Yang Yang
Research Associate NeurosurgeryCards
About
Research
Publications
2024
An Efficient Prototype-Based Clustering Approach for Edge Pruning in Graph Neural Networks to Battle Over-Smoothing
Huang Y, Lu W, Yang Y. An Efficient Prototype-Based Clustering Approach for Edge Pruning in Graph Neural Networks to Battle Over-Smoothing. 2024, 4201-4209. DOI: 10.24963/ijcai.2024/464.Peer-Reviewed Original ResearchGraph neural networksOver-smoothingNeural networkIssue of over-smoothingIntra-class edgesEmbeddings of nodesGroup of nodesGNNs’ performanceNode representationsSupervision signalsClass labelsPreserving smoothingInter-classEfficient clusteringEdge pruningGraph structureDiverse graphsClustering approachTopology augmentationGraphNodesEnhanced accuracyNetworkAccuracyScalabilityModulated Cell Internalization Behavior of Icosahedral DNA Framework with Programmable Surface Modification
Huang K, Yang Q, Bao M, Wang S, Zhao L, Shi Q, Yang Y. Modulated Cell Internalization Behavior of Icosahedral DNA Framework with Programmable Surface Modification. Journal Of The American Chemical Society 2024 PMID: 39038211, DOI: 10.1021/jacs.4c04106.Peer-Reviewed Original ResearchSpatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants
Yang Y, Zhang J, Xu Y, Chen M, Wang S, Lin G, Huang Y, Yang C, Song Y. Spatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants. Angewandte Chemie International Edition 2024, e202412294. PMID: 39030890, DOI: 10.1002/anie.202412294.Peer-Reviewed Original ResearchNanoparticle vaccineReceptor-binding domainHeterotypic antigensBroad-spectrum neutralizing antibodiesSARS-CoV-2 spike trimerVaccine-induced immunityNanotechnology-based strategiesEnhanced immune activationOmicron receptor-binding domainMosaic vaccinesImmune activationSystematic in vitroNeutralizing antibodiesSARS-CoV-2 variantsMosaic nanoparticlesImmunological investigationsExcessive inflammationAntigen distributionAntigenSpike trimerRBD antigenSARS-CoV-2DNAVaccineAntiviral capabilitiesSpatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants
Yang Y, Zhang J, Xu Y, Chen M, Wang S, Lin G, Huang Y, Yang C, Song Y. Spatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants. Angewandte Chemie 2024 DOI: 10.1002/ange.202412294.Peer-Reviewed Original ResearchNanoparticle vaccineReceptor-binding domainHeterotypic antigensBroad-spectrum neutralizing antibodiesSARS-CoV-2 spike trimerVaccine-induced immunityNanotechnology-based strategiesEnhanced immune activationOmicron receptor-binding domainMosaic vaccinesImmune activationSystematic in vitroNeutralizing antibodiesSARS-CoV-2 variantsMosaic nanoparticlesImmunological investigationsExcessive inflammationAntigen distributionAntigenSpike trimerRBD antigenSARS-CoV-2DNAVaccineAntiviral capabilitiesPassing Behavior of Oligonucleotides through a Stacked DNA Nanochannel with Featured Path Design
Zhang R, Xiang Y, Yang Y. Passing Behavior of Oligonucleotides through a Stacked DNA Nanochannel with Featured Path Design. Journal Of The American Chemical Society 2024, 146: 17122-17130. PMID: 38861703, DOI: 10.1021/jacs.4c02734.Peer-Reviewed Original ResearchFusobacterium nucleatum-mimicking nanovehicles to overcome chemoresistance for breast cancer treatment by eliminating tumor-colonizing bacteria
Chen L, Shen J, Kang Z, Zhang Z, Zheng Z, Zhang L, Xiao Z, Zhang Q, Fang H, Zhou J, Wang Y, Yang Y, Liu Z, Chen Q. Fusobacterium nucleatum-mimicking nanovehicles to overcome chemoresistance for breast cancer treatment by eliminating tumor-colonizing bacteria. Chem 2024, 10: 1783-1803. DOI: 10.1016/j.chempr.2024.01.030.Peer-Reviewed Original ResearchBreast cancerRegression of established tumorsLung metastasis of breast cancerMetastasis of breast cancerBroad-spectrum antibioticsBreast cancer treatmentBreast cancer chemotherapyEstablished tumorsIntratumoral microbiomeF. nucleatumLung metastasesChemotherapy efficacyOvercome chemoresistanceCancer therapyPromote chemoresistanceCancer chemotherapyCancer treatmentBreastCancerDrug delivery carriersTumorChemoresistanceDelivery carriersNanovehiclesEfficacyDopamine D1 Receptor Agonists Rescue Age-related Decline in Temporal Order Memory
