Virupakshi Soppina
Research ScientistCards
About
Research
Publications
2024
Substitution Effects on Subcellular Organelle Localization in Live‐cell Imaging
Ghorpade M, Soppina V, Kanvah S. Substitution Effects on Subcellular Organelle Localization in Live‐cell Imaging. ChemBioChem 2024, 25: e202400273. PMID: 38924297, DOI: 10.1002/cbic.202400273.Peer-Reviewed Original ResearchConceptsintramolecular charge transfersubcellular organelle localizationnitro groupphotophysical propertiescompound suitabilitycharge transferlive-cell imagingorganelle localizationmitochondrial localizationfluorescent probemorpholinefluorescence intensitylipid dropletsliving cellslive-cellsubcellular imagingsubstitution effectlysosomesA multipurpose mitochondrial NIR probe for imaging ferroptosis and mitophagy
Rajput D, Pradhan N, Mansuri S, Soppina V, Kanvah S. A multipurpose mitochondrial NIR probe for imaging ferroptosis and mitophagy. Journal Of Materials Chemistry B 2024, 12: 4698-4707. PMID: 38652007, DOI: 10.1039/d4tb00293h.Peer-Reviewed Original ResearchConceptsintramolecular charge transfersignificant Stokes shiftnear-infrared emissionsynthesized fluorophorespyridinium groupsalkyl substitutioncharge transferalkyl chainsStokes shiftC-12charged centresfluorescent scaffoldfluorophoresmitochondrial selectivitystress-induced mitophagypyridiniumNIR probealkylationmonitoring of viscosityNPslive-cell imagingemitted wavelengthmembrane affinitylysosomal uptakevisualize mitochondriaFluorescent styrenes for mitochondrial imaging and viscosity sensing
Singh D, Ghorpade M, Regar R, Collot M, Soppina V, Kanvah S. Fluorescent styrenes for mitochondrial imaging and viscosity sensing. Photochemistry And Photobiology 2024, 100: 936-945. PMID: 38385897, DOI: 10.1111/php.13910.Peer-Reviewed Original ResearchA two-in-one probe: imaging lipid droplets and endoplasmic reticulum in tandem
Mansuri S, Mahalingavelar P, Soppina V, Kanvah S. A two-in-one probe: imaging lipid droplets and endoplasmic reticulum in tandem. Journal Of Materials Chemistry B 2024, 12: 2028-2041. PMID: 38319378, DOI: 10.1039/d4tb00026a.Peer-Reviewed Original ResearchConceptsendoplasmic reticulumlipid dropletsbiogenesis of lipid dropletsimage lipid dropletssub-cellular dynamicspentafluorophenyl moietyLD targetingcellular processespentafluorophenylER regionexcitation wavelengthlipid synthesisstorage organellessubcellular organellesstrong emissionfluorescent probeoverall hydrophobicityorganellesfluorophoresreticulum
2023
Lipid Droplets Specific Fluorophore for Demarcation of Normal and Diseased Tissues
Rajput D, Mahalingavelar P, Patel D, Bait A, Mandal P, Soppina V, Kanvah S. Lipid Droplets Specific Fluorophore for Demarcation of Normal and Diseased Tissues. ChemBioChem 2023, 25: e202300698. PMID: 37889156, DOI: 10.1002/cbic.202300698.Peer-Reviewed Original ResearchImproved lipophilic probe for visualizing lipid droplets in erastin-induced ferroptosis
Rajput D, Mahalingavelar P, Soppina V, Kanvah S. Improved lipophilic probe for visualizing lipid droplets in erastin-induced ferroptosis. Organic & Biomolecular Chemistry 2023, 21: 8554-8562. PMID: 37853800, DOI: 10.1039/d3ob01545a.Peer-Reviewed Original ResearchFluorescent styryl pyridine- N -oxide probes for imaging lipid droplets
Dubey Y, Mahalingavelar P, Rajput D, Shewale D, Soppina V, Kanvah S. Fluorescent styryl pyridine- N -oxide probes for imaging lipid droplets. Organic & Biomolecular Chemistry 2023, 21: 8393-8402. PMID: 37819137, DOI: 10.1039/d3ob01365k.Peer-Reviewed Original ResearchConceptspyridine-<i>N</i>-oxideelectron-donating amino groupssystematic DFT calculationsimage lipid dropletsLUMO stabilizationacceptor moietiesDFT calculationsimaging of lipid dropletsphotophysical propertiescharge separationredox propertiesabsorption/emission spectradipole momentamino groupsstyryl dyespyridinefluorescent moleculesmovement of lipid dropletswater solubilityfluorescent toolsmembrane synthesisLUMOstyrylmoietysolventN -Functionalized fluorophores: detecting urinary albumin and imaging lipid droplets
Ghorpade M, Regar R, Soppina V, Kanvah S. N -Functionalized fluorophores: detecting urinary albumin and imaging lipid droplets. Organic & Biomolecular Chemistry 2023, 21: 6995-7004. PMID: 37584648, DOI: 10.1039/d3ob01010d.Peer-Reviewed Original ResearchStyryl‐NIR Mitochondrial Probes with Rapid HOCl Detection in Live‐Cells
Rajput D, Mahalingavelar P, Soppina V, Kanvah S. Styryl‐NIR Mitochondrial Probes with Rapid HOCl Detection in Live‐Cells. ChemBioChem 2023, 24: e202300084. PMID: 37067194, DOI: 10.1002/cbic.202300084.Peer-Reviewed Original ResearchConceptsnon-bonding orbitalselectrostatic potential surfacedetection of hypochlorous acidelectronic propertiesintramolecular charge transferendogenous detectioncationic probeTDDFT calculationshypochlorous acidsolvatochromic emissionpotential surfacecharge transferhypochlorous acid detectiondetection limitsub-cellular localizationP-conjugationmitochondrial probescell deathfluorophoresmitochondrialiving cellsenzyme activitylive-cellTDDFTDFTAIE active cyanostilbenes for live-cell imaging of lipid droplets
Dahiwadkar R, Rajput D, Singh D, Soppina V, Kanvah S. AIE active cyanostilbenes for live-cell imaging of lipid droplets. New Journal Of Chemistry 2023, 47: 10016-10024. DOI: 10.1039/d3nj00426k.Peer-Reviewed Original Researchaggregation-induced emissionintramolecular charge transferimaging of lipid dropletsjulolidine groupdynamic light scattering experimentsstable organogelstrifluoromethyl substitutiondifferential scanning calorimetrycharge transferlight scattering experimentsscanning electron microscopyscanning calorimetrycyanostilbenejulolidinefluorophoresorganogelsscattering experimentselectron microscopynaphthaleneoleic acid stimulationliving cellslive cell imagingsolvatochromismsubstituentsacceptor