Tingting Wang
Associate Research ScientistAbout
Research
Publications
2025
AT-56 ENHANCES OOCYTE COMPETENCE IN REPRODUCTIVELY AGED MICE
Hua R, Hai Z, Yeung W, Wang T. AT-56 ENHANCES OOCYTE COMPETENCE IN REPRODUCTIVELY AGED MICE. Fertility And Sterility 2025, 124: e181-e182. DOI: 10.1016/j.fertnstert.2025.07.566.Peer-Reviewed Original ResearchP-623 MFF is required for mitochondria-associated ribonucleoprotein domain coalescence and mRNA translation in mammalian oocytes
Hua R, Zhuo H, Gu J, Du H, Xiao Y, Yeung W, Wang T. P-623 MFF is required for mitochondria-associated ribonucleoprotein domain coalescence and mRNA translation in mammalian oocytes. Human Reproduction 2025, 40: deaf097.929. DOI: 10.1093/humrep/deaf097.929.Peer-Reviewed Original ResearchMitochondrial fission factorMitochondrial membrane potentialRNA-binding proteinsMammalian oocytesMouse oocytesMRNA translational activityMRNA translationGerminal vesicle (GV)-stage oocytesCo-IPMitochondrial dynamicsOocyte meiotic maturationRegulation of mitochondrial dynamicsMetaphase I stageTranslational activityGV stageGV oocytesRegulation of translationJC-1 stainingATP metabolic processRegulate mRNA translationWestern blot analysisGene ontology analysisMeiotic maturationWider implicationsOocyte maturationIndole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming
Zhou S, Wang K, Huang J, Xu Z, Yuan Q, Liu L, Wang Z, Miao J, Wang H, Wang T, Guan W, Ding C. Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming. Gut Microbes 2025, 17: 2508949. PMID: 40409349, PMCID: PMC12118437, DOI: 10.1080/19490976.2025.2508949.Peer-Reviewed Original ResearchConceptsIndole-3-lactic acidColorectal cancer patientsColorectal cancerAryl hydrocarbon receptorDownregulated glucose metabolismPotential clinical therapeutic targetsAnti-apoptotic capabilityInfluence tumor progressionGut microbiota metabolismTumor cell proliferationMetagenomic sequencingPhosphorylation sitesXenograft mouse modelGut microbiotaClinical therapeutic targetMetabolic reprogrammingMicrobiota metabolismP-STAT3Tumor progressionTumor malignancyMouse modelTryptophan metabolismCancer cellsIn vitro experimentsCRC developmentBroxyquinoline targets NLRP3 to inhibit inflammasome activation and alleviate NLRP3-associated inflammatory diseases
Tang H, Zou X, Chen P, Wang Y, Gao S, Wang T, Xu Y, Ji S. Broxyquinoline targets NLRP3 to inhibit inflammasome activation and alleviate NLRP3-associated inflammatory diseases. International Immunopharmacology 2025, 156: 114687. PMID: 40253767, DOI: 10.1016/j.intimp.2025.114687.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisNLR family pyrin domain-containing 3Inflammasome activationInflammatory diseasesASC speck formationInflammasome-associated diseasesNEK7-NLRP3 interactionDamage signalingNF-kB pathwayHost defensePyrin domain-containing 3Speck formationAIM2 inflammasome activationActivation of NLRP3 inflammasomeFamily pyrin domain-containing 3Autoimmune encephalomyelitisMurine modelInterleukin-1bIL-1BInhibiting inflammasome activationNLRP3 inflammasome inhibitorAntimicrobial drugsNF-kBProteinTherapeutic agentsPMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression
Xu Z, Qiao S, Wang Z, Peng C, Hou Y, Liu B, Cao G, Wang T. PMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression. Gut Microbes 2025, 17: 2455508. PMID: 39886799, PMCID: PMC11792855, DOI: 10.1080/19490976.2025.2455508.Peer-Reviewed Original ResearchConceptsPMA1 expressionExtracellular vesiclesCell differentiationAdaptor protein CARD9Th17 cell differentiationCARD9 deficiencyActivity of GAPDHVirulence factorsDecreased enzyme activityPma1Immune responseProteomic analysisCARD9Decreased glycolysisIL-17A productionMucosal immune responsesInduce Th17 cell differentiationMesenteric lymph nodesEditing systemAggravated colitisIL-17ALymph nodesColitis progressionAberrant changesGAPDHSalidroside Improves Oocyte Competence of Reproductively Old Mice by Enhancing Mitophagy
