Sonali Vishal
Associate Research Scientist in PathologyCards
About
Research
Publications
2024
Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43 ribonucleoprotein condensates disrupting mRNA transport and local translation in neurons
Wijegunawardana D, Nayak A, Vishal S, Venkatesh N, Gopal P. Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43 ribonucleoprotein condensates disrupting mRNA transport and local translation in neurons. Developmental Cell 2024, 60: 253-269.e5. PMID: 39419034, PMCID: PMC12063900, DOI: 10.1016/j.devcel.2024.09.023.Peer-Reviewed Original ResearchRNA-binding proteinsAtaxin-2PolyQ expansionTDP-43Like-SmLocal translationAmyotrophic lateral sclerosisDNA-binding proteinsTransactive response DNA-binding proteinLocalization of mRNAAssociated with increased riskRNA metabolismCytoskeletal mRNAsMRNA transportPolyglutamine expansionRNP condensatesMotor neuron axonsRegulatory functionsRibonucleoproteinMotor neuron integrityNeuronal integrityCortical neuronsLiquid-like propertiesNeuronal axonsMotility
2023
Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders
Naskar A, Nayak A, Salaikumaran M, Vishal S, Gopal P. Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders. Frontiers In Molecular Neuroscience 2023, 16: 1242925. PMID: 37720552, PMCID: PMC10502346, DOI: 10.3389/fnmol.2023.1242925.Peer-Reviewed Original ResearchAberrant phase transitionsMRNA transportFormation of ribonucleoproteinMembrane-less organellesPathogenic protein aggregationStress granule assemblyALS/frontotemporal dementiaSynaptic functionNeurodegenerative diseasesProcessing bodiesCajal bodiesRNA processingHigher-order structureSpatiotemporal regulationStress granulesTransport granulesAmyotrophic lateral sclerosisGranule assemblyProtein aggregationBiomolecular condensatesMRNA stabilityGene expressionLocal translationPhysiological functionsRBPs
2022
Sequence Determinants of TDP-43 Ribonucleoprotein Condensate Formation and Axonal Transport in Neurons
Vishal SS, Wijegunawardana D, Salaikumaran MR, Gopal PP. Sequence Determinants of TDP-43 Ribonucleoprotein Condensate Formation and Axonal Transport in Neurons. Frontiers In Cell And Developmental Biology 2022, 10: 876893. PMID: 35646935, PMCID: PMC9133736, DOI: 10.3389/fcell.2022.876893.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosisTDP-43A315TAxonal transportTDP-43 variantsMotor neuron degenerationTDP-43 mutationsNeuron degenerationLateral sclerosisTransport deficitsAnterograde transportNeuronsK mutationDisease-linked mutationsMotilityKey determinantPossible mechanismMutationsPrevious findingsRetrograde motilityTransport granulesAdaptor proteinSclerosisDeterminantsGranule transportChapter 11 Role of AMP-activated protein kinase and sirtuins as antiaging proteins
Ramu M, Vishal S, Gogia N. Chapter 11 Role of AMP-activated protein kinase and sirtuins as antiaging proteins. 2022, 241-278. DOI: 10.1016/b978-0-323-90235-9.00015-x.ChaptersProtein kinaseAMP/ATP ratioDifferent cellular compartmentsCommon cellular targetActivity of AMPKFuel-sensing enzymeAge-associated disordersChapter 11 RoleSirtuin isoformsCellular compartmentsAge-related disordersSirtuin modulatorsSirtuin activityDifferent speciesAMPKCellular targetsAMPK pathwayContext of agingMitochondrial functionMitochondrial disordersPotential therapeutic targetATP ratioAge-related processesKinaseSIRT1
2017
Plakoglobin localization to the cell border restores desmosome function in cells lacking 14-3-3γ
Vishal S, Tilwani S, Dalal S. Plakoglobin localization to the cell border restores desmosome function in cells lacking 14-3-3γ. Biochemical And Biophysical Research Communications 2017, 495: 1998-2003. PMID: 29253567, DOI: 10.1016/j.bbrc.2017.12.080.Peer-Reviewed Original ResearchGeneration of mice with tissue specific transgene expression using sperm mediated gene transfer
VISHAL S, TILWANI S, THORAT R, DALAL S. Generation of mice with tissue specific transgene expression using sperm mediated gene transfer. International Journal Of Pharma And Bio Sciences 2017, 8 DOI: 10.22376/ijpbs.2017.8.2.b324-329.Peer-Reviewed Original Research
2014
14-3-3γ-mediated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo
Sehgal L, Mukhopadhyay A, Rajan A, Khapare N, Sawant M, Vishal S, Bhatt K, Ambatipudi S, Antao N, Alam H, Gurjar M, Basu S, Mathur R, Borde L, Hosing A, Vaidya M, Thorat R, Samaniego F, Kolthur-Seetharam U, Dalal S. 14-3-3γ-mediated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo. Journal Of Cell Science 2014, 127: 2174-2188. PMID: 24610948, DOI: 10.1242/jcs.125807.Peer-Reviewed Original ResearchConceptsCell-cell adhesionMouse testisRegulation of cell-cell adhesionHCT116 cellsMouse testes in vivoMicrotubule-dependent transportKnockdown of KIF5BTestis in vivoAssembly in vitroTestis organizationAdhesion in vitroDesmosomal proteinsPlakoglobinDesmosome formationCell bordersTestisKnockdownHCT116In vivoCellsSpermatogenesisMiceProcess of tissue formationKIF5BMorphogenesis