Zhonghua Tang
Research Associate 1 MSCards
About
Research
Publications
2025
Distinct transcriptional and epigenomic programs define Hofbauer cells in term placenta
Baráth B, Bojcsuk D, Bene K, Caballero-Sánchez N, Cseh T, de Freitas J, Tzerpos P, Toth M, Tang Z, Guller S, Krasznai Z, Neuperger P, Szebeni G, Nagy G, Deli T, Nagy L. Distinct transcriptional and epigenomic programs define Hofbauer cells in term placenta. JCI Insight 2025, 11: e195801. PMID: 41433105, PMCID: PMC12892902, DOI: 10.1172/jci.insight.195801.Peer-Reviewed Original ResearchConceptsHofbauer cellsIn vitro stimulation studiesPopulation of macrophagesChromatin accessibility profilesNuclear receptorsLipid transporter CD36Mass cytometry analysisFetal macrophagesNR4A1-3Adult macrophagesPlacental biologyChorionic villusRosiglitazone treatmentEpigenomic featuresIL-4Surface markersHuman placentaGlucocorticoid receptorPlacentaMacrophage stateCytometry analysisTissue remodelingAntimicrobial defenseAccessibility profilesMacrophagesRole of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta
Morris N, Guller S, Tang Z, Zhang Y, Siegman E, Milano K, Rudnick G, Kliman H. Role of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta. Endocrinology 2025, 166: bqaf124. PMID: 40898405, PMCID: PMC12399332, DOI: 10.1210/endocr/bqaf124.Peer-Reviewed Original ResearchConceptsExogenous 5-HTCytotrophoblast nucleiUptake of 5-HTHistone 3Differentiation in vitroMaternal 5-HTTransglutaminase 2Fetal growthIntact placentaPlacental explantsHuman cytotrophoblastsGene expressionSerotonin transporterHuman placentaPlacentaSerotoninRNA expressionWestern blottingCell survivalCell proliferationEscitalopramTrophoblastProtective pathwaysSERTSerotonylation
2023
Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis
Ozmen A, Nwabuobi C, Tang Z, Guo X, Larsen K, Guller S, Blas J, Moore M, Kayisli U, Lockwood C, Guzeloglu-Kayisli O. Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis. International Journal Of Molecular Sciences 2023, 25: 135. PMID: 38203306, PMCID: PMC10778808, DOI: 10.3390/ijms25010135.Peer-Reviewed Original ResearchConceptsIL-6 expressionHofbauer cellsP65 NF-κBIL-6NF-κBLeptin levelsPreeclampsia pathogenesisElevated serum interleukin-6 levelsSerum interleukin-6 levelsERK1/2 MAPKInterleukin-6 levelsPro-inflammatory phenotypeAnti-inflammatory phenotypeLeptin receptor expressionIL-6 productionPathogenesis of PEPlacental leptin productionPhosphorylation levelsERK1/2 MAPK inhibitorIL-6 regulationConcentration-dependent mannerPE patientsHuman pregnancySecond trimesterLeptin concentrations