Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsGreg Rhee, PhD, FACE
Associate Professor Adjunct in PsychiatryDownloadHi-Res Photo
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Associate Professor Adjunct in Psychiatry
Biography
Greg Rhee, PhD, FACE, is Associate Professor of Medicine (Psychiatry) and Public Health (Epidemiology and Biostatistics). He is a pharmaco-epidemiologist and mental health services researcher studying access to care, quality of care, and clinical and patient-reported outcomes in patients with psychiatric and/or substance use disorders. His current research focuses on mood disorders, dementias, and suicide/suicidal behaviors as well as cannabis and opioids.
As an accredited professional statistician (PStat®) certified by the American Statistical Association, his expertise is grounded in (1) population-based observational studies using large databases; (2) systematic reviews and meta-analyses of existing studies; and (3) analyses of clinical trial data. In particular, he has extensive knowledge and experience with administrative claims data (e.g., Medicare and Medicaid), national health and healthcare survey data, and other data sources including electronic health records (e.g., Epic® database from Yale-New Haven Health), RCT data, and mortality data. He also investigates long-term comparative effectiveness and cost-effectiveness of pharmacological and non-pharmacological interventions for psychiatric and/or substance use disorders.
He has 250+ peer-reviewed research articles published in highly respected medical, psychiatric, and healthcare policy journals, such as Lancet, Lancet Neurology, JAMA, JAMA Psychiatry, and American Journal of Psychiatry. He has also been a successful Principal Investigator or Co-Investigator on multiple research projects funded by federal agencies, including Agency for Healthcare Research and Quality (AHRQ), Food and Drug Administration (FDA), and National Institutes of Health (NIH).
Outside Yale Psychiatry, he also serves as an Investigator at the VA Connecticut Healthcare System VISN 1 MIRECC and as a Senior Investigator at the Institute for Health Metrics and Evaluation (IHME).
Last Updated on March 22, 2025.
Departments & Organizations
Education & Training
- NIH Postdoctoral Fellowship
- Yale University School of Medicine (2019)
- PhD
- University of Minnesota, Twin Cities (2017)
- MA
- The University of Chicago (2011)
- AB
- Emory University (2008)
Research
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Overview
Medical Research Interests
Delivery of Health Care; Epidemiologic Methods; Geriatric Psychiatry; Health Services Research; Mental Disorders; Meta-Analysis; Network Meta-Analysis; Population Surveillance; Psychotropic Drugs; Substance-Related Disorders; United States Food and Drug Administration
Public Health Interests
Mental Health; Health Policy; Health Equity, Disparities, Social Determinants and Justice; Aging; Pharmaceuticals and Medical Devices
ORCID
0000-0003-4961-3361
Research at a Glance
Yale Co-Authors
Frequent collaborators of Greg Rhee's published research.
Publications Timeline
A big-picture view of Greg Rhee's research output by year.
Research Interests
Research topics Greg Rhee is interested in exploring.
Joseph Ross, MD, MHS
Samuel Wilkinson, MD
Robert Rosenheck, MD
Sina Nikayin, MD
Gerard Sanacora, PhD, MD
John Havlik, MD, MBA
142Publications
3,460Citations
Substance-Related Disorders
Mental Disorders
Psychotropic Drugs
Delivery of Health Care
Publications
2025
Ketamine and Esketamine: Is There a Meaningful Clinical Difference?
Wilkinson S, Rhee T. Ketamine and Esketamine: Is There a Meaningful Clinical Difference? The Journal Of Clinical Psychiatry 2025, 86 PMID: 41004166, DOI: 10.4088/jcp.25com16003.Peer-Reviewed Original ResearchBeyond symptom improvement: transdiagnostic and disorder‐specific ways to assess functional and quality of life outcomes across mental disorders in adults
Correll C, Cortese S, Solmi M, Boldrini T, Demyttenaere K, Domschke K, Fusar-Poli P, Gorwood P, Harvey P, Keefe R, Knaevelsrud C, Kotov R, Nohr L, Rhee T, Roe D, Rose M, Schneider L, Slade M, Stein D, Sunkel C, McIntyre R. Beyond symptom improvement: transdiagnostic and disorder‐specific ways to assess functional and quality of life outcomes across mental disorders in adults. World Psychiatry 2025, 24: 296-318. PMID: 40948079, PMCID: PMC12434368, DOI: 10.1002/wps.21338.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOutcome domainsMental disordersPersonal recoveryClinical careDomains of self-careGoal of clinical carePersonal recovery outcomesMental health conditionsQuality of life outcomesLeisure time activitiesPost-traumatic stress disorderQuality of lifeClinician-rated measuresDisorder-specific measuresWell-being/life satisfactionSubstance use disordersService useSelf-CareRecovery outcomesHealth conditionsPatient assessmentPersonality disorderAnxiety disordersObsessive-CompulsiveCategorical diagnosisComparing the Cognitive Effects of Repeated Intravenous Ketamine and Electroconvulsive Therapy in Patients With Treatment-Resistant Depression: A Secondary Analysis of the ELEKT-D Trial.
