Expression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma
Xu X, Jin K, Xu X, Yang Y, Zhou B. Expression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma. The Journal Of Gene Medicine 2024, 26: e3735. PMID: 39171952, DOI: 10.1002/jgm.3735.Peer-Reviewed Original ResearchConceptsCell cycle-associated genesLung squamous carcinomaCell cycleMRNA expression dataGene expression profilesAssociated with positive prognosisCause of cancer-related deathExpression dataCancer Genome AtlasExpressed genesSquamous cell carcinomaLung squamous cell carcinomaTargeted therapy trialsGroup of patientsCancer-related deathsExpression of CDK4GenesExpression trendsExpression profilesMolecular studiesGenome AtlasSquamous carcinomaCell carcinomaPathological stagePrognostic valueCGMega: explainable graph neural network framework with attention mechanisms for cancer gene module dissection
Li H, Han Z, Sun Y, Wang F, Hu P, Gao Y, Bai X, Peng S, Ren C, Xu X, Liu Z, Chen H, Yang Y, Bo X. CGMega: explainable graph neural network framework with attention mechanisms for cancer gene module dissection. Nature Communications 2024, 15: 5997. PMID: 39013885, PMCID: PMC11252405, DOI: 10.1038/s41467-024-50426-6.Peer-Reviewed Original ResearchAn emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria
Chen L, Kang Z, Shen J, Zhao R, Miao Y, Zhang L, Zheng Z, Zhang Z, Liu N, Wang C, Fang H, Zhou J, Wang Y, Liu Z, Yang Y, Chen Q. An emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria. Science Bulletin 2024, 69: 2565-2579. PMID: 38918142, DOI: 10.1016/j.scib.2024.06.016.Peer-Reviewed Original ResearchConceptsF. nucleatumColorectal cancerEffective antigen presentationEnhance chemotherapy efficacyT cell activationReduce cancer metastasisPoor treatment outcomesIncreased cancer cell growthCancer cell growthOral anaerobesDendritic cellsFusobacterium nucleatumChemotherapy efficacyAntitumor effectAntigen presentationBiomimetic nanovaccinesEnhanced chemotherapyNanovaccineAlum adjuvantCpG oligonucleotidesTreatment outcomesImmune responseImmune progressionTherapeutic effectVaccine effectiveness