Robert Kleven, PhD, MD
Hospital ResidentCards
Contact Info
Radiology and Biomedical Imaging First Year Residents
20 York St.
New Haven, CT 06510
United States
About
Titles
Hospital Resident
Biography
Robert earned his Ph.D. in Biomedical Engineering at the University of Cincinnati in 2020. His dissertation (under the guidance of Dr. Christy Holland) focused on the development and testing of therapeutic ultrasound in the submegahertz range to treat stroke. He is interested in therapeutic ultrasound techniques and large animal models of disease. Robert obtained his Medical Degree at the University of Cincinnati in 2022 and did his intern year as a surgery preliminary intern at Riverside Methodist Hospital in Columbus Ohio.
Appointments
Departments & Organizations
Education & Training
- General Surgery Preliminary Intern
- OhioHealth Riverside Methodist Hospital (2023)
- MD
- University of Cincinnati, College of Medicine (2022)
- PhD
- University of Cincinnati, Biomedical Engineering (2020)
- BA
- Central College, Physics, Chemistry (2013)
Research
Research at a Glance
Publications Timeline
Publications
2023
Effect of Recombinant Tissue Plasminogen Activator and 120-kHz Ultrasound on Porcine Intracranial Thrombus Density.
Kleven RT, Huang S, Ford SM, Sakthivel K, Thomas SR, Zuccarello M, Herr AB, Holland CK. Effect of Recombinant Tissue Plasminogen Activator and 120-kHz Ultrasound on Porcine Intracranial Thrombus Density. Ultrasound Med Biol 2023, 49: 539-548. PMID: 36336551, DOI: 10.1016/j.ultrasmedbio.2022.10.006.Peer-Reviewed Original Research
2021
Accelerated sonothrombolysis with Definity in a xenographic porcine cerebral thromboembolism model.
Kleven RT, Karani KB, Hilvert N, Ford SM, Mercado-Shekhar KP, Racadio JM, Rao MB, Abruzzo TA, Holland CK. Accelerated sonothrombolysis with Definity in a xenographic porcine cerebral thromboembolism model. Sci Rep 2021, 11: 3987. PMID: 33597659, DOI: 10.1038/s41598-021-83442-3.Peer-Reviewed Original Research
2020
Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery.
Kooiman K, Roovers S, Langeveld SAG, Kleven RT, Dewitte H, O'Reilly MA, Escoffre JM, Bouakaz A, Verweij MD, Hynynen K, Lentacker I, Stride E, Holland CK. Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery. Ultrasound Med Biol 2020, 46: 1296-1325. PMID: 32165014, DOI: 10.1016/j.ultrasmedbio.2020.01.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2019
The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy in vitro.
Kleven RT, Karani KB, Salido NG, Shekhar H, Haworth KJ, Mast TD, Tadesse DG, Holland CK. The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy in vitro. Phys Med Biol 2019, 64: 165015. PMID: 31189149, DOI: 10.1088/1361-6560/ab293b.Peer-Reviewed Original ResearchIn vitro characterization of sonothrombolysis and echocontrast agents to treat ischemic stroke.
Shekhar H, Kleven RT, Peng T, Palaniappan A, Karani KB, Huang S, McPherson DD, Holland CK. In vitro characterization of sonothrombolysis and echocontrast agents to treat ischemic stroke. Sci Rep 2019, 9: 9902. PMID: 31289285, DOI: 10.1038/s41598-019-46112-z.Peer-Reviewed Original Research
2018
Effect of Clot Stiffness on Recombinant Tissue Plasminogen Activator Lytic Susceptibility in Vitro.
Mercado-Shekhar KP, Kleven RT, Aponte Rivera H, Lewis R, Karani KB, Vos HJ, Abruzzo TA, Haworth KJ, Holland CK. Effect of Clot Stiffness on Recombinant Tissue Plasminogen Activator Lytic Susceptibility in Vitro. Ultrasound Med Biol 2018, 44: 2710-2727. PMID: 30268531, DOI: 10.1016/j.ultrasmedbio.2018.08.005.Peer-Reviewed Original Research
Academic Achievements and Community Involvement
activity Disorders with Hand and Thoracic Involvement
OtherRadiological Society of North America Annual MeetingDetails11/26/2023 - 11/26/2023Chicago, IL, United StatesAbstract/SynopsisNumerous medical conditions have multiorgan imaging findings. Here, we review specifically the hand and cardiothoracic findings of selected infectious, inflammatory, connective tissue, neoplastic, and hereditary disorders. These correlations are meant to remind the astute clinician that certain hand findings should trigger a careful radiologic evaluation that includes imaging of the chest.
activity Committee Member
CommitteesM1/M2 Curriculum CommitteeDetails2021 - 2022activity Committee Member
CommitteesClinical Core Competencies CommitteeDetails2021 - 2022activity Sonothrombolysis: Effect of 220 kHz insonation scheme
Oral PresentationAnnual Meeting of the World Federation of Ultrasound in Medicine and BiologyDetails09/06/2019 - 09/09/2019Melbourne, VIC, AustraliaSponsored by Wolrd Federation of Ultrasound in Medicine and BiologyCollaborators- Christy HollandUniversity of Cincinnati
- Kunal KaraniUniversity of Cincinnati
- Nuria Gonzalez-SalidoUniversity of Cincinnati
- Himanshu ShekharUniversity of Cincinnati
- Kevin Haworth University of Cincinnati
activity The Effect of Duty Cycle on the Efficacy of 220 kHz Ultrasound-enhanced rt-PA Thrombolysis in vitro
Poster PresentationInternational Society of Therapeutic Ultrasound Annual ConferenceDetails05/14/2018 - 05/17/2018Nashville, TN, United StatesSponsored by International Society of Therapeutic UltrasoundCollaborators- Christy HollandUniversity of Cincinnati
- Himanshu ShekharUniversity of Cincinnati
- Kevin HaworthUniversity of Cincinnati
- Kunal KaraniUniversity of Cincinnati
Get In Touch
Contacts
Radiology and Biomedical Imaging First Year Residents
20 York St.
New Haven, CT 06510
United States