Yifan Wang, MD, MS
Hospital ResidentCards
About
Research
Publications
2024
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells
Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong S, Link T, Gallup T, Qie Y, Li X, Dong S, Schrank B, Grippin A, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong A, Tainer J, Jiang W, Kim B. Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells. Nature Biomedical Engineering 2024, 8: 593-610. PMID: 38641710, PMCID: PMC11162332, DOI: 10.1038/s41551-024-01194-7.Peer-Reviewed Original ResearchAntigen-presenting cellsInnate immune pathwaysImmune pathwaysPriming of effector T cellsImmune checkpoint inhibitorsAntitumour immune responseEffector T cellsIntracellular DNA-sensing pathwaysMetastatic breast cancerSyngeneic mouse modelMultiple innate immune pathwaysAdaptive immunogenicityAntitumour responseCheckpoint inhibitorsEndoplasmic reticulum stressT cellsSystemic clearanceBreast cancerDNA-sensing pathwayRelease of mitochondrial DNATherapeutic advantageMouse modelImmune responseEfficient primingIntracellular deliveryPlasma MERTK Is a Promising Biomarker for the Diagnosis and Prognosis of Hepatitis B Virus–Related Acute-on-Chronic Liver Failure
Lu Y, Xin J, Liang X, Luo J, Li P, Zhou X, Yang H, Li J, Wang Y. Plasma MERTK Is a Promising Biomarker for the Diagnosis and Prognosis of Hepatitis B Virus–Related Acute-on-Chronic Liver Failure. The Journal Of Infectious Diseases 2024, jiae079. PMID: 38373244, DOI: 10.1093/infdis/jiae079.Peer-Reviewed Original ResearchHBV-ACLF patientsChronic hepatitis BAcute-on-chronic liver failureMer tyrosine kinaseHBV-ACLFArea under the receiver operating characteristic curveNormal controlsLiver failureLiver cirrhosisHBV-related acute-on-chronic liver failurePrognosis of HBV-ACLFHepatitis B-related acute-on-chronic liver failureRisk stratification analysesReceiver operating characteristic curveCut-off valueShort-term mortalityPrognostic rolePrognostic significancePrognostic valueHepatitis BPoor prognosisMerTK expressionImmunohistochemistry stainingDiagnostic accuracyDisease progression
2023
Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity.
Li X, Huntoon K, Wang Y, Lee D, Dong S, Antony A, Walkey C, Kim B, Jiang W. Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity. Molecular Cancer Therapeutics 2023, 23: 330-342. PMID: 37956421, DOI: 10.1158/1535-7163.mct-23-0236.Peer-Reviewed Original ResearchTumor growth inhibitionDendritic cellsAnti-PD-1 checkpoint inhibitorsAntigen-specific T cellsIL-2/ILGreater tumor infiltrationImmune stimulatory mechanismsMurine breast cancer modelAntitumor immune responseCombination of radiotherapyInnate immune activationType I interferon productionImmune-modulatory propertiesIL-15 receptorBreast cancer modelI interferon productionSuperior tumor growth inhibitionGrowth inhibitionInterferon genes (STING) pathwaySystemic immunotherapyWestern blot analysisCheckpoint inhibitorsMetastatic settingAntitumor immunitySurvival benefitAge-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics
Wang Y, Deng W, Lee D, Yan L, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank B, Ha J, Kang M, Yang M, Gong P, Lorenzi P, Tan L, Gallup T, Tang S, Yang Z, Li J, Sanford N, Wang H, Kim B, Jiang W. Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics. Nature Nanotechnology 2023, 19: 255-263. PMID: 37723279, DOI: 10.1038/s41565-023-01502-3.Peer-Reviewed Original ResearchConceptsCancer nanotherapeuticsCancer nanomedicineScavenger receptor MARCOPhagocytic clearanceUptake of nanoparticlesAntitumour responseTumor deliveryTherapeutic blockadeAntitumour efficacyAge-associated decreaseHepatic phagocytesAntitumour effectsYoung miceHepatic macrophagesAged miceTreatment outcomesTreat multiple human diseasesProtein level analysisHepatic uptakeAge-related declineNon-human primatesNanotherapeuticsMiceNanomedicinePhagocytic uptake
2022
Conjugation of Listeriolysin O to Anti-CD47 mAb: Harnessing Listeria Toxin to Weaponize Macrophages against Tumor Cells
Schrank B, Wang Y, Jiang W. Conjugation of Listeriolysin O to Anti-CD47 mAb: Harnessing Listeria Toxin to Weaponize Macrophages against Tumor Cells. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: s42. DOI: 10.1016/j.ijrobp.2022.07.408.Peer-Reviewed Original ResearchAnti-CD47 mAbBone marrow-derived macrophagesTumor cell phagocytosisMarrow-derived macrophagesAntigen presentationTumor cellsIntratumoral injectionWildtype miceCGAS-STING activationCell phagocytosisNon-Hodgkin's lymphomaCell line MDA-MB-468Hematopoietic tumor cellsMonocytic cell line THP-1Treatment of malignanciesMouse bone marrow-derived macrophagesBreast cancer cell line MDA-MB-468Cell line THP-1Suppressed tumor growthListeriolysin O toxinMacrophage-mediated phagocytosisBlood cell countHuman breast cancer cell line MDA-MB-468Dose-dependent mannerListeriolysin OMechanistic insights on cytotoxicity of KOLR, Cinnamomum pauciflorum Nees leaf derived active ingredient, by targeting signaling complexes of phosphodiesterase 3B and rap guanine nucleotide exchange factor 3
Li M, Li F, Chen J, Su H, Chen G, Cao J, Li J, Dong L, Yu Z, Wang Y, Zhou C, Zhu Y, Wei Q, Li Q, Chai K. Mechanistic insights on cytotoxicity of KOLR, Cinnamomum pauciflorum Nees leaf derived active ingredient, by targeting signaling complexes of phosphodiesterase 3B and rap guanine nucleotide exchange factor 3. Phytotherapy Research 2022, 36: 3540-3554. PMID: 35703011, DOI: 10.1002/ptr.7521.Peer-Reviewed Original Research