Yang Zheng, MD, PhD
Postdoctoral AssociateAbout
Research
Publications
2023
Seizures and electrophysiological features in familial cortical myoclonic tremor with epilepsy 1
Ding Y, Cen Z, Zheng Y, Qiu X, Ye Y, Chen X, Hu L, Wang B, Wang Z, Yin H, Shen C, Ming W, Ge Y, Xie F, Yang D, Ouyang Z, Wang H, Wu S, Ding M, Wang S, Luo W. Seizures and electrophysiological features in familial cortical myoclonic tremor with epilepsy 1. Annals Of Clinical And Translational Neurology 2023, 11: 414-423. PMID: 38059543, PMCID: PMC10863925, DOI: 10.1002/acn3.51961.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesIED indexFamilial cortical myoclonic tremorCortical myoclonic tremorElectrophysiological featuresMyoclonic tremorGeneralized interictal epileptiform dischargesDistribution of interictal epileptiform dischargesFocal interictal epileptiform dischargesThirty-one patientsStage I-IIPositive family historyEpileptic seizuresCourse of epilepsySleep-wake cycleFCMTE patientsOvernight EEGProlonged prodromeBenign courseEpileptiform dischargesFamily historyChinese cohortPhotoparoxysmal responseGenetic testingSAMD12 geneExcitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia
Zheng Y, Xu C, Sun J, Ming W, Dai S, Shao Y, Qiu X, Li M, Shen C, Xu J, Fei F, Fang J, Jiang X, Zheng G, Hu W, Wang Y, Wang S, Ding M, Chen Z. Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia. Signal Transduction And Targeted Therapy 2023, 8: 186. PMID: 37193687, PMCID: PMC10188524, DOI: 10.1038/s41392-023-01404-9.Peer-Reviewed Original ResearchConceptsSomatostatin-positive interneuronsCortical dysplasiaSeizure networkDentate gyrusParvalbumin-positive interneuronsSomatostatin-positive neuronsExcitatory transmissionDysplastic lesionsSomatostatin interneuronsPoor prognosisSomatostatin-positiveEpileptic hippocampusImmunohistochemical studiesCalcium imagingDysplasiaInterneuronsElectrophysiological recordingsSeizure generalizationCellular basisSeizuresInhibitory roleHippocampusOptogenetic studiesDentateCellular substrates
2022
Clinical Reasoning: A 60-Year-Old Man With Asymmetric Weakness and Persistent Fever
Zheng Y, Xiang J, Zhang X, Zhang S, Ding M, Huang J. Clinical Reasoning: A 60-Year-Old Man With Asymmetric Weakness and Persistent Fever. Neurology 2022, 100: 530-536. PMID: 36914272, PMCID: PMC10074466, DOI: 10.1212/wnl.0000000000201697.Peer-Reviewed Original ResearchConceptsPeripheral neuropathyPersistent feverAsymmetric weaknessDevelopment of rashElevated inflammatory markersAcute-onset weaknessClinical pattern recognitionDiagnostic challengeInflammatory markersDifferential diagnosisAtypical featuresElectrophysiological studiesAncillary testsTargeted treatmentNeuropathyRight legFeverLeft legDiagnosisRashPatientsInterictal-period-activated neuronal ensemble in piriform cortex retards further seizure development
Lai N, Cheng H, Li Z, Wang X, Ruan Y, Qi Y, Yang L, Fei F, Dai S, Chen L, Zheng Y, Xu C, Fang J, Wang S, Chen Z, Wang Y. Interictal-period-activated neuronal ensemble in piriform cortex retards further seizure development. Cell Reports 2022, 41: 111798. PMID: 36516780, DOI: 10.1016/j.celrep.2022.111798.Peer-Reviewed Original ResearchConceptsGeneralized seizuresActivity-dependent labeling techniquesInterictal periodSeizure developmentIP-enabledNeuronal ensemblesPiriform cortexPotential therapeutic targetCircuit rearrangementsOptogenetic activationHistological evidenceFocal seizuresIctal eventsSeizure generationControlling coherenceCellular mechanismsEpileptic networkSeizuresTherapeutic targetInterictal statePiriformActivated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase
