Shi-Ying Cai, DSc
Senior Research Scientist (Digestive Diseases)Cards
About
Titles
Senior Research Scientist (Digestive Diseases)
Biography
I am a trained molecular biologist. I am associated with Dr. James Boyer and studied molecular mechanisms of bile formation and cholestatic liver injury. My current study is focusing on the mechanism of bile acid initiating inflammatory response in hepatocytes and therapeutic targets of cholestatic liver injury. In addition, I am also interested in using comparative genomic approach to understand the structure and function relationship of bile salt transporters characterized in humans and rodents.
Last Updated on March 18, 2025.
Appointments
Digestive Diseases
Senior Research ScientistPrimary
Other Departments & Organizations
Education & Training
- MS
- University of New Haven (2001)
- DSc
- Beijing Inst of Basic Medical Sciences (1992)
- MS
- Beijing Inst of Basic Medical Sciences (1989)
- BS
- Dalian University of Science and Technology (1986)
Research
Publications
2025
Conjugated bile acid-driven CD14+CD16+ monocyte infiltration promotes cholestatic liver injury by enhancing hepatocyte necroptosis
Zhu Z, Xu Z, Cao X, Zhao N, Lei J, Li L, Li X, Li Y, Li M, Ren T, Liu L, Boyer J, Cai S, Pan Q, Zhang X, Chai J. Conjugated bile acid-driven CD14+CD16+ monocyte infiltration promotes cholestatic liver injury by enhancing hepatocyte necroptosis. JHEP Reports 2025, 7: 101517. PMID: 40980164, PMCID: PMC12448010, DOI: 10.1016/j.jhepr.2025.101517.Peer-Reviewed Original Research
2024
Deficiency of myeloid NPC1 exacerbates liver injury and fibrosis by impairing macrophage efferocytosis
Guan D, Huang P, Liu X, Li Q, Zhang X, Liu N, Wang Y, Wan Y, Chai J, Cai S, Chen R, Ye Z. Deficiency of myeloid NPC1 exacerbates liver injury and fibrosis by impairing macrophage efferocytosis. Journal Of Advanced Research 2024, 72: 213-227. PMID: 39547438, PMCID: PMC12147626, DOI: 10.1016/j.jare.2024.11.020.Peer-Reviewed Original ResearchIntegrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population
Ding J, Liu H, Zhang X, Zhao N, Peng Y, Shi J, Chen J, Chi X, Li L, Zhang M, Liu W, Zhang L, Ouyang J, Yuan Q, Liao M, Tan Y, Li M, Xu Z, Tang W, Xie C, Li Y, Pan Q, Xu Y, Cai S, Byrne C, Targher G, Ouyang X, Zhang L, Jiang Z, Zheng M, Sun F, Chai J. Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population. Science Translational Medicine 2024, 16: eadh9940. PMID: 39504356, DOI: 10.1126/scitranslmed.adh9940.Peer-Reviewed Original ResearchHepatic GDP-fucose transporter SLC35C1 attenuates cholestatic liver injury and inflammation by inducing CEACAM1 N153 fucosylation
Zhang L, Xie P, Li M, Zhang X, Fei S, Zhao N, Li L, Xie Q, Xu Z, Tang W, Zhu G, Zhu Z, Xu Z, Li J, Zhang C, Boyer J, Chen W, Cai S, Pan Q, Chai J. Hepatic GDP-fucose transporter SLC35C1 attenuates cholestatic liver injury and inflammation by inducing CEACAM1 N153 fucosylation. Hepatology 2024, 81: 774-790. PMID: 38985995, PMCID: PMC11825483, DOI: 10.1097/hep.0000000000001003.Peer-Reviewed Original Research
2023
Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans
Pan Q, Zhu G, Xu Z, Zhu J, Ouyang J, Tong Y, Zhao N, Zhang X, Cheng Y, Zhang L, Tan Y, Li J, Zhang C, Chen W, Cai S, Boyer J, Chai J. Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 223-242. PMID: 37146714, PMCID: PMC10394288, DOI: 10.1016/j.jcmgh.2023.04.007.Peer-Reviewed Original ResearchGut Microbiota Deficiency Exacerbates Liver Injury in Bile Duct Ligated Mice via Inflammation and Lipid Metabolism
Zhou X, Zhang X, Zhao N, Zhang L, Qiu W, Song C, Chai J, Cai S, Chen W. Gut Microbiota Deficiency Exacerbates Liver Injury in Bile Duct Ligated Mice via Inflammation and Lipid Metabolism. International Journal Of Molecular Sciences 2023, 24: 3180. PMID: 36834588, PMCID: PMC9960910, DOI: 10.3390/ijms24043180.Peer-Reviewed Original ResearchHepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis
Liao M, Liao J, Qu J, Shi P, Cheng Y, Pan Q, Zhao N, Zhang X, Zhang L, Tan Y, Li Q, Zhu J, Li J, Zhang C, Cai S, Chai J. Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis. Cell Death Discovery 2023, 9: 26. PMID: 36690641, PMCID: PMC9871041, DOI: 10.1038/s41420-023-01326-z.Peer-Reviewed Original ResearchRunt-related transcription factor-1 ameliorates bile acid–induced hepatic inflammation in cholestasis through JAK/STAT3 signaling
Zhang L, Pan Q, Zhang L, Xia H, Liao J, Zhang X, Zhao N, Xie Q, Liao M, Tan Y, Li Q, Zhu J, Li L, Fan S, Li J, Zhang C, Cai S, Boyer J, Chai J. Runt-related transcription factor-1 ameliorates bile acid–induced hepatic inflammation in cholestasis through JAK/STAT3 signaling. Hepatology 2023, 77: 1866-1881. PMID: 36647589, PMCID: PMC10921919, DOI: 10.1097/hep.0000000000000041.Peer-Reviewed Original Research
2021
A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis
Pan Q, Luo G, Qu J, Chen S, Zhang X, Zhao N, Ding J, Yang H, Li M, Li L, Cheng Y, Li X, Xie Q, Li Q, Zhou X, Zou H, Fan S, Zou L, Liu W, Deng G, Cai S, Boyer JL, Chai J. A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis. EMBO Molecular Medicine 2021, 13: emmm202114563. PMID: 34585848, PMCID: PMC8573601, DOI: 10.15252/emmm.202114563.Peer-Reviewed Original Research
2020
The Role of Bile Acid‐Mediated Inflammation in Cholestatic Liver Injury
Cai S, Li M, Boyer J. The Role of Bile Acid‐Mediated Inflammation in Cholestatic Liver Injury. 2020, 728-736. DOI: 10.1002/9781119436812.ch56.Books
Get In Touch
Contacts
Academic Office Number
Mailing Address
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States