Vijay Kuchroo
Research
Publications
2024
TIGIT predominantly regulates the immune response via regulatory T cells
Kurtulus S, Sakuishi K, Ngiow S, Joller N, Tan D, Teng M, Smyth M, Kuchroo V, Anderson A. TIGIT predominantly regulates the immune response via regulatory T cells. Journal Of Clinical Investigation 2024, 134: e183278. PMID: 38949028, PMCID: PMC11213499, DOI: 10.1172/jci183278.Peer-Reviewed Original ResearchAltmetricOncogene induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice
Talvard-Balland N, Braun L, Dixon K, Zwick M, Engel H, Hartmann A, Duquesne S, Penter L, Andrieux G, Rindlisbacher L, Acerbis A, Ehmann J, Köllerer C, Ansuinelli M, Rettig A, Moschallski K, Apostolova P, Brummer T, Illert A, Schramm M, Cheng Y, Köttgen A, Duyster J, Menssen H, Ritz J, Blazar B, Boerries M, Graeff A, Sariipek N, van Galen P, Buescher J, Cabezas-Wallscheid N, Pahl H, Pearce E, Soiffer R, Wu C, Vago L, Becher B, Köhler N, Wertheimer T, Kuchroo V, Zeiser R. Oncogene induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice. Journal Of Clinical Investigation 2024 PMID: 38916965, DOI: 10.1172/jci177460.Peer-Reviewed Original ResearchAltmetricConceptsAcute graft-versus-host diseaseAcute myeloid leukemiaPost-allo-HCTTim-3GVL effectLigand expressionGraft-versus-host diseaseAllogeneic hematopoietic cell transplantationCD8+ T cellsEnhanced GVL effectIFN-g productionLow ligand expressionTim-3 ligandAnti-PD-1TIM-3 blockadeAnti-Tim-3Hematopoietic cell transplantationSurvival of miceCells of patientsAllo-HCTLeukemia relapseCell transplantationCause of deathMyeloid leukemiaT cellsHuman regulatory memory B cells defined by expression of TIM-1 and TIGIT are dysfunctional in multiple sclerosis
Varghese J, Kaskow B, von Glehn F, Case J, Li Z, Julé A, Berdan E, Sui S, Hu Y, Krishnan R, Chitnis T, Kuchroo V, Weiner H, Baecher-Allan C. Human regulatory memory B cells defined by expression of TIM-1 and TIGIT are dysfunctional in multiple sclerosis. Frontiers In Immunology 2024, 15: 1360219. PMID: 38745667, PMCID: PMC11091236, DOI: 10.3389/fimmu.2024.1360219.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsMemory B cell subsetsMemory B cellsB cell subsetsT cell activationB cellsT cellsMultiple sclerosisIL-17ATIM-1Levels of CD4+ T cell activationAllogeneic CD4+ T cellsRelapsing-remittingAssociated with response to therapyAnti-CD20 treated patientsCD4+ T cell activationDouble positive (DPCD4+ T cellsExpression of TIM-1Genes associated with T-cell activationInduction of inflammatory markersInduce T cell proliferationHuman memory B cellsLack of cell surface markersRegulatory B cellsExpression of genes associated with T-cell activationA mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes
Qi L, Iskols M, Shi D, Reddy P, Walker C, Lezgiyeva K, Voisin T, Pawlak M, Kuchroo V, Chiu I, Ginty D, Sharma N. A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Cell 2024, 187: 1508-1526.e16. PMID: 38442711, PMCID: PMC10947841, DOI: 10.1016/j.cell.2024.02.006.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsAuthor Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Huang Y, Zhu C, Kondo Y, Anderson A, Gandhi A, Russell A, Dougan S, Petersen B, Melum E, Pertel T, Clayton K, Raab M, Chen Q, Beauchemin N, Yazaki P, Pyzik M, Ostrowski M, Glickman J, Rudd C, Ploegh H, Franke A, Petsko G, Kuchroo V, Blumberg R. Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature 2024, 626: e19-e19. PMID: 38336833, DOI: 10.1038/s41586-024-07164-y.Peer-Reviewed Original ResearchAltmetricLAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation
Joller N, Anderson A, Kuchroo V. LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation. Immunity 2024, 57: 206-222. PMID: 38354701, PMCID: PMC10919259, DOI: 10.1016/j.immuni.2024.01.010.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLAG-3Tim-3Immune cellsRestraining T-cell responsesImmune checkpoint receptorsT cell responsesRegulation of immune cellsImmune cell typesApplication of therapyPotential tissue toxicityCheckpoint receptorsTissue toxicityT cellsClinical developmentImmune regulationTIGITCell responsesReceptorsCell typesClinicCellsTherapy
2023
Expansion of the Innate Lymphocyte Family: Discovery of IL-22-Producing ILC3s.
Choi H, Kuchroo V. Expansion of the Innate Lymphocyte Family: Discovery of IL-22-Producing ILC3s. The Journal Of Immunology 2023, 211: 1609-1611. PMID: 37983522, DOI: 10.4049/jimmunol.2300390.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsCutting Edge: Serpine1 Negatively Regulates Th1 Cell Responses in Experimental Autoimmune Encephalomyelitis.
Akbar I, Tang R, Baillargeon J, Roy A, Doss P, Zhu C, Kuchroo V, Rangachari M. Cutting Edge: Serpine1 Negatively Regulates Th1 Cell Responses in Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2023, 211: 1762-1766. PMID: 37909848, DOI: 10.4049/jimmunol.2300526.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExperimental autoimmune encephalomyelitisTh1 cellsTim-3Autoimmune encephalomyelitisTh1 cell responsesCell cytokine productionInhibitors of IFNExpression of IFNEAE phenotypeCytokine productionMild diseaseInhibitory receptorsLAG-3T cellsEnhanced severityKnockout miceCell responsesReduced expressionEncephalomyelitisTargeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation
Schnell A, Huang L, Regan B, Singh V, Vonficht D, Bollhagen A, Wang M, Hou Y, Bod L, Sobel R, Chihara N, Madi A, Anderson A, Regev A, Kuchroo V. Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation. Nature Immunology 2023, 24: 1908-1920. PMID: 37828379, PMCID: PMC10864036, DOI: 10.1038/s41590-023-01645-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPeptidoglycan recognition protein 1T cellsMyeloid cellsGenetic deletionPotent antitumor immune responsesCo-inhibitory moleculesExperimental autoimmune encephalomyelitisAntitumor immune responseImmune checkpoint blockadePromising targetSuccessful treatment optionT cell functionCentral nervous systemT cell activationMultiple human cancersAutoimmune neuroinflammationAntitumor immunityAutoimmune encephalomyelitisCheckpoint blockadeCheckpoint moleculesEffector phenotypeAutoimmune diseasesProinflammatory moleculesTissue inflammationTreatment options
2013
Aiolos Silences Il2 Expression and Promotes Th17 Cell Differentiation (S50.002)
Quintana F, Jin H, Burns E, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Kuchroo V. Aiolos Silences Il2 Expression and Promotes Th17 Cell Differentiation (S50.002). Neurology 2013, 80 DOI: 10.1212/wnl.80.7_supplement.s50.002.Peer-Reviewed Original Research