2023
Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers’ Brain Health: A Systematic Review
Aravena J, Lee J, Schwartz A, Nyhan K, Wang S, Levy B. Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers’ Brain Health: A Systematic Review. The Journals Of Gerontology Series A 2023, 79: glad237. PMID: 37792627, PMCID: PMC10803122, DOI: 10.1093/gerona/glad237.Peer-Reviewed Original ResearchBrain healthSocietal factorsAPOE ε4Cognitive outcomesApolipoprotein E ε4APOE ε4 carriersAPOE ε2Beneficial effectsΕ4 carriersSystematic reviewAPOE ε4 allele carriersHigh schoolAPOE ε2 carriersDetrimental effectsBasic needsHealthy People 2030Beneficial impactExternal stimuliHarmful impactSDH categoriesInclusion criteriaAllele carriersAlzheimer's diseaseCommunity-level policySocial determinantsInteractive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning
Lawrence K, Rippey C, Welikson B, Pietrzak R, Adams T. Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning. International Journal Of Geriatric Psychiatry 2023, 38: e5888. PMID: 36757293, PMCID: PMC10168127, DOI: 10.1002/gps.5888.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderThree-way interactionCognitive functioningStress disorderOlder participantsTreatment of PTSDMain effectProbable posttraumatic stress disorderAge-related cognitive impairmentAPOE ε4U.S. military veteransApolipoprotein ε4 genotypeCognitive deficitsPsychomotor performanceAge-related associationsInteractive associationsVeterans StudyMilitary veteransCognitive impairmentPreliminary evidenceTwo-way interactionAPM performanceΕ4 carriersAnalysis of covarianceFunctioning
2020
Positive Age Beliefs Lead to Lower Dementia Risk Even Among Older Persons With High-Risk Gene
Levy B, Slade M, Pietrzak R, Ferrucci L. Positive Age Beliefs Lead to Lower Dementia Risk Even Among Older Persons With High-Risk Gene. Innovation In Aging 2020, 4: 597-597. PMCID: PMC7742059, DOI: 10.1093/geroni/igaa057.2009.Peer-Reviewed Original ResearchOlder individualsLower dementia riskStrong risk factorRetirement Study participantsHigh-risk genesΕ4 variantDementia riskRisk factorsΕ4 carriersAPOE ε4High riskDementiaOlder personsStudy participantsAPOE geneProtective factorsRelevant covariatesRiskTotal sampleBaselineCurrent studyCohortΕ4Individuals
2019
Sex modulates the ApoE ε4 effect on brain tau deposition measured by 18F-AV-1451 PET in individuals with mild cognitive impairment
Liu M, Paranjpe MD, Zhou X, Duy PQ, Goyal MS, Benzinger TLS, Lu J, Wang R, Zhou Y. Sex modulates the ApoE ε4 effect on brain tau deposition measured by 18F-AV-1451 PET in individuals with mild cognitive impairment. Theranostics 2019, 9: 4959-4970. PMID: 31410194, PMCID: PMC6691387, DOI: 10.7150/thno.35366.Peer-Reviewed Original ResearchConceptsBrain tau depositionMild cognitive impairmentAPOE ε4 carrier statusΕ4 carrier statusAPOE ε4Tau depositionCSF tauF-AVP-tauT-tauCognitive impairmentAlzheimer's diseaseSex interaction effectsApolipoprotein E type 4 alleleCerebrospinal fluid (CSF) total tauStrongest genetic risk factorMagnetic resonance imaging (MRI) scansCarrier statusPET spatial normalizationStandardized uptake value ratio (SUVR) imagesCSF p-tauCSF t-tauStructural magnetic resonance imaging (MRI) scansResonance imaging scansType 4 allele
2018
Positive age beliefs protect against dementia even among elders with high-risk gene
Levy BR, Slade MD, Pietrzak RH, Ferrucci L. Positive age beliefs protect against dementia even among elders with high-risk gene. PLOS ONE 2018, 13: e0191004. PMID: 29414991, PMCID: PMC5802444, DOI: 10.1371/journal.pone.0191004.Peer-Reviewed Original Research
2014
Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy
Shoamanesh A, Martinez-Ramirez S, Oliveira-Filho J, Reijmer Y, Falcone GJ, Ayres A, Schwab K, Goldstein JN, Rosand J, Gurol ME, Viswanathan A, Greenberg SM. Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy. Neurology 2014, 83: 1838-1843. PMID: 25320098, PMCID: PMC4240429, DOI: 10.1212/wnl.0000000000000984.Peer-Reviewed Original ResearchConceptsCortical superficial siderosisCerebral amyloid angiopathyCMB countCerebral microbleedsSuperficial siderosisAmyloid angiopathyΕ4 allele frequencyCross-sectional analysisCSS presenceAPOE genotypeAPOE ε4MRI scansAngiopathyMicrobleedsSiderosisCountSeverityGenetic associationLongitudinal research studyCS relativeDistinct patternsAllele frequenciesSubjectsIndividualsTertile
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