George Davis, PhD, BA
Lecturer in PsychiatryCards
About
Titles
Lecturer in Psychiatry
Director, Center for Dialectical & Cognitive Behavioral Therapies, LLC
Education & Training
- Port-Doctoral Fellow
- Yale Psychiatric Institute (1975)
- PhD
- Yale University (1973)
- BA
- Yale College, Culture and Behavior (1968)
Research
Overview
Medical Research Interests
Behavior and Behavior Mechanisms; Mental Disorders
Public Health Interests
Mental Health; Behavioral Health
Publications
2024
Enhancing human capillary tube network assembly and maturation through upregulated expression of pericyte-derived TIMP-3
Yrigoin K, Bernard K, Castaño M, Cleaver O, Sumanas S, Davis G. Enhancing human capillary tube network assembly and maturation through upregulated expression of pericyte-derived TIMP-3. Frontiers In Cell And Developmental Biology 2024, 12: 1465806. PMID: 39544367, PMCID: PMC11560913, DOI: 10.3389/fcell.2024.1465806.Peer-Reviewed Original ResearchTIMP-3Endothelial cellsHuman pericytesPresence of doxycyclineCollagen type IVCo-culture modelIncreasing tube lengthHuman endothelial cellsStabilization networkTissue inhibitorNetwork assemblyPericyte recruitmentCapillary assemblyCo-assemblyType IVUpregulated expressionPericytesCo-cultureTube lengthDoxycycline additionEC-pericyte interactionsTube widthDoxycyclineNetwork of capillary tubesSelective mural cell recruitment of pericytes to networks of assembling endothelial cell-lined tubes
Yrigoin K, Davis G. Selective mural cell recruitment of pericytes to networks of assembling endothelial cell-lined tubes. Frontiers In Cell And Developmental Biology 2024, 12: 1389607. PMID: 38961866, PMCID: PMC11219904, DOI: 10.3389/fcell.2024.1389607.Peer-Reviewed Original ResearchCoronary artery smooth muscle cellsVascular basement membrane matrix depositionVascular basement membrane matrix assemblyEC tubesBasement membrane depositionVascular smooth muscle cellsSmooth muscle cellsInvestigate functional differencesMuscle cellsMatrix assemblyArtery smooth muscle cellsMural cell recruitmentPDGF-DDPlatelet-derived growth factor (PDGF)-BBCollagen matrixMembrane depositionMural cellsHuman coronary artery smooth muscle cellsMinimal recruitmentFunctional differencesEC-derived factorsEndothelin-1CellsMatrix environmentMinimal invasivenessSH2 domain protein E and ABL signaling regulate blood vessel size
Schumacher J, Wright Z, Florat D, Anand S, Dasyani M, Batta S, Laverde V, Ferrari K, Klimkaite L, Bredemeier N, Gurung S, Koller G, Aguera K, Chadwick G, Johnson R, Davis G, Sumanas S. SH2 domain protein E and ABL signaling regulate blood vessel size. PLOS Genetics 2024, 20: e1010851. PMID: 38190417, PMCID: PMC10798624, DOI: 10.1371/journal.pgen.1010851.Peer-Reviewed Original ResearchZebrafish embryosDorsal aortaSrc homology 2 domainMutant phenotypeVascular tubulogenesisCell numberNegative regulatorBiological roleMolecular mechanismsProtein EChemical inhibitionUmbilical vein cellsE proteinEndothelial cell proliferationHuman endothelial cell culturesCell proliferationVein cellsProteinMutantsVascular tubesSpecific overexpressionTubulogenesisEndothelial cell culturesTight junctionsABL
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