisAneurysm sizeBackgroundPrior studiesAge 50PatientsNatural history
2021
Quantitative Computed Tomography Image Analysis to Predict Pancreatic Neuroendocrine Tumor Grade.
Pulvirenti A, Yamashita R, Chakraborty J, Horvat N, Seier K, McIntyre C, Lawrence S, Midya A, Koszalka M, Gonen M, Klimstra D, Reidy D, Allen P, Do R, Simpson A. Quantitative Computed Tomography Image Analysis to Predict Pancreatic Neuroendocrine Tumor Grade. JCO Clinical Cancer Informatics 2021, 5: 679-694. PMID: 34138636, PMCID: PMC8462651, DOI: 10.1200/cci.20.00121.Peer-Reviewed Original ResearchConceptsTumor gradePanNET gradeCT scanComputed tomographyManagement of pancreatic neuroendocrine tumorsPancreatic neuroendocrine tumor gradesRadiographic descriptorsArterial phase CT scansNeuroendocrine tumor gradingTumor grade assessmentPancreatic neuroendocrine tumorsQuantitative image analysisComputed tomography image analysisResected PanNETsGrade tumorsNeuroendocrine tumorsPrimary tumorInstitutional databaseProspective studyTherapeutic managementUnivariate analysisPanNETsTreatment selectionRadiomic featuresTumorEfficacy and safety of chloroquine and hydroxychloroquine for treatment of COVID-19 patients-a systematic review and meta-analysis of randomized controlled trials.
Eze P, Mezue K, Nduka C, Obianyo I, Egbuche O. Efficacy and safety of chloroquine and hydroxychloroquine for treatment of COVID-19 patients-a systematic review and meta-analysis of randomized controlled trials. Am J Cardiovasc Dis 2021, 11: 93-107. PMID: 33815925, PMCID: PMC8012280.Peer-Reviewed Original ResearchRandomized clinical trialsStandard supportive therapyAdverse eventsSupportive therapyMeta-analysis of randomized controlled trialsPublished randomized clinical trialsMeta-analysisSevere adverse eventsSafety of CQSafety of chloroquineJoanna Briggs Institute DatabaseCochrane Collaboration assessment toolTreatment of COVID-19 patientsChinese Clinical Trial RegistryClinical Trials RegistryRandom-effects modelSub-group analysisRandomized Controlled TrialsCOVID-19 patientsRisk of biasMortality meta-analysisIn vivo studiesEfficacy outcomesInstitutional databaseMortality benefitCardiac Surgery Outcomes in an Epicenter of the COVID-19 Pandemic
Farrington WJ, Robinson NB, Rahouma M, Lau C, Hameed I, Iannacone EM, Ivascu NS, Mick SL, Gaudino MF, Girardi LN. Cardiac Surgery Outcomes in an Epicenter of the COVID-19 Pandemic. Seminars In Thoracic And Cardiovascular Surgery 2021, 34: 182-188. PMID: 33444770, PMCID: PMC7801821, DOI: 10.1053/j.semtcvs.2021.01.005.Peer-Reviewed Original ResearchConceptsCardiac surgeryCOVID-19 pandemicPerioperative COVID-19 infectionCOVID-19 negative patientsEmergency cardiac surgeryProper infection controlCardiac surgical careRecovery of patientsCardiac surgery outcomesCOVID-19 infectionCOVID-19Preoperative demographicsHospital stayOperative mortalityAdult patientsNegative patientsPostoperative followPostoperative outcomesCardiopulmonary bypassMedian ageIntraoperative findingsPatient selectionMedian lengthSingle institutionInstitutional database
2020
Effect of Time to Surgery of Colorectal Liver Metastases on Survival
Chen EY, Mayo SC, Sutton T, Kearney MR, Kardosh A, Vaccaro GM, Billingsley KG, Lopez CD. Effect of Time to Surgery of Colorectal Liver Metastases on Survival. Journal Of Gastrointestinal Cancer 2020, 52: 169-176. PMID: 32086781, PMCID: PMC7900034, DOI: 10.1007/s12029-020-00372-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantColorectal NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHepatectomyHumansKaplan-Meier EstimateLiver NeoplasmsMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalPrognosisRetrospective StudiesTime FactorsTime-to-TreatmentYoung AdultConceptsColorectal liver metastasesLong-term OSPostoperative overall survivalOverall survivalLonger TTSLiver metastasesWorse survivalDiagnosis of CLMLong-term survivorsResultsTwo hundred eightyRisk of recurrenceComprehensive cancer centerHigh disease burdenSpecific primary tumorsShorter TTSPerioperative chemotherapyPostoperative chemotherapyPerioperative treatmentResection marginsCancer CenterMetastasis characteristicsInstitutional databasePrimary tumorDisease burdenSimilar survivalThe impact of metastasis location on overall survival among patients with renal cell carcinoma.
Patel D, Ghali F, Meagher M, Meagher M, Bradshaw A, Patel S, Keiner C, Miller N, Dutt R, Murphy J, Derweesh I. The impact of metastasis location on overall survival among patients with renal cell carcinoma. Journal Of Clinical Oncology 2020, 38: 621-621. DOI: 10.1200/jco.2020.38.6_suppl.621.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaRenal cell carcinomaNational Cancer DatabaseLiver/lung metastasisOverall survivalBone metastasesLung metastasesCell carcinomaInstitutional databaseUnivariate analysisMetastasis locationWorse OSSite metastasisDisease locationMultivariable Cox proportional hazardsKaplan-Meier survival analysisCurrent staging guidelinesLung/liver metastasisLog-rank testingWorse overall survivalHeterogeneity of patientsCox proportional hazardsLung/liverLiver metastasesMetastatic disease
2019
Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy
Gusdon AM, Nyquist PA, Torres-Lopez VM, Leasure AC, Falcone GJ, Sheth KN, Sansing LH, Hanley DF, Malani R. Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy. Stroke 2019, 51: 129-136. PMID: 31744426, PMCID: PMC7048624, DOI: 10.1161/strokeaha.119.027085.Peer-Reviewed Original ResearchConceptsBlood product transfusionThirty-day mortalityIntracerebral hemorrhagePerihematomal edemaActive malignancyProduct transfusionPHE volumeICH volumeActive cancerPHE growthPlatelet transfusionsCentral nervous system involvementRecurrence of malignancyNervous system involvementNontraumatic intracerebral hemorrhageCancer-specific dataPHE expansionRecent chemotherapyChart reviewConclusions PatientsControl patientsMost patientsHematoma volumeInstitutional databaseSystem involvementPredictors of ileus following colorectal resections
Sapci I, Hameed I, Ceylan A, Oktem A, Rencuzogullari A, Hull TL, Liska D, Delaney CP, Gorgun E. Predictors of ileus following colorectal resections. The American Journal Of Surgery 2019, 219: 527-529. PMID: 31604485, DOI: 10.1016/j.amjsurg.2019.10.002.Peer-Reviewed Original ResearchConceptsPostoperative ileusColorectal resectionColorectal surgeryPre-operative comorbiditiesInflammatory bowel diseaseUlcerative colitis diagnosisOperation-related variablesDiagnosis of cancerDiverticular diseaseProphylactic therapyPatient demographicsBowel diseaseCrohn's diseaseColorectal cancerMean ageInstitutional databaseMale genderRisk factorsLaparoscopic surgeryColitis diagnosisIleusEarly diagnosisPatientsSignificant burdenSurgery
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