Dima Kuzmin, PhD
Assistant Professor Adjunct of Medicine (Medical Oncology)Cards
About
Research
Publications
2024
A metabolic dependency of EBV can be targeted to hinder B cell transformation
Müller-Durovic B, Jäger J, Engelmann C, Schuhmachers P, Altermatt S, Schlup Y, Duthaler U, Makowiec C, Unterstab G, Roffeis S, Xhafa E, Assmann N, Trulsson F, Steiner R, Edwards-Hicks J, West J, Turner L, Develioglu L, Ivanek R, Azzi T, Dehio P, Berger C, Kuzmin D, Saboz S, Mautner J, Löliger J, Geigges M, Palianina D, Khanna N, Dirnhofer S, Münz C, Bantug G, Hess C, Berger C, Hess C, Koller M, Rossi S, Stampf S, Müller N. A metabolic dependency of EBV can be targeted to hinder B cell transformation. Science 2024, 385: eadk4898. PMID: 38781354, DOI: 10.1126/science.adk4898.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusIndoleamine 2,3-dioxygenase 1B-cell transformationB cellsEBV-driven B-cell transformationIndoleamine 2,3-dioxygenase 1 expressionIndoleamine 2,3-dioxygenase 1 inhibitionInfection of B cellsEBV-infected B cellsEnzyme indoleamine 2,3-dioxygenase 1Epstein-Barr virus protein EBNA2Increased IDO1 activityNicotinamide adenine dinucleotideDevelopment of lymphomaEBV-related diseasesInfected B cellsHumanized miceTransplant patientsImmune dysregulationAdenosine triphosphateMitochondrial complex I activityComplex I activityMetabolic vulnerabilitiesIDO1 activitySerum signature
2022
Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
Lötscher J, Martí I Líndez AA, Kirchhammer N, Cribioli E, Giordano Attianese G, Trefny MP, Lenz M, Rothschild SI, Strati P, Künzli M, Lotter C, Schenk SH, Dehio P, Löliger J, Litzler L, Schreiner D, Koch V, Page N, Lee D, Grählert J, Kuzmin D, Burgener AV, Merkler D, Pless M, Balmer ML, Reith W, Huwyler J, Irving M, King CG, Zippelius A, Hess C. Magnesium sensing via LFA-1 regulates CD8+ T cell effector function. Cell 2022, 185: 585-602.e29. PMID: 35051368, DOI: 10.1016/j.cell.2021.12.039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial InfectionsCaloric RestrictionCD8-Positive T-LymphocytesCell Line, TumorCytotoxicity, ImmunologicHEK293 CellsHumansImmunologic MemoryImmunological SynapsesImmunotherapyLymphocyte ActivationLymphocyte Function-Associated Antigen-1MagnesiumMaleMAP Kinase Signaling SystemMice, Inbred C57BLNeoplasmsPhenotypePhosphorylationProto-Oncogene Proteins c-junConceptsLFA-1CAR TLow serum magnesium levelsMore rapid disease progressionAntibody-treated patientsRapid disease progressionShorter overall survivalSerum magnesium levelsCell effector functionsOverall survivalCellular immunityImmune synapse formationDisease progressionEffector functionsExtracellular magnesiumSpecific cytotoxicityMagnesium levelsSynapse formationCalcium fluxCell functionMetabolic reprogrammingCD8CellsNutrient sensingPatients
2021
The clinical landscape for AAV gene therapies
Kuzmin DA, Shutova MV, Johnston NR, Smith OP, Fedorin VV, Kukushkin YS, van der Loo JCM, Johnstone EC. The clinical landscape for AAV gene therapies. Nature Reviews Drug Discovery 2021, 20: 173-174. PMID: 33495615, DOI: 10.1038/d41573-021-00017-7.Peer-Reviewed Original Research