Yao Xue
Postdoctoral AssociateAbout
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Titles
Postdoctoral Associate
Appointments
Ophthalmology
Postdoctoral AssociatePrimary
Other Departments & Organizations
- All Institutions
- Ophthalmology
Education & Training
- BS (Hon)
- Shanghai Jiaotong University, Biology (2019)
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Yao Xue's published research.
Brian Hafler, MD, PhD
Z. Jimmy Zhou, PhD
Marcello DiStasio, MD, PhD
Seunghoon Lee, PhD
Jaime Grutzendler, MD
Joerg Bewersdorf, PhD
Publications
2026
A hierarchical electrical synaptic circuit mechanism for integrative parallel visual processing in the retina
Xue Y, Fei Y, DiStasio M, Miller S, Hafler B, Liang L, Lee S, Zhou Z. A hierarchical electrical synaptic circuit mechanism for integrative parallel visual processing in the retina. Neuron 2026 PMID: 41720091, PMCID: PMC12927596, DOI: 10.1016/j.neuron.2025.12.042.Peer-Reviewed Original ResearchAltmetricConceptsCone bipolar cellsDual patch-clamp recordingsPatch-clamp recordingsBipolar cellsOFF cone bipolar cellsRetinal bipolar cellsWhole-mounted retinasThalamic neuronsRetinal cellsAwake miceSynaptic transmissionSynaptic integrationTwo-photon imagingElectrical synapsesSynaptic channelsCircuit mechanismsMiceLow-contrast stimuliSustained signalingRetinaSynaptic architectureCellsSlow modeCone bipolar cell typesSynaptically
2025
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids
Miller S, Dhodapkar R, Sutova H, Xue Y, Lee S, Logan R, Ran C, Bhatta S, Gomm A, Ju I, Heyang M, Darji R, DiStasio M, Tanzi R, Zhang C, Zhou Z, Hafler B. SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids. Science Advances 2025, 11: eads5006. PMID: 40614201, PMCID: PMC12227045, DOI: 10.1126/sciadv.ads5006.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAmyloid-bSpike 1 proteinPathogen infectionImmune response to pathogen infectionResponse to pathogen infectionInnate immune response to pathogen infectionEtiology of Alzheimer's diseaseExtracellular protein aggregatesSARS-CoV-2 spike 1 proteinAlzheimer's diseasePharmacological inhibitionPresence of microbesAmyloid plaquesAntimicrobial hypothesisProtein aggregationSARS-CoV-2Inhibition of neuropilin-1Electrophysiologically active neuronsHuman retinal explantsMicrobesRetinal organoidsAlzheimerRetinal explantsNeuropilin-1Human retinal organoids
2023
Single cell in vivo optogenetic stimulation by two-photon excitation fluorescence transfer
Tong L, Han S, Xue Y, Chen M, Chen F, Ke W, Shu Y, Ding N, Bewersdorf J, Zhou Z, Yuan P, Grutzendler J. Single cell in vivo optogenetic stimulation by two-photon excitation fluorescence transfer. IScience 2023, 26: 107857. PMID: 37752954, PMCID: PMC10518705, DOI: 10.1016/j.isci.2023.107857.Peer-Reviewed Original ResearchCitationsAltmetricConcepts
Academic Achievements & Community Involvement
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