Yael Korem Kohanim
Postdoctoral AssociateAbout
Research
Publications
2025
Unifying regulatory motifs in endocrine circuits
Raz M, Glass D, Milo T, Korem Kohanim Y, Karin O, Tendler A, Mayo A, Alon U. Unifying regulatory motifs in endocrine circuits. Nature Communications 2025, 16: 11017. PMID: 41271754, PMCID: PMC12695981, DOI: 10.1038/s41467-025-65924-4.Peer-Reviewed Original ResearchTranscriptomic profiling of shed cells enables spatial mapping of cellular turnover in human organs
Barkai T, Yakubovsky O, Korem Kohanim Y, Bahar Halpern K, Shir S, Oren N, Fine M, Kelmer P, Talmon A, Israeli A, Pencovich N, Pery R, Nachmany I, Itzkovitz S. Transcriptomic profiling of shed cells enables spatial mapping of cellular turnover in human organs. Molecular Systems Biology 2025, 21: 1778-1792. PMID: 41039079, PMCID: PMC12673112, DOI: 10.1038/s44320-025-00154-w.Peer-Reviewed Original ResearchConceptsSingle-cell atlasTranscriptome profilingGene expression statesTurnover rateHuman large intestineExpression atlasTranscriptome dataExpression statesRNA sequencingShed cellsTurnover patternsCellular dynamicsExpression profilesIndividual cellsCellular turnoverFecal washesCellsCell birthTurnoverExpressionGenesRNAGastrointestinal tractOrganizationPro-inflammatory microenvironmentPregnancy and postpartum dynamics revealed by millions of lab tests
Bar A, Moran R, Mendelsohn-Cohen N, Korem Kohanim Y, Mayo A, Toledano Y, Alon U. Pregnancy and postpartum dynamics revealed by millions of lab tests. Science Advances 2025, 11: eadr7922. PMID: 40138427, PMCID: PMC11939066, DOI: 10.1126/sciadv.adr7922.Peer-Reviewed Original ResearchConceptsPhysiology of pregnancyFiltration ratePregnancyWeeks preconceptionCross-sectional analysisWeeks postpartumBlood volumePreconception supplementationRenal filtration ratePostpartumSystem physiologyWeekly intervalsDynamic alterationsWeeksDeliveryPhysiological loadingLab testsPreeclampsiaPhysiological systemsChildbirthDiabetes
2024
A spatial expression atlas of the adult human proximal small intestine
Harnik Y, Yakubovsky O, Hoefflin R, Novoselsky R, Bahar Halpern K, Barkai T, Korem Kohanim Y, Egozi A, Golani O, Addadi Y, Kedmi M, Keidar Haran T, Levin Y, Savidor A, Keren-Shaul H, Mayer C, Pencovich N, Pery R, Shouval D, Tirosh I, Nachmany I, Itzkovitz S. A spatial expression atlas of the adult human proximal small intestine. Nature 2024, 632: 1101-1109. PMID: 39112711, DOI: 10.1038/s41586-024-07793-3.Peer-Reviewed Original ResearchConceptsExpression atlasSingle-molecule fluorescence in situ hybridizationLipid droplet assemblyAdult human gutFluorescence in situ hybridizationHuman proximal small intestineHuman small intestineHuman gutSpatial proteomicsProximal small intestineTip cellsGene expressionSmall intestineIron uptakeSpatial transcriptomicsVillus tip cellsImmune cell typesMouse small intestineCell typesDroplet assemblyImmunosuppressive rolePro-immunogenicAdult human small intestineT cellsZonated expressionPopulation data evidence of interdependence of the limbs of hormonal feedback loops.
Fitzgerald S, Bean N, Falhammar H, Hoermann R, Korem Kohanim Y, Pohlabeln H, Grote Beverborg N, Tomassetti S. Population data evidence of interdependence of the limbs of hormonal feedback loops. Journal Of Endocrinology 2024, 262 PMID: 38727510, DOI: 10.1530/joe-23-0384.Peer-Reviewed Original Research
2023
Tradeoffs in bacterial physiology determine the efficiency of antibiotic killing
Bren A, Glass D, Kohanim Y, Mayo A, Alon U. Tradeoffs in bacterial physiology determine the efficiency of antibiotic killing. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2312651120. PMID: 38096408, PMCID: PMC10742385, DOI: 10.1073/pnas.2312651120.Peer-Reviewed Original ResearchConceptsMinimal inhibitory concentrationBacterial physiologyCyclic adenosine monophosphateImprove antibiotic efficacyGrowth rateHigh-throughput assayEnvironmental conditionsRNA-seqAntibiotic killingAntibiotic actionBacterial deathAntibiotic efficacyInhibitory concentrationAntibiotic effectBactericidal activityGrowth conditionsCyclic adenosine monophosphate levelsAdenosine monophosphatePhysiological propertiesPhysiologyGrowthNonstress environmentsAssayDeathAntibioticsThe cellular states and fates of shed intestinal cells
Bahar Halpern K, Korem Kohanim Y, Biram A, Harnik Y, Egozi A, Yakubovsky O, Shulman Z, Itzkovitz S. The cellular states and fates of shed intestinal cells. Nature Metabolism 2023, 5: 1858-1869. PMID: 37857731, DOI: 10.1038/s42255-023-00905-9.Peer-Reviewed Original ResearchAutoimmune thyroid diseases as a cost of physiological autoimmune surveillance
Milo T, Korem Kohanim Y, Toledano Y, Alon U. Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance. Trends In Immunology 2023, 44: 365-371. PMID: 37061365, DOI: 10.1016/j.it.2023.03.007.Peer-Reviewed Original ResearchConceptsGraves' diseaseHashimoto's thyroiditisT cellsAutoimmune surveillanceAutoreactive T cellsAutoimmune thyroid diseaseToxic nodulesThyroid antigensThyroid diseaseClinical manifestationsProduction of antibodiesAutoimmune diseasesClinical phenotypeThyroid glandHumoral responseMutant cellsRisk factorsThyroidSusceptible individualsDiseasePhysiological processes
2022
Dynamics of thyroid diseases and thyroid‐axis gland masses
Korem Kohanim Y, Milo T, Raz M, Karin O, Bar A, Mayo A, Mendelson Cohen N, Toledano Y, Alon U. Dynamics of thyroid diseases and thyroid‐axis gland masses. Molecular Systems Biology 2022, 18: msb202210919. PMID: 35938225, PMCID: PMC9358402, DOI: 10.15252/msb.202210919.Peer-Reviewed Original ResearchConceptsThyroid disordersThyroid hormonesSerum thyroid stimulating hormone (TSHThyroid-stimulating hormone (TSHTreatment of thyroid disordersLifelong hormone replacementTreat thyroid disordersPeripheral thyroid hormonesHormone replacementGraves' diseaseHashimoto's thyroiditisThyroid diseaseGland massPituitary glandClinical stateThyroidThyroid axisMedical recordsTSHAtrophied glandsHormoneLife yearsDisordersGlandWeeks
2021
Controls for Phylogeny and Robust Analysis in Pareto Task Inference
Adler M, Tendler A, Hausser J, Korem Y, Szekely P, Bossel N, Hart Y, Karin O, Mayo A, Alon U. Controls for Phylogeny and Robust Analysis in Pareto Task Inference. Molecular Biology And Evolution 2021, 39: msab297. PMID: 34633456, PMCID: PMC8763096, DOI: 10.1093/molbev/msab297.Peer-Reviewed Original Research