Skip to Main Content
Yale Institute for Global Health
Yale Home

INFORMATION FOR

    Kevan Herold, MD

    C.N.H. Long Professor of Immunobiology and of Medicine (Endocrinology)
    DownloadHi-Res Photo

    Clinical Specialties

    Endocrinology, Pediatric Endocrinology & Diabetes + 1 more
    Patients Treated
    Child, Adult

    About

    Titles

    C.N.H. Long Professor of Immunobiology and of Medicine (Endocrinology)

    Biography

    My background and research are in translational immunology. I am interested in understanding the basis for autoimmune diseases and developing new therapies based on our understanding of disease mechanisms. My focus has largely been in the field of autoimmune Type 1 diabetes. The work encompasses basic laboratory work as well as clinical studies to understanding the regulation of autoreactive T cells to clinical trials that involve novel therapeutics. As part of these studies my lab has been very interested in analysis of beta cell function in Type 1 diabetes and identifying the cellular mechanisms that can protect them from immune killing. We have also been studying the development of autoimmune diabetes in patients with cancers who are treated with checkpoint inhibitors. Our clinical and basic studies are focused on understanding how beta cells are destroyed and react to inflammation. Finally, with the COVID-19 pandemic, we have been studying the immunologic basis for responses in children and adults who are hospitalized with COVID-19 to understand the mechanisms that can lead to disease protection.

    Appointments

    Other Departments & Organizations

    Education & Training

    Fellow
    University of Chicago (1984)
    Residency
    Temple University Hospital (1982)
    MD
    Jefferson Medical College (1979)
    BS
    Pennsylvania State University (1977)

    Research

    Overview

    The pathogenesis and treatment of autoimmune disease, in particular Type 1 diabetes.

    Studies involve clinical trials with patients and investigations of the mechanism of action of immune therapies and the pathogenesis of disease in patients as well as in animal models when needed to address what cannot be studies in humans. Over the past 7 years, our lab has carried out trials of a humanized non-FcR binding anti-CD3 monoclonal antibody in patients and has studied the mechanism of drug action. These clinical studies have suggested novel mechanisms of immune regulation that are now to be addressed with new clinical studies.

    Medical Research Interests

    Autoimmunity; Diabetes Mellitus, Type 1; Endocrine System Diseases; Immune System Diseases; Metabolism; Polyendocrinopathies, Autoimmune; Translational Research, Biomedical

    Public Health Interests

    Metabolism; Immunology

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Kevan Herold's published research.

    Publications

    2024

    See All Publications

    Clinical Trials

    Current Trials

    See All Current Clinical Trials

    Clinical Care

    Overview

    Kevan Herold, MD, is an endocrinologist who treats adult and child patients with type 1 and type 2 diabetes, diabetes that occurs after therapies for cancer, and hypoglycemia (low blood glucose levels).

    Type 1 diabetes is an autoimmune disease that is often diagnosed in children and teens. The immune system mistakenly attacks healthy body tissues and destroys cells in the pancreas that produce insulin.

    Dr. Herold’s goal is to better understand the mechanisms for type 1 diabetes in order to develop new treatments for his patients. His research revolves around beta cell function. In type 1 diabetes, beta cells produce little or no insulin and are destroyed by T cells from the immune system. Dr. Herold and his lab also research autoimmune diabetes development in cancer patients.

    Recently, Dr. Herold was the principal investigator for a clinical trial that showed the effectiveness of teplizumab, a new drug that could delay type 1 diabetes development by two years. He is chair of NIDDK (National Institute of Diabetes and Digestive Diseases) TrialNet, an international network of type 1 diabetes researchers.

    Dr. Herold is C.N.H. Long Professor of Immunobiology and of Medicine (Endocrinology) at Yale School of Medicine.

    Clinical Specialties

    Endocrinology; Pediatric Endocrinology & Diabetes; Diabetes Medicine & Management

    Fact Sheets

    See All Fact Sheets On Yale Medicine

    Board Certifications

    • Endocrinology & Metabolism

      Certification Organization
      AB of Internal Medicine
      Original Certification Date
      1985

    • Internal Medicine

      Certification Organization
      AB of Internal Medicine
      Original Certification Date
      1982

    Yale Medicine News

    See All News On Yale Medicine

    Are You a Patient?

    View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

    View Doctor Profile

    Get In Touch

    Contacts

    Email
    Academic Office Number
    Appointment Number
    Clinic Fax Number

    Administrative Support

    Locations

    • Patient Care Locations

      Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

      See Patient Care Locations

    Events

    Apr 20258Tuesday