Kumpf K, Wilkinson S, Hu B, Chen R, Krishnan K, Chakrabarti S, Rhee T, Grezmak T, Mathew S, Sanacora G, Murrough J, Goes F, Collins K, Barnett B, Anand A. Comparing the Cognitive Effects of Repeated Intravenous Ketamine and Electroconvulsive Therapy in Patients With Treatment-Resistant Depression: A Secondary Analysis of the ELEKT-D Trial. The Journal Of Clinical Psychiatry 2025, 86 PMID: 40900112, DOI: 10.4088/jcp.25m15781.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTreatment-resistant depressionElectroconvulsive therapyCognitive effectsGlobal self-evaluationsCognitive functionKetamine treatmentCognitive tasksCognitive effects of electroconvulsive therapyIntent-to-treat sampleEffects of electroconvulsive therapyTreated with electroconvulsive therapyRapid-acting antidepressantsIV ketamine treatmentECT-treated patientsSubjective Memory QuestionnaireSuperior cognitive functionMemory Complaint QuestionnaireIntravenous ketamineElectroconvulsive therapy sessionsECT recipientsKetamine-treated patientsTreated with ketamineWithin-group analysisAntidepressant effectsEffects of intravenous ketamineQuestionable Data and Design in Esketamine Study
Wilkinson S, Rhee T. Questionable Data and Design in Esketamine Study. JAMA Psychiatry 2025, 82 PMID: 40833767, DOI: 10.1001/jamapsychiatry.2025.2059.Peer-Reviewed Original ResearchAltmetricA Global Population-Based Study on the Association Between Ketamine and Esketamine With Suicidality Using WHO VigiBase.
Kwan A, Lakhani M, Rosenblat J, Mansur R, Rhee T, Teopiz K, Cao B, Ho R, Wong S, Le G, McIntyre R. A Global Population-Based Study on the Association Between Ketamine and Esketamine With Suicidality Using WHO VigiBase. The Journal Of Clinical Psychiatry 2025, 86 PMID: 40637548, DOI: 10.4088/jcp.24m15534.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSuicidal ideationSuicide attemptsRapid-acting antidepressant effectsConclusion:Methods:Results:Pharmacovigilance cohort studyPopulation-based studyHighest disproportionalityAntidepressant effectsWHO-VigiBaseAntisuicidal effectsEsketamineSuicidal behaviorCohort studyOdds ratioKetamineIdeationSuicideFluoxetineVigiBaseRORDisproportionGlucagon-like Peptide-1 receptor agonists for the prevention and treatment of Parkinson’s disease
Lee S, Yin L, Xiao N, Rhee T, Lo H, Wong S, Fox S, Teopiz K, Lam B, Zheng Y, Le G, Mansur R, Rosenblat J, McIntyre R. Glucagon-like Peptide-1 receptor agonists for the prevention and treatment of Parkinson’s disease. CNS Spectrums 2025, 30: e44. PMID: 40485141, DOI: 10.1017/s109285292510031x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGlucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsGLP-1RAsCentral nervous systemReceptor agonistsEvidence of clinically meaningful benefitFood and Drug Administration (FDA)-approved treatmentsTreatment-emergent adverse eventsParkinson's diseaseEffects of GLP-1RAsEmergent adverse eventsClinically meaningful benefitFDA-approved treatmentClinical trial evidenceNo current therapyTreatment of Parkinson's diseasePreclinical evidenceAdverse eventsCurrent therapiesMeaningful benefitClinical evidenceFeatures of PDTherapeutic benefitTrial evidenceInsulin resistanceA systematic review of anti-suicidal effects of sedative-hypnotics and cognitive behavioral therapy for insomnia
Valentino K, Teopiz K, Wong S, Le G, Badulescu S, Johnson D, Ho R, Rhee T, Cao B, Rosenblat J, Mansur R, McIntyre R. A systematic review of anti-suicidal effects of sedative-hypnotics and cognitive behavioral therapy for insomnia. CNS Spectrums 2025, 30: e45. PMID: 40452498, DOI: 10.1017/s1092852925000318.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsColumbia-Suicide Severity Rating ScaleOrexin receptor antagonistsScale for Suicide IdeationCognitive behavioral therapySuicidal ideationCBT-ISedative-hypnoticsBehavioral therapySuicide completersSuicide attemptsReducing depressive symptom severityEffects of sedative-hypnoticsDepressive symptom severityMeasures of suicidalitySeverity Rating ScaleRisk of suicideSleep-related interventionsAssociated with reduced SIComorbid insomniaSuicidal thoughtsSymptom severityRandomized Controlled TrialsTreating insomniaRating ScaleSleep interventionsSuicide risk in persons with polycystic ovarian syndrome: a systematic review
