William Tyler Frantz, MD, PhD
Hospital ResidentCards
About
Research
Publications
2024
The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in cystic epithelial cells revealing a potential new target for polycystic kidney disease
Smith A, Frantz W, Preval K, Edwards Y, Ceol C, Jonassen J, Pazour G. The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in cystic epithelial cells revealing a potential new target for polycystic kidney disease. PLOS Genetics 2024, 20: e1011510. PMID: 39666736, PMCID: PMC11670935, DOI: 10.1371/journal.pgen.1011510.Peer-Reviewed Original ResearchConceptsTumor-associated calcium signal transducer 2Polycystic kidney diseaseKidney diseaseNormal tissuesPolycystic kidney disease patientsDelivery of cytotoxic drugsCyst initiationCystic epithelial cellsCyst lining cellsNormal kidney cellsSingle cell transcriptomics dataAntibody drug conjugatesCell transcriptome dataHuman tissue biopsiesPotential new targetsUrothelial cancerRelevance to human diseaseSolid tumorsCytotoxic drugsTreatment optionsTissue biopsiesHealthy controlsDisease progressionCystic transformationEpithelial cellsBlockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis.
Rozen E, Frantz W, Wigglesworth K, Vessella T, Zhou H, Shohet J. Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis. Molecular Cancer Therapeutics 2024, 23: 1124-1138. PMID: 38670553, DOI: 10.1158/1535-7163.mct-23-0741.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factor receptor alphaAnaplastic lymphoma kinaseDiscoidin domain receptor 2Proto-oncogeneTumor modelTumor developmentDiscoidin domain receptor 2 expressionActivity of discoidin domain receptor 2Growth factor receptor alphaTH-MYCN transgenic miceSyngeneic tumor modelsEvent free survivalHigh-risk diseaseDecreased overall survivalDrivers of tumor growthRET proto-oncogeneN-myc proto-oncogeneDDR signalingOn-target inhibitionKIT proto-oncogeneMET proto-oncogeneReduced cell proliferationOverall survivalMigration in vitroPediatric neuroblastoma
2023
Tumor-Associated Calcium Signal Transducer 2 (Tacstd2) Expression Is Increased in Early Polycystic Kidney Disease
Smith A, Frantz W, Preval K, Edwards Y, Jonassen J, Pazour G. Tumor-Associated Calcium Signal Transducer 2 (Tacstd2) Expression Is Increased in Early Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2023, 34: 562-562. DOI: 10.1681/asn.20233411s1562a.Peer-Reviewed Original ResearchPigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish
Frantz W, Iyengar S, Neiswender J, Cousineau A, Maehr R, Ceol C. Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish. ELife 2023, 12: e78942. PMID: 37021774, PMCID: PMC10139689, DOI: 10.7554/elife.78942.Peer-Reviewed Original ResearchConceptsProgenitor cellsMelanocyte regenerationHair follicle bulgeMelanocyte lineage cellsNon-hematopoietic tissuesTissue-resident stemResponse to injuryIntermediate cell statesMelanocyte destructionFollicle bulgeKIT signalingLineage cellsDevelopmental signalsPigmented melanocytesAsymmetric divisionTranscriptional signatureTranscriptional changesRAS/MAPK pathwayMelanocyte progenitorsCellular transitionsCell statesMelanocytesZebrafish skinOrgan homeostasisHypopigmentation disorders
2022
Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease
Frantz W, Ceol C. Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease. Journal Of Investigative Dermatology 2022, 142: 499-506.e1. PMID: 35184798, DOI: 10.1016/j.jid.2021.10.016.Peer-Reviewed Original Research
2021
Working together: Heterotypic clusters and collective cell migration in melanoma metastasis
Frantz W, Ceol C. Working together: Heterotypic clusters and collective cell migration in melanoma metastasis. Developmental Cell 2021, 56: 2783-2784. PMID: 34699785, DOI: 10.1016/j.devcel.2021.10.003.Peer-Reviewed Original Research524 BMP signaling is active in early melanoma lesions and promotes melanoma development
Gramann A, Frantz W, Dresser K, Gomes C, Lian C, Deng A, Ceol C. 524 BMP signaling is active in early melanoma lesions and promotes melanoma development. Journal Of Investigative Dermatology 2021, 141: s91. DOI: 10.1016/j.jid.2021.02.550.Peer-Reviewed Original ResearchBMP Signaling Promotes Neural Crest Identity and Accelerates Melanoma Onset
Gramann A, Frantz W, Dresser K, Gomes C, Lian C, Deng A, Ceol C. BMP Signaling Promotes Neural Crest Identity and Accelerates Melanoma Onset. Journal Of Investigative Dermatology 2021, 141: 2067-2070.e1. PMID: 33610560, DOI: 10.1016/j.jid.2021.01.021.Peer-Reviewed Original ResearchAdultAgedAged, 80 and overAnimalsAnimals, Genetically ModifiedBiopsyBone Morphogenetic ProteinsEmbryo, NonmammalianFemaleGene Expression Regulation, DevelopmentalGene Expression Regulation, NeoplasticHumansMaleMelanomaMiddle AgedModels, AnimalNeural CrestSignal TransductionSkinSkin NeoplasmsZebrafish
2020
From Tank to Treatment: Modeling Melanoma in Zebrafish
Frantz W, Ceol C. From Tank to Treatment: Modeling Melanoma in Zebrafish. Cells 2020, 9: 1289. PMID: 32455885, PMCID: PMC7290816, DOI: 10.3390/cells9051289.Peer-Reviewed Original Research
2017
The Birth of Malignancy: Embryogenesis and Melanoma
Gramann A, Frantz W, Ceol C. The Birth of Malignancy: Embryogenesis and Melanoma. 2017, 339-355. DOI: 10.1007/978-3-319-41319-8_13.Peer-Reviewed Original Research