2024
The pathoanatomy of medial ligamentous disruption in the dislocated and multiple ligament injured knee
Park N, Moran J, Petit L, Kahan J, McLaughlin W, Joo P, Lee M, Green J, Vasavada K, Chalem I, Jokl P, Alaia M, Medvecky M. The pathoanatomy of medial ligamentous disruption in the dislocated and multiple ligament injured knee. The Knee 2024, 52: 246-254. PMID: 39642762, DOI: 10.1016/j.knee.2024.11.002.Peer-Reviewed Original ResearchVastus medialis obliqueSuperficial medial collateral ligamentPosterior oblique ligamentInjury patternsMedial patellofemoral ligamentLigament injuriesMedial patellofemoral ligament tearMedial knee ligamentsLevel 1 trauma centerMechanism of injuryInjury detailsNeurovascular statusMultiple ligament injured kneeDistal avulsionInjured kneeLigament injured kneeTrauma centerMedial collateral ligamentZone of injuryKnee ligamentsLigament disruptionOblique ligamentMidsubstance tearsProximal avulsionPatellofemoral ligamentMedial-Sided Repair in Multi-Ligamentous Knee Injury
Patel R, Green J, Moran J, Santos E, Medvecky M. Medial-Sided Repair in Multi-Ligamentous Knee Injury. Video Journal Of Sports Medicine 2024, 4: 26350254241226723. PMID: 40308515, PMCID: PMC11752761, DOI: 10.1177/26350254241226723.Peer-Reviewed Original ResearchMulti-ligamentous knee injuriesSuperficial medial collateral ligamentPosterior oblique ligamentValgus stabilityKnee injuriesDeep medial collateral ligamentMedial collateral ligamentPatient-reported outcomesMedial structuresMedial knee structuresIntra-articular entrapmentKnee loadingCollateral ligamentElite athletesExternal rotationValgus laxityKnee functionTibial plateau fracturesMedial patellofemoral ligament tearThird-degree injuryOrthopedic injuriesKnee stabilityKneeAnatomic alignmentKnee structures
2021
Injury to the Meniscofemoral Portion of the Deep MCL Is Associated with Medial Femoral Condyle Bone Marrow Edema in ACL Ruptures
Moran J, Katz LD, Schneble CA, Li D, Kahan JB, Wang A, Porrino J, Jokl P, Hewett TE, Medvecky MJ. Injury to the Meniscofemoral Portion of the Deep MCL Is Associated with Medial Femoral Condyle Bone Marrow Edema in ACL Ruptures. JBJS Open Access 2021, 6: e21.00069. PMID: 34841192, PMCID: PMC8613370, DOI: 10.2106/jbjs.oa.21.00069.Peer-Reviewed Original ResearchMedial meniscal tearsBone marrow edemaDeep medial collateral ligamentMedial collateral ligamentAcute anterior cruciate ligamentACL ruptureMarrow edemaMCL injuryPosterior hornMedial meniscusPreoperative magnetic resonance imaging (MRI) scansBoard-certified musculoskeletal radiologistsMagnetic resonance imaging (MRI) scansSuperficial medial collateral ligamentSuspicion of injuryACL graft failureACL reconstruction surgeryAnterior cruciate ligamentResonance imaging scansPotential risk factorsChi-square testingMeniscofemoral portionGraft failureInsertion sitePhysical examination
2013
The remarkable migration of the medial collateral ligament
Wang M, Nasiri A, VanHouten JN, Tommasini SM, Broadus AE. The remarkable migration of the medial collateral ligament. Journal Of Anatomy 2013, 224: 490-498. PMID: 24266550, PMCID: PMC3954274, DOI: 10.1111/joa.12145.Peer-Reviewed Original ResearchConceptsMedial collateral ligamentMigratory tractsCollateral ligamentParathyroid hormone-related proteinOsteoclastic bone resorptionHormone-related proteinCortical surfaceInsertions of tendonsInsertion siteBone resorptionLong bone growthPTHrP functionsOsteoclastic activityPeriosteal osteoclastsRegulatory moleculesOsteoblast activityGrowth spurtLong bonesOsteoclastsCortical boneLigamentRecent evidenceHistological techniquesBone surfaceTract
2012
PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth
Wang M, VanHouten JN, Nasiri AR, Johnson RL, Broadus AE. PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth. Journal Of Bone And Mineral Research 2012, 28: 598-607. PMID: 23109045, PMCID: PMC3574208, DOI: 10.1002/jbmr.1801.Peer-Reviewed Original ResearchConceptsCortical bone surfaceCortical surfaceParathyroid hormone-related proteinLong bonesHormone-related proteinMedial collateral ligamentBone cell activityBone surfaceLong bone growthTendon insertionForme frusteCollateral ligamentFibrous enthesesInitial genetic evidenceCell activityInsertion sitePTHrPConditional deletionLinear growthEnthesesLigamentPeriosteal componentBiomechanical controlBoneFruste
2007
Mechanical regulation of PTHrP expression in entheses