Gu J, Hua R, Wu H, Guo C, Hai Z, Xiao Y, Yeung W, Liu K, Babayev E, Wang T. Salidroside Improves Oocyte Competence of Reproductively Old Mice by Enhancing Mitophagy. Aging Cell 2025, 24: e14475. PMID: 39789811, PMCID: PMC12073897, DOI: 10.1111/acel.14475.Peer-Reviewed Original ResearchReproductively old miceImprove oocyte qualityOocyte qualityOld miceDecline of oocyte qualityDevelopmental competence of oocytesReproductively older womenCompetence of oocytesKnowledge of therapeutic optionsOocyte competenceDevelopmental competenceTherapeutic optionsMaternal ageSpindle/chromosome structureAssisted reproductionOld femaleMiceOocytesOlder womenNatural fertilityFemale fertilityMitochondrial function
2024
Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma
Wang T, Liu L, Fang J, Jin H, Natarajan S, Sheppard H, Lu M, Turner G, Confer T, Johnson M, Steinberg J, Ha L, Yadak N, Jain R, Picketts D, Ma X, Murphy A, Davidoff A, Glazer E, Easton J, Chen X, Wang R, Yang J. Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma. Cancer Research 2024, 85: 424-441. PMID: 39531507, PMCID: PMC11786959, DOI: 10.1158/0008-5472.can-24-1142.Peer-Reviewed Original ResearchPancreatic neuroendocrine tumorsC-MycCre recombinaseAnti-GD2 immunotherapyHigh-risk neuroblastomaDopamine B-hydroxylaseActivity of c-MycFDA-approved inhibitorC-Myc overexpressionC-Myc activityC-myc inductionTesting immunotherapyNeuroendocrine tumorsTargeted therapyTumor typesNeuroblastoma developmentNeuroblastoma tumorsNeuroblastoma oncogenesisEffective therapyTyrosine hydroxylaseTarget cellsTumorNeuroblastomaHuman neuroblastomaGenetic featuresBeautoide A, an Anti‐Osteoclastogenic Sterol from Beauveria sp. NBUF147 Associated with an Irciniidae Sponge from the Marine Mesophotic Zone
Ran G, Wang P, Wang H, Wei T, Liu Y, Jin H, Wang T, He S. Beautoide A, an Anti‐Osteoclastogenic Sterol from Beauveria sp. NBUF147 Associated with an Irciniidae Sponge from the Marine Mesophotic Zone. Chemistry & Biodiversity 2024, 21: e202401689. PMID: 39136520, DOI: 10.1002/cbdv.202401689.Peer-Reviewed Original ResearchMesophotic coral ecosystemsMesophotic zoneCoral ecosystemsBeauveria sp.Prednisolone-induced osteoporotic zebrafishMarine bioresourcesMarineEvaluation of biological activityIrciniidaeSterolsBeauveriaBiological activityEcosystemAnti-osteoclastogenicX-ray crystallographyAnalysis of spectroscopic dataSpongeBioactive moleculesDepthZoneZebrafishBioresourcesChemical investigationX-rayGastrodenol suppresses NLRP3/GSDMD mediated pyroptosis and ameliorates inflammatory diseases
Chen P, Wang Y, Tang H, Liu Z, Wang J, Wang T, Xu Y, Ji S. Gastrodenol suppresses NLRP3/GSDMD mediated pyroptosis and ameliorates inflammatory diseases. Cellular Immunology 2024, 405: 104888. PMID: 39486308, DOI: 10.1016/j.cellimm.2024.104888.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCytokinesEncephalomyelitis, Autoimmune, ExperimentalFemaleGasderminsHumansInflammasomesInflammationIntracellular Signaling Peptides and ProteinsLipopolysaccharidesMacrophagesMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinPeritonitisPhosphate-Binding ProteinsPyroptosisConceptsNucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3Caspase activationRecruitment domainNLRP3 oligomerizationPyrin domain-containing protein 3Gasdermin D (GSDMD)-mediated pyroptosisProtein 3PyroptosisSecretion of pro-inflammatory cytokinesOligomerizationHydrogen bondsApoptosis-associated speck like proteinInflammatory diseasesTherapeutic strategiesHelicobacter pyloriPro-inflammatory cytokinesCaspaseExperimental autoimmune encephalomyelitisLipopolysaccharide (LPS)-inducedProteinGasderminAT-56 RESCUES OOCYTE DYSFUNCTION IN OOCYTE-SPECIFIC KNOCKOUT CLPX MICE BY INHIBITING PGD2 SYNTHESIS
Hua R, Hai Z, Gu J, Du H, Yeung W, Wang T. AT-56 RESCUES OOCYTE DYSFUNCTION IN OOCYTE-SPECIFIC KNOCKOUT CLPX MICE BY INHIBITING PGD2 SYNTHESIS. Fertility And Sterility 2024, 122: e171. DOI: 10.1016/j.fertnstert.2024.07.594.Peer-Reviewed Original Research
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