About
Titles
Postdoctoral Associate
Biography
Tianyu Zhu received his Ph.D. in Reproductive Medicine from Nanjing Medical University, China, where his doctoral research focused on the molecular mechanisms underlying sperm flagellum formation and male fertility. He subsequently continued his research at Nanjing Medical University, as postdoc and instructor, investigating the molecular regulation of sperm development and function.
From 2023 to 2024, Tianyu trained as a Postdoctoral Research Fellow at Massachusetts General Hospital and Harvard Medical School, where he studied cilia function and vertebrate left-right patterning using zebrafish genetic models and CRISPR-Cas9 genome editing.
In October 2024, Tianyu joined Jean-Ju Chung’s laboratory in department of Cellular and Molecular Physiology at Yale University. His current research focuses on the molecular mechanisms that regulate sperm signaling, motility, and fertilization, with particular interests in CatSper ion channel complexes and PKA-dependent signaling. His broader research interests include sperm flagellar biology, cilia, reproductive biology, and male fertility.
Appointments
Cellular & Molecular Physiology
Postdoctoral AssociatePrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Research Fellow
- Massachusetts General Hospital, Harvard Medical School (2024)
- PhD
- State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Reproductive Medicine (2021)
Research
Publications
2025
Stage-Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis.
Zhu T, Zhu Y, Jiang X, Zhang X, Wang B, Chen Y, Zhao Y, Wang Y, Zhou Q, Han Z, Qi Y, Luo M, Tu H, Hao B, Gao M, Ren J, Zhou X, Zhang X, Chen X, Li H, Huang Q, Situ C, Guo Y, Zhu H, Li Y, Guo X. Stage-Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis. Adv Sci (Weinh) 2025, 12: e08538. PMID: 40903803, DOI: 10.1002/advs.202508538.Peer-Reviewed Original Research
2024
STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation
Chen Y, Luo M, Tu H, Qi Y, Guo Y, Zhang X, Cui Y, Gao M, Zhou X, Zhu T, Zhu H, Situ C, Li Y, Guo X. STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation. Nature Communications 2024, 15: 44. PMID: 38168070, PMCID: PMC10761714, DOI: 10.1038/s41467-023-44337-1.Peer-Reviewed Original Research
2023
STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis
Yu W, Li Y, Chen H, Cui Y, Situ C, Yao L, Zhang X, Lu S, Liu L, Li L, Ren J, Guo Y, Huo Z, Chen Y, Li H, Jiang T, Gu Y, Wang C, Zhu T, Li Y, Hu Z, Guo X. STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis. Molecular & Cellular Proteomics 2023, 22: 100564. PMID: 37146716, PMCID: PMC10245119, DOI: 10.1016/j.mcpro.2023.100564.Peer-Reviewed Original ResearchAbsence of CEP78 causes photoreceptor and sperm flagella impairments in mice and a human individual.
Zhu T, Zhang Y, Sheng X, Zhang X, Chen Y, Zhu H, Guo Y, Qi Y, Zhao Y, Zhou Q, Chen X, Guo X, Zhao C. Absence of CEP78 causes photoreceptor and sperm flagella impairments in mice and a human individual. Elife 2023, 12 PMID: 36756949, DOI: 10.7554/eLife.76157.Peer-Reviewed Original Research
2022
Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse
Li H, Chen H, Zhang X, Qi Y, Wang B, Cui Y, Ren J, Zhao Y, Chen Y, Zhu T, Wang Y, Yao L, Guo Y, Zhu H, Li Y, Situ C, Guo X. Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse. Cellular And Molecular Life Sciences 2022, 79: 467. PMID: 35930080, PMCID: PMC11071816, DOI: 10.1007/s00018-022-04507-8.Peer-Reviewed Original Research
2021
Progress in the genetic studies of spermatogenesis abnormalities.
Zhang X, Zhu T, Zhang Q, Guo X, Wang C, Jin G, Hu Z. Progress in the genetic studies of spermatogenesis abnormalities. Hereditas (Beijing) 2021, 43: 473-486. PMID: 33972217, DOI: 10.16288/j.yczz.20-343.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
[Advances in proteomic studies of post-translational modifications during spermatogenesis].
Zhu T, Li Y, Liu X, Qi Y, Guo X. [Advances in proteomic studies of post-translational modifications during spermatogenesis]. Acta Physiol Sinica 2020, 72: 75-83. PMID: 32099985.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2019
RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila
Wang Y, Xu R, Cheng Y, Cao H, Wang Z, Zhu T, Jiang J, Zhang H, Wang C, Qi L, Liu M, Guo X, Huang J, Sha J. RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila. Journal Of Genetics And Genomics 2019, 46: 281-290. PMID: 31281031, DOI: 10.1016/j.jgg.2019.05.001.Peer-Reviewed Original ResearchThe Protein Phosphorylation Landscape of Mouse Spermatids during Spermiogenesis
Li Y, Cheng Y, Zhu T, Zhang H, Li W, Guo Y, Qi Y, Chen X, Zhang J, Sha J, Zhou Z, Zhu H, Guo X. The Protein Phosphorylation Landscape of Mouse Spermatids during Spermiogenesis. Proteomics 2019, 19: e1900055. PMID: 30901149, DOI: 10.1002/pmic.201900055.Peer-Reviewed Original Research
2018
Generation of isogenic single and multiplex gene knockout mice by base editing-induced STOP
Yang G, Zhu T, Lu Z, Li G, Zhang H, Feng S, Liu Y, Li J, Zhang Y, Chen J, Guo X, Huang X. Generation of isogenic single and multiplex gene knockout mice by base editing-induced STOP. Science Bulletin 2018, 63: 1101-1107. PMID: 36658989, DOI: 10.1016/j.scib.2018.07.002.Peer-Reviewed Original Research
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Yale School of Medicine
333 Cedar St, Sterling Hall of Medicine
New Haven, CT 06510
United States
Locations
Sterling Hall of Medicine
Lab
333 Cedar Street, Wing B , Fl E, Rm 07
New Haven, CT 06510