Chen X, Macica C, Nasiri A, Judex S, Broadus AE. Mechanical regulation of PTHrP expression in entheses. Bone 2007, 41: 752-759. PMID: 17869201, PMCID: PMC2219696, DOI: 10.1016/j.bone.2007.07.020.Peer-Reviewed Original ResearchConceptsMedial collateral ligamentPTHrP expressionSurgical transectionBone cell populationsTail suspensionType 1 PTH/PTHrP receptorCell populationsPTH/PTHrP receptorDetailed histological evaluationSitu hybridization histochemical techniquesDistinct temporospatial patternLigament insertion sitesMetaphyseal periosteumPTHrP receptorOsteoclastic activityCollateral ligamentHistological evaluationReporter miceKnockin miceInsertion siteKnockin reporter micePTHrPPTHrP geneCD-1PeriosteumA Multidisciplinary Approach to the Evaluation, Reconstruction and Rehabilitation of the Multi-Ligament Injured Athlete
Medvecky MJ, Zazulak BT, Hewett TE. A Multidisciplinary Approach to the Evaluation, Reconstruction and Rehabilitation of the Multi-Ligament Injured Athlete. Sports Medicine 2007, 37: 169-187. PMID: 17241105, DOI: 10.2165/00007256-200737020-00005.Peer-Reviewed Original ResearchConceptsLigament injuryKnee injuriesCruciate ligamentLateral collateral ligament injurySerious knee ligament injuriesFull recoveryCollateral ligament injuriesKnee ligament injuriesLimb-threatening injuriesAnterior cruciate ligamentDiagnostic imaging evaluationRecent surgical advancesPosterior cruciate ligamentMedial collateral ligamentKnee dislocationDevastating injuriesImaging evaluationTotal disabilityImproved outcomesSurgical advancesAllograft tissueCollateral ligamentRehabilitative interventionsRehabilitative techniquesOrthopaedic literature
1999
Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: The use of different viral vectors and the effects of injury
Hildebrand K, Deie M, Allen C, Smith D, Georgescu H, Evans C, Robbins P, Woo S. Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: The use of different viral vectors and the effects of injury. Journal Of Orthopaedic Research® 1999, 17: 37-42. PMID: 10073645, DOI: 10.1002/jor.1100170107.Peer-Reviewed Original ResearchConceptsAnterior cruciate ligamentMedial collateral ligamentCruciate ligamentCollateral ligamentMedial collateralKnee ligamentsBilateral knee surgeryLigament fibroblastsVivo techniquesAnterior cruciate ligament fibroblastsEffects of injuryEx vivo techniquesKnee surgeryLeft kneeRight kneeLacZ marker geneGroup 2Group 1Cytokine deliveryGroup 3Ligament samplesDifferent viral vectorsLigamentGene expressionWeeks
1998
The Effects of Platelet-Derived Growth Factor-BB on Healing of the Rabbit Medial Collateral Ligament
Hildebrand K, Woo S, Smith D, Allen C, Deie M, Taylor B, Schmidt C. The Effects of Platelet-Derived Growth Factor-BB on Healing of the Rabbit Medial Collateral Ligament. The American Journal Of Sports Medicine 1998, 26: 549-554. PMID: 9689377, DOI: 10.1177/03635465980260041401.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBecaplerminBiomechanical PhenomenaCell DivisionCollateral LigamentsDose-Response Relationship, DrugDrug CombinationsEpidermal Growth FactorExtracellular MatrixFibrin Tissue AdhesiveFibroblastsKnee InjuriesMaleMitogensPlatelet-Derived Growth FactorProto-Oncogene Proteins c-sisRabbitsRecombinant ProteinsRuptureTensile StrengthTransforming Growth Factor betaWeight-BearingWound HealingConceptsPlatelet-derived growth factor-BBMedial collateral ligament healingMedial collateral ligamentGrowth factor-BBPlatelet-derived growthCollateral ligamentGrowth factorFactor-BBLigament healingRight medial collateral ligamentFemur-medial collateral ligament-tibia complexRabbit medial collateral ligamentIndividual growth factorsHistologic evaluationHigh doseFibrin sealantControl groupHealing ligamentBiologic approachesFibroblast proliferationLigamentVitro workHealing tissueDosesHealing
1997
The effects of age on rabbit MCL fibroblast matrix synthesis in response to TGF-β1 or EGF
Deie M, Marui T, Allen C, Hildebrand K, Georgescu H, Niyibizi C, Woo S. The effects of age on rabbit MCL fibroblast matrix synthesis in response to TGF-β1 or EGF. Mechanisms Of Ageing And Development 1997, 97: 121-130. PMID: 9226631, DOI: 10.1016/s0047-6374(97)00049-3.Peer-Reviewed Original ResearchConceptsMedial collateral ligamentEffect of ageEpidermal growth factorTotal protein synthesisMCL fibroblastsGrowth factorImmature rabbitsProtein synthesisSenescent groupCollateral ligamentTGF-β1Baseline levelsOwn controlDifferent dosesLigament fibroblastsLess collagenCollagen synthesisEGF doseRabbitsAgeSignificant reductionDoseDosesMatrix synthesisFibroblasts
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply