Yifan Wang, MD, MS
Hospital ResidentCards
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Research
Publications
2026
Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma
Ha J, Wang Y, Ma Y, Wu A, Dong S, Jeong S, Edwards J, Chang M, Chang Y, Wang X, Dufilho M, Najarro Torres M, McCabe S, Deng W, Grippin A, Weinberg J, Raza S, DeMonte F, McCutcheon I, Prabhu S, Ferguson S, Ene C, Akdemir K, Basu S, Jindal S, Schrank B, Hu J, Goswami S, Puduvalli V, Lang F, Huntoon K, Sharma P, Kim B, Jiang W. Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma. Nature Communications 2026 PMID: 41803138, DOI: 10.1038/s41467-026-70221-9.Peer-Reviewed Original ResearchCyclic GMP-AMP synthase-stimulatorMacrophage-mediated phagocytosisPro-phagocytic activityMacrophage-mediated phagocytosis of tumor cellsMouse modelTumor antigen cross-presentationPhagocytosis of tumor cellsMouse model of glioblastomaAnti-PD1 therapyT cell infiltrationMurine GBM modelAntigen Cross-PresentationInnate immune activationInsufficient therapeutic outcomeModels of glioblastomaActivation of macrophagesImmunosuppressive tumorsCheckpoint blockadeAntitumor immunityCancer immunotherapyCross-PresentationImmune surveillanceSurvival outcomesImmune activationTumor cellsCorrection: Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis
Deng J, Hu M, Meng X, Wang T, Wang Y, Chen X, Xu D, He W, Zhang H, Guo W, Jing B, Zhang S, Xu J, Sun B, Sun X, Liu T, Ni N, Zhang T, Cui W, Wu X, Xia L, Yao F, Zhang F, Du J. Correction: Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis. Journal Of Cancer Research And Clinical Oncology 2026, 152: 49. PMID: 41701369, PMCID: PMC12913850, DOI: 10.1007/s00432-026-06433-9.Peer-Reviewed Original ResearchImmediate and long-term effects of orbitofrontal cortex stimulation on EEG microstates in schizophrenia
Zhang K, Hu Q, Zhang Y, Zeng N, Wang M, Li K, Wang Z, Sun J, Wang J, Jiao X. Immediate and long-term effects of orbitofrontal cortex stimulation on EEG microstates in schizophrenia. Translational Psychiatry 2026, 16: 56. PMID: 41577665, PMCID: PMC12873162, DOI: 10.1038/s41398-026-03810-3.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationOrbitofrontal cortexMicrostate CEEG microstatesOrbitofrontal cortex stimulationMicrostate DActive rTMS groupLong-term effectsElectrophysiological impactRepetitive transcranial magnetic stimulation sessionsHealthy controlsResting-state EEG recordingsLong-term therapeutic responseTranscranial magnetic stimulationSchizophreniaExploratory subgroup analysisLong-term modulationRTMS groupCourse of treatmentMicrostate analysisBrain dynamicsSham stimulationClinical respondersEEG responsesTherapeutic responseFACS-based genome-wide CRISPR screening platform identifies modulators of CD47
Yin L, He W, Wang Y, Zhang H, Huang M, Yan Y, Li S, Feng X, Saenz F, Zhang J, Zhu D, Yang C, Ma T, Fu J, Chen J. FACS-based genome-wide CRISPR screening platform identifies modulators of CD47. Frontiers In Immunology 2026, 16: 1684539. PMID: 41601654, PMCID: PMC12832931, DOI: 10.3389/fimmu.2025.1684539.Peer-Reviewed Original ResearchConceptsTumor cellsSurface expressionInnate immune checkpointImmune checkpoint pathwaysMacrophage-mediated clearanceSusceptible to phagocytosisInnate immune evasionCo-culture assayCD47 blockadeCRISPR screensGenetic regulationTumor burdenImmune checkpointsBreast carcinomaCD47 expressionRegulation of CD47Genome-wide CRISPR screenImmune evasionColon adenocarcinomaCD47Cell linesCo-CultureAnalysis of cellsTumorCheckpoint pathway
2025
Sunlight PDT leveraging NIR-II nanospray: painless, hemostatic, anti-inflammatory therapy towards diabetic wound infections
Ding Q, Zhou L, Xiong T, Liu J, Chen L, Yoo J, Xu X, Jia X, Chen S, Chen S, Wang Y, Gong P, Gu M, Jiang W, Kim J. Sunlight PDT leveraging NIR-II nanospray: painless, hemostatic, anti-inflammatory therapy towards diabetic wound infections. National Science Review 2025, 13: nwaf554. PMID: 41608042, PMCID: PMC12839536, DOI: 10.1093/nsr/nwaf554.Peer-Reviewed Original ResearchReactive oxygen speciesPhotodynamic therapyTreatment-associated painSuboptimal therapeutic efficacyDiabetic wound infectionAnti-inflammatory therapyConventional photodynamic therapyResource-limited settingsRisk of scarringRecurrent infectionsTarget pathogensActivation of photosensitizersDiabetic wound careWound infectionWound managementTherapeutic efficacyPatient complianceSystemic phototoxicityROS generationManagement of diabetic woundsClinical utilityLimitation of conventional photodynamic therapyScar formationAntimicrobial actionWound closureSARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade
Grippin A, Marconi C, Copling S, Li N, Braun C, Woody C, Young E, Gupta P, Wang M, Wu A, Jeong S, Soni D, Weidert F, Xie C, Goldenberg E, Kim A, Zhao C, DeVries A, Castillo P, Lohray R, Rooney M, Schrank B, Wang Y, Ma Y, Chang E, Kouzy R, Dyson K, Jafarnia J, Nariman N, Gladish G, New J, Argueta A, Amaya D, Thomas N, Doty A, Chen J, Copling N, Alatrash G, Simon J, Davies A, Dennis W, Liang R, Lewis J, Wei X, Rinsurongkawong W, Vaporciyan A, Johns A, Lee J, Lee J, Sun R, Sharma P, Tran H, Zhang J, Gibbons D, Wargo J, Kim B, Heymach J, Mendez-Gomez H, Jiang W, Sayour E, Lin S. SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade. Nature 2025, 647: 488-497. PMID: 41125896, PMCID: PMC12611756, DOI: 10.1038/s41586-025-09655-y.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsSARS-CoV-2 mRNA vaccinesPD-L1 expressionImmunologically cold tumorsMRNA vaccinesType I interferonPD-L1Cold tumorsSARS-CoV-2Sensitizing tumors to immune checkpoint inhibitorsTumors to immune checkpoint blockadeThree-year overall survivalCD8+ T cellsI interferonImmune checkpoint blockadeTumor-associated antigensMRNA cancer vaccinesInnate immune cellsCheckpoint blockadeCheckpoint inhibitorsICI treatmentCancer vaccinesOverall survivalPersonalized vaccinesPreclinical modelsImbalance of habit-based versus goal-directed learning in internet gaming disorder: evidence from fMRI and behavioral performance
Zheng H, Ma X, Wang M, Wang Z, Lu C, Dong G. Imbalance of habit-based versus goal-directed learning in internet gaming disorder: evidence from fMRI and behavioral performance. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2025, 142: 111524. PMID: 41086991, DOI: 10.1016/j.pnpbp.2025.111524.Peer-Reviewed Original ResearchConceptsInternet gaming disorderRecreational game usersInferior frontal gyrusBehavioral performanceFrontal gyrusGaming disorderMaintenance of addictive behaviorsLeft inferior frontal gyrusRight inferior frontal gyrusInternet gaming disorder groupPrefrontal-striatal circuitsInstrumental learning taskInstrumental learning processesLeft precentral gyrusAddiction severity scoresGoal-directed actionsGoal-directed learningBilateral lingual gyrusFunctional MRI dataNeurocognitive mechanismsAddiction severityHabitual controlAddictive behaviorsBilateral precuneusLingual gyrusTherapeutic restoration of mitochondria–endoplasmic reticulum cross talk for osteoarthritis
Hou M, Ma Y, Deng Y, Wu Y, Zhu Y, Liu Y, Li X, Yu L, He Z, Wang Y, Dong S, Xia X, Yu J, Yu C, Kang K, Lu Y, Sun L, Kim B, Yuan Y, Zhang Y, Jiang W, Zhu X. Therapeutic restoration of mitochondria–endoplasmic reticulum cross talk for osteoarthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2426992122. PMID: 40892916, PMCID: PMC12435279, DOI: 10.1073/pnas.2426992122.Peer-Reviewed Original ResearchConceptsMitochondrial functionSirtuin 3Regulation of mitochondrial functionImpaired mitochondrial functionMitochondrial dynamicsCellular homeostasisER stressMfn2Calcium ion balanceMitochondrial dysfunctionCross-talkMfn2 mRNAExtracellular vesiclesCartilage degenerationTherapeutic targetTherapeutic restorationHomeostasisIon balanceReticulumExploring the heterogeneity of internet gaming disorder: a stage-based framework characterized by evolving euphoria and compulsivity
Kang M, Xu L, Zhang J, Song K, Wang Z, Fang X, Bowden-Jones H, Pallanti S, Zhang J. Exploring the heterogeneity of internet gaming disorder: a stage-based framework characterized by evolving euphoria and compulsivity. Addictive Behaviors 2025, 171: 108457. PMID: 40902308, DOI: 10.1016/j.addbeh.2025.108457.Peer-Reviewed Original ResearchConceptsInternet gaming disorderCross-sectional definitionsPsychometric propertiesInternet gaming disorder symptomsInternet Gaming Disorder ScaleMeasures of cravingClinical staging approachLatent profile analysisLatent transition analysisOne-year stabilityDSM-5Disorder ScaleICD-11Factor structureGaming disorderCore phenotypeLife satisfactionCompulsionStratified interventionsEuphoriaTransition analysisYoung adultsProfile analysisDisordersCravingEfficacy of traditional Chinese medicine prescription in treatment of COVID-19: A prospective cohort study
Huang F, Zhou Y, Jiang C, Wang Y, Cheng J, Lin X, Chen L, Peng C, Pan G, Chen X, Yin L, Chai K. Efficacy of traditional Chinese medicine prescription in treatment of COVID-19: A prospective cohort study. Medicine 2025, 104: e43285. PMID: 40696615, PMCID: PMC12282704, DOI: 10.1097/md.0000000000043285.Peer-Reviewed Original ResearchConceptsDays 2 to 4Prospective cohort studyClinical symptomsDays 0 to 1TCM groupConventional treatmentCohort studyPoor appetiteMulticenter prospective cohort studyDays 6 to 8Symptoms of feverMann-Whitney U testClinical symptoms of COVID-19TCM prescriptionsSymptoms of COVID-19Treatment regimensCOVID-19 inpatientsCOVID-19Treatment of COVID-19Treatment of coronavirus diseaseMann-WhitneyU testPrescriptionControl groupChinese medicine prescription
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