Tingting Wang
Postdoctoral AssociateAbout
Research
Publications
2025
PMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression
Xu Z, Qiao S, Wang Z, Peng C, Hou Y, Liu B, Cao G, Wang T. PMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression. Gut Microbes 2025, 17: 2455508. PMID: 39886799, PMCID: PMC11792855, DOI: 10.1080/19490976.2025.2455508.Peer-Reviewed Original ResearchConceptsPMA1 expressionExtracellular vesiclesCell differentiationAdaptor protein CARD9Th17 cell differentiationCARD9 deficiencyActivity of GAPDHVirulence factorsDecreased enzyme activityPma1Immune responseProteomic analysisCARD9Decreased glycolysisIL-17A productionMucosal immune responsesInduce Th17 cell differentiationMesenteric lymph nodesEditing systemAggravated colitisIL-17ALymph nodesColitis progressionAberrant changesGAPDHSalidroside Improves Oocyte Competence of Reproductively Old Mice by Enhancing Mitophagy
Gu J, Hua R, Wu H, Guo C, Hai Z, Xiao Y, Yeung W, Liu K, Babayev E, Wang T. Salidroside Improves Oocyte Competence of Reproductively Old Mice by Enhancing Mitophagy. Aging Cell 2025, e14475. PMID: 39789811, DOI: 10.1111/acel.14475.Peer-Reviewed Original ResearchReproductively old miceImprove oocyte qualityOocyte qualityOld miceDecline of oocyte qualityDevelopmental competence of oocytesReproductively older womenCompetence of oocytesKnowledge of therapeutic optionsOocyte competenceDevelopmental competenceTherapeutic optionsMaternal ageSpindle/chromosome structureAssisted reproductionOld femaleMiceOocytesOlder womenNatural fertilityFemale fertilityMitochondrial function
2024
Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma
Wang T, Liu L, Fang J, Jin H, Natarajan S, Sheppard H, Lu M, Turner G, Confer T, Johnson M, Steinberg J, Ha L, Yadak N, Jain R, Picketts D, Ma X, Murphy A, Davidoff A, Glazer E, Easton J, Chen X, Wang R, Yang J. Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma. Cancer Research 2024, 85: 424-441. PMID: 39531507, PMCID: PMC11786959, DOI: 10.1158/0008-5472.can-24-1142.Peer-Reviewed Original ResearchPancreatic neuroendocrine tumorsC-mycCre recombinaseAnti-GD2 immunotherapyHigh-risk neuroblastomaDopamine B-hydroxylaseActivity of c-MycFDA-approved inhibitorC-Myc overexpressionC-Myc activityC-myc inductionTesting immunotherapyNeuroendocrine tumorsTargeted therapyTumor typesNeuroblastoma developmentNeuroblastoma tumorsNeuroblastoma oncogenesisEffective therapyTyrosine hydroxylaseTarget cellsTumorNeuroblastomaHuman neuroblastomaGenetic featuresBeautoide A, an Anti‐Osteoclastogenic Sterol from Beauveria sp. NBUF147 Associated with an Irciniidae Sponge from the Marine Mesophotic Zone
Ran G, Wang P, Wang H, Wei T, Liu Y, Jin H, Wang T, He S. Beautoide A, an Anti‐Osteoclastogenic Sterol from Beauveria sp. NBUF147 Associated with an Irciniidae Sponge from the Marine Mesophotic Zone. Chemistry & Biodiversity 2024, 21: e202401689. PMID: 39136520, DOI: 10.1002/cbdv.202401689.Peer-Reviewed Original ResearchMesophotic coral ecosystemsMesophotic zoneCoral ecosystemsBeauveria sp.Prednisolone-induced osteoporotic zebrafishMarine bioresourcesMarineEvaluation of biological activityIrciniidaeSterolsBeauveriaBiological activityEcosystemAnti-osteoclastogenicX-ray crystallographyAnalysis of spectroscopic dataSpongeBioactive moleculesDepthZoneZebrafishBioresourcesChemical investigationX-rayAT-56 RESCUES OOCYTE DYSFUNCTION IN OOCYTE-SPECIFIC KNOCKOUT CLPX MICE BY INHIBITING PGD2 SYNTHESIS
Hua R, Hai Z, Gu J, Du H, Yeung W, Wang T. AT-56 RESCUES OOCYTE DYSFUNCTION IN OOCYTE-SPECIFIC KNOCKOUT CLPX MICE BY INHIBITING PGD2 SYNTHESIS. Fertility And Sterility 2024, 122: e171. DOI: 10.1016/j.fertnstert.2024.07.594.Peer-Reviewed Original ResearchIL-1β mediates Candida tropicalis-induced immunosuppressive function of MDSCs to foster colorectal cancer