Bransom L, Bassett A, Zhou M, Cimino J, Mailman R, Yang Y. Dopamine D1 Receptor Agonists Rescue Age-related Decline in Temporal Order Memory. Neuroscience 2024, 551: 177-184. PMID: 38823551, PMCID: PMC11246218, DOI: 10.1016/j.neuroscience.2024.05.033.Peer-Reviewed Original ResearchTemporal order memoryOrder memoryAge-related declineDopamine D1 receptor agonistTreating age-related cognitive declineAge-related cognitive declineReceptor agonistsSpatial working memoryD1 receptor agonistPoorer memory performanceWorking memoryMemory performanceCognitive declineEffects of ageRecognition taskEffect sizeIndividual ratsMemoryOld ratsOptimal effective doseDopamineImproved therapeutic indexAgonistsTherapeutic indexFunctional selectivityTherapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses
Yang Y, Li F, Du L. Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses. Journal Of Nanobiotechnology 2024, 22: 304. PMID: 38822339, PMCID: PMC11140877, DOI: 10.1186/s12951-024-02573-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, NeutralizingAntibodies, ViralBetacoronavirusCoronavirus InfectionsCOVID-19HumansMiddle East Respiratory Syndrome CoronavirusPandemicsPneumonia, ViralSARS-CoV-2Severe acute respiratory syndrome-related coronavirusSingle-Domain AntibodiesSpike Glycoprotein, CoronavirusVirus InternalizationConceptsReceptor-binding domainPathogenic human CoVsHeavy-chain antibodiesSARS-CoV-2Development of nanobiotechnologiesPathogenic human coronavirusesSingle-domain antibodiesSARS-CoV-2 variantsS proteinViral entry processHuman CoVsViral spikeReemerging pathogensEvaluation of therapeutic agentsSARS-CoVVirus pathogenesisVariable domainsNanobodiesViral structuresPandemic potentialMERS-CoVPathogenic coronavirusesViral entryBinding affinityHuman coronavirusesSpectroscopic Quantification of the Inverted Singlet–Triplet Gap in Pentaazaphenalene
Wilson K, Styers W, Wood S, Woods R, McMahon R, Liu Z, Yang Y, Garand E. Spectroscopic Quantification of the Inverted Singlet–Triplet Gap in Pentaazaphenalene. Journal Of The American Chemical Society 2024, 146: 15688-15692. PMID: 38815061, DOI: 10.1021/jacs.4c05043.Peer-Reviewed Original ResearchSinglet-triplet gapComputational electronic structure methodsInverted singlet-triplet gapAnion photoelectron spectroscopyExcited singlet stateDouble excitation characterElectronic structure methodsHund's multiplicity ruleVisible absorption spectroscopySpectroscopic quantificationArgon matrixLowest singletTriplet stateOrganic chromophoresSinglet stateExcitation characterAbsorption spectroscopyElectronic statesPhotoelectron spectroscopyStructure methodsSpectroscopyAccurate quantificationChromophoreSingletQuantificationMicroglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
Wu J, Zhang J, Chen X, Wettschurack K, Que Z, Deming B, Olivero-Acosta M, Cui N, Eaton M, Zhao Y, Li S, Suzuki M, Chen I, Xiao T, Halurkar M, Mandal P, Yuan C, Xu R, Koss W, Du D, Chen F, Wu L, Yang Y. Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids. Molecular Psychiatry 2024, 1-14. PMID: 38499656, DOI: 10.1038/s41380-024-02518-4.Peer-Reviewed Original ResearchAutism spectrum disorderSpine densityAssociated with autism spectrum disorderLower spine densitySynaptic transmissionHuman cellsPost-synapseProtein-truncating mutationsNeurodevelopmental disorder affecting 1Phagocytosis of synapsesNeuro-immune responsesImpaired learningIntellectual disabilityNeuro-immune interactionsHuman genetic studiesRestoring synaptic transmissionReduced synaptic transmissionAblation of microgliaSpectrum disorderResident immune cellsHuman cerebral organoid modelCerebral organoidsBrain developmentCerebral organoid modelSCN2A mutations