Wong S, Le G, Lo H, Cao B, Lim P, Rhee T, Ho R, Guillen-Burgos H, Teopiz K, Phan L, Rosenblat J, Zhang M, McIntyre R. Suicide risk in persons with polycystic ovarian syndrome: a systematic review. Annals Of General Psychiatry 2025, 24: 38. PMID: 40457354, PMCID: PMC12128235, DOI: 10.1186/s12991-025-00574-w.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIncreased risk of suicidal ideationRisk of suicidal ideationSuicidal ideationSuicide riskPsychiatric comorbiditiesPresence of mental illnessPrevalence of suicidal ideationIncreased risk of depressionRisk of depressionOvarian syndromePCOS populationPsychiatric comorbiditySuicidal behaviorSuicide attemptsCompleted SuicideIncreased suicidalitySuicide outcomesSelf-harmMental illnessBackgroundPolycystic ovarian syndromeIdeationSuicidePolycystic ovarian syndromeDiagnosis of PCOSResearch vistasThe prevalence, clinical impact, and therapeutic considerations of trauma in adults with bipolar disorder: A systematic review
Xiao K, Sayed H, Xing J, Zhang X, Ai J, Teopiz K, Ho R, Rhee T, Lo H, Guillen-Burgos H, Vinberg M, McIntyre R. The prevalence, clinical impact, and therapeutic considerations of trauma in adults with bipolar disorder: A systematic review. Journal Of Affective Disorders 2025, 388: 119507. PMID: 40449746, DOI: 10.1016/j.jad.2025.119507.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBipolar disorderSevere stressful life eventsChildhood emotional maltreatmentChildhood physical maltreatmentStressful life eventsEffects of traumaImpact of traumaChildhood traumaClinical impactEmotional maltreatmentSymptom severityLife eventsPhysical maltreatmentTherapeutic considerationsIllness severityIntegrated model of careModerating effectTreatment responseTreatment outcomesSystematic reviewAssociated with poor prognosisMaltreatmentModality of treatmentNegative clinical impactHistory of traumaNational Trends in Suicidal Thoughts and Suicide Attempts Among High School Students in the United States
Bommersbach T, Olfson M, Rhee T. National Trends in Suicidal Thoughts and Suicide Attempts Among High School Students in the United States. American Journal Of Psychiatry 2025, 182: 639-659. PMID: 40432341, DOI: 10.1176/appi.ajp.20240706.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPast-year suicidal thoughtsSuicidal thoughtsHigh school studentsHealth risk behaviorsSuicidal symptomsSuicide attemptsNon-Hispanic whitesSchool studentsBehavioral risksBlack studentsNational trendsHigh school seniorsU.S. high school studentsDepressive symptomsAttempted SuicideRisk categoriesEstimate national trendsBiennial cross-sectional surveysMultivariate logistic regressionSuicideYouth Risk Behavior SurveySchool seniorsElevated ratesHealth risk categoriesRisk Behavior Survey
Academic Achievements & Community Involvement
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Activities
activity Journal of Clinical Psychiatry
06/01/2022 - PresentJournal ServiceEditorial Board Memberactivity Depression and Anxiety
10/01/2022 - PresentJournal ServiceAssociate Editoractivity American Journal of Geriatric Psychiatry
2023 - PresentJournal ServiceEditorial Board Memberactivity National Institutes of Health Center for Scientific Review (CSR) - Study Section
2023 - PresentPeer Review Groups and Grant Study SectionsCommittee Member
Honors
honor Delta Omega Honorary Society in Public Health
05/05/2023International AwardDelta Omega (Faculty Mentor)honor Fellow
10/29/2022International AwardAmerican College of EpidemiologyDetailsUnited Stateshonor NIMH Advanced Research Institute (ARI) in Aging and Mental Health
02/01/2021National AwardNational Institute of Mental HealthDetailsUnited Stateshonor Research Career Institute in Mental Health of Aging (CIMA) Award
06/25/2019National AwardNational Institute of Mental HealthDetailsUnited Stateshonor Travel Fellowship
06/25/2019National AwardAssociation for Multidisciplinary Education and Research in Substance Use and Addiction (AMERSA)DetailsUnited States
News
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News
- December 18, 2025Source: BMJ Mental Health
Longitudinal Associations of Electroconvulsive Therapy with All-Cause Mortality and Suicide Deaths in Severe Unipolar or Bipolar Depression: A Systematic Review and Meta-Analysis
- October 30, 2025Source: eClinical Medicine
Analysis: Efficacy of Intranasal Esketamine Versus rTMS for Treatment-Resistant Depression
- September 16, 2025Source: World Psychiatry
Beyond Symptom Improvement: Transdiagnostic and Disorder-Specific Ways to Assess Functional and Quality of Life Outcomes Across Mental Disorders in Adults
- May 29, 2025Source: American Journal of Psychiatry
National Trends in Suicidal Thoughts and Suicide Attempts Among High School Students in the United States
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