Jie Li
Financial Analyst 2, YSM FinanceCards
About
Research
Publications
2025
Neurophysiological Markers of Auditory Verbal Hallucinations in Patients with Schizophrenia: An EEG Microstates Study
Li S, Hu R, Yan H, Chu L, Qiu Y, Gao Y, Li M, Li J. Neurophysiological Markers of Auditory Verbal Hallucinations in Patients with Schizophrenia: An EEG Microstates Study. Brain Topography 2025, 38: 29. PMID: 39920494, DOI: 10.1007/s10548-025-01105-2.Peer-Reviewed Original ResearchConceptsAVH patientsAuditory verbal hallucinationsSchizophrenia patientsNon-AVH groupHallucinating patientsMicrostate BEEG microstatesNeurophysiological markersPotential neurophysiological markersMicrostate CSeverity of symptomsVerbal hallucinationsPatientsHigh-density electroencephalography dataTherapeutic interventionsSchizophreniaClass C microstatesSeverityDurationNegative correlationGroupHallucinationsSymptomsOlanzapine Induces Adipogenesis and Glucose Uptake by Activating Glycolysis and Synergizing with the PI3K-AKT Pathway
Li S, Fu Y, Wang W, Qiu J, Huang Y, Li X, Yang K, Yu X, Ma Y, Zhang Y, Zhang M, Li J, Li W. Olanzapine Induces Adipogenesis and Glucose Uptake by Activating Glycolysis and Synergizing with the PI3K-AKT Pathway. Current Neuropharmacology 2025, 23: 412-425. PMID: 39150031, DOI: 10.2174/1570159x22666240815120547.Peer-Reviewed Original ResearchAdministration of olanzapineTreated with olanzapineReactive oxygen speciesDownstream PI3K-Akt signal pathwayAssociated with obesityActive glycolysisAssessed body weightWeight gainDifferentiated 3T3-L1 preadipocytesLiver fat levelsPI3K-Akt pathwayOlanzapineDrug doseFemale miceDietary patternsMetabolic markersPI3K-AktFood intakeGlucose uptakeMouse modelGlycolipid abnormalitiesRodent modelsBody weightGAPDH expressionSignaling pathway
2024
Plasma NGAL, not IFN-γ, predicts early treatment response in drug-naïve Chinese Han schizophrenia patients
Sun X, Li M, Qiu Y, Su Q, Wang J, Bi F, Li J. Plasma NGAL, not IFN-γ, predicts early treatment response in drug-naïve Chinese Han schizophrenia patients. Schizophrenia Research 2024, 274: 457-463. PMID: 39515255, DOI: 10.1016/j.schres.2024.10.025.Peer-Reviewed Original ResearchDrug-naive schizophrenia patientsSchizophrenia patientsNeutrophil gelatinase-associated lipocalinNeutrophil gelatinase-associated lipocalin concentrationsEarly treatment responseDuration of untreated illnessTreatment responseIFN-gHealthy controlsNGAL concentrationsEarly prediction of treatment efficacyPlasma neutrophil gelatinase-associated lipocalinNeutrophil gelatinase-associated lipocalin levelsUntreated illnessPrediction of treatment efficacyPredicting early treatment responsePlasma NGAL concentrationsWeeks of treatmentIFN-g levelsPersonalized treatment strategiesLogistic regression analysisBaseline NGAL concentrationLongitudinal studySchizophreniaTreatment outcomesInhibition of cardiomyocyte neddylation impairs embryonic cardiac morphogenesis
Littlejohn R, Zambrano-Carrasco J, Zou J, Yao Y, Kim I, Zhou J, Li J, Su H. Inhibition of cardiomyocyte neddylation impairs embryonic cardiac morphogenesis. Journal Of Molecular And Cellular Cardiology 2024, 197: 40-44. PMID: 39437885, PMCID: PMC11588525, DOI: 10.1016/j.yjmcc.2024.10.006.Peer-Reviewed Original ResearchSex-specific associations between 10-year cardiovascular risk, clinical symptoms and cognitive impairments in schizophrenia
Jin X, Lu C, Liu N, Li Y, Dong Y, Wang X, Li S, Li J. Sex-specific associations between 10-year cardiovascular risk, clinical symptoms and cognitive impairments in schizophrenia. Journal Of Neural Transmission 2024, 132: 313-322. PMID: 39387913, DOI: 10.1007/s00702-024-02842-7.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScaleRepeatable Battery for the Assessment of Neuropsychological StatusPsychiatric symptomsNegative symptomsCognitive functionSex differencesAssessment of Neuropsychological StatusPANSS total scoreNegative Syndrome ScaleFramingham risk scoreSignificant sex differencesSyndrome ScalePsychopathology scoresImmediate memoryNeuropsychological statusCardiovascular riskSCZTotal scoreCognitive impairmentCardiovascular diseaseSex-specific associationsFasting venous blood samplesHigher Framingham risk scoreGlycolipid metabolism indexesSymptomsThe associations between duration of untreated psychosis, growth factors, and neurocognition in patients with drug-naïve schizophrenia
