Ipek Gassaloglu Guler
Postgraduate AssociateAbout
Research
Publications
Featured Publications
Self-patterning of human stem cells into post-implantation lineages
Pedroza M, Gassaloglu S, Dias N, Zhong L, Hou T, Kretzmer H, Smith Z, Sozen B. Self-patterning of human stem cells into post-implantation lineages. Nature 2023, 622: 574-583. PMID: 37369348, PMCID: PMC10584676, DOI: 10.1038/s41586-023-06354-4.Peer-Reviewed Original ResearchConceptsStem cellsPlacental cell typesPost-implantation embryonic developmentHuman pluripotent stem cellsPluripotent stem cellsHuman embryonic developmentEmbryonic developmentHuman stem cellsCongenital pathologyPost-implantation epiblastDiverse cell statesSingle-cell transcriptomicsAmniotic ectodermExtra-embryonic endodermSpontaneous differentiationSignaling hubThree-dimensional structureSecreted modulatorsCell types
2025
From Single Stem Cells to an In Vitro Model of the Post-implantation Human Embryo: A Step-by-Step Guide
Gassaloglu S, Pedroza M, Sozen B. From Single Stem Cells to an In Vitro Model of the Post-implantation Human Embryo: A Step-by-Step Guide. Methods In Molecular Biology 2025, 1-16. PMID: 40397281, DOI: 10.1007/7651_2025_647.Peer-Reviewed Original ResearchIntegrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model.
Villaronga-Luque A, Savill RG, López-Anguita N, Bolondi A, Garai S, Gassaloglu SI, Rouatbi R, Schmeisser K, Poddar A, Bauer L, Alves T, Traikov S, Rodenfels J, Chavakis T, Bulut-Karslioglu A, Veenvliet JV. Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model. Cell Stem Cell 2025, 32: 759-777.e13. PMID: 40245869, DOI: 10.1016/j.stem.2025.03.012.Peer-Reviewed Original Research
2024
Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids
Bolondi A, Law B, Kretzmer H, Gassaloglu S, Buschow R, Riemenschneider C, Yang D, Walther M, Veenvliet J, Meissner A, Smith Z, Chan M. Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids. Developmental Cell 2024, 59: 1489-1505.e14. PMID: 38579718, PMCID: PMC11187653, DOI: 10.1016/j.devcel.2024.03.024.Peer-Reviewed Original ResearchNeuro-mesodermal progenitorsFate outcomesStem cell-based modelsEmbryonic trunkEnvironmental cuesMorphological phenotypesDownstream lineagesMolecular recordCell-based modelsCell typesTranscriptional signatureComplex tissuesAxial progenitorsLineagesDevelopmental timeNeural lineagesTransient progenitor populationProgenitor populationsDevelopmental windowPhylogeny
2022
Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids.
López-Anguita N, Gassaloglu SI, Stötzel M, Bolondi A, Conkar D, Typou M, Buschow R, Veenvliet JV, Bulut-Karslioglu A. Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids. Development 2022, 149 PMID: 36102628, DOI: 10.1242/dev.200679.Peer-Reviewed Original Research
2021
Generation of Mouse Pluripotent Stem Cell-derived Trunk-like Structures: An in vitro Model of Post-implantation Embryogenesis.
Bolondi A, Haut L, Gassaloglu SI, Burton P, Kretzmer H, Buschow R, Meissner A, Herrmann BG, Veenvliet JV. Generation of Mouse Pluripotent Stem Cell-derived Trunk-like Structures: An in vitro Model of Post-implantation Embryogenesis. Bio Protoc 2021, 11: e4042. PMID: 34250208, DOI: 10.21769/BioProtoc.4042.Peer-Reviewed Original Research
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Mar 20269Monday
Yale Only Ingrid Heumann - Ipek Gassaloglu Guler