Qingji Xu, PhD
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Postdoctoral AssociateDownloadHi-Res Photo
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Postdoctoral Associate
Appointments
Education & Training
- PhD
- Institute of Biophysics, Chinese Academy of Sciences, Cell Biology (2023)
- BS
- College of Life Sciences, Jilin University, Biopharmaceutical Engineering (2017)
Research
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Overview
Medical Research Interests
Biomarkers, Tumor; Gene Expression Regulation, Neoplastic; Immunotherapy; Melanoma; Molecular Targeted Therapy
ORCID
0000-0002-9524-1848Yan Lab@Yale
Cancer Epigenetics and Stem Cell Biology
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Publications
2024
Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma.
McGeary M, Damsky W, Daniels A, Lang S, Xu Q, Song E, Huet-Calderwood C, Lou H, Paradkar S, Micevic G, Kaech S, Calderwood D, Turk B, Yan Q, Iwasaki A, Bosenberg M. Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma. Cancer Immunology Research 2024, 13: 245-257. PMID: 39589394, DOI: 10.1158/2326-6066.cir-23-0514.Peer-Reviewed Original ResearchCitationsAltmetricConceptsT cell infiltrationMHC-I expressionType I interferonImmune clearanceCD8+ T cell-dependent mannerIncreased CD8+ T cell infiltrationCD8+ T cell infiltrationDecreased MHC-I expressionAnti-cancer immune responseT cell-dependent mannerCD8+ T cellsDecreased T-cell infiltrationComplete tumor clearanceImmunity to melanomaIncreased melanoma growthInflamed tumor microenvironmentLoss of SETDB1Type I interferon receptorTreatment of melanomaType I Interferon SignalingWhole-genome CRISPR screenEndogenous retrovirusesType I interferon expressionMetastatic diseaseTumor clearance
2023
CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway
Chen J, Xu Q, Liu D, Li X, Guo M, Chen X, Liao J, Lei R, Li W, Huang H, Saw P, Song E, Yan X, Nie Y. CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway. Cancer Communications 2023, 43: 1244-1266. PMID: 37856423, PMCID: PMC10631482, DOI: 10.1002/cac2.12495.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMalignant phyllodes tumorProgression of phyllodes tumorsMalignant progression of phyllodes tumorsMalignant progressionDomain-containing protein 2Single-cell RNA sequencingPhyllodes tumorLCCL domain-containing protein 2Pull-down assaysPhosphoinositide 3-kinase (PI3K)/protein kinase BTranscriptome sequencingScRNA-seqCo-ImmunoprecipitationColony formation assayRNA sequencingPrognostic significanceProteomic analysisTreatment targetReal-time PCRLack of effective therapeutic strategiesPrognosis markerCollagen contraction assayMolecular mechanismsAkt pathwayKinase B
2021
Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146
Chen X, Yan H, Liu D, Xu Q, Duan H, Feng J, Yan X, Xie C. Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146. IScience 2021, 24: 102417. PMID: 33997697, PMCID: PMC8093899, DOI: 10.1016/j.isci.2021.102417.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTumor growthActivation of endothelial cellsFunction of CD146Binding to CD146Structural basisInhibitory effectFab complexSignaling pathwayCell migrationDomain 4Cell surfaceXenografted melanomasFab bindingJunction regionAA98Cancer therapyImmune responseCD146Cancer metastasisAdhesion moleculesEndothelial cellsMonoclonal antibodiesTumorCellsBinding
2020
Review and prospect of CD146 research
DUAN H, XIONG C, Lin J, XU Q, LIU J, MA X, WANG D, XIANG J, HE Z, Jing F, YAN X. Review and prospect of CD146 research. Scientia Sinica Vitae 2020, 50: 1339-1387. DOI: 10.1360/ssv-2020-0238.Peer-Reviewed Original ResearchCitationsConceptsMarker of melanomaCell membrane receptorsIntracellular signaling pathwaysPregnancy diseasesTargeted therapyClinical stageAutoimmune diseasesImmune responseCD146Functional mechanismsAdhesion moleculesExtracellular signalsMembrane receptorsDiseaseTumorSignaling pathwayCell migrationPhysiological functionsPathological functionsCellsEarly developmentPregnancyMelanomaPrognosisTherapyCD146, from a melanoma cell adhesion molecule to a signaling receptor
Wang Z, Xu Q, Zhang N, Du X, Xu G, Yan X. CD146, from a melanoma cell adhesion molecule to a signaling receptor. Signal Transduction And Targeted Therapy 2020, 5: 148. PMID: 32782280, PMCID: PMC7421905, DOI: 10.1038/s41392-020-00259-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMelanoma cell adhesion moleculeAdhesion moleculesCell adhesion moleculesOverexpression of CD146Cancer-associated deathsCellular surface receptorsPathological processesProgression of cancerLymphatic metastasisCancer therapyCD146Processes of cellsHomophilic adhesionEndothelial cellsGrowth factorSignaling receptorsPathological processes of cellsSurface receptorsMetastasisMelanomaExtracellular matrixCancerReceptorsBidirectional interactions
2018
CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition
Ma Y, Zhang H, Xiong C, Liu Z, Xu Q, Feng J, Zhang J, Wang Z, Yan X. CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition. Cancer Letters 2018, 430: 201-214. PMID: 29777784, DOI: 10.1016/j.canlet.2018.05.016.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsCadherinsCD146 AntigenCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionFemaleFibroblastsGene Knockout TechniquesHumansMiceMiddle AgedNuclear ProteinsOvarian NeoplasmsOvarySignal TransductionSTAT3 Transcription FactorSurvival RateTransforming Growth Factor betaTwist-Related Protein 1ConceptsMouse embryonic fibroblastsE-cadherin to N-cadherinEpithelial-mesenchymal transitionE-cadherin-to-N-cadherin switchCadherin switchCancer metastatic potentialTGF-b signalingCD146 expressionOvarian cancer cellsTranscriptional responseN-cadherin expressionE-cadherin expressionEmbryonic fibroblastsMechanism of epithelial-mesenchymal transitionERK pathwayCD146 overexpressionN-cadherinCadherinCancer cellsE-cadherinTGF-bOvarian cancer patientsElevated expressionCancer metastasisMetastatic potential
2016
Design of hydrogels of 5-hydroxymethyl tolterodine and their studies on pharmacokinetics, pharmacodynamics and transdermal mechanism
Liu W, Teng L, Yu K, Sun X, Fan C, Long C, Liu N, Li S, Wu B, Xu Q, Sun F, Li Y. Design of hydrogels of 5-hydroxymethyl tolterodine and their studies on pharmacokinetics, pharmacodynamics and transdermal mechanism. European Journal Of Pharmaceutical Sciences 2016, 96: 530-541. PMID: 27789373, DOI: 10.1016/j.ejps.2016.10.024.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsTransdermal mechanismAbsolute bioavailabilityProlonged pharmacological responseDrug skin permeationNo skin irritationOveractive bladder modelTolterodine tabletsUrine outputTransdermal routePharmacodynamic studiesRat modelSkin permeationBladder modelPharmacological responsePharmacokinetic studiesMetabolic differencesStratum corneumSingle-factor experimentsTolterodineSkin irritationSkin developmentDrugFourier transform infrared (FTIR) spectroscopyInfrared (FTIR) spectroscopyRats
Academic Achievements & Community Involvement
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Lauder Hall
Lab
310 Cedar Street, Fl 3, Rm 304
New Haven, CT 06510