Su Q, Xuekelaiti Z, Ma H, Qiu Y, Sun X, Bi F, Li M, Li J. The associations between duration of untreated psychosis, growth factors, and neurocognition in patients with drug-naïve schizophrenia. Schizophrenia Research 2024, 274: 113-120. PMID: 39288474, DOI: 10.1016/j.schres.2024.09.011.Peer-Reviewed Original ResearchDuration of untreated psychosisBrain-derived neurotrophic factorMATRICS Consensus Cognitive BatterySpeed of processingVascular endothelial growth factorUntreated psychosisEpidermal growth factorAssociated with speed of processingDuration of untreated psychosis groupGrowth factorConsensus Cognitive BatteryDrug-naive schizophreniaPlasma concentrations of vascular endothelial growth factorPlasma concentrationsConcentrations of vascular endothelial growth factorCognitive batteryVerbal learningAssociated with speedEndothelial growth factorNeurocognitionVisual learningCognitive impairmentEnzyme-linked immunosorbent assayBiological mechanismsNeurotrophic factorDissecting the association between gut microbiota, body mass index and specific depressive symptoms: a mediation Mendelian randomisation study
Yu T, Chen C, Yang Y, Wang M, Yang Y, Feng W, Yuan S, Ma X, Li J, Zhang B. Dissecting the association between gut microbiota, body mass index and specific depressive symptoms: a mediation Mendelian randomisation study. General Psychiatry 2024, 37: e101412. PMID: 38975363, PMCID: PMC11227829, DOI: 10.1136/gpsych-2023-101412.Peer-Reviewed Original ResearchActinobacteria phylumGut microbiotaBody mass indexSpecific depressive symptomsDepressive symptomsMendelian randomisationGenome-wide association studiesTwo-sample Mendelian randomisationMass indexDepressed moodAppetite changesMendelian randomisation studiesBifidobacteriaceae familyAssociation studiesActinobacteriaPhylumMR analysisGenusFamily XIMicrobiotaObservational studyMediation analysisClinical practiceGutProtective effectSex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study
Tian X, Liu X, Bai F, Li M, Qiu Y, Jiao Q, Li J, Zhang X. Sex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study. Brain And Behavior 2024, 14: e3578. PMID: 38844426, PMCID: PMC11156525, DOI: 10.1002/brb3.3578.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleHamilton Depression ScaleHamilton Anxiety ScaleFEDN MDD patientsMDD patientsSuicide attemptsSex differencesDepressive disorderFirst-episodeFactors associated with suicide attemptsRisk of suicide attemptNegative Syndrome ScaleMajor depressive disorderHamilton Depression Scale scoresHamilton Anxiety Scale scoresThyroid peroxidase antibodySubclinical hypothyroidismIncreased suicide attemptsInvestigate sex differencesSignificant sex differencesSyndrome ScalePositive subscaleIncreased riskAnxiety ScaleFEDNSex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-naïve anxious depression: a large-scale cross-sectional study
Luo G, Wang S, Gou L, Li C, Yao C, Jing Y, Xuekelaiti Z, Li J, Zhang X. Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-naïve anxious depression: a large-scale cross-sectional study. Journal Of Neural Transmission 2024, 131: 987-998. PMID: 38743092, DOI: 10.1007/s00702-024-02779-x.Peer-Reviewed Original ResearchFirst-episode drug-naiveSelf-reported suicide attemptsAnxious depressionSuicide attemptsSex differencesHamilton Anxiety Rating Scale scoresAnxiety Rating Scale scoresClinical characteristics of suicide attemptersCharacteristics of suicide attemptersMajor depressive disorderNon-suicide attemptersSelf-reported suicidalityAD patientsRating Scale scoresInvestigate sex differencesMale AD patientsDepressive disorderDrug-naiveClinical psychiatristsSevere anxietySex-specific risk factorsMiddle-aged patientsDepressionThyroid peroxidase antibodyScale scoreTargeted metabolomics-based understanding of the sleep disturbances in drug-naïve patients with schizophrenia
Yan H, Li G, Zhang X, Zhang C, Li M, Qiu Y, Sun W, Dong Y, Li S, Li J. Targeted metabolomics-based understanding of the sleep disturbances in drug-naïve patients with schizophrenia. BMC Psychiatry 2024, 24: 355. PMID: 38741058, PMCID: PMC11089724, DOI: 10.1186/s12888-024-05805-0.Peer-Reviewed Original ResearchConceptsPositive and Negative Symptom ScaleDrug-naive patientsLiquid chromatography-mass spectrometryDrug-naive schizophreniaAssociated with sleep disturbancesOrthogonal partial least squares discriminant analysisSleep disturbancePittsburgh Sleep Quality IndexPartial least-squares discriminant analysisMetabolomics-based approachNegative Symptom ScaleChromatography-mass spectrometryCharacteristic metabolitesSchizophreniaSymptom ScaleMethodsPlasma samplesPotential biological mechanismsSleep Quality IndexClinical symptomsGlycerophospholipid metabolismPartial correlation analysisHealthy controlsMetabolomic analysisPatientsBackgroundSleep disturbance