Zhao J, Sun J, Zheng Y, Zheng Y, Shao Y, Li Y, Fei F, Xu C, Liu X, Wang S, Ruan Y, Liu J, Duan S, Chen Z, Wang Y. Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase. Nature Communications 2022, 13: 7136. PMID: 36414629, PMCID: PMC9681834, DOI: 10.1038/s41467-022-34662-2.Peer-Reviewed Original ResearchConceptsAnti-seizure effectsNa+-K+-ATPasePyramidal neuronsNeocortical seizuresRodent modelsInhibition of pyramidal neuronsExcitation-inhibition imbalanceTreatment of intractable epilepsyNa+-K+-ATPase activityMinimal side effectsAnti-seizure strategyAstrocyte-neuron interactionsOptogenetic activationTherapeutic windowIntractable epilepsyEpilepsy modelSide effectsCalcium signalingTherapeutic effectSeizuresActivity-dependentEpileptic seizuresAstrocyte stimulationAstrocytesPotential targetSeizures and epilepsy in multiple sclerosis, aquaporin 4 antibody‐positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody‐associated disease
Li E, Zheng Y, Cai M, Lai Q, Fang G, Du B, Shen C, Zhang Y, Wu L, Ding M. Seizures and epilepsy in multiple sclerosis, aquaporin 4 antibody‐positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody‐associated disease. Epilepsia 2022, 63: 2173-2191. PMID: 35652436, DOI: 10.1111/epi.17315.Peer-Reviewed Original ResearchConceptsMyelin oligodendrocyte glycoprotein antibody-associated diseaseAquaporin-4 antibody-positive neuromyelitis optica spectrum disorderNeuromyelitis optica spectrum disorderAntibody-associated diseaseMultiple sclerosisCentral nervous system inflammatory demyelinating diseaseAutoimmune-associated epilepsyCerebral cortical encephalitisConcomitant systemic infectionPresence of status epilepticusAcute disseminated encephalomyelitisInflammatory demyelinating diseaseSecondary to inflammationAcute symptomatic seizuresDrug-drug interactionsAQP4-NMOSDCortical encephalitisMultiple relapsesDisseminated encephalomyelitisImpact of treatmentStatus epilepticusDisease activitySymptomatic seizuresAntiseizure medicationsInflammatory mechanismsThe role of Na+‐K+‐ATPase in the epileptic brain
Sun J, Zheng Y, Chen Z, Wang Y. The role of Na+‐K+‐ATPase in the epileptic brain. CNS Neuroscience & Therapeutics 2022, 28: 1294-1302. PMID: 35751846, PMCID: PMC9344081, DOI: 10.1111/cns.13893.Peer-Reviewed Original ResearchPearls & Oy-sters: Parietal Lobe Epilepsy in Disguise
Zheng Y, Ming W, Zheng Z, Jiang H, Chen C, Wu H, Wang Z, Xu S, Zhu J, Ding M, Wang S, Ding Y. Pearls & Oy-sters: Parietal Lobe Epilepsy in Disguise. Neurology 2022, 98: 509-513. PMID: 35101912, DOI: 10.1212/wnl.0000000000200050.Peer-Reviewed Original Research
2021
HMGB1, neuronal excitability and epilepsy
Dai S, Zheng Y, Wang Y, Chen Z. HMGB1, neuronal excitability and epilepsy. Acta Epileptologica 2021, 3: 13. DOI: 10.1186/s42494-021-00048-y.Peer-Reviewed Original ResearchN-methyl-D-aspartateModulation of neuronal excitabilityAnimal models of epilepsyToll-like receptor 4Antiepileptic drug therapyInterleukin (IL)-1bTranslocation of HMGB1Multiple animal modelsDevelopment of epilepsyAnti-epileptic drugsMobility group protein B1HMGB1-related pathwayModels of epilepsyNuclear factor kappa BPotential of HMGB1Advanced glycation end productsFactor kappa BGlycation end productsNeuronal excitabilityBlocking HMGB1Downstream signaling pathwaysGlutamate receptorsHMGB1 signalingHyperexcitable neuronsDrug therapyCase Report: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder Masquerading as Multiple Sclerosis: An Under-Recognized Entity?
Zheng Y, Cai M, Li E, Fang W, Shen C, Zhang Y. Case Report: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder Masquerading as Multiple Sclerosis: An Under-Recognized Entity? Frontiers In Immunology 2021, 12: 671425. PMID: 34220818, PMCID: PMC8249196, DOI: 10.3389/fimmu.2021.671425.Peer-Reviewed Original ResearchConceptsMyelin oligodendrocyte glycoproteinMultiple sclerosisMyelin oligodendrocyte glycoprotein-antibody testingClinical phenotypeConus medullaris involvementUnder-recognized entityProportion of patientsSteroid-dependentMedullary involvementOligodendrocyte glycoproteinMOGADRadiological manifestationsRecurrent episodesTherapeutic responseDisease courseAntibody seropositivityUnder-recognizedPatientsAntibody testMyelitisSclerosisSeropositivityMyelinManifestationsPhenotype