Zhang Z, Chen Y, Pan X, Li P, Ren Z, Wang X, Chen Y, Shen S, Wang T, Lin A. IL-1β mediates Candida tropicalis-induced immunosuppressive function of MDSCs to foster colorectal cancer. Cell Communication And Signaling 2024, 22: 408. PMID: 39164774, PMCID: PMC11337875, DOI: 10.1186/s12964-024-01771-y.Peer-Reviewed Original ResearchConceptsImmunosuppressive function of MDSCsFunction of MDSCsExpression of IL-1bImmunosuppressive functionC. tropicalisColorectal cancerIL-1BProgression of colorectal cancerAntitumor immunityNLRP3 inflammasome activationColon cancer xenograft modelTumor-infiltrating MDSCsInhibit antitumor immunityPotential immunotherapeutic strategyRegulating tumor immunityTreatment of colorectal cancerSeverity of colorectal cancerCancer xenograft modelColon cancer cell linesInflammasome activationHuman colorectal cancerNLRP3 inflammasomeIn vitro supplementationImmunotherapeutic strategiesPromote CRC progressionPericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung adenocarcinoma
Chen Y, Zhang Z, Pan F, Li P, Yao W, Chen Y, Xiong L, Wang T, Li Y, Huang G. Pericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung adenocarcinoma. Journal Of Experimental & Clinical Cancer Research 2024, 43: 210. PMID: 39075504, PMCID: PMC11285179, DOI: 10.1186/s13046-024-03135-3.Peer-Reviewed Original ResearchConceptsAnti-angiogenesis therapyAnti-angiogenesis treatmentVascular normalizationTumor microenvironmentMagnetic-activated cell sortingAnti-angiogenesisTumor tissuesTumor vascular normalizationEfficacy of chemotherapyHuman lung adenocarcinoma cell line A549Expression of CCL28Lung adenocarcinoma cell line A549Adenocarcinoma cell line A549Adenocarcinoma tumor tissuesStabilization of endothelial cellsClinical biopsy samplesRetinoic acidLung adenocarcinoma tumor tissuesCCL28 proteinMurine tumor tissuesCombination therapyTargeted therapyMultiplex immunohistochemistryState of ischemiaPericyte coverageCommensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor
Tian K, Jing D, Lan J, Lv M, Wang T. Commensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor. Immunity Inflammation And Disease 2024, 12: e1316. PMID: 39023417, PMCID: PMC11256888, DOI: 10.1002/iid3.1316.Peer-Reviewed Original ResearchConceptsMucosal immune networkMucosal immune systemImmune systemMaintenance of intestinal healthSite of pathogen invasionPresence of commensal microbiotaImmune responsePattern recognition receptorsGut mucosal immune systemAntigen-presenting cellsMucosal immune cellsGastrointestinal mucosal immunityGut-associated lymphoid tissuePathogen invasionCommensal microbiotaGut homeostasisMicrobial communitiesProtective immune responsesAdaptive immune responsesNon-self antigensCommensal bacteriaCommensal microbiomeIntestinal healthInflammatory bowel diseaseRecognition receptorsO-077 Depletion of MFF from oocytes impairs mitochondrial dynamics, leading to inhibited oocyte maturation and early embryonic development in mice
Hua R, Hai Z, Gu J, Yeung W, Wang T. O-077 Depletion of MFF from oocytes impairs mitochondrial dynamics, leading to inhibited oocyte maturation and early embryonic development in mice. Human Reproduction 2024, 39: deae108.083. DOI: 10.1093/humrep/deae108.083.Peer-Reviewed Original ResearchMitochondrial fission factorEarly embryonic developmentMitochondrial dynamicsGV oocytesOocyte competenceKnockout mouse modelOvulated oocytesOocyte maturationCultured in vitroFemale miceEmbryonic developmentCre-loxP conditional knockout systemMouse modelGerminal vesicleRegulation of mitochondrial dynamicsMethods Female miceIn vitro maturationEmbryo development ratesRegulating mitochondrial dynamicsInhibited oocyte maturationMorphology of mitochondriaEarly embryo developmentPolar body extrusionAbnormal mitochondrial distributionConditional knockout systemP-587 Salidroside improves the reproductive capacity of aged mice via improving oocyte mitochondrial function
Gu J, Hua R, Guo C, Hai Z, Xiao Y, Zhao P, Li Y, Su J, Wang T. P-587 Salidroside improves the reproductive capacity of aged mice via improving oocyte mitochondrial function. Human Reproduction 2024, 39: deae108.919. DOI: 10.1093/humrep/deae108.919.Peer-Reviewed Original ResearchOvarian agingIVM treatment groupsGV oocytesFemale miceTreatment groupsAged miceDays of in vivo treatmentOocyte mitochondrial functionIn vivoOvarian reserve functionIn vitroTreatment of ovarian agingFunction of miceMitochondrial functionFollicle reserveMII oocytesTherapeutic effect of salidrosideAged oocytesParthenogenetic activationC57/B6 miceOocyte qualityMaternal ageParthenogenetic embryosWIDER IMPLICATIONSSalidroside supplementation